SG10201506492PA - Improved antibodies of the class igg4 - Google Patents

Improved antibodies of the class igg4

Info

Publication number
SG10201506492PA
SG10201506492PA SG10201506492PA SG10201506492PA SG10201506492PA SG 10201506492P A SG10201506492P A SG 10201506492PA SG 10201506492P A SG10201506492P A SG 10201506492PA SG 10201506492P A SG10201506492P A SG 10201506492PA SG 10201506492P A SG10201506492P A SG 10201506492PA
Authority
SG
Singapore
Prior art keywords
improved antibodies
class igg4
igg4
class
antibodies
Prior art date
Application number
SG10201506492PA
Other languages
English (en)
Inventor
David Paul Humphreys
Shirley Jane Peters
Ralph Adams
James Heads
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of SG10201506492PA publication Critical patent/SG10201506492PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG10201506492PA 2010-08-20 2011-08-19 Improved antibodies of the class igg4 SG10201506492PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1014033.3A GB201014033D0 (en) 2010-08-20 2010-08-20 Biological products

Publications (1)

Publication Number Publication Date
SG10201506492PA true SG10201506492PA (en) 2015-10-29

Family

ID=42984480

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2013007950A SG187677A1 (en) 2010-08-20 2011-08-19 Improved antibodies of the class igg4
SG10201506492PA SG10201506492PA (en) 2010-08-20 2011-08-19 Improved antibodies of the class igg4

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2013007950A SG187677A1 (en) 2010-08-20 2011-08-19 Improved antibodies of the class igg4

Country Status (14)

Country Link
US (2) US10562966B2 (fr)
EP (1) EP2606063B1 (fr)
JP (1) JP5894160B2 (fr)
KR (1) KR101883792B1 (fr)
CN (2) CN103097410B (fr)
AU (1) AU2011290581B2 (fr)
BR (1) BR112013003262B1 (fr)
CA (2) CA3080547C (fr)
DK (1) DK2606063T3 (fr)
ES (1) ES2632571T3 (fr)
GB (1) GB201014033D0 (fr)
MX (1) MX344040B (fr)
SG (2) SG187677A1 (fr)
WO (1) WO2012022982A2 (fr)

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GB201014033D0 (en) 2010-08-20 2010-10-06 Ucb Pharma Sa Biological products
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GB201203071D0 (en) * 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
ES2874493T3 (es) 2013-02-08 2021-11-05 Novartis Ag Sitios específicos para modificar anticuerpos para generar inmunoconjugados
KR101895634B1 (ko) 2013-05-31 2018-09-05 한미약품 주식회사 변이된 힌지 영역을 포함하는 IgG4 Fc 단편
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
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WO2022152308A1 (fr) * 2021-01-18 2022-07-21 Wuxi Biologics (Shanghai) Co., Ltd. Anticorps anti-trop2 modifié et conjugué anticorps-médicament associé

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Also Published As

Publication number Publication date
WO2012022982A3 (fr) 2012-06-21
SG187677A1 (en) 2013-03-28
CA2807227C (fr) 2021-03-23
CN103097410A (zh) 2013-05-08
JP2013538052A (ja) 2013-10-10
AU2011290581B2 (en) 2015-04-16
CN103097410B (zh) 2016-06-01
US20200157204A1 (en) 2020-05-21
EP2606063A2 (fr) 2013-06-26
DK2606063T3 (en) 2017-08-14
KR20130099950A (ko) 2013-09-06
US12091450B2 (en) 2024-09-17
ES2632571T3 (es) 2017-09-14
CN105859876A (zh) 2016-08-17
MX2013001948A (es) 2013-06-28
CA3080547C (fr) 2023-10-24
GB201014033D0 (en) 2010-10-06
CA2807227A1 (fr) 2012-02-23
BR112013003262B1 (pt) 2022-07-26
WO2012022982A2 (fr) 2012-02-23
CA3080547A1 (fr) 2012-02-23
AU2011290581A1 (en) 2013-04-04
US10562966B2 (en) 2020-02-18
MX344040B (es) 2016-12-02
BR112013003262A2 (pt) 2016-06-14
JP5894160B2 (ja) 2016-03-23
CN105859876B (zh) 2021-04-02
KR101883792B1 (ko) 2018-07-31
EP2606063B1 (fr) 2017-05-17
US20130323236A1 (en) 2013-12-05

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