SE8501452L - NEW 4-AROYLIMIDAZOL-2-ONER - Google Patents
NEW 4-AROYLIMIDAZOL-2-ONERInfo
- Publication number
- SE8501452L SE8501452L SE8501452A SE8501452A SE8501452L SE 8501452 L SE8501452 L SE 8501452L SE 8501452 A SE8501452 A SE 8501452A SE 8501452 A SE8501452 A SE 8501452A SE 8501452 L SE8501452 L SE 8501452L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- alkoxy
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Abstract
A compound for the alleviation of hypotension or the treatment of cardiac failure, having the formula <IMAGE> wherein R is hydrogen, C1-4 alkyl, (C1-4 alkyl) carbonyl or benzoyl; R1 is hydrogen or C1-4 alkyl; and Ar is 2-furyl; 2-thienyl; phenyl; phenyl monosubstituted by halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, trifluoromethyl, -SO2N(R2)2, NR3R4, pyrrolidino, piperidino, morpholino, piperazino or N'-alkylpiperazino in which R2, R3 and R4 are independently selected from hydrogen and C1-4 alkyl; disubstituted phenyl in which one substituent is at the para position and the substituents are independently selected from halogen, hydroxy, C1-4 alkyl and C1-4 alkoxy; or 3,4-methylenedioxy- phenyl in which the methylene group is optionally substituted by one or two methyl groups; or a pharmaceutically acceptable salt thereof. Many compounds of formula I are novel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4980879A | 1979-06-18 | 1979-06-18 | |
| US11920780A | 1980-02-07 | 1980-02-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8501452D0 SE8501452D0 (en) | 1985-03-25 |
| SE8501452L true SE8501452L (en) | 1985-03-25 |
| SE464559B SE464559B (en) | 1991-05-13 |
Family
ID=26727558
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8004253A SE447107B (en) | 1979-06-18 | 1980-06-06 | NEW 4-AROYLIMIDAZOL-2-ONER |
| SE8501452A SE464559B (en) | 1979-06-18 | 1985-03-25 | PHARMACEUTICAL COMPOSITION CONTAINING 4-AROYLIMIDAZOLE-2-ONER WITH ANTIHYPERTENSIVE, CARDIOTONE AND ANTITHROMOBOTIC EFFECTS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8004253A SE447107B (en) | 1979-06-18 | 1980-06-06 | NEW 4-AROYLIMIDAZOL-2-ONER |
Country Status (20)
| Country | Link |
|---|---|
| AT (1) | AT375349B (en) |
| AU (1) | AU532783B2 (en) |
| CA (1) | CA1132554A (en) |
| CH (1) | CH646155A5 (en) |
| DE (1) | DE3021792A1 (en) |
| DK (1) | DK160269C (en) |
| ES (1) | ES8105299A1 (en) |
| FR (1) | FR2459233A1 (en) |
| GB (1) | GB2055364B (en) |
| HK (1) | HK61486A (en) |
| HU (1) | HU186736B (en) |
| IE (1) | IE50646B1 (en) |
| IL (1) | IL60243A (en) |
| IT (1) | IT1143922B (en) |
| MY (1) | MY8600709A (en) |
| NL (2) | NL193752C (en) |
| NO (1) | NO152841C (en) |
| NZ (1) | NZ193935A (en) |
| PH (1) | PH18683A (en) |
| SE (2) | SE447107B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH18106A (en) * | 1981-02-18 | 1985-03-21 | Merrell Dow Pharma | Novel-4-aroylimidazol-2-ones |
| US4405628A (en) * | 1981-03-05 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Pyridylimidazolones and method of use |
| US4329471A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
| US4329470A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
| AU549872B2 (en) * | 1981-05-04 | 1986-02-20 | Merrell Dow Pharmaceuticals Inc. | 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones |
| US4371737A (en) * | 1981-05-04 | 1983-02-01 | Merrell Dow Pharmaceuticals Inc. | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
| US4381393A (en) * | 1981-05-04 | 1983-04-26 | Merrell Dow Pharmaceuticals Inc. | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
| US4526981A (en) * | 1981-05-04 | 1985-07-02 | Merrell Dow Pharmaceuticals Inc. | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates |
| US4367236A (en) | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
| US4410540A (en) * | 1981-11-04 | 1983-10-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 4-aroylimidazolidin-2-ones |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2007530566A (en) * | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | (R) -Enoximone sulfoxide and its use in the treatment of PDE-III mediated diseases |
| CA2560528A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
| EP2218442A1 (en) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2624828T3 (en) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| JP6251038B2 (en) | 2011-03-01 | 2017-12-20 | シナジー ファーマシューティカルズ インコーポレイテッド | Method for preparing guanylate cyclase C agonist |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| KR20160042039A (en) | 2013-08-09 | 2016-04-18 | 알데릭스, 인코포레이티드 | Compounds and methods for inhibiting phosphate transport |
| US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
| CN114539157B (en) * | 2022-03-03 | 2023-12-22 | 曲靖师范学院 | Method for preparing 4-iodo-N-aryl pyrazole compound by iodine-promoted oxidation method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2441933A (en) * | 1945-07-30 | 1948-05-18 | Hoffmann La Roche | Substituted imidazolones and process of making them |
-
1980
- 1980-06-04 NZ NZ193935A patent/NZ193935A/en unknown
- 1980-06-05 IE IE1162/80A patent/IE50646B1/en not_active IP Right Cessation
- 1980-06-06 AU AU59118/80A patent/AU532783B2/en not_active Expired
- 1980-06-06 SE SE8004253A patent/SE447107B/en not_active IP Right Cessation
- 1980-06-06 IL IL60243A patent/IL60243A/en unknown
- 1980-06-09 ES ES492255A patent/ES8105299A1/en not_active Expired
- 1980-06-11 DE DE19803021792 patent/DE3021792A1/en active Granted
- 1980-06-13 AT AT0314280A patent/AT375349B/en not_active IP Right Cessation
- 1980-06-16 CH CH462780A patent/CH646155A5/en not_active IP Right Cessation
- 1980-06-16 PH PH24143A patent/PH18683A/en unknown
- 1980-06-17 FR FR8013434A patent/FR2459233A1/en active Granted
- 1980-06-17 DK DK259080A patent/DK160269C/en not_active IP Right Cessation
- 1980-06-17 CA CA354,197A patent/CA1132554A/en not_active Expired
- 1980-06-17 HU HU801506A patent/HU186736B/en unknown
- 1980-06-17 NO NO801796A patent/NO152841C/en unknown
- 1980-06-17 IT IT48997/80A patent/IT1143922B/en active Protection Beyond IP Right Term
- 1980-06-17 NL NL8003498A patent/NL193752C/en not_active IP Right Cessation
- 1980-06-18 GB GB8019898A patent/GB2055364B/en not_active Expired
-
1985
- 1985-03-25 SE SE8501452A patent/SE464559B/en not_active IP Right Cessation
-
1986
- 1986-08-21 HK HK614/86A patent/HK61486A/en not_active IP Right Cessation
- 1986-12-30 MY MY709/86A patent/MY8600709A/en unknown
-
2000
- 2000-09-04 NL NL300015C patent/NL300015I1/en unknown
Also Published As
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| NAL | Patent in force |
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