SE7801373L - Lett spjelkbara substrat for kvantifiering av proteaser - Google Patents

Lett spjelkbara substrat for kvantifiering av proteaser

Info

Publication number
SE7801373L
SE7801373L SE7801373A SE7801373A SE7801373L SE 7801373 L SE7801373 L SE 7801373L SE 7801373 A SE7801373 A SE 7801373A SE 7801373 A SE7801373 A SE 7801373A SE 7801373 L SE7801373 L SE 7801373L
Authority
SE
Sweden
Prior art keywords
proteases
substrates
group
splable
quantifiation
Prior art date
Application number
SE7801373A
Other languages
English (en)
Swedish (sv)
Inventor
K G Claeson
L E Aurell
L R Simonsson
S Arielly
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Priority to SE7801373A priority Critical patent/SE7801373L/xx
Priority to US06/007,447 priority patent/US4279810A/en
Priority to IL56520A priority patent/IL56520A0/xx
Priority to CA000320702A priority patent/CA1136124A/fr
Priority to ZA79424A priority patent/ZA79424B/xx
Priority to AT0078279A priority patent/AT368773B/de
Priority to AU43945/79A priority patent/AU4394579A/en
Priority to PL1979213217A priority patent/PL116682B1/pl
Priority to FI790376A priority patent/FI790376A/fi
Priority to DE7979850009T priority patent/DE2963358D1/de
Priority to JP54500302A priority patent/JPS6345397B2/ja
Priority to NO790375A priority patent/NO790375L/no
Priority to ES477501A priority patent/ES477501A1/es
Priority to PCT/SE1979/000024 priority patent/WO1979000602A1/fr
Priority to EP79850009A priority patent/EP0004256B1/fr
Priority to DD79210881A priority patent/DD142550A5/de
Publication of SE7801373L publication Critical patent/SE7801373L/xx
Priority to DK420879A priority patent/DK147495C/da
Priority to SU802893256A priority patent/SU1277904A3/ru
Priority to US06/247,488 priority patent/US4335204A/en
Priority to JP62204293A priority patent/JPS63173600A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/20—Coumarin derivatives
    • C12Q2337/22—7-Amino-4-methylcoumarin, i.e. AMC, MCA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444—Factor X (3.4.21.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9723—Urokinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9726—Tissue plasminogen activator
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
SE7801373A 1978-02-07 1978-02-07 Lett spjelkbara substrat for kvantifiering av proteaser SE7801373L (sv)

Priority Applications (20)

Application Number Priority Date Filing Date Title
SE7801373A SE7801373L (sv) 1978-02-07 1978-02-07 Lett spjelkbara substrat for kvantifiering av proteaser
US06/007,447 US4279810A (en) 1978-02-07 1979-01-29 Easily split substrates for the quantification of proteases
IL56520A IL56520A0 (en) 1978-02-07 1979-01-29 Easily split substrates for the quantification of proteases
CA000320702A CA1136124A (fr) 1978-02-07 1979-02-01 Substances facilement brisables pour la quantification des proteases
ZA79424A ZA79424B (en) 1978-02-07 1979-02-01 Easily split substrates for the quantification of proteases
AT0078279A AT368773B (de) 1978-02-07 1979-02-02 Verfahren zur laboratoriumsdiagnostik von proteasen
AU43945/79A AU4394579A (en) 1978-02-07 1979-02-05 Easily split substrates
PL1979213217A PL116682B1 (en) 1978-02-07 1979-02-05 Process for the preparation of novel,easily splittable enzymatic substrates for quantitative determination of proteinases
FI790376A FI790376A (fi) 1978-02-07 1979-02-05 Laett spjaelkbara substrat foer kvantifiering av proteaser
DE7979850009T DE2963358D1 (en) 1978-02-07 1979-02-06 Easily split substrates for the quantification of proteases, a process for their production and a method for the quantification of proteases
JP54500302A JPS6345397B2 (fr) 1978-02-07 1979-02-06
NO790375A NO790375L (no) 1978-02-07 1979-02-06 Substrater for bestemmelse av proteaser
ES477501A ES477501A1 (es) 1978-02-07 1979-02-06 Procedimiento para la obtencion de substratos enzimaticos.
PCT/SE1979/000024 WO1979000602A1 (fr) 1978-02-07 1979-02-06 Substrats facilement dissociables pour la determination quantitative de proteases
EP79850009A EP0004256B1 (fr) 1978-02-07 1979-02-06 Substrats facilement décomposables servant au dosage quantitatif de protéases, procédé pour leur préparation et méthode de dosage quantitatif de protéases
DD79210881A DD142550A5 (de) 1978-02-07 1979-02-07 Diagnostisches mittel
DK420879A DK147495C (da) 1978-02-07 1979-10-05 Tripeptider til anvendelse som enzymsubstrat til kvantitativ beste mmelse af proteaser og fremgangsmaade til laboratoriediagnosticering af proteaser
SU802893256A SU1277904A3 (ru) 1978-02-07 1980-03-06 Способ получени трипептидов
US06/247,488 US4335204A (en) 1978-02-07 1981-03-25 Easily split substrates for the quantification of proteases
JP62204293A JPS63173600A (ja) 1978-02-07 1987-08-19 プロテア−ゼの定量方法およびそれに使用する試薬

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7801373A SE7801373L (sv) 1978-02-07 1978-02-07 Lett spjelkbara substrat for kvantifiering av proteaser

Publications (1)

Publication Number Publication Date
SE7801373L true SE7801373L (sv) 1979-08-08

Family

ID=20333883

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7801373A SE7801373L (sv) 1978-02-07 1978-02-07 Lett spjelkbara substrat for kvantifiering av proteaser

Country Status (18)

Country Link
US (2) US4279810A (fr)
EP (1) EP0004256B1 (fr)
JP (2) JPS6345397B2 (fr)
AT (1) AT368773B (fr)
AU (1) AU4394579A (fr)
CA (1) CA1136124A (fr)
DD (1) DD142550A5 (fr)
DE (1) DE2963358D1 (fr)
DK (1) DK147495C (fr)
ES (1) ES477501A1 (fr)
FI (1) FI790376A (fr)
IL (1) IL56520A0 (fr)
NO (1) NO790375L (fr)
PL (1) PL116682B1 (fr)
SE (1) SE7801373L (fr)
SU (1) SU1277904A3 (fr)
WO (1) WO1979000602A1 (fr)
ZA (1) ZA79424B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
DE3061860D1 (en) * 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
CA1161432A (fr) * 1980-02-12 1984-01-31 Lars G. Svendsen Derives de tripeptides et application pour le dosage des enzymes
JPS57501234A (fr) * 1980-08-25 1982-07-15
FR2497798A1 (fr) * 1981-01-09 1982-07-16 Pharmindustrie Nouveaux peptides portant un fluorophore, procede pour leur preparation et leur application au dosage fluorimetrique des endotoxines
US4388233A (en) * 1981-05-15 1983-06-14 The Regents Of The University Of California Synthetic substrates for enzyme analysis
US4510241A (en) * 1981-09-03 1985-04-09 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
US4491541A (en) * 1982-11-10 1985-01-01 Farmitalia Carlo Erba Peptides
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
EP0128118B1 (fr) * 1983-06-03 1991-08-14 Pentapharm A.G. Dérivés de peptides et leur utilisation comme substrats pour la détermination quantitative d'enzymes
JPS6117956A (ja) * 1984-07-04 1986-01-25 Nitto Boseki Co Ltd 新規な尿中カリクレイン測定用基質
CA1293591C (fr) * 1985-01-11 1991-12-24 Charles A. Kettner Substrats peptidiques pour la detection de l'activite de la protease contre certains virus
US4801534A (en) * 1985-05-28 1989-01-31 Coulter Electronics, Inc. Water soluble zanthylium derivative substrates
US4694070A (en) * 1985-05-28 1987-09-15 Coulter Electronics, Inc. Water soluble xanthylium derivatives substrates
DE3635191A1 (de) * 1986-10-16 1988-04-21 Behringwerke Ag Verfahren zur bestimmung von plasminogen
US5231006A (en) * 1986-10-16 1993-07-27 Behringwerke Aktiengesellschaft Method for the determination of plasminogen
SE8701801L (sv) * 1987-04-30 1988-10-31 Kabivitrum Ab Foerfarande foer identifiering av mikroorganismer
US5115099A (en) * 1988-06-14 1992-05-19 Nitto Boseki Co., Ltd. Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates
JPH06104079B2 (ja) * 1988-07-14 1994-12-21 日東紡績株式会社 新規な酵素活性測定用基質
US5191065A (en) * 1988-11-22 1993-03-02 Hoechst Aktiengesellschaft Process for the preparation of tripeptides
DE3839379A1 (de) * 1988-11-22 1990-05-23 Hoechst Ag Verfahren zur herstellung von tripeptiden
SE8904188D0 (sv) * 1989-12-12 1989-12-12 Kabivitrum Ab Chromogenic substrate
JP2769243B2 (ja) * 1990-02-19 1998-06-25 ノボ ノルディスク アクティーゼルスカブ 溶液、特に発酵溶液から精製ｅｐｉ蛋白質の回収方法
US5776720A (en) * 1995-05-18 1998-07-07 Coulter Corporation Assay reagent
US5733719A (en) * 1995-05-18 1998-03-31 Coulter Corporation Method of making an assay compound
US5871946A (en) * 1995-05-18 1999-02-16 Coulter Corporation Method for determining activity of enzymes in metabolically active whole cells
US5698411A (en) * 1995-05-18 1997-12-16 Coulter Corporation Method for determining activity of enzymes in metabolically active whole cells
AU2001265092A1 (en) * 2000-06-02 2001-12-17 Regents Of The University Of California Profiling of protease specificity using combinatorial fluorogenic substrate libraries
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH622286A5 (fr) * 1975-06-23 1981-03-31 Pentapharm Ag
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
SE437153B (sv) * 1976-12-01 1985-02-11 Kabi Ab Specifika kromogena enzymsubstrat for serinproteaser
US4215047A (en) * 1977-06-06 1980-07-29 Ajinomoto Company Incorporated 7-(Arginylamino)-4-methylcoumarins

Also Published As

Publication number Publication date
SU1277904A3 (ru) 1986-12-15
PL213217A1 (fr) 1980-02-11
US4279810A (en) 1981-07-21
JPS55500076A (fr) 1980-02-14
US4335204A (en) 1982-06-15
DE2963358D1 (en) 1982-09-09
DK147495C (da) 1985-07-15
DD142550A5 (de) 1980-07-02
JPS6345397B2 (fr) 1988-09-09
EP0004256A1 (fr) 1979-09-19
DK420879A (da) 1979-10-05
AU4394579A (en) 1979-08-16
AT368773B (de) 1982-11-10
ES477501A1 (es) 1979-11-16
DK147495B (da) 1984-09-03
ATA78279A (de) 1982-03-15
CA1136124A (fr) 1982-11-23
JPS63173600A (ja) 1988-07-18
PL116682B1 (en) 1981-06-30
IL56520A0 (en) 1979-03-12
ZA79424B (en) 1980-01-30
FI790376A (fi) 1979-08-08
EP0004256B1 (fr) 1982-07-21
NO790375L (no) 1979-08-08
WO1979000602A1 (fr) 1979-08-23

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