FI932212A0 - Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat - Google Patents

Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat

Info

Publication number
FI932212A0
FI932212A0 FI932212A FI932212A FI932212A0 FI 932212 A0 FI932212 A0 FI 932212A0 FI 932212 A FI932212 A FI 932212A FI 932212 A FI932212 A FI 932212A FI 932212 A0 FI932212 A0 FI 932212A0
Authority
FI
Finland
Prior art keywords
pct
morphine
topical composition
transdermal transmission
prodrugs
Prior art date
Application number
FI932212A
Other languages
English (en)
Other versions
FI932212A (fi
Inventor
Hans Bundgaard
Lona Christrup
Joern Drustrup
Ann Erton
Martin Nicklasson
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Publication of FI932212A0 publication Critical patent/FI932212A0/fi
Publication of FI932212A publication Critical patent/FI932212A/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FI932212A 1990-11-16 1993-05-14 Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat FI932212A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs

Publications (2)

Publication Number Publication Date
FI932212A0 true FI932212A0 (fi) 1993-05-14
FI932212A FI932212A (fi) 1993-05-14

Family

ID=20380936

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932212A FI932212A (fi) 1990-11-16 1993-05-14 Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat

Country Status (18)

Country Link
US (1) US5908846A (fi)
EP (1) EP0557385B1 (fi)
JP (1) JP3493434B2 (fi)
AT (1) ATE168560T1 (fi)
AU (1) AU655612B2 (fi)
CA (1) CA2095223C (fi)
DE (1) DE69129861T2 (fi)
DK (1) DK0557385T3 (fi)
ES (1) ES2121793T3 (fi)
FI (1) FI932212A (fi)
IE (1) IE913682A1 (fi)
IL (1) IL99905A (fi)
NO (1) NO931766L (fi)
NZ (1) NZ240349A (fi)
PT (1) PT99513B (fi)
SE (1) SE9003665D0 (fi)
WO (1) WO1992008459A1 (fi)
ZA (1) ZA918512B (fi)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE19508664C2 (de) * 1995-03-14 2001-08-23 Christian Mignat Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
WO1996028451A1 (en) * 1995-03-14 1996-09-19 Euroceltique S.A. Morphine-3-esters
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
DE19602971A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue 7,8-Dihydromorphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19923551A1 (de) * 1999-05-21 2000-11-30 Lohmann Therapie Syst Lts Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
EP1623703B1 (en) 1999-10-29 2011-10-05 Euro-Celtique S.A. Controlled release hydrocodone formulations
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
US20020013331A1 (en) 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
HU230686B1 (en) 2000-10-30 2017-08-28 Euro Celtique Sa Controlled release hydrocodone compositions
US6569449B1 (en) * 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
AU1482102A (en) * 2000-11-14 2002-05-27 Tocovite Pty Ltd Complexes of phosphate derivatives
AUPR549901A0 (en) * 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
ATE506064T1 (de) * 2001-06-05 2011-05-15 Control Delivery Systems Analgetika mit verzögerter wirkstoffabgabe
CN1547475B (zh) * 2001-07-27 2010-12-15 生命健康科学有限公司 含电子转移试剂的磷酸酯衍生物的皮肤制剂
MXPA04005361A (es) * 2001-12-13 2004-09-27 Vital Health Sciences Pyt Ltd Transporte transdermico de compuestos.
AU2002950713A0 (en) * 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
EP1554290B1 (en) * 2002-10-25 2009-09-30 Euro-Celtique S.A. Analogs and prodrugs of buprenorphine
US20040152769A1 (en) * 2002-11-09 2004-08-05 Ekwuribe Nnochiri Nkem Modified carbamate-containing prodrugs and methods of synthesizing same
CA2513427C (en) * 2003-01-17 2012-03-27 Vital Health Sciences Pty Ltd. Compounds having anti-proliferative properties
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
ES2299871T3 (es) * 2003-07-25 2008-06-01 Euro-Celtique S.A. Tratamiento pre-operatorio del dolor post-operatorio.
SI1711502T1 (sl) 2004-02-06 2009-02-28 Euro Celtique Sa Postopki za izdelavo 3-O-zaščitenih morfinonov in 3-O-zaščitenih morfinondienol karboksilatov
SI2351555T1 (sl) 2004-02-23 2017-01-31 Euro-Celtique S.A. Naprava za transdermalno dajanje opioida, varna pred zlorabo
AU2005202477B2 (en) 2004-03-03 2005-12-15 Vital Health Sciences Pty Ltd Alkaloid formulations
WO2006133506A1 (en) 2005-06-17 2006-12-21 Vital Health Sciences Pty Ltd A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
WO2007070981A1 (en) * 2005-12-23 2007-06-28 Vital Health Sciences Pty Ltd Compounds having cytokine modulating properties
EP2123274B1 (en) 2007-03-02 2016-08-24 Teika Pharmaceutical Co., Ltd. Medicinal composition for transdermal absorption, medicinal composition storing unit and transdermal absorption preparation using the same
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US8354116B2 (en) * 2007-06-18 2013-01-15 Biochemics, Inc. Bifunctional synthetic molecules
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
WO2009158667A2 (en) * 2008-06-27 2009-12-30 Comgenrx, Inc. Povidone compositions for wound healing
EP2448408A4 (en) * 2009-07-02 2015-06-03 Kempharm Inc CONJUGATES OF PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID AND HYDROCODONE PRODRUGS, METHODS OF MAKING AND USING THEM
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
EP2531047A4 (en) 2010-02-05 2014-03-19 Phosphagenics Ltd CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE
NZ602572A (en) 2010-03-30 2014-11-28 Phosphagenics Ltd Transdermal delivery patch
CN103491778B (zh) 2010-04-13 2017-05-31 雷尔玛达治疗股份有限公司 1‑甲基‑n‑(2，6‑二甲苯基)‑2‑哌啶甲酰胺的皮肤用药物组合物及其使用方法
TWI590821B (zh) 2011-01-18 2017-07-11 輝瑞有限公司 固體分子分散液
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
MX2017006520A (es) 2014-11-25 2017-08-09 Kempharm Inc * Acido benzoico, derivados de acido benzoico y conjugados de oxicodona de acido heteroaril carboxilico.
JP6882321B2 (ja) 2015-12-09 2021-06-02 フォスファージニクス リミテッド 医薬製剤
CA3045702A1 (en) 2016-12-21 2018-06-28 Phosphagenics Limited Phosphorylation process of complex alcohols

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4879297A (en) * 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US4891377A (en) * 1988-12-02 1990-01-02 Board Of Regents Acting For And On Behalf Of University Of Michigan Transdermal delivery of the narcotic analgesics etorphine and analogs
US5240932A (en) * 1990-03-30 1993-08-31 Yasunori Morimoto Percutaneously absorbable compositions of morphine or analogous analgesics of morphine
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine

Also Published As

Publication number Publication date
EP0557385B1 (en) 1998-07-22
DE69129861D1 (de) 1998-08-27
IL99905A0 (en) 1992-08-18
SE9003665D0 (sv) 1990-11-16
NZ240349A (en) 1993-07-27
NO931766D0 (no) 1993-05-14
US5908846A (en) 1999-06-01
ZA918512B (en) 1992-08-26
EP0557385A1 (en) 1993-09-01
AU655612B2 (en) 1995-01-05
CA2095223C (en) 2002-12-17
FI932212A (fi) 1993-05-14
WO1992008459A1 (en) 1992-05-29
PT99513A (pt) 1992-09-30
DE69129861T2 (de) 1999-04-01
CA2095223A1 (en) 1992-05-17
ATE168560T1 (de) 1998-08-15
AU8938191A (en) 1992-06-11
JPH06502422A (ja) 1994-03-17
IE913682A1 (en) 1992-05-20
ES2121793T3 (es) 1998-12-16
NO931766L (no) 1993-05-14
JP3493434B2 (ja) 2004-02-03
IL99905A (en) 1995-06-29
DK0557385T3 (da) 1999-04-26
PT99513B (pt) 1999-04-30

Similar Documents

Publication Publication Date Title
FI932212A0 (fi) Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat
MY107158A (en) 3-arylcarbonyl; -1h-indoles useful as therapeutic agents.
CY2431B1 (en) Novel phenanthridines substituted in the 6 position.
MX9700886A (es) Nuevas oxazolidinonas sustituidas.
FI954963A (fi) Poly-1-n-alkeeniamiineja ja näitä sisältäviä poltto- ja voiteluainekoostumuksia
GEP20074185B (en) Incclusion complexs of aryl- heterocyclic salts
IL104489A0 (en) Carbamates and crop protection agents containing them
ATE167476T1 (de) Substituierte 2-phenyl-3-methocypropensäurenester als fungizide mittel.
BR9707233A (pt) Fenantridinas
MX9300550A (es) Estructura de fibra absorbente.
NZ332215A (en) Transdermally administered dextromethorphan as antitussive agent
MY106109A (en) 3-arylcarbonyl-1-aminoalkyl-1h-indole-containing antiglaucoma compositions
DE69311541T2 (de) Kosmetische oder pharmazeutische zusammensetzungen zur topischen anwendung die deacylierten glycerophospholipide enthalten
ATE231131T1 (de) Verbindungen mit wachtumshormon freisetzenden eigenschaften
GEP20002031B (en) Substituted Benzothiazols with Herbicidal Action
DE69727385D1 (de) Benzophenanthridinalkaloid-enthaltende pestizide
YU46914B (sh) Metoksimetilna jedinjenja
SE9300106D0 (sv) Komposition foer att paaskynda saarlaekning
BR9609114A (pt) Composição inseticida de terra diatomácea
MX9602949A (es) 2-oxa y tia-zolinas artropodicidas.
DK0669826T3 (da) (-)-Metrifonatholdigt lægemiddel
ZA913920B (en) Therapeutic compound
ES2163503T3 (es) Compuesto ge3.
MY108690A (en) Mildewproofing agent for timber
MX9804797A (es) Nuevos compuestos con efecto analgesico.

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: PHARMACIA AB