CO6920257A2 - Protéinas de fusión para tratar trastornos metabólicos - Google Patents
Protéinas de fusión para tratar trastornos metabólicosInfo
- Publication number
- CO6920257A2 CO6920257A2 CO14064516A CO14064516A CO6920257A2 CO 6920257 A2 CO6920257 A2 CO 6920257A2 CO 14064516 A CO14064516 A CO 14064516A CO 14064516 A CO14064516 A CO 14064516A CO 6920257 A2 CO6920257 A2 CO 6920257A2
- Authority
- CO
- Colombia
- Prior art keywords
- fusion proteins
- metabolic disorders
- treat metabolic
- treat
- disorders
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 208000030159 metabolic disease Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161539280P | 2011-09-26 | 2011-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6920257A2 true CO6920257A2 (es) | 2014-04-10 |
Family
ID=46970456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14064516A CO6920257A2 (es) | 2011-09-26 | 2014-03-26 | Protéinas de fusión para tratar trastornos metabólicos |
Country Status (41)
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10300144B2 (en) | 2006-07-25 | 2019-05-28 | Lipoxen Technologies Limited | N-terminal polysialylation |
| DK2068909T3 (da) | 2007-03-30 | 2012-08-06 | Ambrx Inc | Modificerede FGF-21-polypeptider og anvendelse heraf |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| SMT202200321T1 (it) | 2010-10-01 | 2022-09-14 | Modernatx Inc | Acidi ribonucleici contenenti n1-metil-pseudouracili e loro usi |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| HRP20191713T1 (hr) | 2011-07-01 | 2019-12-27 | Ngm Biopharmaceuticals, Inc. | Pripravci, uporabe i metode za liječenje metaboličkih poremećaja i bolesti |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| TW201315742A (zh) | 2011-09-26 | 2013-04-16 | Novartis Ag | 治療代謝病症之雙功能蛋白質 |
| TWI593708B (zh) * | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
| ES2911677T3 (es) | 2011-10-03 | 2022-05-20 | Modernatx Inc | Nucleósidos, nucleótidos y ácidos nucleicos modificados, y sus usos |
| US20130156849A1 (en) | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| EP2834260A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| AU2013352363B2 (en) | 2012-11-28 | 2018-04-12 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| PL2938740T3 (pl) | 2012-12-27 | 2022-07-11 | Ngm Biopharmaceuticals, Inc. | Chimeryczne peptydy fgf19 do zastosowania w leczeniu zaburzeń gospodarki kwasami żółciowymi |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| US20160235810A1 (en) | 2013-10-18 | 2016-08-18 | Novartis Ag | Methods of treating diabetes and related disorders |
| KR102178945B1 (ko) | 2013-10-28 | 2020-11-13 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 암 모델 및 관련 방법 |
| SG10201806108TA (en) | 2014-01-24 | 2018-08-30 | Ngm Biopharmaceuticals Inc | Binding proteins and methods of use thereof |
| JP6712230B2 (ja) * | 2014-03-11 | 2020-06-17 | ノバルティス アーゲー | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| EP3209681B1 (en) * | 2014-10-23 | 2025-04-02 | NGM Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
| PL3412302T3 (pl) | 2014-10-24 | 2021-11-02 | Bristol-Myers Squibb Company | Zmodyfikowane polipeptydy fgf-21 i ich zastosowania |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| KR20160088656A (ko) | 2015-01-16 | 2016-07-26 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| CA2994516A1 (en) * | 2015-08-03 | 2017-02-09 | Novartis Ag | Methods of treating fgf21-associated disorders |
| KR102670157B1 (ko) * | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| WO2017083276A1 (en) | 2015-11-09 | 2017-05-18 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| TW201731867A (zh) * | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Ｆｇｆ２１變異體 |
| US12281154B2 (en) * | 2016-05-20 | 2025-04-22 | President And Fellows Of Harvard College | Gene therapy methods for age-related diseases and conditions |
| CA3026510A1 (en) * | 2016-05-25 | 2017-11-30 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of secretory disorders |
| CN107759697B (zh) * | 2016-08-19 | 2023-03-24 | 安源医药科技（上海）有限公司 | 制备融合蛋白的方法 |
| CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| WO2018032638A1 (zh) | 2016-08-19 | 2018-02-22 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| EP3503882A4 (en) | 2016-08-26 | 2020-07-29 | NGM Biopharmaceuticals, Inc. | METHOD FOR TREATING FIBROBLAST GROWTH FACTOR-19-MEDIATED CARCINOMAS AND TUMORS |
| AU2017382038A1 (en) | 2016-12-22 | 2019-08-08 | Sanofi | FGF21 compound / GLP-1R agonist combinations with optimized activity ratio |
| ES3014984T3 (en) * | 2017-03-14 | 2025-04-28 | Sunshine Lake Pharma Co Ltd | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
| CN107050429B (zh) * | 2017-04-01 | 2020-12-15 | 杭州生物医药创新研究中心 | 人成纤维生长因子21在制备用于治疗脑卒中药物中的应用 |
| JP2020518287A (ja) | 2017-05-05 | 2020-06-25 | トレフォイル セラピューティクス，インク． | 組み換え修飾された繊維芽細胞成長因子及びその治療用途 |
| CN115109166B (zh) * | 2017-11-24 | 2025-07-18 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的多结构域活性蛋白 |
| CN111518770B (zh) | 2017-12-19 | 2023-01-06 | 北京吉源生物科技有限公司 | 一种表达glp1和fgf21的干细胞及其用途 |
| HRP20240893T1 (hr) | 2017-12-22 | 2024-10-11 | Novartis Ag | Liječenje metaboličkih poremećaja fgf21 varijantama |
| JP7475276B2 (ja) | 2018-02-08 | 2024-04-26 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | Ｆｇｆ２１バリアント、融合タンパク質及びそれらの適用 |
| JP2021528422A (ja) * | 2018-06-21 | 2021-10-21 | サノフイＳａｎｏｆｉ | 最適化された活性比を有するｆｇｆ２１化合物／ｇｌｐ−１ｒアゴニストの組合せ |
| BR112020026512A2 (pt) | 2018-07-03 | 2021-04-06 | Bristol-Myers Squibb Company | Formulações de fgf-21 |
| CN111195234B (zh) * | 2018-11-16 | 2022-08-26 | 鲁南制药集团股份有限公司 | 一种重组FGF21-Fc融合蛋白冻干粉制剂 |
| EP3736574A1 (en) * | 2019-05-07 | 2020-11-11 | Atlas Antibodies AB | A formulation comprising an isotope labeled fusion polypeptide |
| CN111944055B (zh) | 2019-05-16 | 2022-08-02 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
| CN112386575B (zh) * | 2019-08-19 | 2023-03-21 | 鲁南制药集团股份有限公司 | 一种代谢调节融合蛋白的冻干制剂 |
| AU2020345943A1 (en) | 2019-09-10 | 2022-03-31 | Obsidian Therapeutics, Inc. | CA2-IL15 fusion proteins for tunable regulation |
| KR20220119424A (ko) | 2019-12-20 | 2022-08-29 | 노파르티스 아게 | 인테그린 억제제를 사용한 간 질환의 조합 치료 |
| JP6924291B2 (ja) | 2020-01-21 | 2021-08-25 | シャープ株式会社 | 端末装置、方法、および、集積回路 |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
| US20230265152A1 (en) * | 2020-07-02 | 2023-08-24 | Sanofi | Glp-1r agonist / fgf21 fusion proteins |
| WO2022101853A1 (en) | 2020-11-16 | 2022-05-19 | Novartis Ag | Method of determining liver fibrosis |
| CN113265007B (zh) | 2021-06-10 | 2022-02-15 | 江南大学 | 一种治疗代谢疾病的融合蛋白及其制备方法和应用 |
| CN115286705B (zh) * | 2021-12-30 | 2024-05-10 | 长江大学 | 一种黄鳝成纤维细胞因子21重组蛋白及其制备方法和应用 |
| WO2023245543A1 (en) * | 2022-06-23 | 2023-12-28 | Ampsource Biopharma Shanghai Inc. | Uses of fgf21 fusion proteins |
| WO2024123812A1 (en) | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
| WO2025108432A1 (en) * | 2023-11-23 | 2025-05-30 | Therorna Shanghai Co., Ltd. | Circular rna encoding fgf21 and the use thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
| DE3889853D1 (de) | 1987-11-05 | 1994-07-07 | Hybritech Inc | Polysaccharidmodifizierte Immunglobuline mit reduziertem immunogenem Potential oder verbesserter Pharmakokinetik. |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| WO1993015722A1 (en) | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
| US5234784A (en) | 1992-04-01 | 1993-08-10 | Eastman Kodak Company | Method of making a projection viewable transparency comprising an electrostatographic toner image |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| AU728657B2 (en) | 1996-03-18 | 2001-01-18 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7459540B1 (en) * | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| WO2001036640A2 (en) | 1999-11-18 | 2001-05-25 | Chiron Corporation | Human fgf-21 gene and gene expression products |
| US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
| EP1616575B1 (en) | 1999-12-23 | 2012-06-06 | ZymoGenetics, Inc. | Method for treating inflammation |
| AU2002322394A1 (en) | 2001-07-30 | 2003-02-17 | Eli Lilly And Company | Method for treating diabetes and obesity |
| JP2007531707A (ja) | 2003-10-15 | 2007-11-08 | ピーディーエル バイオファーマ， インコーポレイテッド | ＩＧの重鎖定常領域の位置２５０、３１４および／または４２８の変異誘発によるＦｃ融合タンパク質血清半減期の改変 |
| CA2549249A1 (en) * | 2003-12-10 | 2005-07-07 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| EP1751184B1 (en) * | 2004-05-13 | 2009-09-30 | Eli Lilly And Company | Fgf-21 fusion proteins |
| AU2005283025B2 (en) * | 2004-09-02 | 2011-06-30 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| JP2008528487A (ja) | 2005-01-21 | 2008-07-31 | イーライ リリー アンド カンパニー | 心臓血管疾患を治療する方法 |
| JOP20190083A1 (ar) * | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| WO2010048582A1 (en) | 2008-10-24 | 2010-04-29 | Irm Llc | Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues |
| RS65153B1 (sr) * | 2009-05-05 | 2024-02-29 | Amgen Inc | Fgf21 mutanti i njihove upotrebe |
| CA2760674A1 (en) * | 2009-05-05 | 2010-11-11 | Amgen Inc. | Fgf21 mutants and uses thereof |
| AU2010262927A1 (en) * | 2009-06-17 | 2012-01-19 | Amgen Inc. | Chimeric FGF19 polypeptides and uses thereof |
| EP2516458A1 (en) | 2009-12-22 | 2012-10-31 | Novartis AG | Tetravalent cd47-antibody constant region fusion protein for use in therapy |
| DE102010038140B4 (de) * | 2010-10-13 | 2020-06-18 | Hettich-Heinze Gmbh & Co. Kg | Beschlag für eine Schiebetür |
| US9023791B2 (en) | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| TW201315742A (zh) * | 2011-09-26 | 2013-04-16 | Novartis Ag | 治療代謝病症之雙功能蛋白質 |
| TWI593708B (zh) * | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
| JP6712230B2 (ja) | 2014-03-11 | 2020-06-17 | ノバルティス アーゲー | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
-
2012
- 2012-09-25 TW TW101135183A patent/TWI593708B/zh active
- 2012-09-25 JO JOP/2012/0279A patent/JO3476B1/ar active
- 2012-09-25 US US13/626,194 patent/US9006400B2/en active Active
- 2012-09-25 UY UY34346A patent/UY34346A/es active IP Right Grant
- 2012-09-26 DK DK17201957.2T patent/DK3321276T3/da active
- 2012-09-26 EA EA201490695A patent/EA039633B1/ru unknown
- 2012-09-26 ES ES12768999.0T patent/ES2689762T3/es active Active
- 2012-09-26 PE PE2018001106A patent/PE20181159A1/es unknown
- 2012-09-26 AR ARP120103553 patent/AR088044A1/es active IP Right Grant
- 2012-09-26 CU CUP2015000171A patent/CU24314B1/xx unknown
- 2012-09-26 EP EP12768999.0A patent/EP2760475B1/en active Active
- 2012-09-26 AP AP2014007543A patent/AP2014007543A0/xx unknown
- 2012-09-26 PL PL12768999T patent/PL2760475T3/pl unknown
- 2012-09-26 SG SG10201602339XA patent/SG10201602339XA/en unknown
- 2012-09-26 AU AU2012316052A patent/AU2012316052A1/en not_active Abandoned
- 2012-09-26 KR KR1020147010946A patent/KR102085605B1/ko active Active
- 2012-09-26 SG SG11201400538QA patent/SG11201400538QA/en unknown
- 2012-09-26 HR HRP20181558TT patent/HRP20181558T1/hr unknown
- 2012-09-26 CN CN201280057789.3A patent/CN103945871B/zh active Active
- 2012-09-26 DK DK12768999.0T patent/DK2760475T3/en active
- 2012-09-26 PT PT12768999T patent/PT2760475T/pt unknown
- 2012-09-26 JP JP2014532117A patent/JP6186361B2/ja active Active
- 2012-09-26 PL PL17201957T patent/PL3321276T3/pl unknown
- 2012-09-26 MX MX2014003677A patent/MX350273B/es active IP Right Grant
- 2012-09-26 SI SI201231391T patent/SI2760475T1/sl unknown
- 2012-09-26 PE PE2014000418A patent/PE20141551A1/es active IP Right Grant
- 2012-09-26 MY MYPI2014700650A patent/MY166059A/en unknown
- 2012-09-26 WO PCT/US2012/057384 patent/WO2013049247A1/en not_active Ceased
- 2012-09-26 IN IN2043DEN2014 patent/IN2014DN02043A/en unknown
- 2012-09-26 LT LTEP17201957.2T patent/LT3321276T/lt unknown
- 2012-09-26 UA UAA201402419A patent/UA113856C2/uk unknown
- 2012-09-26 EP EP17201957.2A patent/EP3321276B1/en active Active
- 2012-09-26 ES ES17201957T patent/ES2895080T3/es active Active
- 2012-09-26 SI SI201231952T patent/SI3321276T1/sl unknown
- 2012-09-26 HU HUE12768999A patent/HUE039857T2/hu unknown
- 2012-09-26 SM SM20210595T patent/SMT202100595T1/it unknown
- 2012-09-26 BR BR112014007069-5A patent/BR112014007069B1/pt active IP Right Grant
- 2012-09-26 CN CN201710255835.5A patent/CN107266579B/zh active Active
- 2012-09-26 LT LTEP12768999.0T patent/LT2760475T/lt unknown
- 2012-09-26 CA CA2849464A patent/CA2849464C/en active Active
- 2012-09-26 HU HUE17201957A patent/HUE055584T2/hu unknown
- 2012-09-26 RS RS20211120A patent/RS62341B1/sr unknown
- 2012-09-26 HR HRP20211575TT patent/HRP20211575T1/hr unknown
- 2012-09-26 RS RS20181146A patent/RS57868B1/sr unknown
- 2012-09-26 PT PT17201957T patent/PT3321276T/pt unknown
-
2014
- 2014-03-07 ZA ZA2014/01700A patent/ZA201401700B/en unknown
- 2014-03-12 TN TNP2014000109A patent/TN2014000109A1/en unknown
- 2014-03-13 MA MA36824A patent/MA35437B1/fr unknown
- 2014-03-13 IL IL231533A patent/IL231533B/en active IP Right Grant
- 2014-03-25 CL CL2014000736A patent/CL2014000736A1/es unknown
- 2014-03-26 CO CO14064516A patent/CO6920257A2/es unknown
- 2014-03-26 CR CR20140140A patent/CR20140140A/es unknown
- 2014-03-26 GT GT201400055A patent/GT201400055A/es unknown
- 2014-03-26 CU CUP2014000034A patent/CU24206B1/es active IP Right Grant
-
2015
- 2015-02-24 US US14/630,206 patent/US9266935B2/en active Active
-
2016
- 2016-01-04 US US14/987,338 patent/US10076554B2/en active Active
- 2016-09-02 CL CL2016002215A patent/CL2016002215A1/es unknown
-
2017
- 2017-07-28 JP JP2017146984A patent/JP6567613B2/ja active Active
-
2018
- 2018-08-30 US US16/117,960 patent/US11129874B2/en active Active
- 2018-10-03 CY CY181101017T patent/CY1120928T1/el unknown
-
2019
- 2019-07-31 JP JP2019141242A patent/JP2020007314A/ja not_active Withdrawn
-
2021
- 2021-03-08 UY UY0001039119A patent/UY39119A/es not_active Application Discontinuation
- 2021-08-24 US US17/410,307 patent/US11944664B2/en active Active
- 2021-10-06 CY CY20211100868T patent/CY1124697T1/el unknown
- 2021-10-25 AR ARP210102949A patent/AR123908A2/es unknown
-
2022
- 2022-01-11 JP JP2022002030A patent/JP7339372B2/ja active Active
-
2024
- 2024-02-07 US US18/435,440 patent/US20240261372A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6920257A2 (es) | Protéinas de fusión para tratar trastornos metabólicos | |
| CO6920258A2 (es) | Proteínas de función dual para tratar trastornos metabólicos | |
| BR112013023241A8 (pt) | melhorias para entidades biológicas imobilizadas | |
| PL2928905T3 (pl) | Sposób oczyszczania białek terapeutycznych | |
| CO6842021A2 (es) | Análogos de ácido epoxieicosatrienoico y métodos para elaborarlosy utilizarlos | |
| DK2783256T3 (da) | Terapeutiske briller | |
| EP2698386A4 (en) | FUSION PROTEIN | |
| BR112013023465A2 (pt) | método para produzir l-cisteína | |
| BR112013031686A2 (pt) | fusão de moléculas bioativas | |
| IL229081A0 (en) | Isoxazolines as therapeutic agents | |
| BR302012000184S1 (pt) | "configuração aplicada em aparelho para laboratório" | |
| CO6880064A2 (es) | Métodos terapéuticos | |
| BR112014003151A2 (pt) | métodos para produzir biodiesel | |
| FI20115288L (fi) | Murskain | |
| BR112013030090A2 (pt) | métodos para tratar biomassa | |
| TH148777B (th) | ฟิวชั่นโปรตีนสำหรับบำบัดความผิดปกติเกี่ยวกับเมทาบอลิซึม | |
| BR302012002119S1 (pt) | Configuração aplicada em farol para motoneta | |
| ES1075130Y (es) | Ortesis terapeutica para miembro inferior | |
| ES1075577Y (es) | Corbata para solapar | |
| ES1075462Y (es) | Pulsometro para evitar la somnolencia | |
| BRDI7106280S (pt) | Configuração aplicada em paliteiro | |
| BRDI7100220S (pt) | Configuração aplicada em desensiladeira | |
| ES1075603Y (es) | Objeto terapeutico | |
| ES1077877Y (es) | Triciclo para derrapar. |