RO72831B - Process for preparing phenylpiperazines - Google Patents
Process for preparing phenylpiperazinesInfo
- Publication number
- RO72831B RO72831B RO90106A RO9010677A RO72831B RO 72831 B RO72831 B RO 72831B RO 90106 A RO90106 A RO 90106A RO 9010677 A RO9010677 A RO 9010677A RO 72831 B RO72831 B RO 72831B
- Authority
- RO
- Romania
- Prior art keywords
- phenylpiperazines
- radical
- preparing
- alkylsulfonamide
- nitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Abstract
Procedeu pentru prepararea unor fenilpiperazine cu formula I din pag.1 a descrierii, în care substituentul R1 este un radical benzil, alchil cu 2...6 atomi de carbon, fenil eventual substituit cu unul sau doi radicali alesi dintre halogen, C1-4 alchil, C1-4 haloalchenil, amino, C2-4 acilamino, hidroxi, C1-4 alcoxi, nitro si C1-4 alchilsulfonamida, R2 este un radical fenil eventual substituit cu unul sau doi radicali alesi dintre halogen, C1-4 alchil, C1-4 halogenalchil, amino, C2-4 acilamino, hidroxi, C1-4 alcoxi, nitro si C1-4 alchilsulfonamida, R3 este un atom de hidrogen sau un radical alchil cu 1...4 atomi de carbon, Q este un radical de tiazol, m este 1 pîna la 3, iar n este 0 sau 1.A process for the preparation of phenylpiperazines of formula I of the disclosure in which the substituent R1 is a benzyl, alkyl of 2-6 carbon atoms, phenyl optionally substituted by one or two radicals selected from halogen, C1-4 C1-4 alkoxy, nitro and C1-4 alkylsulfonamide; R2 is a phenyl radical optionally substituted by one or two radicals selected from halogen, Amino, C 2-4 acylamino, hydroxy, C 1-4 alkoxy, nitro and C 1-4 alkylsulfonamide, R 3 is a hydrogen atom or an alkyl radical of 1-4 carbon atoms, Q is a radical of thiazole, m is 1 to 3, and n is 0 or 1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB16526/76A GB1575904A (en) | 1976-04-23 | 1976-04-23 | Phenyl piperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO72831B true RO72831B (en) | 1983-07-30 |
| RO72831A RO72831A (en) | 1983-08-03 |
Family
ID=10078930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7790106A RO72831A (en) | 1976-04-23 | 1977-04-20 | PROCESS FOR THE PREPARATION OF FENILPYPERAZINES |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS52151183A (en) |
| AR (2) | AR222003A1 (en) |
| AT (1) | AT355579B (en) |
| AU (1) | AU514822B2 (en) |
| BE (1) | BE853899A (en) |
| BG (2) | BG28055A3 (en) |
| CA (1) | CA1087617A (en) |
| CH (2) | CH633009A5 (en) |
| CS (1) | CS196360B2 (en) |
| DD (1) | DD129790A5 (en) |
| DE (1) | DE2717415A1 (en) |
| DK (1) | DK176177A (en) |
| ES (2) | ES457988A1 (en) |
| FI (1) | FI63937C (en) |
| FR (1) | FR2348925A1 (en) |
| GB (1) | GB1575904A (en) |
| GR (1) | GR64084B (en) |
| HU (1) | HU176820B (en) |
| IE (1) | IE44730B1 (en) |
| IL (1) | IL51787A (en) |
| LU (1) | LU77170A1 (en) |
| MX (1) | MX4596E (en) |
| NL (1) | NL7704456A (en) |
| NO (1) | NO146710C (en) |
| NZ (1) | NZ183715A (en) |
| OA (1) | OA05643A (en) |
| PH (1) | PH14124A (en) |
| PL (1) | PL117466B1 (en) |
| PT (1) | PT66452B (en) |
| RO (1) | RO72831A (en) |
| SE (1) | SE7704536L (en) |
| SU (2) | SU664564A3 (en) |
| YU (1) | YU104477A (en) |
| ZA (1) | ZA771849B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1601310A (en) * | 1978-05-23 | 1981-10-28 | Lilly Industries Ltd | Aryl hydantoins |
| DE3142608A1 (en) * | 1981-10-28 | 1983-05-05 | Basf Ag, 6700 Ludwigshafen | POLYAZO DYES |
| JPH07157477A (en) * | 1993-12-02 | 1995-06-20 | Asahi Kagaku Kogyo Kk | Production of thiazole derivative |
| KR970701705A (en) * | 1994-03-11 | 1997-04-12 | 오노다 마사요시 | 5-HT₃ receptor agonists, novel thiazole derivatives, and intermediates thereof |
| GB9517381D0 (en) * | 1995-08-24 | 1995-10-25 | Pharmacia Spa | Aryl and heteroaryl piperazine derivatives |
| AU2007221021B2 (en) * | 2006-02-28 | 2013-01-17 | Dart Neuroscience (Cayman) Ltd | Therapeutic piperazines as PDE4 inhibitors |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
-
1976
- 1976-04-23 GB GB16526/76A patent/GB1575904A/en not_active Expired
-
1977
- 1977-03-28 NZ NZ183715A patent/NZ183715A/en unknown
- 1977-03-28 ZA ZA00771849A patent/ZA771849B/en unknown
- 1977-03-30 IL IL51787A patent/IL51787A/en unknown
- 1977-03-30 IE IE671/77A patent/IE44730B1/en unknown
- 1977-03-30 CA CA275,160A patent/CA1087617A/en not_active Expired
- 1977-04-13 CH CH525781A patent/CH633009A5/en not_active IP Right Cessation
- 1977-04-13 CH CH455777A patent/CH625802A5/en not_active IP Right Cessation
- 1977-04-13 MX MX775629U patent/MX4596E/en unknown
- 1977-04-14 PH PH19656A patent/PH14124A/en unknown
- 1977-04-18 PT PT66452A patent/PT66452B/en unknown
- 1977-04-18 AU AU24386/77A patent/AU514822B2/en not_active Expired
- 1977-04-19 FR FR7711669A patent/FR2348925A1/en active Granted
- 1977-04-19 GR GR53236A patent/GR64084B/en unknown
- 1977-04-20 BG BG7737191A patent/BG28055A3/en unknown
- 1977-04-20 ES ES457988A patent/ES457988A1/en not_active Expired
- 1977-04-20 RO RO7790106A patent/RO72831A/en unknown
- 1977-04-20 OA OA56149A patent/OA05643A/en unknown
- 1977-04-20 DE DE19772717415 patent/DE2717415A1/en not_active Withdrawn
- 1977-04-20 SE SE7704536A patent/SE7704536L/en not_active Application Discontinuation
- 1977-04-20 BG BG7736062A patent/BG27746A3/en unknown
- 1977-04-21 YU YU01044/77A patent/YU104477A/en unknown
- 1977-04-21 CS CS772668A patent/CS196360B2/en unknown
- 1977-04-21 DK DK176177A patent/DK176177A/en not_active Application Discontinuation
- 1977-04-21 LU LU77170A patent/LU77170A1/xx unknown
- 1977-04-22 AT AT285177A patent/AT355579B/en not_active IP Right Cessation
- 1977-04-22 SU SU772474105A patent/SU664564A3/en active
- 1977-04-22 HU HU77LI311A patent/HU176820B/en unknown
- 1977-04-22 FI FI771287A patent/FI63937C/en not_active IP Right Cessation
- 1977-04-22 BE BE6045977A patent/BE853899A/en not_active IP Right Cessation
- 1977-04-22 PL PL1977197550A patent/PL117466B1/en unknown
- 1977-04-22 DD DD7700198558A patent/DD129790A5/en unknown
- 1977-04-22 NO NO771398A patent/NO146710C/en unknown
- 1977-04-22 AR AR267310A patent/AR222003A1/en active
- 1977-04-22 NL NL7704456A patent/NL7704456A/en not_active Application Discontinuation
- 1977-04-23 JP JP4727677A patent/JPS52151183A/en active Pending
- 1977-12-28 SU SU772558499A patent/SU727146A3/en active
-
1978
- 1978-03-16 ES ES467948A patent/ES467948A1/en not_active Expired
- 1978-03-22 AR AR271519A patent/AR222635A1/en active
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