SG10201708195RA - Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue - Google Patents

Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue

Info

Publication number
SG10201708195RA
SG10201708195RA SG10201708195RA SG10201708195RA SG10201708195RA SG 10201708195R A SG10201708195R A SG 10201708195RA SG 10201708195R A SG10201708195R A SG 10201708195RA SG 10201708195R A SG10201708195R A SG 10201708195RA SG 10201708195R A SG10201708195R A SG 10201708195RA
Authority
SG
Singapore
Prior art keywords
cartilage
tissue
compositions
methods
lineage cells
Prior art date
Application number
SG10201708195RA
Other languages
English (en)
Inventor
Gordon Keller
April M Craft
Original Assignee
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network filed Critical Univ Health Network
Publication of SG10201708195RA publication Critical patent/SG10201708195RA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
SG10201708195RA 2013-04-05 2014-04-02 Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue SG10201708195RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361809050P 2013-04-05 2013-04-05

Publications (1)

Publication Number Publication Date
SG10201708195RA true SG10201708195RA (en) 2017-11-29

Family

ID=51657353

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201708195RA SG10201708195RA (en) 2013-04-05 2014-04-02 Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue

Country Status (11)

Country Link
US (3) US9993504B2 (zh)
EP (2) EP2981606B1 (zh)
JP (4) JP6516724B2 (zh)
KR (4) KR102393716B1 (zh)
CN (2) CN105209607B (zh)
AU (3) AU2014247679A1 (zh)
CA (1) CA2908369C (zh)
HK (1) HK1219293A1 (zh)
SG (1) SG10201708195RA (zh)
WO (1) WO2014161075A1 (zh)
ZA (2) ZA201507731B (zh)

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US11136547B2 (en) 2016-03-23 2021-10-05 Kyoto University Mesoderm induction method having high blood cell differentiation capacity
WO2017170328A1 (ja) * 2016-03-31 2017-10-05 学校法人慶應義塾 分化促進型多能性幹細胞及びその使用
WO2018049382A1 (en) 2016-09-12 2018-03-15 President And Fellows Of Harvard College Transcription factors controlling differentiation of stem cells
WO2018062269A1 (ja) * 2016-09-30 2018-04-05 京都府公立大学法人 体細胞を製造する方法、体細胞、及び組成物
WO2018101466A1 (ja) * 2016-12-02 2018-06-07 タカラバイオ株式会社 内皮細胞の製造方法
GB201621594D0 (en) * 2016-12-19 2017-02-01 Univ Leuven Kath Novel cell based methods for healing of bone, cartilage and joint disorders
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN107365741B (zh) * 2017-06-02 2019-08-30 新乡医学院 NCAM缺失在促进BMSCs向肥大软骨细胞分化中的应用
CN107354126B (zh) * 2017-06-02 2019-08-30 新乡医学院 Ncam沉默在促进atdc5细胞的软骨细胞肥大分化中的应用
EP3417888A1 (de) * 2017-06-25 2018-12-26 co.don AG Verfahren zum herstellen von transplantierbarem knorpelgewebe
US20200121726A1 (en) 2017-06-30 2020-04-23 Kolon Life Science, Inc. Pharmaceutical composition for preventing or treating osteoarthritis
US11696929B2 (en) 2017-09-20 2023-07-11 The Regents Of The University Of California Methods and systems for conserving highly expanded cells
CN112980782A (zh) * 2017-10-25 2021-06-18 雪拉托兹治疗株式会社 新型肌肉骨骼系统干细胞
US11298441B2 (en) 2017-11-08 2022-04-12 The Regents Of The University Of Colorado, A Body Corporate Biodegradable biomimetics of growth plate cartilage for the treatment of physeal injuries
US11788131B2 (en) 2018-04-06 2023-10-17 President And Fellows Of Harvard College Methods of identifying combinations of transcription factors
KR102121602B1 (ko) * 2018-06-27 2020-06-10 주식회사 티아라줄기세포연구소 지방줄기세포배양용 배지 조성물 제조방법, 지방줄기세포배양용 배지 조성물 제조방법과 줄기세포 유효성분 3저 추출법을 이용한 줄기세포파쇄추출물(쉘드줄기세포) 제조방법, 이를 이용한 항관절염 치료용 조성물, 이를 이용한 염증억제 효과를 갖는 조성물 및 세포재생 효과를 갖는 조성물
CN110016461A (zh) * 2019-01-15 2019-07-16 深圳市第二人民医院 一种软骨细胞体外扩增方法
WO2020205720A2 (en) * 2019-03-29 2020-10-08 Kolon Tissuegene, Inc. Mixed-cell gene therapy
JP2022533208A (ja) * 2019-05-22 2022-07-21 ザ クリーブランド クリニック ファウンデーション 背側前腸及び前方ドメイン内胚葉細胞の生成
WO2021037142A1 (en) * 2019-08-27 2021-03-04 The Third Hospital Of Hebei Medical University Multipotent joint progenitor cells, compositions and methods thereof
WO2021054449A1 (ja) * 2019-09-18 2021-03-25 国立大学法人 岡山大学 Ｌｂｍ、ｃｐｃ、ｏｐｃ、それらの調製方法及び品質管理方法、キット、移植材料並びに疾患モデル
EP3872168A1 (en) * 2020-02-28 2021-09-01 Cline Scientific AB Chondrocyte differentiation
JPWO2021220997A1 (zh) * 2020-04-27 2021-11-04
CN111840514B (zh) * 2020-08-14 2021-07-30 武汉大学 Cilp2在制备改善心脏衰老和心肌肥厚的药物中的应用
TW202229343A (zh) 2020-08-21 2022-08-01 美商健臻公司 Fgfr3抗體及使用方法
CN117716021A (zh) * 2021-08-31 2024-03-15 公立大学法人横滨市立大学 可成型且无需支架的软骨组织的制作方法
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Also Published As

Publication number Publication date
AU2020204058A1 (en) 2020-07-09
HK1219293A1 (zh) 2017-03-31
KR102393716B1 (ko) 2022-05-02
US20190111086A1 (en) 2019-04-18
JP2023061961A (ja) 2023-05-02
JP2016515825A (ja) 2016-06-02
EP2981606A1 (en) 2016-02-10
CN105209607B (zh) 2020-02-07
ZA201507731B (en) 2019-03-27
US9993504B2 (en) 2018-06-12
CN105209607A (zh) 2015-12-30
JP6516724B2 (ja) 2019-05-22
JP2021104021A (ja) 2021-07-26
US10736923B2 (en) 2020-08-11
EP2981606A4 (en) 2016-08-10
KR20150140724A (ko) 2015-12-16
CN111269880A (zh) 2020-06-12
EP2981606B1 (en) 2020-09-02
ZA201808312B (en) 2024-04-24
EP3896153A1 (en) 2021-10-20
KR20230152164A (ko) 2023-11-02
KR20220057660A (ko) 2022-05-09
WO2014161075A1 (en) 2014-10-09
US20230330152A1 (en) 2023-10-19
KR102393715B1 (ko) 2022-05-02
JP2019141074A (ja) 2019-08-29
AU2014247679A1 (en) 2015-11-12
CA2908369A1 (en) 2014-10-09
NZ713111A (en) 2021-10-29
KR20210138802A (ko) 2021-11-19
AU2022252839A1 (en) 2022-11-10
US20160038544A1 (en) 2016-02-11
CA2908369C (en) 2023-02-28

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