SG11201407089SA - Cyclosporine-containing, non-irritative nanoemulsion opthalmic composition - Google Patents
Cyclosporine-containing, non-irritative nanoemulsion opthalmic compositionInfo
- Publication number
- SG11201407089SA SG11201407089SA SG11201407089SA SG11201407089SA SG11201407089SA SG 11201407089S A SG11201407089S A SG 11201407089SA SG 11201407089S A SG11201407089S A SG 11201407089SA SG 11201407089S A SG11201407089S A SG 11201407089SA SG 11201407089S A SG11201407089S A SG 11201407089SA
- Authority
- SG
- Singapore
- Prior art keywords
- irritative
- nanoemulsion
- cyclosporine
- opthalmic composition
- opthalmic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Dispersion Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biochemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20120045708A KR101211902B1 (ko) | 2012-04-30 | 2012-04-30 | 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물 |
| PCT/KR2013/000509 WO2013165074A1 (ko) | 2012-04-30 | 2013-01-22 | 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407089SA true SG11201407089SA (en) | 2014-12-30 |
Family
ID=47907577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201407089SA SG11201407089SA (en) | 2012-04-30 | 2013-01-22 | Cyclosporine-containing, non-irritative nanoemulsion opthalmic composition |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9320801B2 (ko) |
| EP (1) | EP2845602B1 (ko) |
| JP (1) | JP5986296B2 (ko) |
| KR (1) | KR101211902B1 (ko) |
| CN (1) | CN104302308B (ko) |
| AU (1) | AU2013255231B2 (ko) |
| ES (1) | ES2651412T3 (ko) |
| RU (1) | RU2578415C1 (ko) |
| SG (1) | SG11201407089SA (ko) |
| WO (1) | WO2013165074A1 (ko) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2887923B1 (en) | 2012-08-24 | 2023-04-05 | Sun Pharmaceutical Industries Limited | Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions |
| KR101587412B1 (ko) | 2014-10-17 | 2016-01-21 | 주식회사 휴온스 | 사이클로스포린 및 트레할로스를 포함하는 안과용 조성물 |
| US10455242B2 (en) * | 2015-03-04 | 2019-10-22 | Qualcomm Incorporated | Signaling output indications in codec-hybrid multi-layer video coding |
| KR101587385B1 (ko) * | 2015-07-29 | 2016-01-21 | 국제약품공업주식회사 | 사이클로스포린 함유 무자극성의 안약조성물 및 편리한 제조방법 |
| FR3041883B1 (fr) * | 2015-10-02 | 2019-03-15 | Chu Clermont-Ferrand | Procede de preparation d'un collyre de ciclosporine a |
| PT3373976T (pt) | 2015-11-10 | 2024-04-02 | Sun Pharmaceutical Ind Ltd | Formulações tópicas e suas utilizações |
| WO2017151657A1 (en) | 2016-02-29 | 2017-09-08 | Ocular Technologies Sarl | Topical cyclosporine-containing formulations and uses thereof |
| RU2620568C1 (ru) * | 2016-04-12 | 2017-05-26 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный педиатрический медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПбГПМУ Минздрава России) | Препарат для лечения синдрома "сухого глаза" |
| US10702578B2 (en) | 2017-08-02 | 2020-07-07 | Shilpa Medicare Limited | Ophthalmic compositions of cyclosporine |
| CN109010270B (zh) * | 2018-09-03 | 2021-07-30 | 辅必成（上海）医药科技有限公司 | 一种阳离子材料制备的眼用乳 |
| JP2022548221A (ja) * | 2019-09-09 | 2022-11-17 | テジュン ファーマシューティカル カンパニー リミテッド | シクロスポリンおよびメントール含有ナノエマルジョン点眼組成物およびその製造方法 |
| CN112957450A (zh) * | 2019-12-20 | 2021-06-15 | 艾棣维欣(苏州)生物制药有限公司 | 一种难溶性药物的水溶液及其制备方法 |
| WO2023190283A1 (ja) * | 2022-03-28 | 2023-10-05 | 中外製薬株式会社 | ポリオキシエチレン構造を含む油性成分を含有する化合物製剤 |
| KR20240115545A (ko) * | 2023-01-19 | 2024-07-26 | 주식회사 스카이테라퓨틱스 | 사이클로스포린 나노 분자회합체, 이를 포함하는 점안 조성물 및 그의 제조방법 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0558906A (ja) * | 1991-09-06 | 1993-03-09 | Sankyo Co Ltd | シクロスポリン点眼製剤 |
| ES2098739T3 (es) * | 1992-05-13 | 1997-05-01 | Sandoz Ltd | Composiciones oftalmicas conteniendo una cyclosporin. |
| NZ247516A (en) * | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| WO1998040094A1 (en) * | 1997-03-12 | 1998-09-17 | Abbott Laboratories | Hydrophilic binary systems for the administration of cyclosporine |
| US6057289A (en) * | 1999-04-30 | 2000-05-02 | Pharmasolutions, Inc. | Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system |
| WO2001028518A1 (de) * | 1999-10-20 | 2001-04-26 | Vesifact Ag | Cyclosporine enthaltende mikroemulsion-prekonzentrate und mikroemulsionen |
| US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
| US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| CN100478025C (zh) * | 2005-03-25 | 2009-04-15 | 中国科学院上海药物研究所 | 一种环孢菌素a眼用微乳制剂及其制备方法 |
| KR100669510B1 (ko) | 2005-08-17 | 2007-01-16 | 보람제약주식회사 | 사이크로스포린을 함유한 나노 에멀젼 농축액 조성물 및 그제조방법 |
| CN101484138A (zh) * | 2006-03-07 | 2009-07-15 | 诺瓦瓦克斯有限公司 | 难溶性药用活性成分的纳米乳液和制备该乳液的方法 |
| US10137083B2 (en) * | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
| JP5026824B2 (ja) * | 2006-03-10 | 2012-09-19 | マルホ株式会社 | シクロスポリンを含有する液晶乳化型医薬組成物 |
| PL2071917T3 (pl) * | 2006-09-29 | 2013-04-30 | Infa Sa | System opakowaniowy dla kompozycji farmaceutycznych oraz zestaw do podawania dożylnego |
| CN101244256A (zh) * | 2007-02-16 | 2008-08-20 | 中国科学院上海药物研究所 | 一种环孢菌素a眼用微/亚微乳原位凝胶制剂及其制备方法 |
| MX340897B (es) * | 2007-10-02 | 2016-07-29 | Theranos Inc | Dispositivos modulares de punto de cuidado y usos de los mismos. |
| WO2009046967A1 (en) * | 2007-10-08 | 2009-04-16 | Fovea Pharmaceuticals Sa | Aqueous ophthalmic formulations |
| US20090130198A1 (en) * | 2007-11-21 | 2009-05-21 | Innopharmax Inc. | Pharmaceutical composition with enhanced bioavailability |
| CA2719803A1 (en) | 2008-03-28 | 2009-10-01 | University Of Massachusetts | Compositions and methods for the preparation of nanoemulsions |
| KR101008189B1 (ko) | 2010-07-29 | 2011-01-17 | 에스씨바이오팜 주식회사 | 안구건조증 치료용 사이클로스포린 함유 안과용 나노에멀젼 조성물 |
-
2012
- 2012-04-30 KR KR20120045708A patent/KR101211902B1/ko active IP Right Grant
-
2013
- 2013-01-22 EP EP13784924.6A patent/EP2845602B1/en active Active
- 2013-01-22 JP JP2015508845A patent/JP5986296B2/ja active Active
- 2013-01-22 CN CN201380016584.5A patent/CN104302308B/zh active Active
- 2013-01-22 SG SG11201407089SA patent/SG11201407089SA/en unknown
- 2013-01-22 ES ES13784924.6T patent/ES2651412T3/es active Active
- 2013-01-22 RU RU2014148138/15A patent/RU2578415C1/ru active
- 2013-01-22 AU AU2013255231A patent/AU2013255231B2/en active Active
- 2013-01-22 US US14/398,012 patent/US9320801B2/en active Active
- 2013-01-22 WO PCT/KR2013/000509 patent/WO2013165074A1/ko active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| US20150125494A1 (en) | 2015-05-07 |
| AU2013255231A1 (en) | 2014-10-02 |
| RU2578415C1 (ru) | 2016-03-27 |
| US9320801B2 (en) | 2016-04-26 |
| KR101211902B1 (ko) | 2012-12-13 |
| EP2845602A1 (en) | 2015-03-11 |
| CN104302308B (zh) | 2018-05-29 |
| AU2013255231B2 (en) | 2015-08-13 |
| JP2015514800A (ja) | 2015-05-21 |
| WO2013165074A1 (ko) | 2013-11-07 |
| EP2845602B1 (en) | 2017-10-11 |
| EP2845602A4 (en) | 2015-12-30 |
| ES2651412T3 (es) | 2018-01-26 |
| JP5986296B2 (ja) | 2016-09-06 |
| CN104302308A (zh) | 2015-01-21 |
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