SE9003665D0 - Morphine prodrugs - Google Patents

Morphine prodrugs

Info

Publication number
SE9003665D0
SE9003665D0 SE9003665A SE9003665A SE9003665D0 SE 9003665 D0 SE9003665 D0 SE 9003665D0 SE 9003665 A SE9003665 A SE 9003665A SE 9003665 A SE9003665 A SE 9003665A SE 9003665 D0 SE9003665 D0 SE 9003665D0
Authority
SE
Sweden
Prior art keywords
pct
morphine
date
sec
prodrugs
Prior art date
Application number
SE9003665A
Other languages
English (en)
Swedish (sv)
Inventor
H Bundgaard
Original Assignee
Kabivitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab
Priority to SE9003665A priority Critical patent/SE9003665D0/xx
Publication of SE9003665D0 publication Critical patent/SE9003665D0/xx
Priority to IE368291A priority patent/IE913682A1/en
Priority to NZ240349A priority patent/NZ240349A/en
Priority to ZA918512A priority patent/ZA918512B/xx
Priority to IL9990591A priority patent/IL99905A/en
Priority to US08/050,336 priority patent/US5908846A/en
Priority to DK91920399T priority patent/DK0557385T3/da
Priority to EP91920399A priority patent/EP0557385B1/en
Priority to JP50056892A priority patent/JP3493434B2/ja
Priority to AT91920399T priority patent/ATE168560T1/de
Priority to AU89381/91A priority patent/AU655612B2/en
Priority to PCT/SE1991/000760 priority patent/WO1992008459A1/en
Priority to ES91920399T priority patent/ES2121793T3/es
Priority to DE69129861T priority patent/DE69129861T2/de
Priority to CA002095223A priority patent/CA2095223C/en
Priority to PT99513A priority patent/PT99513B/pt
Priority to FI932212A priority patent/FI932212A0/fi
Priority to NO93931766A priority patent/NO931766L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SE9003665A 1990-11-16 1990-11-16 Morphine prodrugs SE9003665D0 (sv)

Priority Applications (18)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs
IE368291A IE913682A1 (en) 1990-11-16 1991-10-21 Morphine prodrugs
NZ240349A NZ240349A (en) 1990-11-16 1991-10-25 Topical compositions for transdermal delivery of morphine prodrugs
ZA918512A ZA918512B (en) 1990-11-16 1991-10-25 Morphine prodrugs
IL9990591A IL99905A (en) 1990-11-16 1991-10-30 Topical compositions for transdermal delivery of morphine prodrugs
CA002095223A CA2095223C (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of prodrug derivatives of morphine
JP50056892A JP3493434B2 (ja) 1990-11-16 1991-11-11 モルヒネのプロドラッグ誘導体の経皮供給用の局所組成物
DK91920399T DK0557385T3 (da) 1990-11-16 1991-11-11 Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin
EP91920399A EP0557385B1 (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of produg derivatives of morphine
US08/050,336 US5908846A (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of prodrug derivatives of morphine
AT91920399T ATE168560T1 (de) 1990-11-16 1991-11-11 Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
AU89381/91A AU655612B2 (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of produg derivatives of morphine
PCT/SE1991/000760 WO1992008459A1 (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of produg derivatives of morphine
ES91920399T ES2121793T3 (es) 1990-11-16 1991-11-11 Composiciones de uso local para la administracion transdermica de derivados profarmacos de morfina.
DE69129861T DE69129861T2 (de) 1990-11-16 1991-11-11 Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
PT99513A PT99513B (pt) 1990-11-16 1991-11-14 Processo para a preparacao de composicoes farmaceuticas contendo profarmacos de morfina para administracao topica por via transdermica
FI932212A FI932212A0 (fi) 1990-11-16 1993-05-14 Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat
NO93931766A NO931766L (no) 1990-11-16 1993-05-14 Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs

Publications (1)

Publication Number Publication Date
SE9003665D0 true SE9003665D0 (sv) 1990-11-16

Family

ID=20380936

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs

Country Status (18)

Country Link
US (1) US5908846A (pt)
EP (1) EP0557385B1 (pt)
JP (1) JP3493434B2 (pt)
AT (1) ATE168560T1 (pt)
AU (1) AU655612B2 (pt)
CA (1) CA2095223C (pt)
DE (1) DE69129861T2 (pt)
DK (1) DK0557385T3 (pt)
ES (1) ES2121793T3 (pt)
FI (1) FI932212A0 (pt)
IE (1) IE913682A1 (pt)
IL (1) IL99905A (pt)
NO (1) NO931766L (pt)
NZ (1) NZ240349A (pt)
PT (1) PT99513B (pt)
SE (1) SE9003665D0 (pt)
WO (1) WO1992008459A1 (pt)
ZA (1) ZA918512B (pt)

Families Citing this family (47)

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US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE19508664C2 (de) * 1995-03-14 2001-08-23 Christian Mignat Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
AU5108596A (en) * 1995-03-14 1996-10-02 Mundipharma Gmbh Morphine-3-esters
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
DE19602964A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19923551A1 (de) * 1999-05-21 2000-11-30 Lohmann Therapie Syst Lts Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
MXPA02004293A (es) 1999-10-29 2002-10-31 Euro Celtique Sa Formulaciones de hidrocodona de liberacion controlada..
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
US20020013331A1 (en) 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
CN100518827C (zh) 2000-10-30 2009-07-29 欧罗赛铁克股份有限公司 控释氢可酮制剂
US6569449B1 (en) * 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
KR100612398B1 (ko) * 2000-11-14 2006-08-16 바이탈 헬스 사이언시즈 피티와이 리미티드 포스페이트 유도체의 착체
AUPR549901A0 (en) * 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
KR20040014544A (ko) * 2001-06-05 2004-02-14 컨트롤 딜리버리 시스템즈 인코포레이티드 서방 진통제 화합물
AU2002317053B2 (en) * 2001-07-27 2004-08-05 Vital Health Sciences Pty Ltd Dermal therapy using phosphate derivatives of electron transfer agents
WO2003049774A1 (en) * 2001-12-13 2003-06-19 Vital Health Sciences Pty Ltd Transdermal transport of compounds
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
DE60329515D1 (de) * 2002-10-25 2009-11-12 Euro Celtique Sa Analoga und prodrugs von buprenorphin
WO2004043396A2 (en) * 2002-11-09 2004-05-27 Nobex Corporation Modified carbamate-containing prodrugs and methods of synthesizing same
US20060241085A1 (en) * 2003-01-17 2006-10-26 West Simon M Compounds having anti-proliferative properties
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
EP1638492B1 (en) * 2003-07-25 2008-01-02 Euro-Celtique S.A. Preoperative treatment of post operative pain
ATE451374T1 (de) 2004-02-06 2009-12-15 Euro Celtique Sa Verfahren zur herstellung 3-o-geschützter morphinone und 3-o-geschützter morphinon-dienol- carboxylate
RS50963B (sr) 2004-02-23 2010-10-31 Euro-Celtique S.A. Opioidni transdermalni preparat otporan na zloupotrebu
EP1720551B9 (en) 2004-03-03 2011-09-21 Vital Health Sciences Pty Ltd. Alkaloid formulations
EP1893159B1 (en) 2005-06-17 2015-09-30 Vital Health Sciences Pty Ltd. A carrier comprising one or more di- and/or monophosphate derivatives of electron transfer agents
EP1973547A1 (en) * 2005-12-23 2008-10-01 Vital Health Sciences Pty Ltd. Compounds having cytokine modulating properties
CN101621999B (zh) 2007-03-02 2012-09-26 帝化制药株式会社 经皮吸收医药组合物、医药组合物储存单元以及利用了该储存单元的经皮吸收制剂
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US8354116B2 (en) * 2007-06-18 2013-01-15 Biochemics, Inc. Bifunctional synthetic molecules
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
WO2009158667A2 (en) * 2008-06-27 2009-12-30 Comgenrx, Inc. Povidone compositions for wound healing
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
CA2765836C (en) 2009-07-02 2014-10-07 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
UA102916C2 (uk) * 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
EP2531047A4 (en) 2010-02-05 2014-03-19 Phosphagenics Ltd CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE
ES2829386T3 (es) 2010-03-30 2021-05-31 Phosphagenics Ltd Parche de administración transdérmica
US11607407B2 (en) 2010-04-13 2023-03-21 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-methyl-2′,6′-pipecoloxylidide and method of use
TWI590821B (zh) 2011-01-18 2017-07-11 輝瑞有限公司 固體分子分散液
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
RU2683317C2 (ru) 2014-11-25 2019-03-28 Кемфарм, Инк. Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой
CN108601732A (zh) 2015-12-09 2018-09-28 磷肌酸有限公司 药物制剂
MX2019006845A (es) 2016-12-21 2019-10-15 Avecho Biotechnology Ltd Proceso.

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US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4879297A (en) * 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US4891377A (en) * 1988-12-02 1990-01-02 Board Of Regents Acting For And On Behalf Of University Of Michigan Transdermal delivery of the narcotic analgesics etorphine and analogs
WO1991015241A1 (en) * 1990-03-30 1991-10-17 Yasunori Morimoto Percutaneously absorbable composition of narcotic and nonnarcotic analgesics
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine

Also Published As

Publication number Publication date
US5908846A (en) 1999-06-01
DK0557385T3 (da) 1999-04-26
FI932212A (fi) 1993-05-14
DE69129861T2 (de) 1999-04-01
ES2121793T3 (es) 1998-12-16
WO1992008459A1 (en) 1992-05-29
AU655612B2 (en) 1995-01-05
DE69129861D1 (de) 1998-08-27
PT99513A (pt) 1992-09-30
JPH06502422A (ja) 1994-03-17
CA2095223A1 (en) 1992-05-17
NO931766D0 (no) 1993-05-14
IE913682A1 (en) 1992-05-20
IL99905A0 (en) 1992-08-18
PT99513B (pt) 1999-04-30
NO931766L (no) 1993-05-14
EP0557385A1 (en) 1993-09-01
JP3493434B2 (ja) 2004-02-03
IL99905A (en) 1995-06-29
NZ240349A (en) 1993-07-27
EP0557385B1 (en) 1998-07-22
FI932212A0 (fi) 1993-05-14
AU8938191A (en) 1992-06-11
CA2095223C (en) 2002-12-17
ZA918512B (en) 1992-08-26
ATE168560T1 (de) 1998-08-15

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