SG10201805934RA - Antibodies directed against interleukin-33 (il-33) - Google Patents
Antibodies directed against interleukin-33 (il-33)Info
- Publication number
- SG10201805934RA SG10201805934RA SG10201805934RA SG10201805934RA SG10201805934RA SG 10201805934R A SG10201805934R A SG 10201805934RA SG 10201805934R A SG10201805934R A SG 10201805934RA SG 10201805934R A SG10201805934R A SG 10201805934RA SG 10201805934R A SG10201805934R A SG 10201805934RA
- Authority
- SG
- Singapore
- Prior art keywords
- chain polypeptide
- directed against
- antibodies directed
- against interleukin
- interleukin
- Prior art date
Links
- 102000017761 Interleukin-33 Human genes 0.000 title abstract 7
- 108010067003 Interleukin-33 Proteins 0.000 title abstract 7
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 abstract 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461925946P | 2014-01-10 | 2014-01-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201805934RA true SG10201805934RA (en) | 2018-08-30 |
Family
ID=53524474
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201605580RA SG11201605580RA (en) | 2014-01-10 | 2015-01-09 | Antibodies directed against interleukin-33 (il-33) |
SG10201805934RA SG10201805934RA (en) | 2014-01-10 | 2015-01-09 | Antibodies directed against interleukin-33 (il-33) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201605580RA SG11201605580RA (en) | 2014-01-10 | 2015-01-09 | Antibodies directed against interleukin-33 (il-33) |
Country Status (14)
Country | Link |
---|---|
US (4) | US10059764B2 (fr) |
EP (1) | EP3092253B1 (fr) |
JP (2) | JP2017503506A (fr) |
KR (1) | KR102446386B1 (fr) |
CN (1) | CN106103480B (fr) |
AU (1) | AU2015204674B2 (fr) |
BR (1) | BR112016016020B1 (fr) |
CA (1) | CA2936366A1 (fr) |
ES (1) | ES2866935T3 (fr) |
MX (2) | MX2016009047A (fr) |
NZ (1) | NZ722445A (fr) |
RU (2) | RU2693084C2 (fr) |
SG (2) | SG11201605580RA (fr) |
WO (1) | WO2015106080A2 (fr) |
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JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
AU2014240101B2 (en) | 2013-03-15 | 2018-05-17 | Regeneron Pharmaceuticals, Inc. | IL-33 antagonists and uses thereof |
WO2015099175A1 (fr) | 2013-12-26 | 2015-07-02 | 田辺三菱製薬株式会社 | Anticorps monoclonal neutralisant humain anti-il-33 |
BR112016016020B1 (pt) | 2014-01-10 | 2024-02-27 | Anaptysbio, Inc | Agente de ligação (il-33) de interleucina-33, célula procariótica isolada, composição e uso do referido agente |
EP3218515B1 (fr) | 2014-11-10 | 2023-04-26 | F. Hoffmann-La Roche AG | Méthodes thérapeutiques et diagnostiques pour les troubles à médiation par l'il-33 |
EA201791029A1 (ru) | 2014-11-10 | 2017-12-29 | Дженентек, Инк. | Антитела против интерлейкина-33 и их применение |
BR112018014247A2 (pt) * | 2016-01-14 | 2018-12-18 | Anaptysbio Inc | inibição de reação alérgica usando um inibidor il-33 |
MX2018013038A (es) * | 2016-04-27 | 2019-03-28 | Pfizer | Anticuerpos anti-il-33, composiciones, metodos y usos de los mismos. |
CA3030298A1 (fr) | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | Anticorps monoclonaux humanises ciblant ve-ptp (hptp-ss) |
JOP20190093A1 (ar) * | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
ES2971126T3 (es) | 2016-12-19 | 2024-06-03 | Medimmune Ltd | Anticuerpos contra LIF y usos de los mismos |
WO2018115960A1 (fr) | 2016-12-19 | 2018-06-28 | Mosaic Biomedicals, S.L. | Anticorps anti-lif et leurs utilisations |
RU2771485C2 (ru) | 2017-02-10 | 2022-05-04 | Дженентек, Инк. | Антитела против триптазы, их композиции и применения |
EP3610041A1 (fr) | 2017-04-13 | 2020-02-19 | Regeneron Pharmaceuticals, Inc. | Traitement et inhibition des maladies pulmonaires inflammatoires chez des patients possédant des allèles de risque dans les gènes codant pour l'il33 et il1rl1 |
WO2019045075A1 (fr) | 2017-08-31 | 2019-03-07 | 田辺三菱製薬株式会社 | Agent thérapeutique contenant un antagoniste de l'il-33 pour traiter l'endométriose |
WO2019074912A1 (fr) | 2017-10-09 | 2019-04-18 | Anaptysbio, Inc. | Therapie anti-il-33 pour la dermatite atopique |
AU2019218128A1 (en) | 2018-02-09 | 2020-09-17 | Genentech, Inc. | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases |
WO2019183639A1 (fr) * | 2018-03-23 | 2019-09-26 | Anaptysbio, Inc. | Inhibition de la réaction allergique à un allergène arachide à l'aide d'un inhibiteur de l'il-33 |
IL277890B2 (en) | 2018-04-11 | 2024-03-01 | Regeneron Pharma | Methods for quantification of IL-33 |
TW202021983A (zh) | 2018-09-21 | 2020-06-16 | 美商安納普提斯生物公司 | 用於嗜伊紅性氣喘之抗il-33療法 |
CN113164597A (zh) | 2018-09-24 | 2021-07-23 | 爱尔皮奥制药公司 | 靶向HPTP-β(VE-PTP)和VEGF的多特异性抗体 |
JP2023500492A (ja) | 2019-11-04 | 2023-01-06 | メドイミューン・リミテッド | Il-33アンタゴニストの使用方法 |
CA3158366A1 (fr) | 2019-11-04 | 2021-05-14 | Medimmune Limited | Agent therapeutique anti-il-33 pour le traitement de troubles renaux |
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WO2021180858A1 (fr) | 2020-03-13 | 2021-09-16 | Medimmune Limited | Méthodes thérapeutiques pour le traitement de sujets présentant des allèles à risque dans l'il33 |
CN115867575A (zh) | 2020-04-06 | 2023-03-28 | 免疫医疗有限公司 | 用il-33轴结合拮抗剂治疗急性呼吸窘迫综合征 |
BR112022022620A2 (pt) | 2020-05-11 | 2022-12-20 | Medimmune Ltd | Formulações de anticorpos anti-il-33 |
US12065507B2 (en) * | 2020-06-01 | 2024-08-20 | University Of Kentucky Research Foundation | Compounds and methods for use in connection with opioid use disorders |
WO2022011037A2 (fr) * | 2020-07-07 | 2022-01-13 | The General Hospital Corporation | Inhibition de l'interleukine 33 (il-33) pour le traitement du cancer, de la fibrose et de l'inflammation |
KR20220022226A (ko) * | 2020-08-18 | 2022-02-25 | 성균관대학교산학협력단 | Il-33 항체 또는 이의 항원 결합 단편 |
CN114249825A (zh) | 2020-09-25 | 2022-03-29 | 三生国健药业(上海)股份有限公司 | 结合人il-33的抗体、其制备方法和用途 |
CN113603775B (zh) | 2021-09-03 | 2022-05-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素-33单克隆抗体及其应用 |
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KR101567758B1 (ko) | 2013-10-17 | 2015-11-11 | 인하대학교 산학협력단 | 항-Siglec-8 항체 또는 항-Siglec-F 항체, 및 항-IL-33 항체를 포함하는 알러지 질환의 예방 또는 치료용 조성물 |
AR098155A1 (es) | 2013-10-23 | 2016-05-04 | Genentech Inc | Métodos para diagnosticar y tratar trastornos eosinofílicos |
WO2015099175A1 (fr) | 2013-12-26 | 2015-07-02 | 田辺三菱製薬株式会社 | Anticorps monoclonal neutralisant humain anti-il-33 |
BR112016016020B1 (pt) | 2014-01-10 | 2024-02-27 | Anaptysbio, Inc | Agente de ligação (il-33) de interleucina-33, célula procariótica isolada, composição e uso do referido agente |
WO2015143343A2 (fr) | 2014-03-21 | 2015-09-24 | The Brigham And Women's Hospital, Inc. | Procédés et compositions pour le traitement de maladies immunitaires ou de troubles et/ou la surveillance thérapeutique |
GB201406608D0 (en) | 2014-04-12 | 2014-05-28 | Psioxus Therapeutics Ltd | Virus |
EP3134120B1 (fr) | 2014-04-21 | 2024-01-24 | The Children's Hospital of Philadelphia | Compositions et méthodes pour le traitement de troubles liés aux cytokines |
EA201791029A1 (ru) | 2014-11-10 | 2017-12-29 | Дженентек, Инк. | Антитела против интерлейкина-33 и их применение |
EP3218515B1 (fr) | 2014-11-10 | 2023-04-26 | F. Hoffmann-La Roche AG | Méthodes thérapeutiques et diagnostiques pour les troubles à médiation par l'il-33 |
CA2978449A1 (fr) | 2015-03-02 | 2016-09-09 | 180 Therapeutics Lp | Methode de traitement d'un trouble fibrotique localise a l'aide d'un antagoniste de l'il-33 |
EP3095440B1 (fr) | 2015-05-19 | 2020-01-15 | PLS-Design GmbH | Immunothérapie spécifique d'un antigène à l'aide de liposomes de tolérance |
MA50638A (fr) | 2015-10-06 | 2020-08-05 | Regeneron Pharma | Biomarqueurs associés aux maladies médiées par l'interleukine-33 (il-33) et leurs utilisations |
BR112018014247A2 (pt) | 2016-01-14 | 2018-12-18 | Anaptysbio Inc | inibição de reação alérgica usando um inibidor il-33 |
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