ES475120A1 - Imidazopyridazines and their use as therapeutic agents - Google Patents
Imidazopyridazines and their use as therapeutic agentsInfo
- Publication number
- ES475120A1 ES475120A1 ES475120A ES475120A ES475120A1 ES 475120 A1 ES475120 A1 ES 475120A1 ES 475120 A ES475120 A ES 475120A ES 475120 A ES475120 A ES 475120A ES 475120 A1 ES475120 A1 ES 475120A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- aryl
- alkyl
- aralkyl
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title 1
- 150000005233 imidazopyridazines Chemical class 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000005840 aryl radicals Chemical class 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000005330 8 membered heterocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000001257 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- AKJQYWFGJWOGKD-UHFFFAOYSA-N imidazo[1,5-b]pyridazine Chemical compound N1=CC=CC2=CN=CN21 AKJQYWFGJWOGKD-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
Abstract
A process for the production of imidazo [1,5-b] pyridazine of general formula (1): *** see image 01 AND physiologically acceptable and non-toxic salts thereof, where R1 represents alkoxy, hydrogen or a group -NR4R5 where, R4 represents a hydrogen atom or an alkyl or alkenyl group and R5 represents a hydrogen atom or an amino group, Alkyl, alkenyl, aryl or aralkyl, where the aryl group or aryl radical of the aralkyl group may be optionally substituted with one or more hydroxy or alkoxy groups and where the group R5 may also represent an acyl function R6CO-, where R6 is a hydrogen atom or an adjacent nitrogen alkyl group may form a saturated 4- to 8-membered heterocyclic ring, which may contain an additional heteroatom and may contain substituents, R2 and R3, which may be the same or different, represent a straight or branched chain alkyl or alkenyl group or an aryl or aralkyl group where the aryl group or the aryl radical of the aralkyl group may be substituted with one or more hydroxy or alkoxy groups or halogen atoms and where R3 may additionally represent hydrogen atoms. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5289/77A GB1583911A (en) | 1977-02-09 | 1977-02-09 | Imidazopyridazines and their use as therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475120A1 true ES475120A1 (en) | 1979-05-16 |
Family
ID=9793329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466795A Expired ES466795A1 (en) | 1977-02-09 | 1978-02-08 | Imidazopyridazines and their use as therapeutic agents |
| ES475120A Expired ES475120A1 (en) | 1977-02-09 | 1978-11-15 | Imidazopyridazines and their use as therapeutic agents |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466795A Expired ES466795A1 (en) | 1977-02-09 | 1978-02-08 | Imidazopyridazines and their use as therapeutic agents |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS53101397A (en) |
| AU (1) | AU515804B2 (en) |
| BE (1) | BE863759A (en) |
| DE (1) | DE2804909A1 (en) |
| DK (1) | DK46078A (en) |
| ES (2) | ES466795A1 (en) |
| FI (1) | FI780350A (en) |
| FR (1) | FR2380281A1 (en) |
| GB (1) | GB1583911A (en) |
| IE (1) | IE46317B1 (en) |
| IT (1) | IT1155821B (en) |
| NL (1) | NL7801469A (en) |
| NZ (1) | NZ186370A (en) |
| SE (1) | SE7801489L (en) |
| ZA (1) | ZA78554B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2473522A1 (en) * | 1980-01-16 | 1981-07-17 | Synthelabo | NOVEL DIHYDRO-2,3 IMIDAZO (1,2-B) PYRIDAZINE SUBSTITUTED DERIVATIVES AND MEDICAMENTS, PARTICULARLY USEFUL AS ANTIDEPRESSANTS, CONTAINING THEM |
| US4391807A (en) * | 1982-07-12 | 1983-07-05 | The Dow Chemical Company | 6-Substituted tetrahydroimidazo[2,1-a]phthalazines and use as bronchodilators |
| US4485106A (en) * | 1982-07-12 | 1984-11-27 | The Dow Chemical Company | Substituted tetrahydrotetrazolo[5,1-a]phthalazines |
| US4391806A (en) * | 1982-07-12 | 1983-07-05 | The Dow Chemical Company | Substituted tetrahydropyridazino-(1,6-A)benzimidazoles and use as bronchodilators |
| GB8429694D0 (en) * | 1984-11-23 | 1985-01-03 | Glaxo Group Ltd | Chemical compounds |
| JPH07107404B2 (en) * | 1991-04-22 | 1995-11-15 | 上西鉄工株式会社 | Cylinder device |
-
1977
- 1977-02-09 GB GB5289/77A patent/GB1583911A/en not_active Expired
-
1978
- 1978-01-27 IE IE186/78A patent/IE46317B1/en unknown
- 1978-01-30 ZA ZA00780554A patent/ZA78554B/en unknown
- 1978-01-31 DK DK46078A patent/DK46078A/en not_active Application Discontinuation
- 1978-02-01 NZ NZ186370A patent/NZ186370A/en unknown
- 1978-02-03 FI FI780350A patent/FI780350A/en not_active Application Discontinuation
- 1978-02-06 DE DE19782804909 patent/DE2804909A1/en not_active Withdrawn
- 1978-02-08 IT IT7847968A patent/IT1155821B/en active
- 1978-02-08 AU AU33122/78A patent/AU515804B2/en not_active Expired
- 1978-02-08 ES ES466795A patent/ES466795A1/en not_active Expired
- 1978-02-08 SE SE7801489A patent/SE7801489L/en unknown
- 1978-02-08 BE BE184997A patent/BE863759A/en unknown
- 1978-02-08 NL NL7801469A patent/NL7801469A/en not_active Application Discontinuation
- 1978-02-09 JP JP1403578A patent/JPS53101397A/en active Pending
- 1978-02-09 FR FR7803669A patent/FR2380281A1/en active Granted
- 1978-11-15 ES ES475120A patent/ES475120A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE7801489L (en) | 1978-08-10 |
| DE2804909A1 (en) | 1978-08-10 |
| FR2380281A1 (en) | 1978-09-08 |
| FR2380281B1 (en) | 1982-03-12 |
| IT1155821B (en) | 1987-01-28 |
| IT7847968A0 (en) | 1978-02-08 |
| ZA78554B (en) | 1978-12-27 |
| IE780186L (en) | 1978-08-19 |
| FI780350A (en) | 1978-08-10 |
| IE46317B1 (en) | 1983-05-04 |
| JPS53101397A (en) | 1978-09-04 |
| AU515804B2 (en) | 1981-04-30 |
| BE863759A (en) | 1978-08-08 |
| NZ186370A (en) | 1981-03-16 |
| GB1583911A (en) | 1981-02-04 |
| ES466795A1 (en) | 1979-01-16 |
| DK46078A (en) | 1978-08-10 |
| AU3312278A (en) | 1979-08-16 |
| NL7801469A (en) | 1978-08-11 |
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