JPS572220A - Production of interferon - Google Patents

Production of interferon

Info

Publication number
JPS572220A
JPS572220A JP7669080A JP7669080A JPS572220A JP S572220 A JPS572220 A JP S572220A JP 7669080 A JP7669080 A JP 7669080A JP 7669080 A JP7669080 A JP 7669080A JP S572220 A JPS572220 A JP S572220A
Authority
JP
Japan
Prior art keywords
poly
interferon
microcarrier
acid
inducer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7669080A
Other languages
Japanese (ja)
Other versions
JPS641119B2 (en
Inventor
Masahiko Iizuka
Emiko Sano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP7669080A priority Critical patent/JPS572220A/en
Publication of JPS572220A publication Critical patent/JPS572220A/en
Publication of JPS641119B2 publication Critical patent/JPS641119B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To obtain interferon in high yield, by stimulating an animal cell grown on a microcarrier having positively charged chemical residues with an inducer consisting of polyriboinosinic acid (poly I) and polyribocytidylic acid (poly C) in a specific proportion.
CONSTITUTION: An animal cell, e.g. human dipolid cell, grown on a microcarrier, e.g. a crosslinked dextran microcarrier having diethylaminoethyl groups, having positively charged chemical residues is stimulated with an interferon inducer consisting of a polyriboinosinic acid (poly I) and polyribocytidylic acid (poly C) as constituents to produce interferon. In the process, the inducer is used in a range in which the molar fraction of the hypoxanthine base in the poly I over that of the cytosine base in the poly C, particularly I/C=1.1W1.3. The production of the interferon reaches 2.7 times that in the case of the conventional I/C=1.
COPYRIGHT: (C)1982,JPO&Japio
JP7669080A 1980-06-09 1980-06-09 Production of interferon Granted JPS572220A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7669080A JPS572220A (en) 1980-06-09 1980-06-09 Production of interferon

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7669080A JPS572220A (en) 1980-06-09 1980-06-09 Production of interferon

Publications (2)

Publication Number Publication Date
JPS572220A true JPS572220A (en) 1982-01-07
JPS641119B2 JPS641119B2 (en) 1989-01-10

Family

ID=13612453

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7669080A Granted JPS572220A (en) 1980-06-09 1980-06-09 Production of interferon

Country Status (1)

Country Link
JP (1) JPS572220A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59179095A (en) * 1983-03-29 1984-10-11 Yamasa Shoyu Co Ltd Production of interferon
JPS61163763A (en) * 1985-01-14 1986-07-24 Fujitsu Ltd Carrier wave recovery system
WO2006131023A1 (en) * 2005-06-08 2006-12-14 Newbiomed Pika Pte Ltd Polyinosinic acid-polycytidylic acid-based adjuvant
US8303966B2 (en) 2006-01-13 2012-11-06 Yisheng Biopharma (Singapore) Pte. Ltd. Immunogenic substances comprising a polyinosinic acid—polycytidilic acid based adjuvant

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59179095A (en) * 1983-03-29 1984-10-11 Yamasa Shoyu Co Ltd Production of interferon
JPS61163763A (en) * 1985-01-14 1986-07-24 Fujitsu Ltd Carrier wave recovery system
WO2006131023A1 (en) * 2005-06-08 2006-12-14 Newbiomed Pika Pte Ltd Polyinosinic acid-polycytidylic acid-based adjuvant
US7838017B2 (en) 2005-06-08 2010-11-23 Newbiomed Pika Pte Ltd Polyinosinic acid-polycytidylic acid-based adjuvant
US8303965B2 (en) 2005-06-08 2012-11-06 Yisheng Biopharma (Singapore) Pte. Ltd. Polyinosinic acid-polycytidylic acid-based adjuvant
US8303966B2 (en) 2006-01-13 2012-11-06 Yisheng Biopharma (Singapore) Pte. Ltd. Immunogenic substances comprising a polyinosinic acid—polycytidilic acid based adjuvant

Also Published As

Publication number Publication date
JPS641119B2 (en) 1989-01-10

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