NL300015I2 - 1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition. - Google Patents
1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition.Info
- Publication number
- NL300015I2 NL300015I2 NL300015C NL300015C NL300015I2 NL 300015 I2 NL300015 I2 NL 300015I2 NL 300015 C NL300015 C NL 300015C NL 300015 C NL300015 C NL 300015C NL 300015 I2 NL300015 I2 NL 300015I2
- Authority
- NL
- Netherlands
- Prior art keywords
- cardiotonic
- aroyl
- hypertensive
- dihydro
- imidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4980879A | 1979-06-18 | 1979-06-18 | |
US11920780A | 1980-02-07 | 1980-02-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
NL300015I2 true NL300015I2 (en) | 2000-10-02 |
NL300015I1 NL300015I1 (en) | 2000-11-01 |
Family
ID=26727558
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL8003498A NL193752C (en) | 1979-06-18 | 1980-06-17 | 1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition. |
NL300015C NL300015I1 (en) | 1979-06-18 | 2000-09-04 | 1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL8003498A NL193752C (en) | 1979-06-18 | 1980-06-17 | 1,3-Dihydro-4- (aroyl) -2H-imidazole-2-ones and anti-hypertensive, cardiotonic and anti-thrombotic active pharmaceutical composition. |
Country Status (20)
Country | Link |
---|---|
AT (1) | AT375349B (en) |
AU (1) | AU532783B2 (en) |
CA (1) | CA1132554A (en) |
CH (1) | CH646155A5 (en) |
DE (1) | DE3021792A1 (en) |
DK (1) | DK160269C (en) |
ES (1) | ES8105299A1 (en) |
FR (1) | FR2459233A1 (en) |
GB (1) | GB2055364B (en) |
HK (1) | HK61486A (en) |
HU (1) | HU186736B (en) |
IE (1) | IE50646B1 (en) |
IL (1) | IL60243A (en) |
IT (1) | IT1143922B (en) |
MY (1) | MY8600709A (en) |
NL (2) | NL193752C (en) |
NO (1) | NO152841C (en) |
NZ (1) | NZ193935A (en) |
PH (1) | PH18683A (en) |
SE (2) | SE447107B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH18106A (en) * | 1981-02-18 | 1985-03-21 | Merrell Dow Pharma | Novel-4-aroylimidazol-2-ones |
US4405628A (en) * | 1981-03-05 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Pyridylimidazolones and method of use |
US4329471A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
US4526981A (en) * | 1981-05-04 | 1985-07-02 | Merrell Dow Pharmaceuticals Inc. | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates |
US4371737A (en) * | 1981-05-04 | 1983-02-01 | Merrell Dow Pharmaceuticals Inc. | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
US4381393A (en) * | 1981-05-04 | 1983-04-26 | Merrell Dow Pharmaceuticals Inc. | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
JPS57185266A (en) * | 1981-05-04 | 1982-11-15 | Merrell Dow Pharma | 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazole- 2-one |
US4329470A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
US4410540A (en) * | 1981-11-04 | 1983-10-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 4-aroylimidazolidin-2-ones |
US4367236A (en) | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
JP2007530566A (en) * | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | (R) -Enoximone sulfoxide and its use in the treatment of PDE-III mediated diseases |
EP1737448A1 (en) * | 2004-03-22 | 2007-01-03 | Myogen, Inc. | (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
JP2009514969A (en) | 2005-11-09 | 2009-04-09 | コンビナトアールエックス インコーポレーティッド | Methods, compositions, and kits for treating medical conditions |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
ES2522968T3 (en) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
ES2624828T3 (en) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CN108676076A (en) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | The method for preparing guanosine cyclic mono-phosphate agonist |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
WO2014131024A2 (en) | 2013-02-25 | 2014-08-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (en) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | Ultra high purity agonist of guanylate cyclase C, method for producing and using the same |
MX2016001714A (en) | 2013-08-09 | 2016-10-03 | Ardelyx Inc | Compounds and methods for inhibiting phosphate transport. |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
CN114539157B (en) * | 2022-03-03 | 2023-12-22 | 曲靖师范学院 | Method for preparing 4-iodo-N-aryl pyrazole compound by iodine-promoted oxidation method |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2441933A (en) * | 1945-07-30 | 1948-05-18 | Hoffmann La Roche | Substituted imidazolones and process of making them |
-
1980
- 1980-06-04 NZ NZ193935A patent/NZ193935A/en unknown
- 1980-06-05 IE IE1162/80A patent/IE50646B1/en not_active IP Right Cessation
- 1980-06-06 AU AU59118/80A patent/AU532783B2/en not_active Expired
- 1980-06-06 IL IL60243A patent/IL60243A/en unknown
- 1980-06-06 SE SE8004253A patent/SE447107B/en not_active IP Right Cessation
- 1980-06-09 ES ES492255A patent/ES8105299A1/en not_active Expired
- 1980-06-11 DE DE19803021792 patent/DE3021792A1/en active Granted
- 1980-06-13 AT AT0314280A patent/AT375349B/en not_active IP Right Cessation
- 1980-06-16 CH CH462780A patent/CH646155A5/en not_active IP Right Cessation
- 1980-06-16 PH PH24143A patent/PH18683A/en unknown
- 1980-06-17 NL NL8003498A patent/NL193752C/en not_active IP Right Cessation
- 1980-06-17 NO NO801796A patent/NO152841C/en unknown
- 1980-06-17 FR FR8013434A patent/FR2459233A1/en active Granted
- 1980-06-17 DK DK259080A patent/DK160269C/en not_active IP Right Cessation
- 1980-06-17 CA CA354,197A patent/CA1132554A/en not_active Expired
- 1980-06-17 HU HU801506A patent/HU186736B/en unknown
- 1980-06-17 IT IT48997/80A patent/IT1143922B/en active Protection Beyond IP Right Term
- 1980-06-18 GB GB8019898A patent/GB2055364B/en not_active Expired
-
1985
- 1985-03-25 SE SE8501452A patent/SE464559B/en not_active IP Right Cessation
-
1986
- 1986-08-21 HK HK614/86A patent/HK61486A/en not_active IP Right Cessation
- 1986-12-30 MY MY709/86A patent/MY8600709A/en unknown
-
2000
- 2000-09-04 NL NL300015C patent/NL300015I1/en unknown
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