SE8006993L - CELLKULTURMIKROBERARE - Google Patents

CELLKULTURMIKROBERARE

Info

Publication number
SE8006993L
SE8006993L SE8006993A SE8006993A SE8006993L SE 8006993 L SE8006993 L SE 8006993L SE 8006993 A SE8006993 A SE 8006993A SE 8006993 A SE8006993 A SE 8006993A SE 8006993 L SE8006993 L SE 8006993L
Authority
SE
Sweden
Prior art keywords
cells
microcarriers
growth
microcarrier
products
Prior art date
Application number
SE8006993A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE460906B (en
Inventor
D W Levine
W G Thilly
D I C Wang
J S Wong
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of SE8006993L publication Critical patent/SE8006993L/en
Publication of SE460906B publication Critical patent/SE460906B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C12N5/0075—General culture methods using substrates using microcarriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides

Abstract

A process for the cultivation of anchorage-dependent cells in which microcarriers in the cell culture are used is described. These microcarriers have on their surface an amount of positively charged chemical groups such that an exchange capacity which is in the range from 0.1 to 4.5 milliequivalents per gram of dry, untreated microcarrier is ensured. This exchange capacity ensures good growth of the cells, and the cells are cultivated in a culture medium in which the microcarrier is suspended, and the cell culture is left under conditions such that growth of the cells is elicited. The cells obtained in this cultivation process can be harvested, or by-products of the cell growth, such as, for example, viruses, vaccines, hormones, interferon or other by-products of cell growth, can be isolated. The microcarriers and process for their production are also described.
SE8006993A 1976-11-11 1980-10-07 CELLKULTURMIKROBAERARE SE460906B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74099376A 1976-11-11 1976-11-11

Publications (2)

Publication Number Publication Date
SE8006993L true SE8006993L (en) 1980-10-07
SE460906B SE460906B (en) 1989-12-04

Family

ID=24978920

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7712700A SE417108C (en) 1976-11-11 1977-11-10 CULTURE TO CULTURE ANCHORABLE TISSUE CELL CELLS ON MICROBATORS
SE8006993A SE460906B (en) 1976-11-11 1980-10-07 CELLKULTURMIKROBAERARE

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7712700A SE417108C (en) 1976-11-11 1977-11-10 CULTURE TO CULTURE ANCHORABLE TISSUE CELL CELLS ON MICROBATORS

Country Status (14)

Country Link
JP (3) JPS5362889A (en)
AU (1) AU508398B2 (en)
BE (1) BE860721A (en)
BR (1) BR7707551A (en)
CA (1) CA1063050A (en)
CH (1) CH615947A5 (en)
DE (2) DE2749989C3 (en)
FI (1) FI60407C (en)
FR (1) FR2370792A1 (en)
GB (1) GB1535150A (en)
IN (1) IN147612B (en)
NL (1) NL177926C (en)
SE (2) SE417108C (en)
ZA (1) ZA776251B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA776251B (en) * 1976-11-11 1978-07-26 Massachusetts Inst Technology Improved cell culture microcarriers
FR2470794A1 (en) * 1979-12-05 1981-06-12 Pasteur Institut NOVEL MICROPARTICLES, THEIR PREPARATION AND THEIR APPLICATIONS IN BIOLOGY, PARTICULARLY TO THE CULTURE OF HUMAN DIPLOID CELLS
US4448884A (en) * 1982-03-03 1984-05-15 Kms Fusion, Inc. Glass-surface microcarrier for growth of cell cultures
JPS592735U (en) * 1982-06-28 1984-01-09 シャープ株式会社 Remaining paper amount indicator in paper cassette
JPS60126453U (en) * 1984-02-02 1985-08-26 富士ゼロックス株式会社 Paper remaining amount display device such as facsimile
IL74259A0 (en) * 1984-02-06 1985-05-31 Surface Concepts Pty Ltd Improved method for cell culture
JPS60145139U (en) * 1984-03-07 1985-09-26 日本電信電話株式会社 Remaining amount display device for sheet recording paper
SE454518B (en) * 1984-05-21 1988-05-09 Statens Bakteriologiska Lab PROCEDURE FOR CULTURING DIPLOID CELLS IN THE PRESENTATION OF CELLULOSA FIBERS
JP2606213B2 (en) * 1986-04-22 1997-04-30 味の素株式会社 Complexes of Modified Microbial Cellulose with Gels and Animal Cell Membrane
DE3633891A1 (en) * 1986-10-04 1988-04-07 Akzo Gmbh METHOD AND DEVICE FOR CULTIVATING ANIMAL CELLS
US20140170748A1 (en) * 2012-12-14 2014-06-19 DePuy Synthes Products, LLC Nutrient Enriched Media for hUTC Growth
CN113249311B (en) * 2020-05-25 2022-06-28 北京唐颐惠康生物医学技术有限公司 Preparation method of degradable microcarrier for mesenchymal stem cell culture, product and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1436323A (en) * 1972-04-26 1976-05-19 Wellcome Found Cell and virus culture systems
US3901095A (en) * 1974-06-17 1975-08-26 Joseph W Wechsler Bicycle gear shift
US3935067A (en) * 1974-11-22 1976-01-27 Wyo-Ben Products, Inc. Inorganic support for culture media
ZA776251B (en) * 1976-11-11 1978-07-26 Massachusetts Inst Technology Improved cell culture microcarriers
JPS5614270A (en) * 1979-07-14 1981-02-12 Ricoh Co Ltd Wet type development after treating device

Also Published As

Publication number Publication date
BR7707551A (en) 1978-06-20
SE417108B (en) 1981-02-23
DE2749989C3 (en) 1980-07-03
JPS5362889A (en) 1978-06-05
CH615947A5 (en) 1980-02-29
DE2749989A1 (en) 1978-05-18
CA1063050A (en) 1979-09-25
JPS5699789A (en) 1981-08-11
FI773377A (en) 1978-05-12
JPS5735953B2 (en) 1982-07-31
DE2759579C2 (en) 1983-08-25
AU508398B2 (en) 1980-03-20
JPS575514B2 (en) 1982-01-30
ZA776251B (en) 1978-07-26
NL177926C (en) 1985-12-16
SE7712700L (en) 1978-05-12
AU3049177A (en) 1979-06-28
GB1535150A (en) 1978-12-06
FR2370792A1 (en) 1978-06-09
DE2749989B2 (en) 1979-10-25
FR2370792B1 (en) 1983-07-29
SE460906B (en) 1989-12-04
FI60407B (en) 1981-09-30
BE860721A (en) 1978-03-01
JPS5614270B2 (en) 1981-04-03
FI60407C (en) 1982-01-11
IN147612B (en) 1980-05-03
NL177926B (en) 1985-07-16
SE417108C (en) 1989-04-06
NL7712202A (en) 1978-05-16
JPS5699790A (en) 1981-08-11

Similar Documents

Publication Publication Date Title
SE8006993L (en) CELLKULTURMIKROBERARE
DE69027526T2 (en) PRODUCTION OF PROTEINS BY HOMOLOGOUS RECOMBINATION
ES2120946T3 (en) CELLULAR CULTURE SYSTEMS AND MEANS.
FI65448B (en) FRAMEWORK FOR THE PRODUCTION OF BACTERIOSTATIC ACTIVITIES
ES8104405A1 (en) Influenza virus vaccines, process for preparing them and process for propagating influenza viruses.
US4169761A (en) Process for the cultivation of viruses
ATE15693T1 (en) CELL CULTURE PROCEDURE.
JPS5765178A (en) Plant tissue or cell culture
ATE1552T1 (en) METHODS OF MAINTAINING LIVING MICROORGANISMS.
SE8301406D0 (en) IMMOBILIZED MICROORGANISM
DE3573273D1 (en) Cell culture microcarrier, process for preparing it and its use for culturing anchorage-dependent cells
SE8300990D0 (en) MICROBATCHERS FOR CULTIVATING CELL CULTURES
DE69116240D1 (en) Process for the production of cell protein with anti-HIV activity
JPS54163885A (en) Production of stable culture medium of lactobacilus microorganism
Mock et al. Laboratory cultivation of Licea alexopouli
DE3786698D1 (en) IMMOBILIZATION OF NON-ANCHOR-DEPENDENT CELLS.
GB2003177A (en) A method and an apparatus of highly concentrated cultivation of yeasts.
ATE18135T1 (en) METHOD OF PRODUCTION OF AN IMPROVED MUTANT STRAIN OF BORDETELLA BRONCHISEPTICA AND LIVE ATTACHED VACCINE CONTAINING IT.
ES381368A1 (en) A method of cultivating a genero of heteroploid human epithelial hepatic cells. (Machine-translation by Google Translate, not legally binding)
JPS572220A (en) Production of interferon
GB1522756A (en) Microbiological production of protein
Bolton A new species of Marssonina on strawberry
JPS5534039A (en) Preparation of phsophatidylinositol phospholipase c from bacillus thuringiensis
ES477013A1 (en) Process for the manufacture from cells of an immunological active substance complex which acts against malignant growth
JPS5558092A (en) Method of culturing tubercle bacillus

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8006993-3

Effective date: 19940610

Format of ref document f/p: F