SG11201400538QA - Fusion proteins for treating metabolic disorders - Google Patents

Fusion proteins for treating metabolic disorders

Info

Publication number
SG11201400538QA
SG11201400538QA SG11201400538QA SG11201400538QA SG11201400538QA SG 11201400538Q A SG11201400538Q A SG 11201400538QA SG 11201400538Q A SG11201400538Q A SG 11201400538QA SG 11201400538Q A SG11201400538Q A SG 11201400538QA SG 11201400538Q A SG11201400538Q A SG 11201400538QA
Authority
SG
Singapore
Prior art keywords
fusion proteins
metabolic disorders
treating metabolic
treating
disorders
Prior art date
Application number
SG11201400538QA
Other languages
English (en)
Inventor
Brian R Boettcher
Shari L Caplan
Douglas S Daniels
Norio Hamamatsu
Stuart Licht
Stephen Craig Weldon
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11201400538QA publication Critical patent/SG11201400538QA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
SG11201400538QA 2011-09-26 2012-09-26 Fusion proteins for treating metabolic disorders SG11201400538QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161539280P 2011-09-26 2011-09-26
PCT/US2012/057384 WO2013049247A1 (en) 2011-09-26 2012-09-26 Fusion proteins for treating metabolic disorders

Publications (1)

Publication Number Publication Date
SG11201400538QA true SG11201400538QA (en) 2014-06-27

Family

ID=46970456

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201400538QA SG11201400538QA (en) 2011-09-26 2012-09-26 Fusion proteins for treating metabolic disorders
SG10201602339XA SG10201602339XA (en) 2011-09-26 2012-09-26 Fusion proteins for treating metabolic disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201602339XA SG10201602339XA (en) 2011-09-26 2012-09-26 Fusion proteins for treating metabolic disorders

Country Status (41)

Country Link
US (6) US9006400B2 (forum.php)
EP (2) EP3321276B1 (forum.php)
JP (4) JP6186361B2 (forum.php)
KR (1) KR102085605B1 (forum.php)
CN (2) CN107266579B (forum.php)
AP (1) AP2014007543A0 (forum.php)
AR (2) AR088044A1 (forum.php)
AU (1) AU2012316052A1 (forum.php)
BR (1) BR112014007069B1 (forum.php)
CA (1) CA2849464C (forum.php)
CL (2) CL2014000736A1 (forum.php)
CO (1) CO6920257A2 (forum.php)
CR (1) CR20140140A (forum.php)
CU (2) CU24314B1 (forum.php)
CY (2) CY1120928T1 (forum.php)
DK (2) DK2760475T3 (forum.php)
EA (1) EA039633B1 (forum.php)
ES (2) ES2689762T3 (forum.php)
GT (1) GT201400055A (forum.php)
HR (2) HRP20211575T1 (forum.php)
HU (2) HUE039857T2 (forum.php)
IL (1) IL231533B (forum.php)
IN (1) IN2014DN02043A (forum.php)
JO (1) JO3476B1 (forum.php)
LT (2) LT2760475T (forum.php)
MA (1) MA35437B1 (forum.php)
MX (1) MX350273B (forum.php)
MY (1) MY166059A (forum.php)
PE (2) PE20181159A1 (forum.php)
PL (2) PL2760475T3 (forum.php)
PT (2) PT3321276T (forum.php)
RS (2) RS62341B1 (forum.php)
SG (2) SG11201400538QA (forum.php)
SI (2) SI2760475T1 (forum.php)
SM (1) SMT202100595T1 (forum.php)
TN (1) TN2014000109A1 (forum.php)
TW (1) TWI593708B (forum.php)
UA (1) UA113856C2 (forum.php)
UY (2) UY34346A (forum.php)
WO (1) WO2013049247A1 (forum.php)
ZA (1) ZA201401700B (forum.php)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602007006492D1 (de) 2006-07-25 2010-06-24 Lipoxen Technologies Ltd Derivatisierung des granulozytenkoloniestimulierenden faktors
KR20140012199A (ko) 2007-03-30 2014-01-29 암브룩스, 인코포레이티드 변형된 fgf-21 폴리펩티드 및 그 용도
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT4108671T (pt) 2010-10-01 2024-12-23 Modernatx Inc Nucleosídeos, nucleotídeos e ácidos nucleicos modificados e suas utilizações
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
ES2748038T3 (es) 2011-07-01 2020-03-12 Ngm Biopharmaceuticals Inc Composiciones, usos y métodos para el tratamiento de trastornos y enfermedades metabólicos
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
JO3476B1 (ar) * 2011-09-26 2020-07-05 Novartis Ag بروتينات مندمجة لعلاج الاضطرابات الايضية
US9458214B2 (en) 2011-09-26 2016-10-04 Novartis Ag Dual function fibroblast growth factor 21 proteins
CA2850624A1 (en) 2011-10-03 2013-04-11 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
RS63244B1 (sr) 2011-12-16 2022-06-30 Modernatx Inc Kompozicije modifikovane mrna
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2833894A4 (en) 2012-04-02 2016-08-17 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF COSMETIC PROTEINS AND PEPTIDES
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
EP3798228A1 (en) 2012-11-28 2021-03-31 NGM Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
PL2938740T3 (pl) 2012-12-27 2022-07-11 Ngm Biopharmaceuticals, Inc. Chimeryczne peptydy fgf19 do zastosowania w leczeniu zaburzeń gospodarki kwasami żółciowymi
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
WO2015051214A1 (en) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
US20160235810A1 (en) 2013-10-18 2016-08-18 Novartis Ag Methods of treating diabetes and related disorders
BR112016009099A2 (pt) 2013-10-28 2017-09-19 Ngm Biopharmaceuticals Inc Método para determinar se um indivíduo de teste tendo um distúrbio metabólico é um candidato para o tratamento com uma variante de fgf19, método para determinar se uma variante de fgf19 é um candidato para tratar um indivíduo de teste, uso de uma variante fgf19, modelo para determinar se uma variante de fgf19 é um candidato para prevenir uma doença
PT3097122T (pt) 2014-01-24 2020-07-21 Ngm Biopharmaceuticals Inc Anticorpos de ligação de domínio 2 de beta klotho e métodos de utilização dos mesmos
WO2015138278A1 (en) * 2014-03-11 2015-09-17 Novartis Ag Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling
WO2015183890A2 (en) 2014-05-28 2015-12-03 Ngm Biopharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders and diseases
CA2951153A1 (en) 2014-06-16 2015-12-23 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
FI3209681T3 (fi) * 2014-10-23 2025-05-20 Ngm Biopharmaceuticals Inc Peptidivariantteja käsittäviä farmaseuttisia koostumuksia ja niiden käyttömenetelmiä
MX2017004947A (es) 2014-10-24 2017-06-29 Bristol Myers Squibb Co Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos.
WO2016073855A1 (en) 2014-11-07 2016-05-12 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
KR20160088656A (ko) 2015-01-16 2016-07-26 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
RU2752530C2 (ru) 2015-08-03 2021-07-29 Новартис Аг Способы лечения расстройств, связанных с fgf21
KR102670157B1 (ko) * 2015-10-28 2024-05-29 주식회사유한양행 이중 작용 단백질 및 이를 포함하는 약학적 조성물
ES2871036T3 (es) 2015-11-09 2021-10-28 Ngm Biopharmaceuticals Inc Método para el tratamiento de trastornos relacionados con ácidos biliares
TW201731867A (zh) * 2015-12-02 2017-09-16 賽諾菲公司 Fgf21變異體
BR112018073861A2 (pt) * 2016-05-20 2019-02-26 President And Fellows Of Harvard College métodos de terapia de genes para doenças e condições relacionadas com a idade
MX2018014475A (es) * 2016-05-25 2019-05-23 Univ Texas Métodos y composiciones para el tratamiento de trastornos secretorios.
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技(上海)有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
EP3502143A4 (en) 2016-08-19 2020-07-15 Ampsource Biopharma Shanghai Inc. BINDING PEPTIDE FOR THE CONSTRUCTION OF A FUSION PROTEIN
CN107759696A (zh) * 2016-08-19 2018-03-06 安源医药科技(上海)有限公司 人白介素7融合蛋白及其制备方法
WO2018039557A1 (en) 2016-08-26 2018-03-01 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
WO2018115401A1 (en) 2016-12-22 2018-06-28 Sanofi Fgf21 compound / glp-1r agonist combinations with optimized activity ratio
US12145974B2 (en) 2017-03-14 2024-11-19 Sunshine Lake Pharma Co., Ltd. Dual-target fusion proteins comprising FGF21 and GLP-1, connected through a Fc portion of an immunoglobulin
CN107050429B (zh) * 2017-04-01 2020-12-15 杭州生物医药创新研究中心 人成纤维生长因子21在制备用于治疗脑卒中药物中的应用
KR20200078425A (ko) 2017-05-05 2020-07-01 트레포일 테라퓨틱스, 인크. 재조합 변형된 섬유아세포 성장 인자 및 이의 치료적 용도
CN115109166B (zh) * 2017-11-24 2025-07-18 浙江道尔生物科技有限公司 一种治疗代谢疾病的多结构域活性蛋白
WO2019119673A1 (zh) 2017-12-19 2019-06-27 北京吉源生物科技有限公司 一种双基因修饰的干细胞及其用途
CN119386162A (zh) * 2017-12-22 2025-02-07 诺华股份有限公司 用fgf21变体治疗代谢障碍的方法
US11679143B2 (en) 2018-02-08 2023-06-20 Sunshine Lake Pharma Co., Ltd. FGF21 variant, fusion protein and application thereof
CN112566655B (zh) * 2018-06-21 2025-11-07 赛诺菲 具有优化的活性比率的fgf21化合物/glp-1r激动剂组合
JP7492463B2 (ja) 2018-07-03 2024-05-29 ブリストル-マイヤーズ スクイブ カンパニー Fgf-21製剤
CN111195234B (zh) * 2018-11-16 2022-08-26 鲁南制药集团股份有限公司 一种重组FGF21-Fc融合蛋白冻干粉制剂
EP3736574A1 (en) * 2019-05-07 2020-11-11 Atlas Antibodies AB A formulation comprising an isotope labeled fusion polypeptide
CN111944055B (zh) 2019-05-16 2022-08-02 浙江道尔生物科技有限公司 一种治疗代谢疾病的融合蛋白
CN112386575B (zh) * 2019-08-19 2023-03-21 鲁南制药集团股份有限公司 一种代谢调节融合蛋白的冻干制剂
CN114651003A (zh) 2019-09-10 2022-06-21 黑曜石疗法公司 用于可调调节的ca2-il15融合蛋白
IL293894A (en) 2019-12-20 2022-08-01 Novartis Ag Combination treatment of liver diseases using integrin inhibitors
JP6924291B2 (ja) 2020-01-21 2021-08-25 シャープ株式会社 端末装置、方法、および、集積回路
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation
US20230265152A1 (en) * 2020-07-02 2023-08-24 Sanofi Glp-1r agonist / fgf21 fusion proteins
WO2022101853A1 (en) 2020-11-16 2022-05-19 Novartis Ag Method of determining liver fibrosis
CN113265007B (zh) 2021-06-10 2022-02-15 江南大学 一种治疗代谢疾病的融合蛋白及其制备方法和应用
CN115286705B (zh) * 2021-12-30 2024-05-10 长江大学 一种黄鳝成纤维细胞因子21重组蛋白及其制备方法和应用
WO2023245543A1 (en) * 2022-06-23 2023-12-28 Ampsource Biopharma Shanghai Inc. Uses of fgf21 fusion proteins
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases
WO2025108432A1 (en) * 2023-11-23 2025-05-30 Therorna Shanghai Co., Ltd. Circular rna encoding fgf21 and the use thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
EP0088046B1 (de) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
DE3474511D1 (en) 1983-11-01 1988-11-17 Terumo Corp Pharmaceutical composition containing urokinase
DE3889853D1 (de) 1987-11-05 1994-07-07 Hybritech Inc Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik.
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
WO1993015722A1 (en) 1992-02-07 1993-08-19 Syntex (Usa) Inc. Controlled delivery of pharmaceuticals from preformed porous microparticles
US5234784A (en) 1992-04-01 1993-08-10 Eastman Kodak Company Method of making a projection viewable transparency comprising an electrostatographic toner image
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US6716626B1 (en) 1999-11-18 2004-04-06 Chiron Corporation Human FGF-21 nucleic acids
AU1922101A (en) 1999-11-18 2001-05-30 Chiron Corporation Human fgf-21 gene and gene expression products
CA2395406C (en) 1999-12-23 2013-07-16 Zymogenetics, Inc. Method for treating inflammation
AU2002322394A1 (en) 2001-07-30 2003-02-17 Eli Lilly And Company Method for treating diabetes and obesity
WO2005037867A1 (en) 2003-10-15 2005-04-28 Pdl Biopharma, Inc. ALTERATION OF Fc-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS OF POSITIONS 250, 314 AND/OR 428 OF THE HEAVY CHAIN CONSTANT REGION OF IG
KR20060135648A (ko) * 2003-12-10 2006-12-29 일라이 릴리 앤드 캄파니 섬유모세포 성장인자 21의 뮤테인
SI1751184T1 (sl) * 2004-05-13 2010-01-29 Lilly Co Eli Fgf-21 fuzijski proteini
DE602005016946D1 (de) * 2004-09-02 2009-11-12 Lilly Co Eli Muteine des fibroblasten-wachstumsfaktors 21
EP1846019A2 (en) 2005-01-21 2007-10-24 Eli Lilly And Company Method for treating cardiovascular disease
JOP20190083A1 (ar) * 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
EA021001B1 (ru) 2008-10-24 2015-03-31 Новартис Аг Биосинтетический пирролинкарбоксилизин и сайт-специфичные модификации белка за счет химической модификации остатков пирролинкарбоксилизина и пирролизина
CA2760674A1 (en) 2009-05-05 2010-11-11 Amgen Inc. Fgf21 mutants and uses thereof
EP2427208B1 (en) * 2009-05-05 2017-04-26 Amgen, Inc Fgf21 mutants and uses thereof
MX2011013903A (es) * 2009-06-17 2012-05-08 Amgen Inc Polipeptidos quimericos y usos de los mismos.
CN102939303A (zh) 2009-12-22 2013-02-20 诺瓦提斯公司 四价cd47-抗体恒定区融合蛋白用于治疗
DE102010038140B4 (de) * 2010-10-13 2020-06-18 Hettich-Heinze Gmbh & Co. Kg Beschlag für eine Schiebetür
US9023791B2 (en) 2010-11-19 2015-05-05 Novartis Ag Fibroblast growth factor 21 mutations
JO3476B1 (ar) 2011-09-26 2020-07-05 Novartis Ag بروتينات مندمجة لعلاج الاضطرابات الايضية
US9458214B2 (en) 2011-09-26 2016-10-04 Novartis Ag Dual function fibroblast growth factor 21 proteins
WO2015138278A1 (en) 2014-03-11 2015-09-17 Novartis Ag Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling

Also Published As

Publication number Publication date
LT2760475T (lt) 2018-10-25
DK3321276T3 (da) 2021-10-25
KR20140069250A (ko) 2014-06-09
TW201326213A (zh) 2013-07-01
CN107266579B (zh) 2022-07-12
CY1124697T1 (el) 2022-07-22
JP2020007314A (ja) 2020-01-16
CU20140034A7 (es) 2014-08-28
MA35437B1 (fr) 2014-09-01
US10076554B2 (en) 2018-09-18
CL2016002215A1 (es) 2016-10-28
EA201490695A1 (ru) 2015-10-30
UY34346A (es) 2013-04-30
IL231533B (en) 2018-06-28
US20210386824A1 (en) 2021-12-16
PT2760475T (pt) 2018-10-25
MY166059A (en) 2018-05-22
LT3321276T (lt) 2021-11-10
JP7339372B2 (ja) 2023-09-05
PL3321276T3 (pl) 2022-01-17
CU24206B1 (es) 2016-10-28
US20160193297A1 (en) 2016-07-07
JP2018023370A (ja) 2018-02-15
SI2760475T1 (sl) 2018-10-30
CN103945871A (zh) 2014-07-23
PT3321276T (pt) 2021-10-27
RS62341B1 (sr) 2021-10-29
US11944664B2 (en) 2024-04-02
EA039633B1 (ru) 2022-02-18
BR112014007069B1 (pt) 2020-12-15
HUE055584T2 (hu) 2021-12-28
MX2014003677A (es) 2014-04-30
EP3321276A2 (en) 2018-05-16
CR20140140A (es) 2014-07-15
IL231533A0 (en) 2014-04-30
AR088044A1 (es) 2014-05-07
CL2014000736A1 (es) 2014-10-03
SI3321276T1 (sl) 2021-11-30
CA2849464C (en) 2024-01-30
US11129874B2 (en) 2021-09-28
JO3476B1 (ar) 2020-07-05
PE20141551A1 (es) 2014-10-26
HRP20211575T1 (hr) 2022-02-04
HK1251238A1 (en) 2019-01-25
ES2689762T3 (es) 2018-11-15
RS57868B1 (sr) 2018-12-31
CO6920257A2 (es) 2014-04-10
HUE039857T2 (hu) 2019-02-28
EP3321276B1 (en) 2021-07-28
CA2849464A1 (en) 2013-04-04
EP3321276A3 (en) 2018-06-20
IN2014DN02043A (forum.php) 2015-05-15
US20180369332A1 (en) 2018-12-27
EP2760475B1 (en) 2018-07-04
US20130079500A1 (en) 2013-03-28
US9006400B2 (en) 2015-04-14
CY1120928T1 (el) 2019-12-11
DK2760475T3 (en) 2018-10-15
UA113856C2 (xx) 2017-03-27
TWI593708B (zh) 2017-08-01
UY39119A (es) 2021-04-30
CN107266579A (zh) 2017-10-20
JP6567613B2 (ja) 2019-08-28
US20150166622A1 (en) 2015-06-18
NZ622998A (en) 2016-07-29
PL2760475T3 (pl) 2018-11-30
JP2014534172A (ja) 2014-12-18
WO2013049247A1 (en) 2013-04-04
BR112014007069A2 (pt) 2017-03-28
EP2760475A1 (en) 2014-08-06
ES2895080T3 (es) 2022-02-17
ZA201401700B (en) 2015-01-28
SG10201602339XA (en) 2016-05-30
SMT202100595T1 (it) 2022-01-10
PE20181159A1 (es) 2018-07-19
AR123908A2 (es) 2023-01-25
US20240261372A1 (en) 2024-08-08
MX350273B (es) 2017-08-31
AU2012316052A1 (en) 2014-04-17
JP6186361B2 (ja) 2017-08-23
GT201400055A (es) 2017-09-28
KR102085605B1 (ko) 2020-03-06
AP2014007543A0 (en) 2014-03-31
TN2014000109A1 (en) 2015-07-01
JP2022058546A (ja) 2022-04-12
CU20150171A7 (es) 2016-07-29
US9266935B2 (en) 2016-02-23
CN103945871B (zh) 2017-04-26
CU24314B1 (es) 2018-02-08
HRP20181558T1 (hr) 2018-11-30

Similar Documents

Publication Publication Date Title
IL231533B (en) Fusion proteins for the treatment of metabolic disorders
IL231647A0 (en) Proteins with dual activity for the treatment of metabolic disorders
IL237032A0 (en) Fusion proteins for the treatment of metabolic syndrome
PT2726099T (pt) Método para o tratamento de distúrbios metabólicos
IL229254A0 (en) Therapeutic antibodies
PT2783256T (pt) Óculos terapêuticos
ZA201502595B (en) Therapeutic methods
GB201107189D0 (en) Fusion proteins
GB201114701D0 (en) Fusion proteins
ZA201308992B (en) Therapeutic antibodies
HUP1100282A2 (en) Protein factor
TH148777B (th) ฟิวชั่นโปรตีนสำหรับบำบัดความผิดปกติเกี่ยวกับเมทาบอลิซึม
GB201103169D0 (en) Protein expression
GB201107212D0 (en) Eyewear
GB201104152D0 (en) Fusion Polypeptide