SG10201805267UA - Piperazine derivatives having multimodal activity against pain - Google Patents
Piperazine derivatives having multimodal activity against painInfo
- Publication number
- SG10201805267UA SG10201805267UA SG10201805267UA SG10201805267UA SG10201805267UA SG 10201805267U A SG10201805267U A SG 10201805267UA SG 10201805267U A SG10201805267U A SG 10201805267UA SG 10201805267U A SG10201805267U A SG 10201805267UA SG 10201805267U A SG10201805267U A SG 10201805267UA
- Authority
- SG
- Singapore
- Prior art keywords
- activity against
- piperazine derivatives
- against pain
- compounds
- pain
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13384006 | 2013-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201805267UA true SG10201805267UA (en) | 2018-07-30 |
Family
ID=49998042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201805267UA SG10201805267UA (en) | 2013-12-20 | 2014-12-19 | Piperazine derivatives having multimodal activity against pain |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10351535B2 (fr) |
| EP (1) | EP3083563A1 (fr) |
| JP (1) | JP6553615B2 (fr) |
| KR (1) | KR20160098506A (fr) |
| CN (1) | CN105829287B (fr) |
| AU (1) | AU2014368368C1 (fr) |
| CA (1) | CA2932051A1 (fr) |
| IL (1) | IL245808B (fr) |
| MA (1) | MA39145B1 (fr) |
| MX (1) | MX2016008130A (fr) |
| MY (1) | MY179509A (fr) |
| PH (1) | PH12016500978A1 (fr) |
| RU (1) | RU2709482C1 (fr) |
| SG (1) | SG10201805267UA (fr) |
| TN (1) | TN2016000203A1 (fr) |
| UA (1) | UA120754C2 (fr) |
| WO (1) | WO2015092009A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2991937A1 (fr) | 2015-07-29 | 2017-02-02 | Laboratorios Del Dr. Esteve, S.A. | Derives d'amide substitues ayant une activite multimodale contre la douleur |
| ES2760625T3 (es) * | 2015-07-29 | 2020-05-14 | Esteve Pharmaceuticals Sa | Derivados de N-(2-(3-(bencil(metil)amino)pirrolidin-1-il)etil)-N-fenil)propionamida y compuestos relacionados como ligandos duales de receptores sigma 1 y opioide mu y para el tratamiento del dolor |
| EP3458450B1 (fr) | 2016-05-20 | 2020-07-01 | Esteve Pharmaceuticals, S.A. | Composés de tétrahydropyrane ayant une activité multimodale contre la douleur |
| JP7365237B2 (ja) * | 2017-03-21 | 2023-10-19 | テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | シグマ－２受容体の新規調節物質およびその使用方法 |
| WO2018175190A1 (fr) * | 2017-03-21 | 2018-09-27 | Temple University-Of The Commonwealth System Of Higher Education | Modulateurs du récepteur 7 de la 5-hydroxytryptamine et utilisation de ces derniers en tant qu'agents thérapeutiques |
| LT3762368T (lt) | 2018-03-08 | 2022-06-10 | Incyte Corporation | Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai |
| WO2020010003A1 (fr) | 2018-07-02 | 2020-01-09 | Incyte Corporation | DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ |
| EP3753932A1 (fr) * | 2019-06-17 | 2020-12-23 | Esteve Pharmaceuticals, S.A. | Dérivés bicycliques substitués ayant une activité pluri-modale contre la douleur |
| WO2022187206A1 (fr) * | 2021-03-01 | 2022-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Ligands à double cible des récepteurs des opiacés mu et dopaminergiques d3 ; préparation et utilisation correspondants |
| WO2024105225A1 (fr) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Combinaisons synergiques d'un antagoniste du récepteur sigma 1 (s1r) et d'un inhibiteur d'époxyde hydrolase soluble (sehi) et leur utilisation dans le traitement de la douleur |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2580648B1 (fr) * | 1985-04-17 | 1987-05-15 | Adir | Nouveaux derives du triazole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| IL81669A (en) * | 1986-02-27 | 1990-11-29 | Duphar Int Res | Aryl-substituted(n-piperidinyl)methyl-and(n-piperazinyl)-methylazoles,their preparation and pharmaceutical compositions containing them |
| SE0103818D0 (sv) * | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US8163746B2 (en) * | 2006-04-19 | 2012-04-24 | Astellas Pharma Inc. | Azolecarboxamide derivative |
| WO2008008480A2 (fr) * | 2006-07-12 | 2008-01-17 | Cumbre Pharmaceuticals Inc. | Dérivés de rifamycine contenant du nitrohétéroaryl |
| AR062011A1 (es) * | 2006-07-21 | 2008-08-10 | Irm Llc | Derivados de diazol y sus composiciones como inhibidores de itpkb |
| WO2008054702A1 (fr) | 2006-10-31 | 2008-05-08 | Schering Corporation | Dérivés d'anilinopipérazine et leurs méthodes d'utilisation |
| MX2009006517A (es) | 2006-12-27 | 2009-06-26 | Sanofi Aventis | Nuevos derivados de isoquinolina e isoquinolinona sustituidos. |
| CA2683461A1 (fr) | 2007-04-16 | 2008-10-23 | Gruenenthal Gmbh | Nouveaux ligands du recepteur vanilloide et leur utilisation pour la fabrication de medicaments |
| EP1982714A1 (fr) | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Pyrano-pyrazole-aminés |
| CN101861312B (zh) * | 2007-05-11 | 2014-09-03 | 伊莱利利公司 | 2-[4-(吡唑-4-基烷基)哌嗪-1-基]-3-苯基吡嗪和吡啶及3-[4-(吡唑-4-基烷基)哌嗪-1-基]-2-苯基吡啶作为5-ht7受体拮抗剂 |
| WO2008157844A1 (fr) | 2007-06-21 | 2008-12-24 | Forest Laboratories Holdings Limited | Nouveaux dérivés de pipérazine en tant qu'inhibiteurs de stéaroyl-coa désaturase |
| TW200914020A (en) | 2007-08-28 | 2009-04-01 | Lilly Co Eli | Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists |
| CA2697051C (fr) | 2007-08-31 | 2013-12-17 | Purdue Pharma L.P. | Composes de piperidine de type quinoxaline substituee et leurs utilisations |
| WO2010046780A2 (fr) | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Composés antiviraux |
| US8853202B2 (en) * | 2008-11-04 | 2014-10-07 | Chemocentryx, Inc. | Modulators of CXCR7 |
| DK2349273T3 (en) * | 2008-11-04 | 2015-07-13 | Chemocentryx Inc | Modulators of CXCR7 |
| WO2010080864A1 (fr) | 2009-01-12 | 2010-07-15 | Array Biopharma Inc. | Composés contenant de la pipéridine et leurs utilisations |
| NZ602368A (en) | 2010-02-12 | 2014-10-31 | Pharmascience Inc | Iap bir domain binding compounds |
| EP2395003A1 (fr) * | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Composés pyrazoliques en tant qu'inhibiteurs du récepteur sigma |
| US20130064770A1 (en) | 2010-05-28 | 2013-03-14 | Ge Healthcare Limited | Radiolabeled compounds and methods thereof |
-
2014
- 2014-12-19 RU RU2016129110A patent/RU2709482C1/ru not_active IP Right Cessation
- 2014-12-19 TN TN2016000203A patent/TN2016000203A1/en unknown
- 2014-12-19 UA UAA201607879A patent/UA120754C2/uk unknown
- 2014-12-19 AU AU2014368368A patent/AU2014368368C1/en not_active Ceased
- 2014-12-19 MA MA39145A patent/MA39145B1/fr unknown
- 2014-12-19 MY MYPI2016701867A patent/MY179509A/en unknown
- 2014-12-19 US US15/106,423 patent/US10351535B2/en not_active Expired - Fee Related
- 2014-12-19 SG SG10201805267UA patent/SG10201805267UA/en unknown
- 2014-12-19 WO PCT/EP2014/078852 patent/WO2015092009A1/fr active Application Filing
- 2014-12-19 EP EP14815384.4A patent/EP3083563A1/fr not_active Withdrawn
- 2014-12-19 KR KR1020167019809A patent/KR20160098506A/ko not_active Application Discontinuation
- 2014-12-19 CA CA2932051A patent/CA2932051A1/fr not_active Abandoned
- 2014-12-19 CN CN201480069503.2A patent/CN105829287B/zh not_active Expired - Fee Related
- 2014-12-19 JP JP2016539896A patent/JP6553615B2/ja not_active Expired - Fee Related
- 2014-12-19 MX MX2016008130A patent/MX2016008130A/es unknown
-
2016
- 2016-05-24 IL IL245808A patent/IL245808B/en active IP Right Grant
- 2016-05-25 PH PH12016500978A patent/PH12016500978A1/en unknown
-
2019
- 2019-05-30 US US16/426,024 patent/US10745361B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014368368B2 (en) | 2019-01-31 |
| RU2709482C1 (ru) | 2019-12-18 |
| UA120754C2 (uk) | 2020-02-10 |
| KR20160098506A (ko) | 2016-08-18 |
| AU2014368368C1 (en) | 2019-06-27 |
| CN105829287A (zh) | 2016-08-03 |
| US10745361B2 (en) | 2020-08-18 |
| MA39145B1 (fr) | 2018-05-31 |
| AU2014368368A1 (en) | 2016-07-07 |
| EP3083563A1 (fr) | 2016-10-26 |
| CA2932051A1 (fr) | 2015-06-25 |
| US20190276415A1 (en) | 2019-09-12 |
| MY179509A (en) | 2020-11-09 |
| WO2015092009A1 (fr) | 2015-06-25 |
| MA39145A1 (fr) | 2017-10-31 |
| MX2016008130A (es) | 2016-10-13 |
| JP6553615B2 (ja) | 2019-07-31 |
| JP2016540792A (ja) | 2016-12-28 |
| RU2016129110A (ru) | 2018-01-23 |
| CN105829287B (zh) | 2019-08-27 |
| TN2016000203A1 (en) | 2017-10-06 |
| IL245808B (en) | 2020-03-31 |
| US20170001967A1 (en) | 2017-01-05 |
| US10351535B2 (en) | 2019-07-16 |
| IL245808A0 (en) | 2016-08-02 |
| PH12016500978A1 (en) | 2016-06-20 |
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