SG10201705806YA - Methods and systems for optimizing perfusion cell culture system - Google Patents
Methods and systems for optimizing perfusion cell culture systemInfo
- Publication number
- SG10201705806YA SG10201705806YA SG10201705806YA SG10201705806YA SG10201705806YA SG 10201705806Y A SG10201705806Y A SG 10201705806YA SG 10201705806Y A SG10201705806Y A SG 10201705806YA SG 10201705806Y A SG10201705806Y A SG 10201705806YA SG 10201705806Y A SG10201705806Y A SG 10201705806YA
- Authority
- SG
- Singapore
- Prior art keywords
- systems
- methods
- cell culture
- culture system
- perfusion cell
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000010412 perfusion Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/02—Percolation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261712190P | 2012-10-10 | 2012-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201705806YA true SG10201705806YA (en) | 2017-08-30 |
Family
ID=49448331
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201705806YA SG10201705806YA (en) | 2012-10-10 | 2013-10-09 | Methods and systems for optimizing perfusion cell culture system |
| SG11201502741WA SG11201502741WA (en) | 2012-10-10 | 2013-10-09 | Methods and systems for optimizing perfusion cell culture system |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201502741WA SG11201502741WA (en) | 2012-10-10 | 2013-10-09 | Methods and systems for optimizing perfusion cell culture system |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20140099711A1 (enExample) |
| EP (1) | EP2906677A1 (enExample) |
| JP (1) | JP6393267B2 (enExample) |
| KR (1) | KR20150063541A (enExample) |
| CN (1) | CN104822821A (enExample) |
| AR (1) | AR092967A1 (enExample) |
| AU (1) | AU2013329318A1 (enExample) |
| CA (1) | CA2887581A1 (enExample) |
| HK (1) | HK1213285A1 (enExample) |
| IL (1) | IL238179A0 (enExample) |
| MX (1) | MX2015004516A (enExample) |
| RU (1) | RU2015117547A (enExample) |
| SG (2) | SG10201705806YA (enExample) |
| TW (1) | TW201418455A (enExample) |
| WO (1) | WO2014059035A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9944894B2 (en) | 2015-01-16 | 2018-04-17 | General Electric Company | Pluripotent stem cell expansion and passage using a rocking platform bioreactor |
| CN105385731B (zh) * | 2015-12-25 | 2018-10-30 | 上海莱士血液制品股份有限公司 | 一种表达重组八因子的灌注培养方法 |
| ITUB20160272A1 (it) * | 2016-01-22 | 2017-07-22 | Univ Degli Studi Di Palermo | Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D |
| JP6943449B2 (ja) * | 2016-03-21 | 2021-09-29 | グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー | 撹拌タンクバイオリアクタを用いた多能性幹細胞の増殖および継代 |
| EP3692358A1 (en) | 2017-10-06 | 2020-08-12 | Lonza Ltd | Automated control of cell culture using raman spectroscopy |
| SG11202002339XA (en) | 2017-10-16 | 2020-04-29 | Regeneron Pharma | Perfusion bioreactor and related methods of use |
| WO2019226618A1 (en) * | 2018-05-22 | 2019-11-28 | Nantkwest, Inc. | Methods and systems for cell bed formation during bioprocessing |
| EP3802780A4 (en) * | 2018-06-01 | 2022-03-23 | Gennova Biopharmaceuticals Limited | PROCEDURE FOR THE PRODUCTION OF RECOMBINANT TNK-TPA BY A PACKED BED PERFUSION SYSTEM |
| JP7453151B2 (ja) * | 2018-11-02 | 2024-03-19 | 協和キリン株式会社 | 液体培地の調製方法 |
| GB201903813D0 (en) * | 2019-03-20 | 2019-05-01 | Cn Bio Innovations Ltd | Dual circulation microphysiological system |
| WO2020232183A1 (en) * | 2019-05-15 | 2020-11-19 | Life Technologies Corporation | Cell settler apparatus systems and methods for perfusion processes |
| WO2021089661A1 (en) | 2019-11-07 | 2021-05-14 | Merck Patent Gmbh | Methods and systems for performing perfusion cell culture |
| CN114901794B (zh) | 2019-11-15 | 2026-05-01 | 隆萨有限公司 | 用于生产接种物的过程和系统 |
| WO2021110870A1 (en) | 2019-12-05 | 2021-06-10 | Acib Gmbh | Method for producing a fermentation product |
| EP4077629A1 (en) * | 2019-12-19 | 2022-10-26 | Universität für Bodenkultur Wien | Continuous reconstitution of process materials from solids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6338964B1 (en) | 1999-05-07 | 2002-01-15 | Bayer Corporation | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration |
| US20040185534A1 (en) * | 2000-10-02 | 2004-09-23 | Knudsen Ida Molgaard | Industrial-scale serum-free production of recombinant proteins in mammalian cells |
| WO2005042768A2 (en) * | 2003-11-03 | 2005-05-12 | Centocor, Inc. | Method for maintaining low shear in a bioprocessing system |
| WO2007071072A1 (en) * | 2005-12-22 | 2007-06-28 | Corporation De L'ecole Polytechnique De Montreal | High-rate perfusion bioreactor |
| KR20090021339A (ko) * | 2006-04-21 | 2009-03-03 | 바이엘 헬스케어 엘엘씨 | 관류 배양을 위한 포유류 세포에서의 항-세포소멸성 유전자의 적용 |
| EP2188371B1 (en) * | 2007-08-09 | 2017-12-20 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| WO2009152413A1 (en) * | 2008-06-13 | 2009-12-17 | Centocor Ortho Biotech Inc. | Methods for obtaining high viable cell density in mammalian cell culture |
| EP2686415B1 (en) * | 2011-03-18 | 2017-11-15 | GE Healthcare Bio-Sciences AB | Flexible bag for cultivation of cells |
-
2013
- 2013-10-09 SG SG10201705806YA patent/SG10201705806YA/en unknown
- 2013-10-09 HK HK16101154.2A patent/HK1213285A1/zh unknown
- 2013-10-09 MX MX2015004516A patent/MX2015004516A/es unknown
- 2013-10-09 EP EP13780035.5A patent/EP2906677A1/en not_active Withdrawn
- 2013-10-09 SG SG11201502741WA patent/SG11201502741WA/en unknown
- 2013-10-09 TW TW102136546A patent/TW201418455A/zh unknown
- 2013-10-09 CN CN201380064458.7A patent/CN104822821A/zh active Pending
- 2013-10-09 RU RU2015117547A patent/RU2015117547A/ru not_active Application Discontinuation
- 2013-10-09 US US14/049,676 patent/US20140099711A1/en not_active Abandoned
- 2013-10-09 CA CA2887581A patent/CA2887581A1/en not_active Abandoned
- 2013-10-09 US US14/434,913 patent/US20150299638A1/en not_active Abandoned
- 2013-10-09 KR KR1020157011445A patent/KR20150063541A/ko not_active Withdrawn
- 2013-10-09 AU AU2013329318A patent/AU2013329318A1/en not_active Abandoned
- 2013-10-09 WO PCT/US2013/064159 patent/WO2014059035A1/en not_active Ceased
- 2013-10-09 JP JP2015536869A patent/JP6393267B2/ja not_active Expired - Fee Related
- 2013-10-10 AR ARP130103674A patent/AR092967A1/es unknown
-
2015
- 2015-04-12 IL IL238179A patent/IL238179A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20140099711A1 (en) | 2014-04-10 |
| HK1213285A1 (zh) | 2016-06-30 |
| JP2015531241A (ja) | 2015-11-02 |
| WO2014059035A1 (en) | 2014-04-17 |
| US20150299638A1 (en) | 2015-10-22 |
| JP6393267B2 (ja) | 2018-09-19 |
| CN104822821A (zh) | 2015-08-05 |
| IL238179A0 (en) | 2015-05-31 |
| MX2015004516A (es) | 2015-10-14 |
| RU2015117547A (ru) | 2016-12-10 |
| AR092967A1 (es) | 2015-05-06 |
| AU2013329318A1 (en) | 2015-05-14 |
| TW201418455A (zh) | 2014-05-16 |
| SG11201502741WA (en) | 2015-05-28 |
| EP2906677A1 (en) | 2015-08-19 |
| KR20150063541A (ko) | 2015-06-09 |
| CA2887581A1 (en) | 2014-04-17 |
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