SE9802864D0 - Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder - Google Patents

Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder

Info

Publication number
SE9802864D0
SE9802864D0 SE9802864A SE9802864A SE9802864D0 SE 9802864 D0 SE9802864 D0 SE 9802864D0 SE 9802864 A SE9802864 A SE 9802864A SE 9802864 A SE9802864 A SE 9802864A SE 9802864 D0 SE9802864 D0 SE 9802864D0
Authority
SE
Sweden
Prior art keywords
overactive bladder
tolterodine
treatment
antimuscarinic agent
transdermally administered
Prior art date
Application number
SE9802864A
Other languages
English (en)
Swedish (sv)
Inventor
Lene Orup Jacobsen
Bo Kreilgaard
Ulla Hoeck
Helle Kristensen
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20412370&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE9802864(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Priority to SE9802864A priority Critical patent/SE9802864D0/xx
Publication of SE9802864D0 publication Critical patent/SE9802864D0/xx
Priority to IL13629499A priority patent/IL136294A/en
Priority to HK01104868.0A priority patent/HK1034664B/xx
Priority to APAP/P/2000/001823A priority patent/AP1529A/en
Priority to IDP20001006A priority patent/ID25824A/id
Priority to DE69939382T priority patent/DE69939382D1/de
Priority to MEP-2001-331A priority patent/ME00850B/me
Priority to IL15641499A priority patent/IL156414A0/xx
Priority to AU58918/99A priority patent/AU745190B2/en
Priority to MYPI99003665A priority patent/MY127946A/en
Priority to CZ20001924A priority patent/CZ302630B6/cs
Priority to GE3951A priority patent/GEP20043354B/en
Priority to UA2000052950A priority patent/UA72882C2/uk
Priority to ES99946521T priority patent/ES2353765T3/es
Priority to PCT/SE1999/001464 priority patent/WO2000012070A1/en
Priority to US09/763,654 priority patent/US6517864B1/en
Priority to AT99946522T priority patent/ATE405254T1/de
Priority to NZ504618A priority patent/NZ504618A/xx
Priority to PCT/SE1999/001463 priority patent/WO2000012069A1/en
Priority to NZ509928A priority patent/NZ509928A/en
Priority to ARP990104280A priority patent/AR029311A1/es
Priority to EP99946522A priority patent/EP1105111B1/en
Priority to SK749-2000A priority patent/SK287111B6/sk
Priority to US09/582,498 priority patent/US6770295B1/en
Priority to CNB99801916XA priority patent/CN1239152C/zh
Priority to OA1200000309A priority patent/OA11636A/en
Priority to TR2000/01998T priority patent/TR200001998T1/xx
Priority to JP2000567189A priority patent/JP2002523446A/ja
Priority to PT99946521T priority patent/PT1039882E/pt
Priority to AU58919/99A priority patent/AU758399B2/en
Priority to EP09173927A priority patent/EP2153825A1/en
Priority to CA2311755A priority patent/CA2311755C/en
Priority to ES99946522T priority patent/ES2310942T3/es
Priority to SI9931050T priority patent/SI1039882T1/sl
Priority to HU0100437A priority patent/HUP0100437A3/hu
Priority to AT99946521T priority patent/ATE487471T1/de
Priority to EP99946521A priority patent/EP1039882B1/en
Priority to CA002341063A priority patent/CA2341063C/en
Priority to DK99946521.4T priority patent/DK1039882T3/da
Priority to DE69942928T priority patent/DE69942928D1/de
Priority to EA200000468A priority patent/EA002720B1/ru
Priority to TW088114752A priority patent/TWI253349B/zh
Priority to ZA200002488A priority patent/ZA200002488B/xx
Priority to BG104476A priority patent/BG65168B1/bg
Priority to NO20002977A priority patent/NO329830B1/no
Priority to IS5537A priority patent/IS2976B/is
Priority to US10/301,719 priority patent/US7008637B2/en
Priority to CY20101101027T priority patent/CY1111088T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE9802864A 1998-08-27 1998-08-27 Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder SE9802864D0 (sv)

Priority Applications (48)

Application Number Priority Date Filing Date Title
SE9802864A SE9802864D0 (sv) 1998-08-27 1998-08-27 Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder
IL13629499A IL136294A (en) 1998-08-27 1999-08-26 Use of toltrodine, 5-hydroxy methyl metabolite or its resmat in the preparation of drugs for the treatment of unstable or overactive bladder
HK01104868.0A HK1034664B (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
APAP/P/2000/001823A AP1529A (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release.
IDP20001006A ID25824A (id) 1998-08-27 1999-08-26 Formulasi terapeutik untuk memberikan tolterodin dengan pelepasan yang terkendali
DE69939382T DE69939382D1 (de) 1998-08-27 1999-08-26 Transdermal verabreichtes tolterodin als antimuskarin-wirkstoff zur behandlung der hyperaktiven blase
MEP-2001-331A ME00850B (me) 1998-08-27 1999-08-26 Nove perle sa kontrolisanim oslobađanjem, postupak za njihovu proizvodnju i višestruka jedinična formulacija koja ih sadrži
IL15641499A IL156414A0 (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
AU58918/99A AU745190B2 (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
MYPI99003665A MY127946A (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
CZ20001924A CZ302630B6 (cs) 1998-08-27 1999-08-26 Farmaceutický prostredek obsahující tolterodin nebo tolterodinu príbuznou slouceninu
GE3951A GEP20043354B (en) 1998-08-27 1999-08-26 Therapeutic Formulation for Administering Tolterodine with Controlled Release
UA2000052950A UA72882C2 (uk) 1998-08-27 1999-08-26 Спосіб лікування нестабільності чи надактивності сечового міхура, фармацевтична композиція з регульованим вивільненням та використання толтеродину
ES99946521T ES2353765T3 (es) 1998-08-27 1999-08-26 Formulación terapeútica para administrar tolterodina con liberación controlada.
PCT/SE1999/001464 WO2000012070A1 (en) 1998-08-27 1999-08-26 Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
US09/763,654 US6517864B1 (en) 1998-08-27 1999-08-26 Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
AT99946522T ATE405254T1 (de) 1998-08-27 1999-08-26 Transdermal verabreichtes tolterodin als antimuskarin-wirkstoff zur behandlung der hyperaktiven blase
NZ504618A NZ504618A (en) 1998-08-27 1999-08-26 Controlled release therapeutic formulation for administering tolterodine maintaining a constant serum level
PCT/SE1999/001463 WO2000012069A1 (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
NZ509928A NZ509928A (en) 1998-08-27 1999-08-26 Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
ARP990104280A AR029311A1 (es) 1998-08-27 1999-08-26 UN MÉTODO PARA EL TRATAMIENTO DE LA VEJIGA URINARIA INESTABLE O HIPERACTIVA CON UNA FORMULACIoN DE LIBERACIoN CONTROLADA DE TOLTERODINA O COMPUESTOS RELACIONADOS; DICHA FORMULACIoN FARMACÉUTICA Y USO DE TOLTERODINA O DE COMPUESTOS RELACIONADOS.
EP99946522A EP1105111B1 (en) 1998-08-27 1999-08-26 Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
SK749-2000A SK287111B6 (sk) 1998-08-27 1999-08-26 Farmaceutický prípravok obsahujúci tolterodin s regulovaným uvoľňovaním
US09/582,498 US6770295B1 (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
CNB99801916XA CN1239152C (zh) 1998-08-27 1999-08-26 控释给药托耳替罗地的治疗制剂
OA1200000309A OA11636A (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release.
TR2000/01998T TR200001998T1 (tr) 1998-08-27 1999-08-26 Kontrollü salıverilen tolterodin uygulamak için ilaç formülasyonu
JP2000567189A JP2002523446A (ja) 1998-08-27 1999-08-26 過活動性膀胱の治療のための抗ムスカリン剤としての経皮投与トルテロジン
PT99946521T PT1039882E (pt) 1998-08-27 1999-08-26 Formulação terapêutica para administrar tolterodina com libertação controlada
AU58919/99A AU758399B2 (en) 1998-08-27 1999-08-26 Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
EP09173927A EP2153825A1 (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
CA2311755A CA2311755C (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
ES99946522T ES2310942T3 (es) 1998-08-27 1999-08-26 Tolterodina administrada por via transdermica como agente anti-muscarinico para el tratamiento de vejiga hiperactiva.
SI9931050T SI1039882T1 (sl) 1998-08-27 1999-08-26 Terapevtska formulacija za dajanje tolterodina s kontroliranim sproščanjem
HU0100437A HUP0100437A3 (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
AT99946521T ATE487471T1 (de) 1998-08-27 1999-08-26 Therapeutische formulierung zur verabreichung von tolterodin mit kontrollierter freisetzung
EP99946521A EP1039882B1 (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
CA002341063A CA2341063C (en) 1998-08-27 1999-08-26 Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
DK99946521.4T DK1039882T3 (da) 1998-08-27 1999-08-26 Terapeutisk formulering til indgivelse af tolterodin med kontrolleret frigivelse
DE69942928T DE69942928D1 (de) 1998-08-27 1999-08-26 Therapeutische formulierung zur verabreichung von tolterodin mit kontrollierter freisetzung
EA200000468A EA002720B1 (ru) 1998-08-27 1999-08-26 Терапевтическая композиция для введения толтеродина с контролируемым высвобождением и способ лечения мочевого пузыря с её использованием
TW088114752A TWI253349B (en) 1998-08-27 1999-08-27 Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
ZA200002488A ZA200002488B (en) 1998-08-27 2000-05-19 Therapeutic formulation for administering tolterodine with controlled release.
BG104476A BG65168B1 (bg) 1998-08-27 2000-05-26 Фармацевтична форма на толтеродин с контролирано освобождаване
NO20002977A NO329830B1 (no) 1998-08-27 2000-06-09 Oral farmasoytisk formulering inneholdende tolterodin og med kontrollert frigivelse
IS5537A IS2976B (is) 1998-08-27 2000-06-15 Lyfjablanda til inntöku um munn sem inniheldur tolteródín og hefur stýrða losun
US10/301,719 US7008637B2 (en) 1998-08-27 2002-11-22 Transdermally administered tolterodine as anti-muscarinic agent for the treatment of overactive bladder
CY20101101027T CY1111088T1 (el) 1998-08-27 2010-11-17 Θεραπευτικη φαρμακοτεχνικη μορφη για χορηγηση τολτεροδινης με ελεγχομενη απελευθερωση

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9802864A SE9802864D0 (sv) 1998-08-27 1998-08-27 Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder

Publications (1)

Publication Number Publication Date
SE9802864D0 true SE9802864D0 (sv) 1998-08-27

Family

ID=20412370

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9802864A SE9802864D0 (sv) 1998-08-27 1998-08-27 Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder

Country Status (13)

Country Link
US (2) US6517864B1 (https=)
EP (1) EP1105111B1 (https=)
JP (1) JP2002523446A (https=)
AT (1) ATE405254T1 (https=)
AU (1) AU758399B2 (https=)
CA (1) CA2341063C (https=)
DE (1) DE69939382D1 (https=)
ES (2) ES2353765T3 (https=)
NZ (1) NZ509928A (https=)
SE (1) SE9802864D0 (https=)
TW (1) TWI253349B (https=)
WO (1) WO2000012070A1 (https=)
ZA (1) ZA200002488B (https=)

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EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
SE9802864D0 (sv) * 1998-08-27 1998-08-27 Pharmacia & Upjohn Ab Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder
PT1031346E (pt) 1999-01-27 2002-09-30 Idea Ag Vacinacao nao invasiva atraves da pele
SI1031347T1 (en) 1999-01-27 2002-10-31 Idea Ag Transnasal transport/immunisation with highly adaptable carriers
DE19922662C1 (de) 1999-05-18 2000-12-28 Sanol Arznei Schwarz Gmbh Transdermales therapeutisches System (TTS) Tolterodin enthaltend
WO2001001962A1 (en) * 1999-07-05 2001-01-11 Idea Ag. A method for the improvement of transport across adaptable semi-permeable barriers
DE19932651A1 (de) * 1999-07-13 2001-01-18 Hexal Ag Transdermales therapeutisches System zur Anwendung von Tolterodin
JP2005513080A (ja) * 2001-12-20 2005-05-12 フェムファーマ, インコーポレイテッド 薬物の膣送達
JP2006515026A (ja) * 2003-01-02 2006-05-18 フェムファーマ ホールディング カンパニー, インコーポレイテッド 乳房の疾患および障害の処置のための薬学的調製物
US9173836B2 (en) 2003-01-02 2015-11-03 FemmeParma Holding Company, Inc. Pharmaceutical preparations for treatments of diseases and disorders of the breast
US20040191345A1 (en) * 2003-03-26 2004-09-30 Fredrik Nicklasson New formulations and use thereof
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
JP5548329B2 (ja) * 2003-08-04 2014-07-16 杏林製薬株式会社 経皮吸収型製剤
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
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US7803778B2 (en) 2006-05-23 2010-09-28 Theracos, Inc. Glucose transport inhibitors and methods of use
US7893053B2 (en) 2006-06-16 2011-02-22 Theracos, Inc. Treating psychological conditions using muscarinic receptor M1 antagonists
US8748419B2 (en) 2006-06-16 2014-06-10 Theracos, Inc. Treating obesity with muscarinic receptor M1 antagonists
US20080153789A1 (en) * 2006-12-26 2008-06-26 Femmepharma Holding Company, Inc. Topical administration of danazol
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JP5583003B2 (ja) 2007-04-02 2014-09-03 セラコス・インコーポレイテッド ベンジルグルコシド誘導体およびその用途
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NZ583369A (en) 2007-08-23 2011-08-26 Theracos Inc Benzylbenzene derivatives and methods of use
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