SE8004364L - Analogiforfarande for framstellning av nya terapeutiskt aktiva fenylureaforeningar - Google Patents

Analogiforfarande for framstellning av nya terapeutiskt aktiva fenylureaforeningar

Info

Publication number
SE8004364L
SE8004364L SE8004364A SE8004364A SE8004364L SE 8004364 L SE8004364 L SE 8004364L SE 8004364 A SE8004364 A SE 8004364A SE 8004364 A SE8004364 A SE 8004364A SE 8004364 L SE8004364 L SE 8004364L
Authority
SE
Sweden
Prior art keywords
general formula
corn
alkyl
picture
lower alkyl
Prior art date
Application number
SE8004364A
Other languages
English (en)
Inventor
B R Neustadt
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of SE8004364L publication Critical patent/SE8004364L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (1)

Potontkrov
1. Analogiforfarande ffir framstAlln1ng av nya terapeu - tiskt akt1va fenylkarbanider mad den alleAnna formeln X4 2 var1 R betecknar vats, lAgre alkyl, alkox1-1Agre alkyl slier dlalkox1-1Agre alkyl, R2 betecknar vats, metyl, etyl eller 2-haloetyl, enders av X2 och X4 utodres av en hydroxlpolyhalcasopropylgrupp betecknad R6 och son uppvlsar forneln CY3 -413cH Ia var1 symbolerna Y oberoende av varandra betecknar vAte, klor alien- fluor och den r."',a av X2 och Xe'etecknar vAte, iaqrs alkyl, halogen, 'Agra alkoxi, hydroxi-lXgre alkyl, nitro, ilgrs alkox1karbonyl eller aminokarbonyl, och X, och X6 D. N-alkylering av en fdren1ng, corn har den allmAnna formai% VII van i X2, X4, X2 och X6 har oven anglven betydelse, mad ett alkyleringsmedol R Q3, var1 Q2 kr on reaktiv grupp corn Scan elimineras under de anvAnda reaktlonsbetingelserna och R betecknar Mere alkyl, alkox1-1Agre alkyl slier dialkox1-1Agre alkyl. X6 h.CO.NRR2 F2Y Picture Picture oberoende av varandra botecknar vats, lagre alkyl, lagre alkoxi eller halogen, shier tillsammans mod de kolatomer till vilka de Br bundna betecknar en ansluton bensenoidring, vilken ring ken vara substituerad mad lagre alkyl slier halogen,kannetecknat &tray, att farfarandet utgar ett av fOljande forfaranden A-D: A. reaktion av en amin, corn har den allmanna formeln Picture Ix med ett reaktivt derivat av en karbamidsyra, nom bar den allmanna formeln R2NH.COOH van i R, 02, X2, X4, 05 Oct X6 tar den vid formal I anglvna betydelsen; R. reaktion av ett reaktivt derivat av en N-fenylkarba- midsyra, corn bar den allmanna formeln Picture III med en main, som bar den allmNnna formeln 02002 van i R, R2, X2, X4, Is och X6 her den vid formal I angivna betydelsen; C. infOrande av en halo- eller nitrosubstituent bensenoidringen vid en position corn jigger i orto-stallning till gruppen -NR.CO.NHR2 genom halogenering slier nitratering av en motsvarande dehalo- eller denitrofarening, corn bar den allmanna formeln It och
SE8004364A 1974-12-02 1980-06-11 Analogiforfarande for framstellning av nya terapeutiskt aktiva fenylureaforeningar SE8004364L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52860374A 1974-12-02 1974-12-02

Publications (1)

Publication Number Publication Date
SE8004364L true SE8004364L (sv) 1980-06-11

Family

ID=24106378

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7513331A SE7513331L (sv) 1974-12-02 1975-11-26 Substituerade ureidoforeningar
SE8004364A SE8004364L (sv) 1974-12-02 1980-06-11 Analogiforfarande for framstellning av nya terapeutiskt aktiva fenylureaforeningar

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7513331A SE7513331L (sv) 1974-12-02 1975-11-26 Substituerade ureidoforeningar

Country Status (26)

Country Link
JP (1) JPS5182239A (sv)
AR (2) AR219478A1 (sv)
AT (1) AT357557B (sv)
AU (1) AU501512B2 (sv)
BE (1) BE835899A (sv)
CA (1) CA1063112A (sv)
CH (1) CH623044A5 (sv)
CS (1) CS188259B2 (sv)
DD (1) DD124730A5 (sv)
DE (1) DE2552933A1 (sv)
DK (1) DK535275A (sv)
FI (1) FI753332A (sv)
FR (1) FR2346000A1 (sv)
GB (1) GB1507340A (sv)
HU (1) HU175541B (sv)
IE (1) IE42759B1 (sv)
IL (1) IL48557A (sv)
IT (1) IT1051024B (sv)
LU (1) LU73888A1 (sv)
NL (1) NL7513804A (sv)
NO (1) NO146497C (sv)
PH (1) PH14474A (sv)
PL (2) PL102327B1 (sv)
SE (2) SE7513331L (sv)
SU (2) SU655311A3 (sv)
ZA (1) ZA757457B (sv)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52111541A (en) * 1976-02-19 1977-09-19 Scherico Ltd Substituted ureido compound and medical composition containing it as active ingredient
US4107303A (en) 1976-06-24 1978-08-15 E. I. Du Pont De Nemours And Company Antihypertensive hexafluorohydroxyisopropyl benzazepines and benzazocines
DE2839462A1 (de) * 1978-09-11 1980-03-27 Basf Ag Aroylharnstoffe
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
EP1476425A4 (en) 2002-01-30 2010-05-05 Amgen Inc Heterocyclic Aryl Sulphonamidocyclic Compounds
CA2474433A1 (en) 2002-01-30 2003-08-07 Tularik Inc. Arylsulfonamidobenzylic compounds
US20030199578A1 (en) * 2002-04-19 2003-10-23 Turner Sean C. Naphthalene amides as potassium channel openers
RU2712163C2 (ru) * 2014-10-24 2020-01-24 Оно Фармасьютикал Ко., Лтд. Активатор kcnq2-5 каналов
JP6197971B1 (ja) * 2016-04-22 2017-09-20 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453284A (en) * 1966-01-19 1969-07-01 Du Pont Certain 2-(substituted-anilino)-2-oxazolines
DE1670751A1 (de) * 1966-09-27 1970-12-23 Bayer Ag Verfahren zur Herstellung von 2-Phenylamino-2-oxazolinen
FR1543534A (fr) * 1966-09-27 1968-10-25 Bayer Ag Procédé de fabrication de 2-phénylimino-oxazolidines
DE1670752A1 (de) * 1966-09-27 1970-12-23 Bayer Ag Verfahren zur Herstellung von 2-Phenylamino-oxazolinen
FR1543535A (fr) * 1966-09-27 1968-10-25 Bayer Ag Procédé de fabrication de 2-phénylamino-2-oxazolines

Also Published As

Publication number Publication date
SU655311A3 (ru) 1979-03-30
ZA757457B (en) 1976-11-24
DE2552933A1 (de) 1976-06-10
DK535275A (da) 1976-06-03
FR2346000A1 (fr) 1977-10-28
AR218436A1 (es) 1980-06-13
LU73888A1 (sv) 1976-09-06
AU501512B2 (en) 1979-06-21
JPS5182239A (sv) 1976-07-19
IE42759L (en) 1976-06-02
CA1063112A (en) 1979-09-25
CH623044A5 (en) 1981-05-15
IL48557A0 (en) 1976-01-30
AR219478A1 (es) 1980-08-29
BE835899A (fr) 1976-05-25
FR2346000B1 (sv) 1978-11-17
PH14474A (en) 1981-08-07
NO753984L (sv) 1976-06-03
NO146497B (no) 1982-07-05
FI753332A (sv) 1976-06-03
IE42759B1 (en) 1980-10-08
SE7513331L (sv) 1976-06-03
CS188259B2 (en) 1979-02-28
PL99122B1 (pl) 1978-06-30
SU685146A3 (ru) 1979-09-05
IT1051024B (it) 1981-04-21
AT357557B (de) 1980-07-25
AU8698975A (en) 1977-06-02
DD124730A5 (sv) 1977-03-09
NO146497C (no) 1982-10-13
GB1507340A (en) 1978-04-12
IL48557A (en) 1979-05-31
ATA898575A (de) 1979-12-15
HU175541B (hu) 1980-08-28
PL102327B1 (pl) 1979-03-31
NL7513804A (nl) 1976-06-04

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