SG10202007111TA - Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors - Google Patents
Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitorsInfo
- Publication number
- SG10202007111TA SG10202007111TA SG10202007111TA SG10202007111TA SG10202007111TA SG 10202007111T A SG10202007111T A SG 10202007111TA SG 10202007111T A SG10202007111T A SG 10202007111TA SG 10202007111T A SG10202007111T A SG 10202007111TA SG 10202007111T A SG10202007111T A SG 10202007111TA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- treating cancer
- axis binding
- mek inhibitors
- binding antagonists
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462024988P | 2014-07-15 | 2014-07-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202007111TA true SG10202007111TA (en) | 2020-09-29 |
Family
ID=53783950
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202007111TA SG10202007111TA (en) | 2014-07-15 | 2015-07-15 | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
SG11201700074YA SG11201700074YA (en) | 2014-07-15 | 2015-07-15 | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700074YA SG11201700074YA (en) | 2014-07-15 | 2015-07-15 | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
Country Status (17)
Country | Link |
---|---|
US (2) | US10946093B2 (ja) |
EP (2) | EP3563870A1 (ja) |
JP (2) | JP6673896B2 (ja) |
KR (1) | KR20170026630A (ja) |
CN (2) | CN106573060A (ja) |
AR (1) | AR101210A1 (ja) |
AU (1) | AU2015289672A1 (ja) |
BR (1) | BR112017000672A2 (ja) |
CA (1) | CA2954508A1 (ja) |
ES (1) | ES2742500T3 (ja) |
IL (2) | IL250021B (ja) |
MX (1) | MX2017000546A (ja) |
PL (1) | PL3169361T3 (ja) |
RU (1) | RU2733735C2 (ja) |
SG (2) | SG10202007111TA (ja) |
WO (1) | WO2016011160A1 (ja) |
ZA (1) | ZA201701109B (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA026924B1 (ru) | 2011-08-01 | 2017-05-31 | Дженентек, Инк. | Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek |
US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
AR101210A1 (es) | 2014-07-15 | 2016-11-30 | Genentech Inc | Métodos de tratamiento de cáncer usando antagonistas de unión al eje pd-1 e inhibidores de mek |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
KR20180040138A (ko) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 |
AU2017205089B2 (en) | 2016-01-08 | 2023-10-05 | F. Hoffmann-La Roche Ag | Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies |
MX2018012132A (es) * | 2016-04-07 | 2019-03-28 | Chemocentryx Inc | Reduccion de carga tumoral mediante administracion de antagonistas de ccr1 en combinacion con inhibidores de muerte-1 programada (pd-1) o inhibidores de ligando-1 de muerte-1 programada (pd-l1). |
RU2018145184A (ru) * | 2016-05-26 | 2020-06-26 | Мерк Патент Гмбх | Pd-1 / pd-l1 ингибиторы для лечения злокачественного новообразования |
JP2019517549A (ja) * | 2016-06-10 | 2019-06-24 | ノバルティス アーゲー | C−raf阻害薬の治療的使用 |
EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
CN108503691B (zh) * | 2017-02-25 | 2021-07-23 | 复旦大学 | 一种人pd-l1蛋白高亲和性肽及其应用 |
CA3057744A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-cd25 antibody-drug conjugate |
US20200129637A1 (en) | 2017-04-20 | 2020-04-30 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
PT3630112T (pt) | 2017-06-02 | 2024-04-23 | Bayer Healthcare Llc | Combinação de regorafenib e nivolumab para tratamento de cancro |
KR102442736B1 (ko) | 2017-06-14 | 2022-09-16 | 에이디씨 테라퓨틱스 에스에이 | 항-cd19 adc의 투여를 위한 투약량 체제 |
WO2019023786A1 (en) * | 2017-08-01 | 2019-02-07 | University Health Network | COMBINED THERAPIES FOR THE INHIBITION OF TTK PROTEIN KINASE |
BR112020006371A2 (pt) * | 2017-10-13 | 2020-09-29 | Merck Patent Gmbh | combinação de um inibidor de parp e um antagonista de ligação de eixo de pd-1 |
US20200368205A1 (en) * | 2018-01-10 | 2020-11-26 | Array Biopharma Inc. | Methods and combination therapy to treat cancer |
CN113286616A (zh) | 2018-05-23 | 2021-08-20 | Adc治疗有限公司 | 分子佐剂 |
WO2020052551A1 (en) * | 2018-09-10 | 2020-03-19 | Genesail Biotech (Shanghai) Co. Ltd. | A modified oncolytic virus, composition and use thereof |
CN109053891B (zh) * | 2018-09-17 | 2021-12-21 | 苏州泓迅生物科技股份有限公司 | 一种抗pd-l1抗体及其制备方法和应用 |
CN109879855B (zh) * | 2019-03-26 | 2021-01-05 | 中国医学科学院医药生物技术研究所 | 靶向肿瘤细胞表面pd-l1分子的抑制剂及其应用 |
GB201917254D0 (en) | 2019-11-27 | 2020-01-08 | Adc Therapeutics Sa | Combination therapy |
CN110981943B (zh) * | 2019-12-02 | 2021-08-03 | 清华大学 | 多肽及其在制备药物中的用途和药物 |
GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
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-
2015
- 2015-07-15 AR ARP150102249A patent/AR101210A1/es unknown
- 2015-07-15 JP JP2017501642A patent/JP6673896B2/ja active Active
- 2015-07-15 EP EP19172991.2A patent/EP3563870A1/en not_active Withdrawn
- 2015-07-15 ES ES15747647T patent/ES2742500T3/es active Active
- 2015-07-15 SG SG10202007111TA patent/SG10202007111TA/en unknown
- 2015-07-15 AU AU2015289672A patent/AU2015289672A1/en not_active Abandoned
- 2015-07-15 BR BR112017000672A patent/BR112017000672A2/pt not_active Application Discontinuation
- 2015-07-15 KR KR1020177003776A patent/KR20170026630A/ko not_active Application Discontinuation
- 2015-07-15 MX MX2017000546A patent/MX2017000546A/es unknown
- 2015-07-15 CN CN201580030345.4A patent/CN106573060A/zh active Pending
- 2015-07-15 PL PL15747647T patent/PL3169361T3/pl unknown
- 2015-07-15 CA CA2954508A patent/CA2954508A1/en not_active Abandoned
- 2015-07-15 SG SG11201700074YA patent/SG11201700074YA/en unknown
- 2015-07-15 CN CN202310512479.6A patent/CN116617401A/zh active Pending
- 2015-07-15 EP EP15747647.4A patent/EP3169361B1/en active Active
- 2015-07-15 WO PCT/US2015/040582 patent/WO2016011160A1/en active Application Filing
- 2015-07-15 RU RU2017102926A patent/RU2733735C2/ru active
-
2017
- 2017-01-05 US US15/399,118 patent/US10946093B2/en active Active
- 2017-01-10 IL IL250021A patent/IL250021B/en active IP Right Grant
- 2017-02-14 ZA ZA2017/01109A patent/ZA201701109B/en unknown
-
2019
- 2019-11-21 JP JP2019210780A patent/JP2020059721A/ja active Pending
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2020
- 2020-07-27 IL IL276314A patent/IL276314A/en unknown
-
2021
- 2021-02-11 US US17/174,019 patent/US20220105180A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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US20220105180A1 (en) | 2022-04-07 |
CN116617401A (zh) | 2023-08-22 |
ZA201701109B (en) | 2021-07-28 |
WO2016011160A1 (en) | 2016-01-21 |
IL276314A (en) | 2020-09-30 |
EP3169361A1 (en) | 2017-05-24 |
JP2017522307A (ja) | 2017-08-10 |
ES2742500T8 (es) | 2020-02-27 |
BR112017000672A2 (pt) | 2017-11-14 |
PL3169361T3 (pl) | 2019-11-29 |
RU2017102926A3 (ja) | 2018-12-21 |
AU2015289672A1 (en) | 2017-03-02 |
IL250021A0 (en) | 2017-03-30 |
EP3169361B1 (en) | 2019-06-19 |
JP2020059721A (ja) | 2020-04-16 |
US20170112925A1 (en) | 2017-04-27 |
RU2017102926A (ru) | 2018-08-15 |
MX2017000546A (es) | 2017-03-08 |
SG11201700074YA (en) | 2017-02-27 |
RU2733735C2 (ru) | 2020-10-06 |
AR101210A1 (es) | 2016-11-30 |
CA2954508A1 (en) | 2016-01-21 |
EP3563870A1 (en) | 2019-11-06 |
KR20170026630A (ko) | 2017-03-08 |
ES2742500T3 (es) | 2020-02-14 |
IL250021B (en) | 2020-08-31 |
US10946093B2 (en) | 2021-03-16 |
CN106573060A (zh) | 2017-04-19 |
JP6673896B2 (ja) | 2020-03-25 |
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