ES467948A1 - Phenyl piperazines - Google Patents
Phenyl piperazinesInfo
- Publication number
- ES467948A1 ES467948A1 ES467948A ES467948A ES467948A1 ES 467948 A1 ES467948 A1 ES 467948A1 ES 467948 A ES467948 A ES 467948A ES 467948 A ES467948 A ES 467948A ES 467948 A1 ES467948 A1 ES 467948A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- group
- vii
- alkyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Phenylpiperazine derivatives of formula (I) < IMAGE > as well as their pharmaceutically acceptable salts, are prepared. R<1> represents benzyl, C1-6 alkyl or an optionally substituted phenyl R<2> represents an optionally substituted phenyl, R<3> represents hydrogen or C1-4 alkyl, Q represents furan, thiophene, oxazole or thiazole, m is an integer from 1 to 3 and n is 0 or 1. When m is 2 and n is 0, R<1> cannot represent a methyl group when Q is the thiazol-5-yl group. The preparation is carried out by condensation of a compound of formula (VII): R<1>-Q-(CH2)m-(CHR<3>)n-L (VII) in which L represents the split group, with a compound of formula (VIII): < IMAGE > The compounds of formula (I) and their pharmaceutically acceptable salts are useful in the prophylactic and therapeutic treatment of diseases of immediate hypersensitiveness, especially asthma in mammals. They have a low toxicity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB16526/76A GB1575904A (en) | 1976-04-23 | 1976-04-23 | Phenyl piperazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES467948A1 true ES467948A1 (en) | 1978-11-01 |
Family
ID=10078930
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES457988A Expired ES457988A1 (en) | 1976-04-23 | 1977-04-20 | Phenyl piperazines |
| ES467948A Expired ES467948A1 (en) | 1976-04-23 | 1978-03-16 | Phenyl piperazines |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES457988A Expired ES457988A1 (en) | 1976-04-23 | 1977-04-20 | Phenyl piperazines |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS52151183A (en) |
| AR (2) | AR222003A1 (en) |
| AT (1) | AT355579B (en) |
| AU (1) | AU514822B2 (en) |
| BE (1) | BE853899A (en) |
| BG (2) | BG28055A3 (en) |
| CA (1) | CA1087617A (en) |
| CH (2) | CH625802A5 (en) |
| CS (1) | CS196360B2 (en) |
| DD (1) | DD129790A5 (en) |
| DE (1) | DE2717415A1 (en) |
| DK (1) | DK176177A (en) |
| ES (2) | ES457988A1 (en) |
| FI (1) | FI63937C (en) |
| FR (1) | FR2348925A1 (en) |
| GB (1) | GB1575904A (en) |
| GR (1) | GR64084B (en) |
| HU (1) | HU176820B (en) |
| IE (1) | IE44730B1 (en) |
| IL (1) | IL51787A (en) |
| LU (1) | LU77170A1 (en) |
| MX (1) | MX4596E (en) |
| NL (1) | NL7704456A (en) |
| NO (1) | NO146710C (en) |
| NZ (1) | NZ183715A (en) |
| OA (1) | OA05643A (en) |
| PH (1) | PH14124A (en) |
| PL (1) | PL117466B1 (en) |
| PT (1) | PT66452B (en) |
| RO (1) | RO72831A (en) |
| SE (1) | SE7704536L (en) |
| SU (2) | SU664564A3 (en) |
| YU (1) | YU104477A (en) |
| ZA (1) | ZA771849B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1601310A (en) * | 1978-05-23 | 1981-10-28 | Lilly Industries Ltd | Aryl hydantoins |
| DE3142608A1 (en) * | 1981-10-28 | 1983-05-05 | Basf Ag, 6700 Ludwigshafen | POLYAZO DYES |
| JPH07157477A (en) * | 1993-12-02 | 1995-06-20 | Asahi Kagaku Kogyo Kk | Production of thiazole derivative |
| WO1995024399A1 (en) * | 1994-03-11 | 1995-09-14 | Yamanouchi Pharmaceutical Co., Ltd. | 5-ht3 receptor agonist, novel thiazole derivative, and intermediate therefor |
| GB9517381D0 (en) * | 1995-08-24 | 1995-10-25 | Pharmacia Spa | Aryl and heteroaryl piperazine derivatives |
| SG171635A1 (en) * | 2006-02-28 | 2011-06-29 | Helicon Therapeutics Inc | Therapeutic piperazines as pde4 inhibitors |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
-
1976
- 1976-04-23 GB GB16526/76A patent/GB1575904A/en not_active Expired
-
1977
- 1977-03-28 ZA ZA00771849A patent/ZA771849B/en unknown
- 1977-03-28 NZ NZ183715A patent/NZ183715A/en unknown
- 1977-03-30 IE IE671/77A patent/IE44730B1/en unknown
- 1977-03-30 IL IL51787A patent/IL51787A/en unknown
- 1977-03-30 CA CA275,160A patent/CA1087617A/en not_active Expired
- 1977-04-13 CH CH455777A patent/CH625802A5/en not_active IP Right Cessation
- 1977-04-13 CH CH525781A patent/CH633009A5/en not_active IP Right Cessation
- 1977-04-13 MX MX775629U patent/MX4596E/en unknown
- 1977-04-14 PH PH19656A patent/PH14124A/en unknown
- 1977-04-18 AU AU24386/77A patent/AU514822B2/en not_active Expired
- 1977-04-18 PT PT66452A patent/PT66452B/en unknown
- 1977-04-19 GR GR53236A patent/GR64084B/en unknown
- 1977-04-19 FR FR7711669A patent/FR2348925A1/en active Granted
- 1977-04-20 OA OA56149A patent/OA05643A/en unknown
- 1977-04-20 BG BG037191A patent/BG28055A3/en unknown
- 1977-04-20 ES ES457988A patent/ES457988A1/en not_active Expired
- 1977-04-20 DE DE19772717415 patent/DE2717415A1/en not_active Withdrawn
- 1977-04-20 RO RO7790106A patent/RO72831A/en unknown
- 1977-04-20 BG BG036062A patent/BG27746A3/en unknown
- 1977-04-20 SE SE7704536A patent/SE7704536L/en not_active Application Discontinuation
- 1977-04-21 CS CS772668A patent/CS196360B2/en unknown
- 1977-04-21 LU LU77170A patent/LU77170A1/xx unknown
- 1977-04-21 DK DK176177A patent/DK176177A/en not_active Application Discontinuation
- 1977-04-21 YU YU01044/77A patent/YU104477A/en unknown
- 1977-04-22 AR AR267310A patent/AR222003A1/en active
- 1977-04-22 FI FI771287A patent/FI63937C/en not_active IP Right Cessation
- 1977-04-22 NO NO771398A patent/NO146710C/en unknown
- 1977-04-22 SU SU772474105A patent/SU664564A3/en active
- 1977-04-22 BE BE6045977A patent/BE853899A/en not_active IP Right Cessation
- 1977-04-22 AT AT285177A patent/AT355579B/en not_active IP Right Cessation
- 1977-04-22 PL PL1977197550A patent/PL117466B1/en unknown
- 1977-04-22 NL NL7704456A patent/NL7704456A/en not_active Application Discontinuation
- 1977-04-22 DD DD7700198558A patent/DD129790A5/en unknown
- 1977-04-22 HU HU77LI311A patent/HU176820B/en unknown
- 1977-04-23 JP JP4727677A patent/JPS52151183A/en active Pending
- 1977-12-28 SU SU772558499A patent/SU727146A3/en active
-
1978
- 1978-03-16 ES ES467948A patent/ES467948A1/en not_active Expired
- 1978-03-22 AR AR271519A patent/AR222635A1/en active
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