SG100789A1 - Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives - Google Patents

Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Info

Publication number
SG100789A1
SG100789A1 SG200202485A SG200202485A SG100789A1 SG 100789 A1 SG100789 A1 SG 100789A1 SG 200202485 A SG200202485 A SG 200202485A SG 200202485 A SG200202485 A SG 200202485A SG 100789 A1 SG100789 A1 SG 100789A1
Authority
SG
Singapore
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
SG200202485A
Other languages
English (en)
Inventor
Sklavounos Constantine
Lloyd Tucker John
Wei Lulin
Peter Mahon Kerry Jr
Dietrich Hammen Philip
Teresa Negri Joanna
Shelton Lehner Richard
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SG100789A1 publication Critical patent/SG100789A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SG200202485A 2001-04-27 2002-04-24 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives SG100789A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28720301P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
SG100789A1 true SG100789A1 (en) 2003-12-26

Family

ID=23101880

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200202485A SG100789A1 (en) 2001-04-27 2002-04-24 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Country Status (23)

Country Link
US (1) US6825327B2 (fr)
EP (2) EP1383780A1 (fr)
JP (3) JP4104463B2 (fr)
KR (1) KR100474225B1 (fr)
CN (4) CN100413879C (fr)
AR (1) AR035871A1 (fr)
AU (1) AU784362B2 (fr)
BR (2) BR0209241A (fr)
CA (2) CA2445306C (fr)
CZ (1) CZ303716B6 (fr)
DK (1) DK1253153T3 (fr)
ES (1) ES2608848T3 (fr)
HK (2) HK1050370A1 (fr)
HU (1) HU230717B1 (fr)
IL (3) IL158059A0 (fr)
MX (2) MXPA03009786A (fr)
PL (2) PL371766A1 (fr)
PT (1) PT1253153T (fr)
RU (2) RU2263117C2 (fr)
SG (1) SG100789A1 (fr)
WO (1) WO2002088158A1 (fr)
YU (1) YU29502A (fr)
ZA (2) ZA200203252B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA82359C2 (uk) * 2003-04-03 2008-04-10 Schering Plough Ltd Композиція (варіанти) і спосіб лікування мікробних і паразитних інфекцій у великої рогатої худоби і інших тварин
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
EP1776109B1 (fr) 2004-08-13 2008-12-31 Schering-Plough Ltd. Formulation pharmaceutique comprenant un antibiotique, un triazole et un corticosteroide
CN101065352A (zh) 2004-09-23 2007-10-31 先灵-普劳有限公司 使用新的三氟甲磺酰苯胺肟醚衍生物控制动物中的寄生虫
DE602005017419D1 (de) 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
EP1841437B1 (fr) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Azalides 9a-carbamoyle et thiocarbamoyle avec activite antipaludique
PE20070108A1 (es) * 2005-06-09 2007-02-09 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n-[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CN101600686A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 氯霉素、甲砜霉素及其类似物的水溶性前药
MX2009006282A (es) * 2006-12-13 2009-06-23 Schering Plough Ltd Profarmacos solubles en agua de florfenicol y sus analogos.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
PL2957284T3 (pl) 2007-06-27 2018-08-31 E. I. Du Pont De Nemours And Company Sposób zwalczania szkodników zwierzęcych
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
JP2011529895A (ja) * 2008-07-30 2011-12-15 インターベツト・インターナシヨナル・ベー・ベー フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
WO2010086351A1 (fr) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9-déoxo-9a-méthyl-9a-azahomoérythromycine 3'-n-substituée ayant une activité antipaludique
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
WO2011017347A2 (fr) 2009-08-05 2011-02-10 E. I. Du Pont De Nemours And Company Pesticides méso-ioniques
KR20120050467A (ko) 2009-08-05 2012-05-18 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
HUE028501T2 (en) 2010-05-27 2016-12-28 Du Pont 4- [5- [3-Chloro-5- (trifluoromethyl) phenyl] -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N- [2-oxo-2 - [(2.2, 2-Trifluoroethyl) amino] ethyl] -1-naphthalenecarboxamide crystalline form
EP4324524A2 (fr) * 2010-07-01 2024-02-21 Elanco Tiergesundheit AG Compositions antibiotiques
WO2012038372A1 (fr) 2010-09-20 2012-03-29 Novartis Ag Nouveau procédé de préparation de 9-déoxo-9a-aza-9a-homoérythromycine a modifiée dans le c-4'' du cycle cladinose par un groupe époxyde
WO2012087630A1 (fr) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Composés de pyridine et de pyrimidine utilisés pour lutter contre des nuisibles invertébrés
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (fr) * 2011-07-27 2013-01-31 Farma Grs, D.O.O. Nouvelles formes cristallines de tulathromycine
WO2013158422A1 (fr) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Composés hétérocycliques pour la lutte contre des animaux nuisibles invertébrés
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
ES2858585T3 (es) * 2016-01-18 2021-09-30 Zhejiang Hisun Pharm Co Ltd Método y producto intermedio para preparar tulatromicina
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN106434797A (zh) * 2016-08-25 2017-02-22 艾美科健（中国）生物医药有限公司 一种酶法合成泰拉霉素的工艺
CN106939029B (zh) * 2017-04-28 2020-10-13 艾美科健（中国）生物医药有限公司 一种泰拉霉素的制备方法
CN107556351B (zh) * 2017-08-29 2019-10-18 博瑞生物医药（苏州）股份有限公司 一种泰拉菌素的制备方法
CN107400152B (zh) * 2017-08-29 2019-10-15 博瑞生物医药（苏州）股份有限公司 泰拉菌素草酸盐
CN109535210A (zh) * 2018-12-19 2019-03-29 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CA3136369A1 (fr) * 2019-04-18 2020-10-22 Azura Ophthalmics Ltd. Composes et procedes pour le traitement de troubles oculaires
CN111072730B (zh) * 2019-12-16 2021-01-12 浙江国邦药业有限公司 一种泰拉霉素中间体盐的制备方法及应用
CN112225769A (zh) * 2020-09-21 2021-01-15 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CN113493483A (zh) * 2021-07-05 2021-10-12 上海应用技术大学 一种泰拉霉素的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056802A1 (fr) * 1997-06-11 1998-12-17 Pfizer Products Inc. Derives de homo-erythromycine -9-deoxo-9a-aza-9aa substitution en position 4
WO1998056801A1 (fr) * 1997-06-11 1998-12-17 Pfizer Products Inc. Derives de macrolide substitue en c-4''
WO2000031097A1 (fr) * 1998-11-20 2000-06-02 Pfizer Products Inc. Azalides a 13 elements et leur utilisation en tant qu'antibiotiques

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4512982A (en) 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US4518590A (en) 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
CA2064634C (fr) 1991-04-04 1998-08-04 James V. Heck Derives de 9-desoxo-8a-aza-8a-homoerythromycine a modifies en positions 4"- et 8a
EP0549040A1 (fr) 1991-12-20 1993-06-30 Merck & Co. Inc. Méthodes pour fabriquer 4" dérivés de 9-désoxo-8a-aza-8a-alkyl-8a-homoérythromycin A
US5441939A (en) 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
CN1203084C (zh) * 1999-05-18 2005-05-25 辉瑞产品公司 大环内酯抗生素的新晶形

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056802A1 (fr) * 1997-06-11 1998-12-17 Pfizer Products Inc. Derives de homo-erythromycine -9-deoxo-9a-aza-9aa substitution en position 4
WO1998056801A1 (fr) * 1997-06-11 1998-12-17 Pfizer Products Inc. Derives de macrolide substitue en c-4''
WO2000031097A1 (fr) * 1998-11-20 2000-06-02 Pfizer Products Inc. Azalides a 13 elements et leur utilisation en tant qu'antibiotiques

Also Published As

Publication number Publication date
HU0201385D0 (fr) 2002-06-29
PT1253153T (pt) 2016-12-29
HK1065803A1 (en) 2005-03-04
MXPA02004231A (es) 2002-11-13
BR0201437A (pt) 2003-06-10
CA2445306A1 (fr) 2002-11-07
IL149226A0 (en) 2002-11-10
IL182418A (en) 2012-07-31
BRPI0201437B1 (pt) 2017-11-28
JP4100955B2 (ja) 2008-06-11
CA2445306C (fr) 2008-02-12
CN1384108A (zh) 2002-12-11
JP4104463B2 (ja) 2008-06-18
CA2383409A1 (fr) 2002-10-27
PL213731B1 (pl) 2013-04-30
AR035871A1 (es) 2004-07-21
IL158059A0 (en) 2004-03-28
CN1167708C (zh) 2004-09-22
US6825327B2 (en) 2004-11-30
ZA200307506B (en) 2005-01-26
CN100413879C (zh) 2008-08-27
ES2608848T3 (es) 2017-04-17
CN1295240C (zh) 2007-01-17
CA2383409C (fr) 2007-01-02
HK1050370A1 (en) 2003-06-20
JP2007091754A (ja) 2007-04-12
US20030064939A1 (en) 2003-04-03
DK1253153T3 (da) 2017-01-02
EP1383780A1 (fr) 2004-01-28
IL149226A (en) 2008-06-05
WO2002088158A1 (fr) 2002-11-07
RU2263117C2 (ru) 2005-10-27
IL182418A0 (en) 2008-01-06
JP2002326998A (ja) 2002-11-15
AU784362B2 (en) 2006-03-16
KR20020083474A (ko) 2002-11-02
YU29502A (sh) 2005-03-15
BR0209241A (pt) 2004-06-15
CN1530370A (zh) 2004-09-22
RU2003131351A (ru) 2005-02-27
HUP0201385A2 (hu) 2003-12-29
KR100474225B1 (ko) 2005-03-08
BRPI0201437B8 (pt) 2021-05-25
EP1253153A1 (fr) 2002-10-30
AU3563002A (en) 2002-10-31
PL353633A1 (en) 2002-11-04
CZ303716B6 (cs) 2013-04-03
CZ20021417A3 (cs) 2003-05-14
HU230717B1 (hu) 2017-11-28
CN1297564C (zh) 2007-01-31
CN1503804A (zh) 2004-06-09
PL371766A1 (en) 2005-06-27
RU2233287C2 (ru) 2004-07-27
JP2004528353A (ja) 2004-09-16
ZA200203252B (en) 2003-10-24
CN1715289A (zh) 2006-01-04
EP1253153B1 (fr) 2016-11-02
MXPA03009786A (es) 2004-01-29

Similar Documents

Publication Publication Date Title
IL158059A0 (en) Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
IL209827A0 (en) A process for preparing pyrazole derivatives
IL140079A0 (en) Process for producing bisphennol a
HUP0402027A3 (en) Process for the preparation of a xantophyll
IL189161A0 (en) A process for the preparing a 2-nitro-2'-carboxy-diphenylsulfide derivative
PL352291A1 (en) Process for making a pipa-polyol
IL160193A0 (en) Process for the preparation of a 14-hydroxynormorphinone derivative
HUP0004884A3 (en) Process for preparing 1,4-dihydropyridine derivatives
GB0125191D0 (en) Process for preparing imadacloprid
SI1047666T1 (en) Process for preparing a ketimine
HUP0301649A3 (en) Process for preparing azacycloalkanoylaminothiazoles
HUP0300114A3 (en) Process for preparing flavonoid-derivatives
GB2350611B (en) Process for producing a diarylamine
HUP0204145A3 (en) Process for preparing a quinolylacrylonitrile derivative and its intermediate and the novel intermediate
HUP0200187A3 (en) A process for the preparation of 1,4,7,10-tetraazacyclododecane
HUP0401989A3 (en) A process for the preparation of the 14 beta-hydroxy-baccatin iii-1,14-carbonate
PL361225A1 (en) Method for preparing 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin a derivatives from 9-deoxo-9(z)-hydroxyiminoerythromycin a
IL137364A0 (en) A process for the preparation of 6,6-dimethylhept-1-en-4-yn-3-ol
HK1087414A1 (en) Process for preparing 4"-substituted-9-deoxo-9A-aza-9A-homoerythromycin a derivatives
IL146810A0 (en) Process for preparing 10, 11-methanobenzosuberane derivatives
HUP0004469A3 (en) Process for producing trifluormethyl-aniline derivatives
HUP0300259A3 (en) Process for preparing 5'-acetylstavudine
EP1451178A4 (fr) Procedes de preparation de derives de beta-d-ribofuranose
HUP0204443A3 (en) Process for preparing fluoroformates
HUP0000208A3 (en) Process for producing secondary-alkoxy-1-alkene derivatives