ATE444296T1 - Analoga und prodrugs von buprenorphin - Google Patents

Analoga und prodrugs von buprenorphin

Info

Publication number
ATE444296T1
ATE444296T1 AT03779164T AT03779164T ATE444296T1 AT E444296 T1 ATE444296 T1 AT E444296T1 AT 03779164 T AT03779164 T AT 03779164T AT 03779164 T AT03779164 T AT 03779164T AT E444296 T1 ATE444296 T1 AT E444296T1
Authority
AT
Austria
Prior art keywords
buprenorphine
prodrugs
analogue
analogs
disclosed
Prior art date
Application number
AT03779164T
Other languages
English (en)
Inventor
Peter Boer
Robert Kupper
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE444296T1 publication Critical patent/ATE444296T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT03779164T 2002-10-25 2003-10-24 Analoga und prodrugs von buprenorphin ATE444296T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42134702P 2002-10-25 2002-10-25
PCT/US2003/033465 WO2004039317A2 (en) 2002-10-25 2003-10-24 Analogs and prodrugs of buprenorphine

Publications (1)

Publication Number Publication Date
ATE444296T1 true ATE444296T1 (de) 2009-10-15

Family

ID=32230225

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03779164T ATE444296T1 (de) 2002-10-25 2003-10-24 Analoga und prodrugs von buprenorphin

Country Status (6)

Country Link
US (1) US7084150B2 (de)
EP (1) EP1554290B1 (de)
AT (1) ATE444296T1 (de)
AU (1) AU2003285934A1 (de)
DE (1) DE60329515D1 (de)
WO (1) WO2004039317A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8449908B2 (en) 2000-12-22 2013-05-28 Alltranz, Llc Transdermal delivery of cannabidiol
EP1928881A2 (de) * 2005-08-19 2008-06-11 Pharmacofore, Inc. Prodrugs von wirkstoffen
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
WO2008036980A1 (en) 2006-09-22 2008-03-27 Alltranz Inc. Transdermally deliverable buprenorphine prodrugs and abuse-resistant compositions thereof
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
MX2009009851A (es) * 2007-03-12 2009-09-24 Nektar Therapeutics Conjugados de agonistas de oligomeros-opioides.
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
EP2176208B1 (de) * 2007-07-30 2015-01-21 Zynerba Pharmaceuticals, Inc. Prodgrugs von cannabidiol, zusammensetzungen mit prodgrugs von cannabidiol und verfahren zu ihrer verwendung
JP2011515495A (ja) * 2008-03-26 2011-05-19 オールトランツ インコーポレイティド オピエートアゴニスト及びアゴニスト−アンタゴニストの乱用抑制経皮製剤
ES2555258T3 (es) * 2010-04-02 2015-12-30 Zynerba Pharmaceuticals, Inc. Profármacos de opioides administrables por vía transdérmica, composiciones que no inducen al abuso y procedimientos de uso de los profármacos opioides
MX2013003354A (es) 2010-09-21 2013-06-24 Purdue Pharma Lp Analogos de buprenorfina.
FR2975912B1 (fr) 2011-05-30 2013-06-14 Flamel Tech Sa Composition a liberation controlee de buprenorphine
RU2506265C1 (ru) * 2012-08-21 2014-02-10 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Фторсодержащие производные тевинола и орвинола и способы их получения (варианты)
US9315514B2 (en) * 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
EP3333156A3 (de) 2012-11-09 2018-09-26 Purdue Pharma L.P. Benzomorphan-analoge und ihre verwendung
US9175000B2 (en) 2012-12-07 2015-11-03 Purdue Pharma L.P. Buprenorphine analogs
TWI513697B (zh) 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
WO2014091297A1 (en) 2012-12-14 2014-06-19 Purdue Pharma L.P. Spirocyclic morphinans and their use
US9056836B2 (en) 2013-01-31 2015-06-16 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
US9867818B2 (en) 2013-09-10 2018-01-16 Insys Development Company, Inc. Sublingual buprenorphine spray
US9839611B2 (en) 2013-09-10 2017-12-12 Insys Development Company, Inc. Sublingual buprenorphine spray
ES2802976T3 (es) 2013-09-10 2021-01-22 Fresh Cut Dev Llc Pulverizador de buprenorfina sublingual
US9918981B2 (en) 2013-09-10 2018-03-20 Insys Development Company, Inc. Liquid buprenorphine formulations
EP3087073B1 (de) 2013-12-26 2018-07-04 Purdue Pharma LP 10-substituierte morphinanhydantoine
EP3087079B1 (de) 2013-12-26 2019-04-03 Purdue Pharma LP Opioidrezeptormodulierende oxabicyclo[2.2.2]oktanmorphinane
EP3087078B1 (de) 2013-12-26 2019-05-15 Purdue Pharma LP 7-beta-alkyl-analoga von orvinolen
AU2014370062A1 (en) 2013-12-26 2016-08-11 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US10550088B2 (en) 2013-12-27 2020-02-04 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
EP3137080B1 (de) 2014-04-28 2019-09-04 Orphomed, Inc. Durch phenolische hydroxylgruppe verknüpfte, pharmazeutisch aktive dimere
JP2017521373A (ja) 2014-05-27 2017-08-03 パーデュー、ファーマ、リミテッド、パートナーシップ スピロ環モルフィナン及びその使用
EP3154972A4 (de) 2014-06-13 2017-11-22 Purdue Pharma L.P. Azamophinanderivate und verwendung davon
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
AU2016344309A1 (en) * 2015-10-26 2018-05-17 Orphomed, Inc. Ethylene glycol ether of buprenorphine
EP3360545A4 (de) * 2015-11-12 2019-05-22 MEDRx Co., Ltd. Vorrichtung zur verabreichung eines perkutanen absorptionsmittels und herstellungsverfahren dafür
PL3512518T3 (pl) 2016-09-13 2023-03-27 Alar Pharmaceuticals Inc. Preparaty buprenorfiny o przedłużonym uwalnianiu
US10745402B2 (en) 2017-01-02 2020-08-18 Purdue Pharma L.P. Morphinan derivatives and use thereof
CN112236142A (zh) 2018-01-22 2021-01-15 逸达生物科技股份有限公司 用于缓释递送丁丙诺啡的药物组合物
EP3790881A4 (de) 2018-05-11 2022-03-09 Alar Pharmaceuticals Inc. Langwirkende injizierbare formulierungen und kristalline formen von buprenorphinderivaten
WO2023102489A1 (en) * 2021-12-03 2023-06-08 Board Of Regents Of The University Of Nebraska Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4806341A (en) * 1985-02-25 1989-02-21 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration
US5026556A (en) * 1988-11-10 1991-06-25 Norwich Eaton Pharmaceuticals, Inc. Compositions for the transdermal delivery of pharmaceutical actives
US5240711A (en) * 1989-11-29 1993-08-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system comprising as active component buprenorphine
EP0484543B1 (de) * 1990-04-24 1995-12-13 Teijin Limited Pflaster
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine
SE9003665D0 (sv) * 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
PL166095B1 (pl) * 1991-04-03 1995-03-31 Warszawskie Zaklady Farma Sposób wytwarzania N-cyklopropylometylo-7a -[(S)-1-hydroksy-1,2,2-trimetylopropylo] endo-etano-6,7,8,14-tetrahydronororipaviny
DE4446600A1 (de) 1994-12-24 1996-06-27 Lohmann Therapie Syst Lts Transdermale Resorption von Wirkstoffen aus unterkühlten Schmelzen
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US6231866B1 (en) * 1998-04-30 2001-05-15 Douglas G. Mann Infused vegetable, fruit, herb, and/or seed fiber product and dietary supplements containing same
ATE382050T1 (de) * 2002-11-25 2008-01-15 Chi Mei Foundation Medical Ct Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel

Also Published As

Publication number Publication date
AU2003285934A8 (en) 2004-05-25
EP1554290B1 (de) 2009-09-30
WO2004039317A2 (en) 2004-05-13
AU2003285934A1 (en) 2004-05-25
US20040192714A1 (en) 2004-09-30
EP1554290A4 (de) 2006-07-05
US7084150B2 (en) 2006-08-01
DE60329515D1 (de) 2009-11-12
WO2004039317A3 (en) 2004-09-23
EP1554290A2 (de) 2005-07-20

Similar Documents

Publication Publication Date Title
DE60329515D1 (de) Analoga und prodrugs von buprenorphin
NO20034056D0 (no) Proliferative sykdommer
ATE510534T1 (de) Naltrexonhydrochlorid-zusammensetzungen
ATE520674T1 (de) Natriumkanalblocker
BR0310092A (pt) Combinação de compostos orgânicos
PT1178958E (pt) N-cianometilamidas como inibidores de proteases
ATE508735T1 (de) Pulmonale verabreichung von aminoglykosiden
DE60332358D1 (de) Protease-resistente modifizierte interferon alpha polypeptide
UY27774A1 (es) Inhibidores de metaloproteinas de triaril-oxi-aril-espiropirimidina-2,4,6-triona
HUP0202570A1 (hu) Izoflavonokat és analogonjait tartalmazó készítmények és terápiás alkalmazásuk
NO20035025L (no) Anvendelse av osteopontin for behandling og/eller for a hindre nevrologiske sykdommer, samt farmasoytisk sammensetning omfattende osteopontin eller en antagonist med osteopontinaktivitet.
MY146509A (en) Novel use of peptide compounds for treating essential tremor and other tremor syndromes
SE0203825D0 (sv) Novel fused heterocycles and uses thereof
DK1686997T3 (da) Inhibitorer af mutantformen af KIT
MXPA05001885A (es) El uso de una combinacion de ciclesonida y antihistaminas para el tratamiento de la rinitis alergica.
MXPA05013226A (es) Carbamatos de piperidina sustituidos, para el uso como inhibidores de la lipasa sensible a hormonas.
DE60316128D1 (de) N-sulfonylurea-apoptosis-förderer
GB0207653D0 (en) Methods of using lamellar bodies for therapeutic purposes
NO20054668L (no) Aplidin for multippelt myelom-behandling
DE60328022D1 (de) Neue verwendung von rapamycin und strukturellen analoga hiervon
DE60315666D1 (de) Furopyridin- und furopyrimidinderivate zur behandlung von hyperproliferativen erkrankungen
DE60322577D1 (de) Tablette enthaltend efletirizin und pseudoephedrin
DE60305727D1 (de) Hypoestoxide, derivate und agonisten davon zur verwendung bei der behandlung und prophylaxe von hyperlipidämie
TNSN05154A1 (en) Use of levocetirizine for the treatment of persistent allergic rhinitis
ITFI20020080A1 (it) Analoghi ciclici dell'urotensina-ii

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties