SG10201809901SA - Generating Pluripotent Cells De Novo - Google Patents

Generating Pluripotent Cells De Novo

Info

Publication number
SG10201809901SA
SG10201809901SA SG10201809901SA SG10201809901SA SG10201809901SA SG 10201809901S A SG10201809901S A SG 10201809901SA SG 10201809901S A SG10201809901S A SG 10201809901SA SG 10201809901S A SG10201809901S A SG 10201809901SA SG 10201809901S A SG10201809901S A SG 10201809901SA
Authority
SG
Singapore
Prior art keywords
novo
pluripotent cells
generating pluripotent
generating
assays
Prior art date
Application number
SG10201809901SA
Other languages
English (en)
Inventor
Charles A Vacanti
Martin P Vacanti
Koji Kojima
Haruko Obokata
Teruhiko Wakayama
Yoshiki Sasai
Masayuki Yamato
Original Assignee
Vcell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vcell Therapeutics Inc filed Critical Vcell Therapeutics Inc
Publication of SG10201809901SA publication Critical patent/SG10201809901SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
SG10201809901SA 2012-04-24 2013-04-24 Generating Pluripotent Cells De Novo SG10201809901SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261637631P 2012-04-24 2012-04-24
US201361779533P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
SG10201809901SA true SG10201809901SA (en) 2018-12-28

Family

ID=49483852

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201407768QA SG11201407768QA (en) 2012-04-24 2013-04-24 Generating pluripotent cells de novo
SG10201809901SA SG10201809901SA (en) 2012-04-24 2013-04-24 Generating Pluripotent Cells De Novo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201407768QA SG11201407768QA (en) 2012-04-24 2013-04-24 Generating pluripotent cells de novo

Country Status (11)

Country Link
US (1) US11963977B2 (enExample)
EP (2) EP3483261B1 (enExample)
JP (5) JP2015516812A (enExample)
KR (2) KR20150045935A (enExample)
CN (2) CN104718283A (enExample)
AU (2) AU2013251649B2 (enExample)
CA (1) CA2885576A1 (enExample)
ES (1) ES2972525T3 (enExample)
RU (1) RU2696071C2 (enExample)
SG (2) SG11201407768QA (enExample)
WO (1) WO2013163296A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014013664A2 (pt) 2011-12-05 2020-11-03 Factor Bioscience Inc. métodos e produtos para transfectar células
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
BR122019025681B1 (pt) 2012-11-01 2023-04-18 Factor Bioscience Inc Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
US9857360B2 (en) 2013-01-25 2018-01-02 Xcell Biosciences, Inc. Cancer analysis system
JP6495658B2 (ja) 2013-02-08 2019-04-03 国立大学法人京都大学 巨核球及び血小板の製造方法
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US9624471B2 (en) 2013-06-12 2017-04-18 University Of Washington Through Its Center For Commercialization Methods for maturing cardiomyocytes and uses thereof
US9770489B2 (en) 2014-01-31 2017-09-26 Factor Bioscience Inc. Methods and products for nucleic acid production and delivery
IL247890B2 (en) * 2014-03-19 2024-08-01 Vcell Therapeutics Inc Methods related to stem cells
WO2016089178A1 (ko) * 2014-12-04 2016-06-09 가톨릭관동대학교산학협력단 에너지를 이용한 다능성 세포 유도 장치 및 방법
US11773387B2 (en) 2014-12-04 2023-10-03 Stemon Inc. Device and method for inducing pluripotent cells using energy
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
ES2917884T3 (es) * 2015-06-18 2022-07-12 Yeda Res & Dev Protocolos de acondicionamiento y uso de los mismos para la regeneración de tejidos
WO2017155166A1 (ko) * 2016-03-11 2017-09-14 가톨릭관동대학교기술지주 주식회사 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법
WO2017155167A1 (ko) * 2016-03-11 2017-09-14 가톨릭관동대학교산학협력단 세포 리프로그래밍 장치
KR102050852B1 (ko) * 2016-03-11 2019-12-03 주식회사 스템온 세포 리프로그래밍 장치
KR101855967B1 (ko) * 2016-03-11 2018-05-10 가톨릭관동대학교산학협력단 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법
US10426796B2 (en) 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10576167B2 (en) 2016-08-17 2020-03-03 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
CA3043166A1 (en) * 2016-11-07 2018-05-11 K2 Research Holdings, Llc Production and therapeutic uses of epinul pluripotent cells and differentiated cells derived therefrom
EP3601530A1 (en) * 2017-03-20 2020-02-05 IFOM Fondazione Istituto Firc di Oncologia Molecolare Method of generating 2 cell-like stem cells
AU2018281936A1 (en) * 2017-06-10 2020-01-30 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
CN107729932B (zh) * 2017-10-10 2019-07-26 杭州智微信息科技有限公司 骨髓细胞标记方法和系统
KR102416171B1 (ko) 2018-10-02 2022-07-06 주식회사 스템온 세포의 리프로그래밍을 유도하는 리프로좀 및 그 제조 방법
KR20220039719A (ko) 2019-07-03 2022-03-29 팩터 바이오사이언스 인크. 양이온성 지질 및 이의 용도
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
JP2022546578A (ja) * 2019-09-04 2022-11-04 ブイセル セラピューティックス，インコーポレイテッド 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法
US12091684B2 (en) 2020-02-14 2024-09-17 Hackensack Meridian Health, Inc. Platelet-derived mitochondria treatment and method of generating multipotent cells

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
FR2687404B1 (fr) 1992-02-19 1994-05-20 Centre Nal Recherc Scientifique Peptides immunologiquement apparentes aux proteines d'un agent viral et leurs applications biologiques.
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5672346A (en) 1992-07-27 1997-09-30 Indiana University Foundation Human stem cell compositions and methods
ATE200625T1 (de) 1992-10-09 2001-05-15 Advanced Tissue Sciences Inc Leberreservezellen
US5753431A (en) * 1993-10-13 1998-05-19 Northeastern Ohio University Cholesterol 7 α-hydroxdylase gene regulatory elements and transcription factors
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
GB9502022D0 (en) 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US20020151050A1 (en) 2000-10-30 2002-10-17 Vacanti Charles A. Isolation of spore-like cells from tissues exposed to extreme conditions
GB0113118D0 (en) 2001-05-31 2001-07-18 Intercytex Ltd Stem Cells
US7575321B2 (en) 2003-10-30 2009-08-18 Welch Allyn, Inc. Apparatus and method of diagnosis of optically identifiable ophthalmic conditions
ES2579804T3 (es) * 2003-12-02 2016-08-16 Celavie Biosciences, Llc Composiciones y métodos para la propagación de células progenitoras neurales
WO2006028723A1 (en) * 2004-09-03 2006-03-16 Moraga Biotechnology Inc. Non-embryonic totipotent blastomer-like stem cells and methods therefor
US20060084167A1 (en) 2004-10-16 2006-04-20 Cohenford Menashi A Formation of Hybrid Cells by Fusion of Lineage Committed Cells with Stem Cells
WO2006113534A1 (en) * 2005-04-15 2006-10-26 The Johns Hopkins University Immortilization of cells including neuronal cells
FR2885368A1 (fr) * 2005-05-04 2006-11-10 Fred Zacouto Systemes et procedes de regeneration cellulaire et utilisations de telles cellules regenerees
WO2007030693A2 (en) * 2005-09-08 2007-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for promoting stem cell proliferation and survival
US20070087437A1 (en) 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US20070190646A1 (en) 2006-02-10 2007-08-16 The Trustees Of The University Of Pennsylvania Regulating stem cell differentiation by controlling matrix elasticity
US20090252711A1 (en) 2006-05-11 2009-10-08 Andrew Craig Boquest Stem Cells And Methods Of Making And Using Stem Cells
US20100135970A1 (en) 2006-10-27 2010-06-03 Caritas St. Elizabeth Medical Center Of Boston, In Methods for Reprogramming Adult Somatic Cells and Uses Thereof
EP3878949B1 (en) * 2007-04-07 2025-06-04 Whitehead Institute for Biomedical Research Reprogramming of somatic cells
DK2220488T3 (da) * 2007-10-30 2013-04-22 Le Ct Nat De La Rech Scient Cnrs Fremgangsmåde til udførelse af en test til neutralisering af antistoffer
AU2008297024B2 (en) 2007-10-31 2014-08-28 Kyoto University Nuclear reprogramming method
US20090280518A1 (en) * 2008-05-12 2009-11-12 Massachusetts Institute Of Technology System for high throughput measurement of mechanical properties of cells
US9550975B2 (en) 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
EP2312341B1 (en) * 2009-10-06 2019-05-29 Canon Kabushiki Kaisha Rear attachment lens and imaging optical system including the same
JPWO2011125948A1 (ja) * 2010-04-02 2013-07-11 独立行政法人理化学研究所 Ｅｓ細胞の製造方法
KR20120002134A (ko) 2010-06-30 2012-01-05 서울대학교산학협력단 지방 기질 세포의 역분화를 유도하는 방법
BR112013000605B1 (pt) 2010-07-09 2021-11-09 The Gid Group, Inc. Aparelho utilizável para a coleta de material biológico humano e processamento póscoleta do material coletado, conjunto e método para processar material biológico humano

Also Published As

Publication number Publication date
US11963977B2 (en) 2024-04-23
KR20150045935A (ko) 2015-04-29
ES2972525T3 (es) 2024-06-13
JP2015516812A (ja) 2015-06-18
CN104718283A (zh) 2015-06-17
JP2025106394A (ja) 2025-07-15
AU2013251649A1 (en) 2014-11-06
CN112048466A (zh) 2020-12-08
EP3483261A1 (en) 2019-05-15
CA2885576A1 (en) 2013-10-31
KR20200084916A (ko) 2020-07-13
JP2018183145A (ja) 2018-11-22
EP2844738A1 (en) 2015-03-11
EP3483261B1 (en) 2023-11-29
US20150110749A1 (en) 2015-04-23
RU2696071C2 (ru) 2019-07-30
AU2019203943A1 (en) 2019-06-27
JP2023002805A (ja) 2023-01-10
AU2019203943B2 (en) 2021-10-07
SG11201407768QA (en) 2015-01-29
WO2013163296A1 (en) 2013-10-31
AU2013251649B2 (en) 2019-04-04
RU2014147093A (ru) 2016-06-10
JP2020182480A (ja) 2020-11-12
EP2844738A4 (en) 2015-12-23

Similar Documents

Publication Publication Date Title
SG10201809901SA (en) Generating Pluripotent Cells De Novo
WO2012087965A3 (en) Cell culture platform for single cell sorting and enhanced reprogramming of ipscs
EP2633036A4 (en) DIFFERENTIATION METHOD FOR THE PRODUCTION OF GLIA CELL POPULATIONS
MX2010000348A (es) Cultivo de celulas madre pluripotentes individuales.
WO2012112730A3 (en) Compositions and methods for delivering nucleic acid to a cell
MX2013001045A (es) Organoide hepatico, sus usos y metodo de cultivo para obtenerlos.
MY159971A (en) Multipotent/pluripotent cells and methods
SG10201810110RA (en) Extreme pcr
MX366912B (es) Producción de vacuna recombinante en e. coli mediante conjugación enzimática.
WO2010111422A3 (en) Induced pluripotent stem cell generation using two factors and p53 inactivation
SG10201809452RA (en) Cell culture compositions with antioxidants and methods for polypeptide production
SG196784A1 (en) Stem cell cultures
WO2011130624A3 (en) Sustained polypeptide expression from synthetic, modified rnas and uses thereof
MY183741A (en) Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
SG10201901417UA (en) Production of proteins in glutamine-free cell culture media
SG10201810830UA (en) Cell culture compositions and methods for polypeptide production
EP4527921A3 (en) Renal cell populations and uses thereof
WO2012003479A3 (en) Methods for culturing undifferentiated cells using sustained release compositions
MX2012002019A (es) Sistema de placa de pozos profundos con tapa.
PH12014501019A1 (en) Kit comprising serum replacement and labile factors
EP2582792A4 (en) HEART OF CARDIOMYOCYTES WITH DIALYSATED SERUM
MX2015011781A (es) Medio de cultivo celular y metodos de produccion de anticuerpos.
WO2011100286A3 (en) Compositions and methods of generating a differentiated mesodermal cell
WO2015073625A3 (en) Synergistic genome-nonintegrating reprogramming by micrornas and transcription factors
MX2022000516A (es) Metodos relacionados con celulas pluripotentes.