SG11201500329WA - Stem cell microparticles - Google Patents
Stem cell microparticlesInfo
- Publication number
- SG11201500329WA SG11201500329WA SG11201500329WA SG11201500329WA SG11201500329WA SG 11201500329W A SG11201500329W A SG 11201500329WA SG 11201500329W A SG11201500329W A SG 11201500329WA SG 11201500329W A SG11201500329W A SG 11201500329WA SG 11201500329W A SG11201500329W A SG 11201500329WA
- Authority
- SG
- Singapore
- Prior art keywords
- stem cell
- cell microparticles
- microparticles
- stem
- cell
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1212848.4A GB201212848D0 (en) | 2012-07-19 | 2012-07-19 | Stem cell product |
| GBGB1302468.2A GB201302468D0 (en) | 2013-02-12 | 2013-02-12 | Stem cell product |
| PCT/GB2013/051923 WO2014013258A1 (fr) | 2012-07-19 | 2013-07-18 | Microparticules de cellules souches |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201500329WA true SG11201500329WA (en) | 2015-02-27 |
Family
ID=48877279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201500329WA SG11201500329WA (en) | 2012-07-19 | 2013-07-18 | Stem cell microparticles |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20150164955A1 (fr) |
| EP (1) | EP2877187B1 (fr) |
| JP (1) | JP2015529450A (fr) |
| KR (1) | KR20150059168A (fr) |
| CN (1) | CN104703609B (fr) |
| AU (1) | AU2013291761B2 (fr) |
| CA (1) | CA2879322A1 (fr) |
| SG (1) | SG11201500329WA (fr) |
| WO (1) | WO2014013258A1 (fr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| KR101640381B1 (ko) * | 2008-02-22 | 2016-07-18 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 중간엽 줄기세포 입자 |
| US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
| EP2882445B1 (fr) | 2012-08-13 | 2019-04-24 | Cedars-Sinai Medical Center | Exosomes et acides micro-ribonucléiques pour la régénération de tissus |
| HUE040323T2 (hu) | 2012-12-21 | 2019-02-28 | Epizyme Inc | PRMT5-inhibitorok és alkalmazásaik |
| EP2956147B1 (fr) * | 2013-02-12 | 2022-08-24 | Reneuron Limited | Procédé de production de microparticules |
| WO2014197421A1 (fr) | 2013-06-05 | 2014-12-11 | Biotime, Inc. | Compositions et procédés pour la régénération de tissus induite chez des espèces mammaliennes |
| GB201317887D0 (en) | 2013-10-09 | 2013-11-20 | Reneuron Ltd | Product |
| AU2014307750A1 (en) * | 2013-08-14 | 2016-02-25 | Reneuron Limited | Stem cell microparticles and miRNA |
| US9982233B2 (en) | 2013-12-12 | 2018-05-29 | Samsung Life Public Welfare Foundation | Method for promoting generation of stem cell-derived exosome by using thrombin |
| JP6353073B2 (ja) | 2013-12-20 | 2018-07-04 | アドヴァンスド リジェン メディカル テクノロジーズ，エルエルシー | 細胞回復のための組成物並びにその作製及び使用方法 |
| US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
| US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
| US9919011B2 (en) | 2014-03-18 | 2018-03-20 | Samsung Life Public Welfare Foundation | Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome |
| KR102511402B1 (ko) | 2014-06-18 | 2023-03-17 | 국립연구개발법인 고쿠리츠간켄큐센터 | 폐암의 검출 키트 또는 디바이스 및 검출 방법 |
| US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
| AU2015327812B2 (en) | 2014-10-03 | 2021-04-15 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| EP3204117A4 (fr) * | 2014-10-06 | 2018-05-09 | Cedars-Sinai Medical Center | Polarisation de macrophages vers un phénotype de cicatrisation par des cellules dérivées de la cardiosphère et par les exosomes sécrétés par ces cellules |
| CN111773173B (zh) | 2014-11-07 | 2024-03-22 | 胞外体干细胞株式会社 | 用于成脂分化诱导、脂肪组织再生、皮肤美白或改善皱纹的包含干细胞来源外泌体的组合物 |
| KR101673059B1 (ko) * | 2014-11-26 | 2016-11-07 | 가톨릭관동대학교산학협력단 | 중간엽줄기세포 유래 미세소포체를 포함하는 발모촉진 또는 창상 치료용 약제학적 조성물 |
| WO2016126122A2 (fr) * | 2015-02-04 | 2016-08-11 | 한양대학교 에리카산학협력단 | Composition pour induction de différenciation de chondrocyte ou régérération de tissu cartilagineux à base d'exosomes extraits de cellules souches se différenciant en chondrocytes |
| US11357798B2 (en) | 2015-08-03 | 2022-06-14 | Osaka University | Mesenchymal stem cell-derived exosome |
| US11857575B2 (en) * | 2015-11-02 | 2024-01-02 | Takeda Pharmaceutical Company Limited | Mesenchymal stem cell-derived exosomes and their uses |
| WO2017123662A1 (fr) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cellules dérivées de cardiosphères et exosomes sécrétés par ces cellules dans le traitement d'une insuffisance cardiaque à fraction d'éjection préservée |
| KR20170085010A (ko) * | 2016-01-12 | 2017-07-21 | 주식회사 강스템바이오텍 | 고함량의 성장인자를 함유한 줄기세포 유래 엑소좀 |
| WO2017156591A1 (fr) * | 2016-03-18 | 2017-09-21 | Murdoch Childrens Research Institute | Miarn d'ostéo-arthrite |
| JP6999575B2 (ja) | 2016-04-29 | 2022-01-18 | アドヴァンスド リジェン メディカル テクノロジーズ，エルエルシー | マイクロｒｎａ組成物並びにその作製及び使用方法 |
| WO2017191234A1 (fr) | 2016-05-06 | 2017-11-09 | Unicyte Ev Ag | Supports pharmaceutiques contenant des miarn pour utilisation dans le traitement des maladies fibrotiques provoquées par l'hyperglycémie |
| US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
| CN105861728A (zh) * | 2016-06-12 | 2016-08-17 | 上海市第十人民医院 | 循环miRNA作为年龄相关黄斑变性诊断标志物中的应用 |
| WO2018057542A1 (fr) | 2016-09-20 | 2018-03-29 | Cedars-Sinai Medical Center | Cellules dérivées de cardiosphères et leurs vésicules extracellulaires pour retarder ou inverser le vieillissement et des troubles liés à l'âge |
| JP6629770B2 (ja) * | 2017-01-19 | 2020-01-15 | シスメックス株式会社 | 細胞の分化状態を評価する方法 |
| JP6918062B2 (ja) * | 2017-01-19 | 2021-08-11 | シスメックス株式会社 | 細胞の分化状態を評価する方法 |
| AU2018255346B2 (en) | 2017-04-19 | 2024-05-02 | Capricor Inc | Methods and compositions for treating skeletal muscular dystrophy |
| KR101985941B1 (ko) * | 2017-05-31 | 2019-06-04 | 충북대학교 산학협력단 | 줄기세포로부터 엑소좀 분비를 촉진시키는 방법 및 줄기세포 유래 엑소좀을 유효성분으로 포함하는 기능성 화장료 조성물 |
| WO2019004436A1 (fr) | 2017-06-29 | 2019-01-03 | 東レ株式会社 | Kit, dispositif et procédé de détection d'un cancer du poumon |
| AU2018308978A1 (en) * | 2017-08-01 | 2020-03-19 | Temple University-Of The Commonwealth System Of Higher Education | Exosomes derived from cortical bone stem cells can augment heart function after cardiac injury |
| GB201716408D0 (en) * | 2017-10-06 | 2017-11-22 | Reneuron Ltd | Stem cell microparticles for cancer therapy |
| CN107937342B (zh) * | 2017-11-06 | 2021-07-06 | 中国人民解放军第四军医大学 | 一种通过内皮细胞来源的外泌体扩增神经干细胞的方法 |
| CN108042805B (zh) * | 2017-11-20 | 2021-03-19 | 华中科技大学 | 一种肿瘤载药微颗粒制剂及其制备方法 |
| CN108553486A (zh) * | 2017-12-13 | 2018-09-21 | 上海市浦东医院 | 一种神经干细胞制剂及其制备方法和应用 |
| WO2019126068A1 (fr) | 2017-12-20 | 2019-06-27 | Cedars-Sinai Medical Center | Vésicules extracellulaires modifiées pour une administration tissulaire améliorée |
| US10717981B2 (en) | 2018-01-18 | 2020-07-21 | Advanced ReGen Medical Technologies, LLC | Therapeutic compositions and methods of making and using the same |
| WO2020097440A1 (fr) * | 2018-11-09 | 2020-05-14 | University Of Maryland, Baltimore | Procédés de prédiction de récupération fonctionnelle de tissu à l'aide d'exosomes circulants dérivés de cellules transplantées |
| IT201900002155A1 (it) * | 2019-02-14 | 2020-08-14 | Univ Degli Studi Padova | Vescicole extracellulari da cellule geneticamente modificate iperesprimenti SerpinB3 per uso come agenti terapeutici |
| CN112143698B (zh) * | 2019-06-28 | 2023-06-06 | 上海嘉慷生物工程有限公司 | 经跨膜IL-21激活的CIK细胞分泌的外泌体及其相关miRNA在抗菌中的应用 |
| KR102312937B1 (ko) * | 2019-11-28 | 2021-10-15 | 의료법인 성광의료재단 | 시신경 질환 예방 및 치료용 약학적 조성물 |
| GB201919021D0 (en) | 2019-12-20 | 2020-02-05 | Reneuron Ltd | Nucleic acid constructs for delivering polynucleotides into exosomes |
| CN111154648B (zh) * | 2019-12-27 | 2022-10-25 | 新乡医学院三全学院 | 一种干细胞源性外泌体培养装置 |
| KR102184428B1 (ko) * | 2020-05-25 | 2020-11-30 | 주식회사 씨케이엑소젠 | 중배엽줄기세포 유래의 엑소좀 생산방법 및 이로부터 제조된 배양액 |
| JP2023533684A (ja) * | 2020-06-24 | 2023-08-04 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 初回刺激された間葉系間質細胞からの臨床使用のためのエキソソームの大規模産生 |
| CN111850047B (zh) * | 2020-07-28 | 2022-08-12 | 枣庄学院 | 一种miR-16与miR-30c联合表达载体及其构建方法与应用 |
| CN112007049A (zh) * | 2020-09-21 | 2020-12-01 | 济南磐升生物技术有限公司 | 一种用于治疗膝骨关节炎的干细胞外泌体组合物 |
| GB202114441D0 (en) | 2021-10-08 | 2021-11-24 | Reneuron Ltd | Proteins and extracellular vesicles |
| WO2023182507A1 (fr) * | 2022-03-24 | 2023-09-28 | 北海道公立大学法人 札幌医科大学 | Composition pharmaceutique, procédé de production d'une culture tridimensionnelle de cellules souches mésenchymateuses, procédé de production d'exosomes, et procédé de production d'une composition pharmaceutique |
Family Cites Families (25)
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|---|---|---|---|---|
| US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5753506A (en) | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| FR2788780B1 (fr) * | 1999-01-27 | 2001-03-30 | Ap Cells Inc | Procede de preparation de vesicules membranaires |
| US6468794B1 (en) | 1999-02-12 | 2002-10-22 | Stemcells, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| EP1261357B1 (fr) | 2000-02-11 | 2010-07-14 | The Schepens Eye Research Institute, Inc. | Isolation et transplantation de cellules souches retiniennes |
| GB2414995B (en) | 2004-06-09 | 2006-11-15 | Univ Edinburgh | Neural stem cells |
| DK1645626T3 (da) | 2004-09-30 | 2008-01-21 | Reneuron Ltd | Cellelinie |
| US20070264712A1 (en) * | 2006-01-10 | 2007-11-15 | Theradigm, Inc. | Expansion and differentiation of neural stem cells under low oxygen conditions |
| CA2711218C (fr) * | 2008-01-04 | 2019-08-06 | Lydac Neuroscience Limited | Procede de production d'une population de cellules differenciees |
| KR101640381B1 (ko) * | 2008-02-22 | 2016-07-18 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 중간엽 줄기세포 입자 |
| KR101067742B1 (ko) * | 2009-01-05 | 2011-09-28 | 서울대학교산학협력단 | 인간 신경 줄기세포 유래 면역조절 활성을 갖는 미세소낭 및 이를 유효성분으로 하는 면역조절제 |
| SG10201403202XA (en) * | 2009-07-23 | 2014-08-28 | Agency Science Tech & Res | Pre-natal mesenchymal stem cells |
| WO2011062244A1 (fr) * | 2009-11-18 | 2011-05-26 | Kuroda Masahiko | Véhicule, son procédé de production, et ses applications |
| WO2011069100A2 (fr) * | 2009-12-04 | 2011-06-09 | Duke University | Microarn et utilisation de celui-ci dans l'identification de malignités à lymphocytes b |
| EP2611918A1 (fr) * | 2010-05-28 | 2013-07-10 | Vereniging Voor Christelijk Hoger Onderwijs, Weten | Arnmi impliqués dans la fonction de barrière hémato-encéphalique |
| US20130150256A1 (en) * | 2010-06-11 | 2013-06-13 | Jane Synnergren | Novel micrornas for the detection and isolation of human embryonic stem cell-derived cardiac cell types |
| GB201011589D0 (en) * | 2010-07-09 | 2010-08-25 | Reneuron Ltd | Therapeutic cells |
| US20140004601A1 (en) * | 2010-12-20 | 2014-01-02 | Agency For Science, Technology And Research | Method of purifying exosomes |
| JP2014526032A (ja) * | 2011-06-07 | 2014-10-02 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． | 癌に対する循環バイオマーカー |
| GB201302468D0 (en) * | 2013-02-12 | 2013-03-27 | Reneuron Ltd | Stem cell product |
| US20150079046A1 (en) * | 2012-04-03 | 2015-03-19 | Reneuron Limited | Stem cell microparticles |
| EP2956147B1 (fr) * | 2013-02-12 | 2022-08-24 | Reneuron Limited | Procédé de production de microparticules |
| AU2014307750A1 (en) * | 2013-08-14 | 2016-02-25 | Reneuron Limited | Stem cell microparticles and miRNA |
| GB201317887D0 (en) * | 2013-10-09 | 2013-11-20 | Reneuron Ltd | Product |
-
2013
- 2013-07-18 EP EP13742261.4A patent/EP2877187B1/fr active Active
- 2013-07-18 SG SG11201500329WA patent/SG11201500329WA/en unknown
- 2013-07-18 AU AU2013291761A patent/AU2013291761B2/en active Active
- 2013-07-18 US US14/414,670 patent/US20150164955A1/en not_active Abandoned
- 2013-07-18 JP JP2015522170A patent/JP2015529450A/ja active Pending
- 2013-07-18 CN CN201380038368.0A patent/CN104703609B/zh active Active
- 2013-07-18 KR KR1020157004106A patent/KR20150059168A/ko not_active Application Discontinuation
- 2013-07-18 CA CA2879322A patent/CA2879322A1/fr not_active Abandoned
- 2013-07-18 WO PCT/GB2013/051923 patent/WO2014013258A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP2877187A1 (fr) | 2015-06-03 |
| AU2013291761B2 (en) | 2018-03-15 |
| KR20150059168A (ko) | 2015-05-29 |
| JP2015529450A (ja) | 2015-10-08 |
| AU2013291761A1 (en) | 2015-02-26 |
| CN104703609B (zh) | 2019-02-19 |
| CA2879322A1 (fr) | 2014-01-23 |
| EP2877187B1 (fr) | 2019-06-12 |
| WO2014013258A1 (fr) | 2014-01-23 |
| CN104703609A (zh) | 2015-06-10 |
| US20150164955A1 (en) | 2015-06-18 |
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