DE69712888D1 - ZUSAMMENSTELLUNGEN DIE beta-AMYLOID PROTEIN BEDINGTE ZYTOTOXIZITÄT VERHINDERN - Google Patents

ZUSAMMENSTELLUNGEN DIE beta-AMYLOID PROTEIN BEDINGTE ZYTOTOXIZITÄT VERHINDERN

Info

Publication number
DE69712888D1
DE69712888D1 DE69712888T DE69712888T DE69712888D1 DE 69712888 D1 DE69712888 D1 DE 69712888D1 DE 69712888 T DE69712888 T DE 69712888T DE 69712888 T DE69712888 T DE 69712888T DE 69712888 D1 DE69712888 D1 DE 69712888D1
Authority
DE
Germany
Prior art keywords
amyloid protein
compilations
optionally substituted
cytotoxicity
prevent beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69712888T
Other languages
English (en)
Inventor
Masaomi Miyamoto
Keisuke Hirai
Giichi Goto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69712888D1 publication Critical patent/DE69712888D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69712888T 1996-07-11 1997-07-10 ZUSAMMENSTELLUNGEN DIE beta-AMYLOID PROTEIN BEDINGTE ZYTOTOXIZITÄT VERHINDERN Expired - Lifetime DE69712888D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18209596 1996-07-11
PCT/JP1997/002391 WO1998002149A2 (en) 1996-07-11 1997-07-10 Use of idebenone and analogues against beta amyloid induced cytotoxicity

Publications (1)

Publication Number Publication Date
DE69712888D1 true DE69712888D1 (de) 2002-07-04

Family

ID=16112269

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69712888T Expired - Lifetime DE69712888D1 (de) 1996-07-11 1997-07-10 ZUSAMMENSTELLUNGEN DIE beta-AMYLOID PROTEIN BEDINGTE ZYTOTOXIZITÄT VERHINDERN

Country Status (7)

Country Link
US (1) US6271266B1 (de)
EP (1) EP0915696B1 (de)
AT (1) ATE218060T1 (de)
AU (1) AU3458997A (de)
CA (1) CA2252519A1 (de)
DE (1) DE69712888D1 (de)
WO (1) WO1998002149A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1888059T3 (en) 2005-06-01 2015-03-30 Edison Pharmaceuticals Inc Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers
PL1933821T3 (pl) * 2005-09-15 2021-01-11 Ptc Therapeutics, Inc. Warianty łańcucha końcowego środków terapeutycznych o aktywności redoks do leczenia chorób mitochondrialnych i innych stanów oraz do modulacji biomarkerów energetycznych
EP1986636B1 (de) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol- und 1,4-benzochinon-derivate zur verwendung in der behandlung von erkrankungen der mitochondrien
EP1891946A1 (de) * 2006-08-14 2008-02-27 Santhera Pharmaceuticals (Schweiz) AG Transmukosale Verabreichung von 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinon
EP3018122B1 (de) 2007-11-06 2018-10-10 BioElectron Technology Corporation 4-(p-quinonyl)-2-hydroxybutanamid-derivate zur behandlung von mitochondrialen erkrankungen
EP2344142B1 (de) 2008-09-10 2024-06-26 PTC Therapeutics, Inc. Behandlung von pervasiven entwicklungsstörungen mit redox-aktiven therapeutika
US8263094B2 (en) * 2008-09-23 2012-09-11 Eastman Chemical Company Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof
RS55173B1 (sr) * 2010-08-16 2017-01-31 Santhera Pharmaceuticals (Schweiz) Ag Uređaj i sistem za proizvodnju aerosola sa poboljšanim protokom vazduha
WO2014035356A1 (en) * 2012-08-31 2014-03-06 Mahmut Bilgic Tablet formulations comprising a quinone derivative active agent
EP3233786B1 (de) 2014-12-16 2022-03-16 PTC Therapeutics, Inc. Polymorphe und amorphe formen von (r) (-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)buttersäureamid
US10703701B2 (en) 2015-12-17 2020-07-07 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
US10934253B2 (en) 2017-04-21 2021-03-02 University Of Tasmania Therapeutic compounds and methods
ES2968957T3 (es) 2018-10-17 2024-05-14 Ptc Therapeutics Inc 2,3,5-trimetil-6-nonilciclohexa-2,5-dieno-1,4-diona para la supresión y el tratamiento de alfa-sinucleinopatías, taupatías y otros trastornos
KR20240032997A (ko) 2021-07-08 2024-03-12 피티씨 테라퓨틱스, 인크. 2,3,5-트리메틸-6-노닐사이클로헥사-2,5-디엔-1,4-디온을 포함하는 약제학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08768B2 (ja) 1989-08-24 1996-01-10 武田薬品工業株式会社 神経成長因子分泌誘導剤
JP2849286B2 (ja) * 1992-07-09 1999-01-20 三菱電機株式会社 半導体装置の製造方法
ATE184788T1 (de) * 1993-06-18 1999-10-15 Takeda Chemical Industries Ltd Idebenone-haltige zusammensetzungen zur behandlung von m. alzheimer

Also Published As

Publication number Publication date
CA2252519A1 (en) 1998-01-22
EP0915696A2 (de) 1999-05-19
ATE218060T1 (de) 2002-06-15
EP0915696B1 (de) 2002-05-29
WO1998002149A3 (en) 1998-06-04
WO1998002149A2 (en) 1998-01-22
AU3458997A (en) 1998-02-09
US6271266B1 (en) 2001-08-07

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