NO931766L - Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfin - Google Patents
Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfinInfo
- Publication number
- NO931766L NO931766L NO93931766A NO931766A NO931766L NO 931766 L NO931766 L NO 931766L NO 93931766 A NO93931766 A NO 93931766A NO 931766 A NO931766 A NO 931766A NO 931766 L NO931766 L NO 931766L
- Authority
- NO
- Norway
- Prior art keywords
- morphine
- transdermal delivery
- preservant
- pct
- topical preparations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Topisk preparat for transdermal avlevering av morfin. Preparatet omfat- ter en effektiv mengde av en morfin-ester sammen med en topisk, farmasøytisk bærer som gir oppløsninger, suspensjoner, salver, lotions, kremer, geler, pastaer, geleer, sprayer og aerosoler, og/eller sammen med en medisinsk anord- ning. Oppfinnelsen vedrører også bruken av morfinesterne for fremstilling av et topisk medikament for transdermal av- levering for lindring av smerte eller beroligelse av et pattedyr.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9003665A SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Morphine prodrugs |
PCT/SE1991/000760 WO1992008459A1 (en) | 1990-11-16 | 1991-11-11 | Topical compositions for transdermal delivery of produg derivatives of morphine |
Publications (2)
Publication Number | Publication Date |
---|---|
NO931766L true NO931766L (no) | 1993-05-14 |
NO931766D0 NO931766D0 (no) | 1993-05-14 |
Family
ID=20380936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO931766A NO931766D0 (no) | 1990-11-16 | 1993-05-14 | Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfin |
Country Status (18)
Country | Link |
---|---|
US (1) | US5908846A (no) |
EP (1) | EP0557385B1 (no) |
JP (1) | JP3493434B2 (no) |
AT (1) | ATE168560T1 (no) |
AU (1) | AU655612B2 (no) |
CA (1) | CA2095223C (no) |
DE (1) | DE69129861T2 (no) |
DK (1) | DK0557385T3 (no) |
ES (1) | ES2121793T3 (no) |
FI (1) | FI932212A (no) |
IE (1) | IE913682A1 (no) |
IL (1) | IL99905A (no) |
NO (1) | NO931766D0 (no) |
NZ (1) | NZ240349A (no) |
PT (1) | PT99513B (no) |
SE (1) | SE9003665D0 (no) |
WO (1) | WO1992008459A1 (no) |
ZA (1) | ZA918512B (no) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
DE4403709A1 (de) * | 1994-02-07 | 1995-08-10 | Lohmann Therapie Syst Lts | Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid |
JPH07267862A (ja) * | 1994-03-29 | 1995-10-17 | Sekisui Chem Co Ltd | 経皮吸収貼付剤 |
DE19508664C2 (de) * | 1995-03-14 | 2001-08-23 | Christian Mignat | Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung |
WO1996028451A1 (en) * | 1995-03-14 | 1996-09-19 | Euroceltique S.A. | Morphine-3-esters |
GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
DE19602965A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
DE19923551A1 (de) * | 1999-05-21 | 2000-11-30 | Lohmann Therapie Syst Lts | Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht |
MXPA02004293A (es) | 1999-10-29 | 2002-10-31 | Euro Celtique Sa | Formulaciones de hidrocodona de liberacion controlada.. |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US20020013331A1 (en) * | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
EP1337244A4 (en) | 2000-10-30 | 2006-01-11 | Euro Celtique Sa | HYDROCODON FORMULATIONS WITH CONTROLLED RELEASE |
US6569449B1 (en) * | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
AUPR549901A0 (en) * | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
WO2002040034A1 (en) * | 2000-11-14 | 2002-05-23 | Vital Health Sciences Pty Ltd. | Complexes of phosphate derivatives |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
IL158882A0 (en) * | 2001-06-05 | 2004-05-12 | Control Delivery Sys Inc | Sustained-release analgesic compounds |
MXPA04000654A (es) * | 2001-07-27 | 2004-03-19 | Vital Health Sciences Pty Ltd | Terapia dermica usando derivados de fosfato de agente de transferencia de electrones. |
CA2466536C (en) * | 2001-12-13 | 2012-02-07 | Vital Health Sciences Pty Ltd | Transdermal transport of compounds |
AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
ATE444296T1 (de) * | 2002-10-25 | 2009-10-15 | Euro Celtique Sa | Analoga und prodrugs von buprenorphin |
US20040152769A1 (en) * | 2002-11-09 | 2004-08-05 | Ekwuribe Nnochiri Nkem | Modified carbamate-containing prodrugs and methods of synthesizing same |
WO2004064831A1 (en) * | 2003-01-17 | 2004-08-05 | Vital Health Sciences Pty Ltd | Compounds having anti-proliferative properties |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
KR20080011248A (ko) * | 2003-07-25 | 2008-01-31 | 유로-셀띠끄 소시에떼 아노님 | 수술후 통증의 수술전 치료 |
PT1864987E (pt) | 2004-02-06 | 2010-03-09 | Euro Celtique Sa | Processos para a produção de morfinonas protegidas em 3-o e carboxilatos de dienol e morfinonas protegidos em 3-o |
PT1718258E (pt) | 2004-02-23 | 2009-06-16 | Euro Celtique Sa | Dispositivo de administração transdérmica de opióides com resistência ao abuso |
CA2557354C (en) | 2004-03-03 | 2013-05-07 | Vital Health Sciences Pty Ltd. | Alkaloid formulations |
NZ565049A (en) | 2005-06-17 | 2012-02-24 | Vital Health Sciences Pty Ltd | A carrier comprising one or more DI and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
BRPI0621081A2 (pt) * | 2005-12-23 | 2011-11-29 | Vital Health Sciences Pty Ltd | método de modulação de uma ou mais citocinas imuno-reguladoras, uso de um ou mais derivados de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos, método de inibição de uma resposta inflamatória e/ou de estimulação de uma resposta anti-inflamatória, método de tratamento e/ou de profilaxia de distúbios imunológicos, distúrbios inflamatórios e/ou distúrbios proliferativos celulares, agente imuno-modulador, agente anti-inflamatório ou agente anti-cáncer e um ou mais derivado de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos |
KR101521989B1 (ko) | 2007-03-02 | 2015-05-28 | 테이카 세이야쿠 가부시키가이샤 | 경피흡수 의약조성물, 의약조성물 저장유닛 및 이것을 이용하는 경피흡수제제 |
US9511016B2 (en) * | 2007-06-12 | 2016-12-06 | Epicentrx, Inc. | Topical composition for treating pain |
US8354116B2 (en) * | 2007-06-18 | 2013-01-15 | Biochemics, Inc. | Bifunctional synthetic molecules |
US20090130048A1 (en) * | 2007-11-19 | 2009-05-21 | Oronsky Bryan Todd | Topical Composition for Treating Pain |
US8784872B2 (en) | 2007-11-19 | 2014-07-22 | Comgenrx, Inc. | Formulation for decreasing tobacco, alcohol, drug or food consumption |
WO2009158667A2 (en) * | 2008-06-27 | 2009-12-30 | Comgenrx, Inc. | Povidone compositions for wound healing |
US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
US8871780B2 (en) | 2009-07-02 | 2014-10-28 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof |
EP2531047A4 (en) | 2010-02-05 | 2014-03-19 | Phosphagenics Ltd | CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE |
EP2552486B1 (en) | 2010-03-30 | 2020-08-12 | Phosphagenics Limited | Transdermal delivery patch |
JP5927506B2 (ja) | 2010-04-13 | 2016-06-01 | レルマダ セラピューティクス、インク. | 1−メチル−2’,6’−ピペコロキシリダイドの皮膚医薬組成物および使用方法 |
TWI590821B (zh) | 2011-01-18 | 2017-07-11 | 輝瑞有限公司 | 固體分子分散液 |
US9561243B2 (en) | 2011-03-15 | 2017-02-07 | Phosphagenics Limited | Composition comprising non-neutralised tocol phosphate and a vitamin A compound |
RU2683317C2 (ru) | 2014-11-25 | 2019-03-28 | Кемфарм, Инк. | Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой |
JP6882321B2 (ja) | 2015-12-09 | 2021-06-02 | フォスファージニクス リミテッド | 医薬製剤 |
AU2017381395A1 (en) | 2016-12-21 | 2019-06-20 | Phosphagenics Limited | Process |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
US4908389A (en) * | 1986-08-27 | 1990-03-13 | Warner-Lambert Company | Penetration enhancement system |
US4940586A (en) * | 1987-02-26 | 1990-07-10 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
US4879297A (en) * | 1987-06-01 | 1989-11-07 | Warner-Lambert Company | Fatty acids and their small chain esters as penetration enhancers in aqueous systems |
US4891377A (en) * | 1988-12-02 | 1990-01-02 | Board Of Regents Acting For And On Behalf Of University Of Michigan | Transdermal delivery of the narcotic analgesics etorphine and analogs |
US5240932A (en) * | 1990-03-30 | 1993-08-31 | Yasunori Morimoto | Percutaneously absorbable compositions of morphine or analogous analgesics of morphine |
US5069909A (en) * | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
-
1990
- 1990-11-16 SE SE9003665A patent/SE9003665D0/xx unknown
-
1991
- 1991-10-21 IE IE368291A patent/IE913682A1/en not_active IP Right Cessation
- 1991-10-25 ZA ZA918512A patent/ZA918512B/xx unknown
- 1991-10-25 NZ NZ240349A patent/NZ240349A/en not_active IP Right Cessation
- 1991-10-30 IL IL9990591A patent/IL99905A/en not_active IP Right Cessation
- 1991-11-11 CA CA002095223A patent/CA2095223C/en not_active Expired - Fee Related
- 1991-11-11 AU AU89381/91A patent/AU655612B2/en not_active Ceased
- 1991-11-11 JP JP50056892A patent/JP3493434B2/ja not_active Expired - Fee Related
- 1991-11-11 EP EP91920399A patent/EP0557385B1/en not_active Expired - Lifetime
- 1991-11-11 US US08/050,336 patent/US5908846A/en not_active Expired - Fee Related
- 1991-11-11 DK DK91920399T patent/DK0557385T3/da active
- 1991-11-11 ES ES91920399T patent/ES2121793T3/es not_active Expired - Lifetime
- 1991-11-11 DE DE69129861T patent/DE69129861T2/de not_active Expired - Fee Related
- 1991-11-11 WO PCT/SE1991/000760 patent/WO1992008459A1/en active IP Right Grant
- 1991-11-11 AT AT91920399T patent/ATE168560T1/de not_active IP Right Cessation
- 1991-11-14 PT PT99513A patent/PT99513B/pt not_active IP Right Cessation
-
1993
- 1993-05-14 NO NO931766A patent/NO931766D0/no unknown
- 1993-05-14 FI FI932212A patent/FI932212A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
US5908846A (en) | 1999-06-01 |
IL99905A0 (en) | 1992-08-18 |
FI932212A0 (fi) | 1993-05-14 |
ES2121793T3 (es) | 1998-12-16 |
DE69129861D1 (de) | 1998-08-27 |
ATE168560T1 (de) | 1998-08-15 |
IE913682A1 (en) | 1992-05-20 |
JPH06502422A (ja) | 1994-03-17 |
CA2095223C (en) | 2002-12-17 |
DK0557385T3 (da) | 1999-04-26 |
PT99513B (pt) | 1999-04-30 |
EP0557385A1 (en) | 1993-09-01 |
NZ240349A (en) | 1993-07-27 |
AU655612B2 (en) | 1995-01-05 |
CA2095223A1 (en) | 1992-05-17 |
SE9003665D0 (sv) | 1990-11-16 |
DE69129861T2 (de) | 1999-04-01 |
WO1992008459A1 (en) | 1992-05-29 |
AU8938191A (en) | 1992-06-11 |
NO931766D0 (no) | 1993-05-14 |
FI932212A (fi) | 1993-05-14 |
PT99513A (pt) | 1992-09-30 |
IL99905A (en) | 1995-06-29 |
ZA918512B (en) | 1992-08-26 |
JP3493434B2 (ja) | 2004-02-03 |
EP0557385B1 (en) | 1998-07-22 |
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