SG10201912341SA - TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES - Google Patents
TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASESInfo
- Publication number
- SG10201912341SA SG10201912341SA SG10201912341SA SG10201912341SA SG10201912341SA SG 10201912341S A SG10201912341S A SG 10201912341SA SG 10201912341S A SG10201912341S A SG 10201912341SA SG 10201912341S A SG10201912341S A SG 10201912341SA SG 10201912341S A SG10201912341S A SG 10201912341SA
- Authority
- SG
- Singapore
- Prior art keywords
- ttr
- transthyretin
- treating
- methods
- associated diseases
- Prior art date
Links
- 108010071690 Prealbumin Proteins 0.000 title 2
- 102000009190 Transthyretin Human genes 0.000 title 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C12Q2600/00—Oligonucleotides characterized by their use
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- C12Q2600/00—Oligonucleotides characterized by their use
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Psychiatry (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199563P | 2015-07-31 | 2015-07-31 | |
| US201662287518P | 2016-01-27 | 2016-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201912341SA true SG10201912341SA (en) | 2020-02-27 |
Family
ID=56682264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201912341SA SG10201912341SA (en) | 2015-07-31 | 2016-07-28 | TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US10208307B2 (ru) |
| EP (1) | EP3329002B1 (ru) |
| JP (3) | JP6896703B2 (ru) |
| KR (2) | KR20240074895A (ru) |
| CN (2) | CN116064515A (ru) |
| BR (1) | BR112018000542B1 (ru) |
| CA (1) | CA2994285A1 (ru) |
| CL (1) | CL2018000198A1 (ru) |
| CY (1) | CY1124545T1 (ru) |
| DK (1) | DK3329002T3 (ru) |
| EA (1) | EA201890394A1 (ru) |
| ES (1) | ES2842300T3 (ru) |
| FI (1) | FIC20230006I1 (ru) |
| FR (1) | FR23C1008I2 (ru) |
| HK (2) | HK1256494A1 (ru) |
| HR (1) | HRP20202082T1 (ru) |
| HU (2) | HUE051998T2 (ru) |
| IL (2) | IL296476B1 (ru) |
| LT (2) | LT3329002T (ru) |
| MA (1) | MA43335B1 (ru) |
| MX (2) | MX2018000981A (ru) |
| MY (1) | MY195720A (ru) |
| NL (1) | NL301216I2 (ru) |
| NO (1) | NO2023007I1 (ru) |
| PL (1) | PL3329002T3 (ru) |
| PT (1) | PT3329002T (ru) |
| RS (1) | RS61297B1 (ru) |
| SG (1) | SG10201912341SA (ru) |
| SI (1) | SI3329002T1 (ru) |
| TW (3) | TWI807302B (ru) |
| UA (1) | UA126276C2 (ru) |
| WO (1) | WO2017023660A1 (ru) |
| ZA (2) | ZA201800571B (ru) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| IN2012DN00720A (ru) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
| EP2563920B1 (en) | 2010-04-29 | 2017-03-15 | Ionis Pharmaceuticals, Inc. | Modulation of transthyretin expression |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| JP6128529B2 (ja) | 2011-07-19 | 2017-05-17 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | 官能化核酸の合成のための方法 |
| JP2015502931A (ja) | 2011-11-18 | 2015-01-29 | アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 修飾ＲＮＡｉ剤 |
| IN2014CN03463A (ru) * | 2011-11-18 | 2015-10-09 | Alnylam Pharmaceuticals Inc | |
| DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| WO2014012081A2 (en) | 2012-07-13 | 2014-01-16 | Ontorii, Inc. | Chiral control |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| KR20220106232A (ko) | 2014-01-16 | 2022-07-28 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| KR20240074895A (ko) * | 2015-07-31 | 2024-05-28 | 알닐람 파마슈티칼스 인코포레이티드 | 트랜스티레틴(TTR) iRNA 조성물 및 TTR-관련 질병을 치료하거나, 예방하기 위한 그의 사용 방법 |
| JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| TW202317151A (zh) * | 2016-12-16 | 2023-05-01 | 美商阿尼拉製藥公司 | 使用甲狀腺素運載蛋白（ＴＴＲ）ｉＲＮＡ組成物於治療或預防ＴＴＲ相關疾病之方法 |
| MA50267A (fr) | 2017-09-19 | 2020-07-29 | Alnylam Pharmaceuticals Inc | Compositions et méthodes de traitement de l'amylose médiée par la transthyrétine (ttr) |
| JP2021504415A (ja) * | 2017-12-01 | 2021-02-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドＳｕｚｈｏｕ Ｒｉｂｏ Ｌｉｆｅ Ｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ． | 二本鎖オリゴヌクレオチド、二本鎖オリゴヌクレオチドを含む組成物および複合体ならびに調製方法と使用 |
| TW202028465A (zh) | 2018-09-28 | 2020-08-01 | 美商阿尼拉製藥公司 | 甲狀腺素運載蛋白（ＴＴＲ）ｉＲＮＡ組成物及其治療或預防ＴＴＲ相關眼部疾病之使用方法 |
| WO2021041884A1 (en) | 2019-08-30 | 2021-03-04 | Alnylam Pharmaceuticals, Inc. | Neurofilament light chain (nfl) as a biomarker for transthyretin amyloidosis polyneuropathy |
| JP2023516748A (ja) | 2020-03-06 | 2023-04-20 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | トランスサイレチン（ｔｔｒ）の発現を阻害するための組成物および方法 |
| JP2023548005A (ja) * | 2020-10-28 | 2023-11-15 | ノヴォ ノルディスク アー／エス | 抗トランスサイレチン抗体およびその使用方法 |
| AR126070A1 (es) | 2021-06-08 | 2023-09-06 | Alnylam Pharmaceuticals Inc | Composiciones y métodos para tratar o prevenir la enfermedad de stargardt y/o trastornos asociados con la proteína transportadora de retinol 4 (rbp4) |
| EP4381067A1 (en) | 2021-08-03 | 2024-06-12 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030027216A1 (en) | 2001-07-02 | 2003-02-06 | Kiernan Urban A. | Analysis of proteins from biological fluids using mass spectrometric immunoassay |
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