SG10202003299PA - Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide - Google Patents
Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamideInfo
- Publication number
- SG10202003299PA SG10202003299PA SG10202003299PA SG10202003299PA SG10202003299PA SG 10202003299P A SG10202003299P A SG 10202003299PA SG 10202003299P A SG10202003299P A SG 10202003299PA SG 10202003299P A SG10202003299P A SG 10202003299PA SG 10202003299P A SG10202003299P A SG 10202003299PA
- Authority
- SG
- Singapore
- Prior art keywords
- dioxocyclohexa
- butanamide
- dienyl
- polymorphic
- trimethyl
- Prior art date
Links
- BAANPNDZFYBQIB-CQSZACIVSA-N (2r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide Chemical compound CC1=C(C)C(=O)C(CC[C@@](C)(O)C(N)=O)=C(C)C1=O BAANPNDZFYBQIB-CQSZACIVSA-N 0.000 title 1
Classifications
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- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
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- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462092743P | 2014-12-16 | 2014-12-16 | |
US201562133276P | 2015-03-13 | 2015-03-13 |
Publications (1)
Publication Number | Publication Date |
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SG10202003299PA true SG10202003299PA (en) | 2020-05-28 |
Family
ID=55071223
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201704968XA SG11201704968XA (en) | 2014-12-16 | 2015-12-16 | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
SG10202003299PA SG10202003299PA (en) | 2014-12-16 | 2015-12-16 | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201704968XA SG11201704968XA (en) | 2014-12-16 | 2015-12-16 | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
Country Status (21)
Country | Link |
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US (5) | US10251847B2 (fr) |
EP (2) | EP3233786B1 (fr) |
JP (4) | JP6810692B2 (fr) |
KR (1) | KR102626895B1 (fr) |
CN (2) | CN114702406A (fr) |
AU (3) | AU2015364640B2 (fr) |
BR (1) | BR112017012988B1 (fr) |
CA (1) | CA2971252A1 (fr) |
DK (1) | DK3233786T3 (fr) |
ES (1) | ES2912585T3 (fr) |
HU (1) | HUE058877T2 (fr) |
IL (1) | IL252953A0 (fr) |
MX (2) | MX2017008063A (fr) |
NZ (1) | NZ733528A (fr) |
PL (1) | PL3233786T3 (fr) |
PT (1) | PT3233786T (fr) |
RU (1) | RU2770091C2 (fr) |
SG (2) | SG11201704968XA (fr) |
SI (1) | SI3233786T1 (fr) |
WO (1) | WO2016100579A1 (fr) |
ZA (1) | ZA201704639B (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2564842A1 (fr) | 2005-06-01 | 2013-03-06 | Edison Pharmaceuticals, Inc. | Produits thérapeutiques actifs en réduction-oxydation destines au traitement de maladies mitochondriales et d'autres états ainsi que la modulation de bio-marqueurs d'énergie |
HUE028502T2 (en) | 2007-11-06 | 2016-12-28 | Edison Pharmaceuticals Inc | 4- (P-Quinonyl) -2-hydroxybutanamide derivatives for the treatment of mitochondrial diseases |
CN102264730B (zh) | 2008-10-28 | 2016-04-13 | 爱迪生药物公司 | 用于生产生育三烯酚及衍生物的方法 |
JP2014520894A (ja) | 2011-07-19 | 2014-08-25 | エジソン ファーマシューティカルズ, インコーポレイテッド | 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法 |
ES2912585T3 (es) | 2014-12-16 | 2022-05-26 | Ptc Therapeutics Inc | Formas polimórficas y amorfas de la (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociclohexa-1,4-dienil)butanamida |
WO2017106786A1 (fr) | 2015-12-16 | 2017-06-22 | Bioelectron Technology Corporation | Procédés améliorés pour l'enrichissement en alpha-tocotriénol à partir de compositions de tocol mixtes |
CA3008849A1 (fr) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Derives fluoroalkyle, fluoroalcoxy, phenoxy, heteroaryloxy, alcoxy, et amine 1,4-benzoquinone pour le traitement de troubles du stress oxydatif |
JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩 |
MX2021004329A (es) | 2018-10-17 | 2021-06-08 | Ptc Therapeutics Inc | 2,3,5-trimetil-6-nonilciclohexa-2,5-dien-1,4-diona para suprimir y tratar alfa-sinucleinopatias, tauopatias y otros trastornos. |
KR20220143897A (ko) * | 2020-02-21 | 2022-10-25 | 스미토모 파마 가부시키가이샤 | 광학 분할된 트롤록스 중간체 및 그 제조 방법 |
EP4366700A1 (fr) | 2021-07-08 | 2024-05-15 | PTC Therapeutics, Inc. | Compositions pharmaceutiques comprenant de la 2,3,5-triméthyl-6-nonylcyclohexa -2,5-diène-1,4-dione |
WO2024058099A1 (fr) * | 2022-09-12 | 2024-03-21 | 住友ファーマ株式会社 | Granules pour suspension |
WO2024071372A1 (fr) * | 2022-09-30 | 2024-04-04 | 住友ファーマ株式会社 | Procédé de clivage oxydatif d'amide de trolox |
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WO1997007109A1 (fr) | 1995-08-21 | 1997-02-27 | Takeda Chemical Industries, Ltd. | Compose de quinone, sa production et son utilisation |
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JP3093170B2 (ja) | 1996-09-19 | 2000-10-03 | 株式会社ジャパンエナジー | ヒドロキノン誘導体及びその医薬用途 |
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