CU20150171A7 - Proteínas de fusión que comprenden factor de crecimiento de fibroblastos útil en desórdenes metabólicos - Google Patents

Proteínas de fusión que comprenden factor de crecimiento de fibroblastos útil en desórdenes metabólicos

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Publication number
CU20150171A7
CU20150171A7 CUP2015000171A CU20150171A CU20150171A7 CU 20150171 A7 CU20150171 A7 CU 20150171A7 CU P2015000171 A CUP2015000171 A CU P2015000171A CU 20150171 A CU20150171 A CU 20150171A CU 20150171 A7 CU20150171 A7 CU 20150171A7
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CU
Cuba
Prior art keywords
growth factor
fusion proteins
fibroblast growth
metabolic disorders
include useful
Prior art date
Application number
CUP2015000171A
Other languages
English (en)
Other versions
CU24314B1 (es
Inventor
Brian R Boettcher
Shari L Caplan
Douglas S Daniels
Norio Hamamatsu
Stuart Licht
Stephen Craig Weldon
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20150171A7 publication Critical patent/CU20150171A7/es
Publication of CU24314B1 publication Critical patent/CU24314B1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a la identificación de proteínas de fusión que comprenden variantes polipeptídicos y proteicos del factor de crecimiento de fibroblastos 21 (FGF21) que tienen propiedades farmacéuticas mejoradas. También se describen métodos para el tratamiento de trastornos asociados con el FGF21, incluyendo trastornos mEtabólicos.
CUP2015000171A 2011-09-26 2012-09-26 Proteínas de fusión que comprenden factor de crecimiento de fibroblastos útil en desórdenes metabólicos CU24314B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161539280P 2011-09-26 2011-09-26
PCT/US2012/057384 WO2013049247A1 (en) 2011-09-26 2012-09-26 Fusion proteins for treating metabolic disorders

Publications (2)

Publication Number Publication Date
CU20150171A7 true CU20150171A7 (es) 2016-07-29
CU24314B1 CU24314B1 (es) 2018-02-08

Family

ID=46970456

Family Applications (2)

Application Number Title Priority Date Filing Date
CUP2015000171A CU24314B1 (es) 2011-09-26 2012-09-26 Proteínas de fusión que comprenden factor de crecimiento de fibroblastos útil en desórdenes metabólicos
CUP2014000034A CU24206B1 (es) 2011-09-26 2014-03-26 Proteínas de fusión que comprenden factor de crecimiento de fibroblastos útil en desórdenes metabólicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CUP2014000034A CU24206B1 (es) 2011-09-26 2014-03-26 Proteínas de fusión que comprenden factor de crecimiento de fibroblastos útil en desórdenes metabólicos

Country Status (41)

Country Link
US (5) US9006400B2 (es)
EP (2) EP2760475B1 (es)
JP (4) JP6186361B2 (es)
KR (1) KR102085605B1 (es)
CN (2) CN103945871B (es)
AP (1) AP2014007543A0 (es)
AR (2) AR088044A1 (es)
AU (1) AU2012316052A1 (es)
BR (1) BR112014007069B1 (es)
CA (1) CA2849464C (es)
CL (2) CL2014000736A1 (es)
CO (1) CO6920257A2 (es)
CR (1) CR20140140A (es)
CU (2) CU24314B1 (es)
CY (2) CY1120928T1 (es)
DK (2) DK2760475T3 (es)
EA (1) EA039633B1 (es)
ES (2) ES2895080T3 (es)
GT (1) GT201400055A (es)
HK (1) HK1251238A1 (es)
HR (2) HRP20211575T1 (es)
HU (2) HUE039857T2 (es)
IL (1) IL231533B (es)
IN (1) IN2014DN02043A (es)
JO (1) JO3476B1 (es)
LT (2) LT2760475T (es)
MA (1) MA35437B1 (es)
MX (1) MX350273B (es)
MY (1) MY166059A (es)
PE (2) PE20141551A1 (es)
PL (2) PL3321276T3 (es)
PT (2) PT3321276T (es)
RS (2) RS57868B1 (es)
SG (2) SG10201602339XA (es)
SI (2) SI3321276T1 (es)
TN (1) TN2014000109A1 (es)
TW (1) TWI593708B (es)
UA (1) UA113856C2 (es)
UY (2) UY34346A (es)
WO (1) WO2013049247A1 (es)
ZA (1) ZA201401700B (es)

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