SE7704536L - PROCEDURE FOR THE PREPARATION OF PHENYL PIPERAZINE DERIVATIVES - Google Patents

PROCEDURE FOR THE PREPARATION OF PHENYL PIPERAZINE DERIVATIVES

Info

Publication number
SE7704536L
SE7704536L SE7704536A SE7704536A SE7704536L SE 7704536 L SE7704536 L SE 7704536L SE 7704536 A SE7704536 A SE 7704536A SE 7704536 A SE7704536 A SE 7704536A SE 7704536 L SE7704536 L SE 7704536L
Authority
SE
Sweden
Prior art keywords
formula
preparation
procedure
group
vii
Prior art date
Application number
SE7704536A
Other languages
Swedish (sv)
Inventor
J P Verge
W B Jamieson
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of SE7704536L publication Critical patent/SE7704536L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Abstract

Phenylpiperazine derivatives of formula (I) <IMAGE> as well as their pharmaceutically acceptable salts, are prepared. R<1> represents benzyl, C1-6 alkyl or an optionally substituted phenyl; R<2> represents an optionally substituted phenyl, R<3> represents hydrogen or C1-4 alkyl, Q represents furan, thiophene, oxazole or thiazole, m is an integer from 1 to 3 and n is 0 or 1. When m is 2 and n is 0, R<1> cannot represent a methyl group when Q is the thiazol-5-yl group. The preparation is carried out by condensation of a compound of formula (VII): R<1>-Q-(CH2)m-(CHR<3>)n-L (VII) in which L represents the split group, with a compound of formula (VIII): <IMAGE> The compounds of formula (I) and their pharmaceutically acceptable salts are useful in the prophylactic and therapeutic treatment of diseases of immediate hypersensitiveness, especially asthma in mammals. They have a low toxicity.
SE7704536A 1976-04-23 1977-04-20 PROCEDURE FOR THE PREPARATION OF PHENYL PIPERAZINE DERIVATIVES SE7704536L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB16526/76A GB1575904A (en) 1976-04-23 1976-04-23 Phenyl piperazines

Publications (1)

Publication Number Publication Date
SE7704536L true SE7704536L (en) 1977-10-24

Family

ID=10078930

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7704536A SE7704536L (en) 1976-04-23 1977-04-20 PROCEDURE FOR THE PREPARATION OF PHENYL PIPERAZINE DERIVATIVES

Country Status (34)

Country Link
JP (1) JPS52151183A (en)
AR (2) AR222003A1 (en)
AT (1) AT355579B (en)
AU (1) AU514822B2 (en)
BE (1) BE853899A (en)
BG (2) BG28055A3 (en)
CA (1) CA1087617A (en)
CH (2) CH633009A5 (en)
CS (1) CS196360B2 (en)
DD (1) DD129790A5 (en)
DE (1) DE2717415A1 (en)
DK (1) DK176177A (en)
ES (2) ES457988A1 (en)
FI (1) FI63937C (en)
FR (1) FR2348925A1 (en)
GB (1) GB1575904A (en)
GR (1) GR64084B (en)
HU (1) HU176820B (en)
IE (1) IE44730B1 (en)
IL (1) IL51787A (en)
LU (1) LU77170A1 (en)
MX (1) MX4596E (en)
NL (1) NL7704456A (en)
NO (1) NO146710C (en)
NZ (1) NZ183715A (en)
OA (1) OA05643A (en)
PH (1) PH14124A (en)
PL (1) PL117466B1 (en)
PT (1) PT66452B (en)
RO (1) RO72831A (en)
SE (1) SE7704536L (en)
SU (2) SU664564A3 (en)
YU (1) YU104477A (en)
ZA (1) ZA771849B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601310A (en) * 1978-05-23 1981-10-28 Lilly Industries Ltd Aryl hydantoins
DE3142608A1 (en) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen POLYAZO DYES
JPH07157477A (en) * 1993-12-02 1995-06-20 Asahi Kagaku Kogyo Kk Production of thiazole derivative
KR970701705A (en) * 1994-03-11 1997-04-12 오노다 마사요시 5-HT₃ receptor agonists, novel thiazole derivatives, and intermediates thereof
GB9517381D0 (en) * 1995-08-24 1995-10-25 Pharmacia Spa Aryl and heteroaryl piperazine derivatives
AU2007221021B2 (en) * 2006-02-28 2013-01-17 Dart Neuroscience (Cayman) Ltd Therapeutic piperazines as PDE4 inhibitors
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines

Also Published As

Publication number Publication date
NO146710B (en) 1982-08-16
FI63937C (en) 1983-09-12
CS196360B2 (en) 1980-03-31
PH14124A (en) 1981-02-26
BG28055A3 (en) 1980-02-25
AT355579B (en) 1980-03-10
ATA285177A (en) 1979-08-15
AR222003A1 (en) 1981-04-15
FI771287A (en) 1977-10-24
ES457988A1 (en) 1978-07-16
DE2717415A1 (en) 1977-11-10
RO72831B (en) 1983-07-30
ZA771849B (en) 1978-11-29
AU2438677A (en) 1978-10-26
HU176820B (en) 1981-05-28
CH633009A5 (en) 1982-11-15
NZ183715A (en) 1980-04-28
RO72831A (en) 1983-08-03
AR222635A1 (en) 1981-06-15
PT66452A (en) 1977-05-01
SU664564A3 (en) 1979-05-25
DK176177A (en) 1977-10-24
FI63937B (en) 1983-05-31
JPS52151183A (en) 1977-12-15
IL51787A (en) 1980-02-29
AU514822B2 (en) 1981-02-26
FR2348925A1 (en) 1977-11-18
PL117466B1 (en) 1981-08-31
BG27746A3 (en) 1979-12-12
CA1087617A (en) 1980-10-14
PL197550A1 (en) 1979-05-21
OA05643A (en) 1981-04-30
NL7704456A (en) 1977-10-25
BE853899A (en) 1977-10-24
DD129790A5 (en) 1978-02-08
NO146710C (en) 1982-11-24
YU104477A (en) 1983-01-21
NO771398L (en) 1977-10-25
LU77170A1 (en) 1979-01-18
GB1575904A (en) 1980-10-01
GR64084B (en) 1980-01-21
ES467948A1 (en) 1978-11-01
CH625802A5 (en) 1981-10-15
IE44730L (en) 1977-10-23
SU727146A3 (en) 1980-04-05
MX4596E (en) 1982-06-25
IE44730B1 (en) 1982-03-10
IL51787A0 (en) 1977-05-31
PT66452B (en) 1979-03-09
FR2348925B1 (en) 1980-04-11

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