SG10202005315SA - Agent for treating and/or preventing diseases associated with immune abnormalities by combining biguanide antidiabetic drug with immunosuppressive factor blocking agent or costimulatory receptor agonist - Google Patents
Agent for treating and/or preventing diseases associated with immune abnormalities by combining biguanide antidiabetic drug with immunosuppressive factor blocking agent or costimulatory receptor agonistInfo
- Publication number
- SG10202005315SA SG10202005315SA SG10202005315SA SG10202005315SA SG10202005315SA SG 10202005315S A SG10202005315S A SG 10202005315SA SG 10202005315S A SG10202005315S A SG 10202005315SA SG 10202005315S A SG10202005315S A SG 10202005315SA SG 10202005315S A SG10202005315S A SG 10202005315SA
- Authority
- SG
- Singapore
- Prior art keywords
- agent
- combining
- treating
- receptor agonist
- diseases associated
- Prior art date
Links
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 title 1
- 229940123208 Biguanide Drugs 0.000 title 1
- 229940127003 anti-diabetic drug Drugs 0.000 title 1
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 239000002981 blocking agent Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 108091008034 costimulatory receptors Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000009390 immune abnormality Effects 0.000 title 1
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/55—IL-2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
- G01N2333/57—IFN-gamma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Rehabilitation Therapy (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014166593 | 2014-08-19 | ||
JP2015085556 | 2015-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202005315SA true SG10202005315SA (en) | 2020-07-29 |
Family
ID=55350709
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700978SA SG11201700978SA (en) | 2014-08-19 | 2015-08-17 | Method for enhancing immune cell function and method for assessing immune cell multifunctionality |
SG10202005315SA SG10202005315SA (en) | 2014-08-19 | 2015-08-17 | Agent for treating and/or preventing diseases associated with immune abnormalities by combining biguanide antidiabetic drug with immunosuppressive factor blocking agent or costimulatory receptor agonist |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700978SA SG11201700978SA (en) | 2014-08-19 | 2015-08-17 | Method for enhancing immune cell function and method for assessing immune cell multifunctionality |
Country Status (15)
Country | Link |
---|---|
US (2) | US20170231929A1 (fr) |
EP (2) | EP3232199B1 (fr) |
JP (3) | JP6629211B2 (fr) |
KR (1) | KR20170042778A (fr) |
CN (1) | CN107148274A (fr) |
AU (1) | AU2015304448B2 (fr) |
BR (1) | BR112017002807A2 (fr) |
CA (1) | CA2958573A1 (fr) |
ES (1) | ES2915849T3 (fr) |
IL (1) | IL250639B (fr) |
MX (1) | MX2017002134A (fr) |
PH (1) | PH12017500224B1 (fr) |
RU (2) | RU2731098C2 (fr) |
SG (2) | SG11201700978SA (fr) |
WO (1) | WO2016027764A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2161336T1 (sl) * | 2005-05-09 | 2013-11-29 | Ono Pharmaceutical Co., Ltd. | Humana monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka ob uporabi anti-PD-1 protiteles samih ali v kombinaciji z drugimi imunoterapevtiki |
PT3081576T (pt) | 2013-12-12 | 2019-10-15 | Jiangsu Hengrui Medicine Co | Anticorpo pd-1, fragmento de ligação ao antigénio do mesmo e aplicação médica do mesmo |
CN110023337B (zh) | 2016-10-11 | 2024-01-05 | 艾吉纳斯公司 | 抗lag-3抗体及其使用方法 |
CN107082812B (zh) * | 2017-03-29 | 2018-11-13 | 上海科医联创生物科技有限公司 | 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用 |
FI3630112T3 (fi) * | 2017-06-02 | 2024-05-02 | Bayer Healthcare Llc | Regorafenibin ja nivolumabin yhdistelmä syövän hoidossa |
WO2019069449A1 (fr) * | 2017-10-06 | 2019-04-11 | 純児 赤木 | Procédé de mesure |
WO2019124423A1 (fr) * | 2017-12-19 | 2019-06-27 | 国立大学法人 岡山大学 | Agent pour l'arrêt de l'évolution, le traitement, la prophylaxie et/ou la prévention de la récurrence du cancer |
JP2019112353A (ja) * | 2017-12-25 | 2019-07-11 | 合同会社チューモス | 自家腫瘍ワクチン及び免疫誘導方法 |
CA3086825A1 (fr) * | 2017-12-26 | 2019-07-04 | Tamio Yamauchi | Methode, systeme et programme permettant la fourniture d'informations immunodynamiques |
SG10201900072VA (en) * | 2018-01-05 | 2019-08-27 | Gnt Biotech & Medicals Corp | A pharmaceutical combination and method for regulation of tumor microenvironment and immunotherapy |
WO2019202473A1 (fr) * | 2018-04-16 | 2019-10-24 | Université de Lausanne | Agents induisant ucp2 pour le traitement du cancer résistant au blocage des points de contrôle immunitaires |
WO2020118208A1 (fr) * | 2018-12-07 | 2020-06-11 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Procédé de détermination du risque de développement du cancer de la peau et de prévention thérapeutique du cancer de la peau par mesure des membres de la voie de signalisation pd-1/pd-l1 |
KR102510381B1 (ko) * | 2019-10-16 | 2023-03-15 | 한국과학기술원 | 메트포민을 유효성분으로 포함하는 뇌암의 예방 또는 치료용 면역치료제 조성물 |
WO2022072745A1 (fr) * | 2020-10-01 | 2022-04-07 | The Regents Of The University Of California | Méthodes et compositions pour traiter et prévenir des infections virales et un syndrome de détresse respiratoire aiguë |
CN112791182A (zh) * | 2020-12-31 | 2021-05-14 | 中山大学 | 二甲双胍和抗pd-1抗体药物组合物在制备肝癌药物中的应用 |
CN113421627B (zh) * | 2021-05-11 | 2023-04-07 | 深圳市罗湖区人民医院 | 体外评估药物对nk细胞抗衰作用的系统 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0624207B2 (ja) * | 1986-06-25 | 1994-03-30 | 新電元工業株式会社 | 高耐圧半導体装置の製造方法 |
US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
US5260275A (en) * | 1990-08-14 | 1993-11-09 | Amylin Pharmaceuticals, Inc. | Hypoglycemics |
US5620889A (en) * | 1993-10-14 | 1997-04-15 | Immunex Corporation | Human anti-Fas IgG1 monoclonal antibodies |
NZ524519A (en) * | 2000-08-07 | 2004-09-24 | Ranbaxy Signature Llc | Liquid formulation of metformin |
EP2243493A1 (fr) * | 2002-07-03 | 2010-10-27 | Ono Pharmaceutical Co., Ltd. | Composition immunostimulante |
SI2161336T1 (sl) | 2005-05-09 | 2013-11-29 | Ono Pharmaceutical Co., Ltd. | Humana monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka ob uporabi anti-PD-1 protiteles samih ali v kombinaciji z drugimi imunoterapevtiki |
WO2009030257A1 (fr) * | 2007-09-05 | 2009-03-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Procédés et composés pour traiter des maladies provoquées par des espèces réactives de l'oxygène |
EP2470170A4 (fr) * | 2009-08-25 | 2013-01-02 | Harvard College | Utilisation de metformine dans le traitement et la prévention du cancer |
US20130059916A1 (en) * | 2010-05-26 | 2013-03-07 | Stephane Rocchi | Biguanide compounds and its use for treating cancer |
WO2012095379A1 (fr) * | 2011-01-11 | 2012-07-19 | Universität Basel | Combinaison de syrosingopine et d'inhibiteurs mitochondriaux pour traiter le cancer et l'immunosuppression |
WO2013009535A1 (fr) * | 2011-07-08 | 2013-01-17 | Merck Sharp & Dohme Corp. | Antagonistes de l'il-23 utilisables en vue du traitement ou de la prévention d'éruptions cutanées associées à un traitement par des inhibiteurs de la voie pi3k/akt |
CN103371991A (zh) * | 2012-04-18 | 2013-10-30 | 中国人民解放军第二军医大学 | 二甲双胍在制备预防或治疗肝细胞癌药物中的应用 |
PL2872646T3 (pl) * | 2012-07-12 | 2018-03-30 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Sposoby przewidywania czasu przeżycia i responsywności na leczenie pacjenta cierpiącego na nowotwór lity z sygnaturą przynajmniej 7 genów |
AU2013301609B2 (en) * | 2012-08-06 | 2019-03-14 | Assistance Publique Hopitaux De Paris | Methods and kits for screening patients with a cancer |
HUE035503T2 (en) * | 2012-10-02 | 2018-05-02 | Bristol Myers Squibb Co | Combination of anti-anti-antibodies and anti-PD-1 antibodies to treat cancer |
WO2014083095A1 (fr) * | 2012-11-29 | 2014-06-05 | Universitaet Basel | Combinaisons de metformine avec d'autres composés pour le traitement du cancer et pour l'immunosuppression |
PT2941258T (pt) * | 2013-01-02 | 2019-12-12 | Decoy Biosystems Inc | Composições e métodos para o tratamento de cancro utilizando bactérias |
JP6242071B2 (ja) * | 2013-04-23 | 2017-12-06 | 国立大学法人 岡山大学 | 免疫疲弊cd8+t細胞の機能改善薬、がん治療薬及びメタボリック症候群の予防または治療薬 |
-
2015
- 2015-08-17 SG SG11201700978SA patent/SG11201700978SA/en unknown
- 2015-08-17 AU AU2015304448A patent/AU2015304448B2/en not_active Ceased
- 2015-08-17 CN CN201580043408.XA patent/CN107148274A/zh active Pending
- 2015-08-17 WO PCT/JP2015/073011 patent/WO2016027764A1/fr active Application Filing
- 2015-08-17 RU RU2017108754A patent/RU2731098C2/ru active
- 2015-08-17 CA CA2958573A patent/CA2958573A1/fr not_active Abandoned
- 2015-08-17 US US15/503,247 patent/US20170231929A1/en not_active Abandoned
- 2015-08-17 SG SG10202005315SA patent/SG10202005315SA/en unknown
- 2015-08-17 KR KR1020177007514A patent/KR20170042778A/ko not_active Application Discontinuation
- 2015-08-17 EP EP17174222.4A patent/EP3232199B1/fr active Active
- 2015-08-17 RU RU2020127099A patent/RU2020127099A/ru unknown
- 2015-08-17 MX MX2017002134A patent/MX2017002134A/es unknown
- 2015-08-17 JP JP2016544195A patent/JP6629211B2/ja active Active
- 2015-08-17 ES ES17174222T patent/ES2915849T3/es active Active
- 2015-08-17 EP EP15833898.8A patent/EP3192517A4/fr not_active Withdrawn
- 2015-08-17 BR BR112017002807A patent/BR112017002807A2/pt not_active IP Right Cessation
-
2017
- 2017-02-07 PH PH12017500224A patent/PH12017500224B1/en unknown
- 2017-02-16 IL IL250639A patent/IL250639B/en active IP Right Grant
- 2017-04-20 JP JP2017083767A patent/JP6672217B2/ja active Active
- 2017-06-20 US US15/628,600 patent/US20170281569A1/en not_active Abandoned
-
2020
- 2020-03-03 JP JP2020035992A patent/JP2020109098A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PH12017500224A1 (en) | 2017-07-10 |
WO2016027764A1 (fr) | 2016-02-25 |
US20170231929A1 (en) | 2017-08-17 |
JPWO2016027764A1 (ja) | 2017-06-01 |
EP3232199B1 (fr) | 2022-05-04 |
JP6672217B2 (ja) | 2020-03-25 |
EP3192517A1 (fr) | 2017-07-19 |
EP3192517A4 (fr) | 2018-04-25 |
US20170281569A1 (en) | 2017-10-05 |
IL250639A0 (en) | 2017-04-30 |
SG11201700978SA (en) | 2017-03-30 |
ES2915849T3 (es) | 2022-06-27 |
EP3232199A2 (fr) | 2017-10-18 |
CA2958573A1 (fr) | 2016-02-25 |
KR20170042778A (ko) | 2017-04-19 |
AU2015304448B2 (en) | 2020-04-30 |
RU2017108754A3 (fr) | 2019-03-29 |
RU2020127099A (ru) | 2020-09-02 |
CN107148274A (zh) | 2017-09-08 |
BR112017002807A2 (pt) | 2017-12-19 |
EP3232199A3 (fr) | 2018-02-14 |
IL250639B (en) | 2020-02-27 |
MX2017002134A (es) | 2017-09-13 |
RU2731098C2 (ru) | 2020-08-28 |
AU2015304448A1 (en) | 2017-03-09 |
JP6629211B2 (ja) | 2020-01-15 |
PH12017500224B1 (en) | 2017-07-10 |
EP3232199A8 (fr) | 2017-12-13 |
JP2017165752A (ja) | 2017-09-21 |
JP2020109098A (ja) | 2020-07-16 |
RU2017108754A (ru) | 2018-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG10202005315SA (en) | Agent for treating and/or preventing diseases associated with immune abnormalities by combining biguanide antidiabetic drug with immunosuppressive factor blocking agent or costimulatory receptor agonist | |
ZA201904616B (en) | Glp-1 receptor agonists and uses thereof | |
ZA201702634B (en) | Therapeutic agent delivery device | |
IL257077B (en) | A multi-ligand agent for drug delivery | |
HRP20182134T1 (hr) | Triazinski spoj i njegova upotreba u medicinske svrhe | |
HK1244488A1 (zh) | 雙胍化合物及其用途 | |
GB201612516D0 (en) | Medicament delivery device | |
GB201506788D0 (en) | Medicament delivery device | |
IL257652A (en) | A drug formulation based on particles containing a polysaccharide-vitamin conjugate | |
PL3421038T3 (pl) | Związek naftyrydyny, kompozycja farmaceutyczna i ich zastosowanie | |
PT3622986T (pt) | Dispositivo de aplicação de medicamento | |
GB201619562D0 (en) | Medicament delivery device | |
IL251456A0 (en) | Substances with agonist activity for gpr119, processes for their preparation and preparations containing them | |
GB201701400D0 (en) | Compound for use in medicine | |
GB2537639B (en) | Medicament delivery device | |
EP3474836C0 (fr) | Médicament ophtalmique contenant du salbutamol. | |
GB201619556D0 (en) | Medicament delivery device | |
PL3167139T3 (pl) | Urządzenie do zatrzymywania, zwalniania i przywracania położenia siatek okiennych typu roleta | |
EP3189853A4 (fr) | Composition favorisant l'induction immunitaire et comprenant un ligand des récepteurs nucléaires, et composition pharmaceutique vaccinale | |
GB201410507D0 (en) | Drug delivery enhancement agents | |
ZA201704737B (en) | Fungicidal composition effective against alternaria on citrus | |
GB201616880D0 (en) | Compound for use in medicine | |
GB201701388D0 (en) | Compound for use in medicine | |
IL247874A0 (en) | Drug delivery device | |
GB201506781D0 (en) | Improved medicament delivery device |