IT8048997A0 - 4-AROILIMIDAZOL-2-ONS EQUIPPED WITH ANTI-HYPERTENSIVE CARDIOTONIC AND ANTITHROMBOTIC PROPERTIES AND PROCEDURE FOR THEIR PREPARATION - Google Patents
4-AROILIMIDAZOL-2-ONS EQUIPPED WITH ANTI-HYPERTENSIVE CARDIOTONIC AND ANTITHROMBOTIC PROPERTIES AND PROCEDURE FOR THEIR PREPARATIONInfo
- Publication number
- IT8048997A0 IT8048997A0 IT8048997A IT4899780A IT8048997A0 IT 8048997 A0 IT8048997 A0 IT 8048997A0 IT 8048997 A IT8048997 A IT 8048997A IT 4899780 A IT4899780 A IT 4899780A IT 8048997 A0 IT8048997 A0 IT 8048997A0
- Authority
- IT
- Italy
- Prior art keywords
- aroilimidazol
- cardiotonic
- ons
- hypertensive
- procedure
- Prior art date
Links
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 230000002785 anti-thrombosis Effects 0.000 title 1
- 230000003177 cardiotonic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4980879A | 1979-06-18 | 1979-06-18 | |
US11920780A | 1980-02-07 | 1980-02-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8048997A0 true IT8048997A0 (en) | 1980-06-17 |
IT1143922B IT1143922B (en) | 1986-10-29 |
Family
ID=26727558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT48997/80A IT1143922B (en) | 1979-06-18 | 1980-06-17 | 4-AROILIMIDAZOL-2-ONI EQUIPPED WITH CARDIOTONIC AND ANTI-THROMBOTIC ANTI-HYPERTENSIVE PROPERTIES AND PROCEDURE FOR THEIR PREPARATION |
Country Status (20)
Country | Link |
---|---|
AT (1) | AT375349B (en) |
AU (1) | AU532783B2 (en) |
CA (1) | CA1132554A (en) |
CH (1) | CH646155A5 (en) |
DE (1) | DE3021792A1 (en) |
DK (1) | DK160269C (en) |
ES (1) | ES8105299A1 (en) |
FR (1) | FR2459233A1 (en) |
GB (1) | GB2055364B (en) |
HK (1) | HK61486A (en) |
HU (1) | HU186736B (en) |
IE (1) | IE50646B1 (en) |
IL (1) | IL60243A (en) |
IT (1) | IT1143922B (en) |
MY (1) | MY8600709A (en) |
NL (2) | NL193752C (en) |
NO (1) | NO152841C (en) |
NZ (1) | NZ193935A (en) |
PH (1) | PH18683A (en) |
SE (2) | SE447107B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH18106A (en) * | 1981-02-18 | 1985-03-21 | Merrell Dow Pharma | Novel-4-aroylimidazol-2-ones |
US4405628A (en) * | 1981-03-05 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Pyridylimidazolones and method of use |
US4329470A (en) | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
US4381393A (en) * | 1981-05-04 | 1983-04-26 | Merrell Dow Pharmaceuticals Inc. | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
US4329471A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
ZA822990B (en) * | 1981-05-04 | 1983-03-30 | Merrell Dow Pharma | 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones |
US4526981A (en) * | 1981-05-04 | 1985-07-02 | Merrell Dow Pharmaceuticals Inc. | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates |
US4371737A (en) * | 1981-05-04 | 1983-02-01 | Merrell Dow Pharmaceuticals Inc. | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
US4410540A (en) * | 1981-11-04 | 1983-10-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 4-aroylimidazolidin-2-ones |
US4367236A (en) * | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
WO2005092333A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
US20060025463A1 (en) * | 2004-03-22 | 2006-02-02 | Michael Bristow | Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases |
AU2006311577B2 (en) | 2005-11-09 | 2013-02-07 | Zalicus Inc. | Methods, compositions, and kits for the treatment of medical conditions |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
MX357121B (en) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Process of preparing guanylate cyclase c agonists. |
WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
BR112015030326A2 (en) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | ULTRAPURE GUANYLATE CYCLASE C AGONISTS, METHOD OF MANUFACTURING AND USING THEM |
WO2015021358A2 (en) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
CN114539157B (en) * | 2022-03-03 | 2023-12-22 | 曲靖师范学院 | Method for preparing 4-iodo-N-aryl pyrazole compound by iodine-promoted oxidation method |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2441933A (en) * | 1945-07-30 | 1948-05-18 | Hoffmann La Roche | Substituted imidazolones and process of making them |
-
1980
- 1980-06-04 NZ NZ193935A patent/NZ193935A/en unknown
- 1980-06-05 IE IE1162/80A patent/IE50646B1/en not_active IP Right Cessation
- 1980-06-06 SE SE8004253A patent/SE447107B/en not_active IP Right Cessation
- 1980-06-06 AU AU59118/80A patent/AU532783B2/en not_active Expired
- 1980-06-06 IL IL60243A patent/IL60243A/en unknown
- 1980-06-09 ES ES492255A patent/ES8105299A1/en not_active Expired
- 1980-06-11 DE DE19803021792 patent/DE3021792A1/en active Granted
- 1980-06-13 AT AT0314280A patent/AT375349B/en not_active IP Right Cessation
- 1980-06-16 CH CH462780A patent/CH646155A5/en not_active IP Right Cessation
- 1980-06-16 PH PH24143A patent/PH18683A/en unknown
- 1980-06-17 NO NO801796A patent/NO152841C/en unknown
- 1980-06-17 CA CA354,197A patent/CA1132554A/en not_active Expired
- 1980-06-17 NL NL8003498A patent/NL193752C/en not_active IP Right Cessation
- 1980-06-17 HU HU801506A patent/HU186736B/en unknown
- 1980-06-17 DK DK259080A patent/DK160269C/en not_active IP Right Cessation
- 1980-06-17 IT IT48997/80A patent/IT1143922B/en active Protection Beyond IP Right Term
- 1980-06-17 FR FR8013434A patent/FR2459233A1/en active Granted
- 1980-06-18 GB GB8019898A patent/GB2055364B/en not_active Expired
-
1985
- 1985-03-25 SE SE8501452A patent/SE464559B/en not_active IP Right Cessation
-
1986
- 1986-08-21 HK HK614/86A patent/HK61486A/en not_active IP Right Cessation
- 1986-12-30 MY MY709/86A patent/MY8600709A/en unknown
-
2000
- 2000-09-04 NL NL300015C patent/NL300015I1/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ITCP | Complementary protection certificate |
Free format text: CCP 156 |
|
MEDD | Supplementary protection certificate for pharmaceutical products: granted |
Free format text: CCP 156, 19920424; MERREL DOW PHARMACEUTICALS INC. |
|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950419 |