DK147495C - Tripeptider til anvendelse som enzymsubstrat til kvantitativ beste mmelse af proteaser og fremgangsmaade til laboratoriediagnosticering af proteaser - Google Patents

Tripeptider til anvendelse som enzymsubstrat til kvantitativ beste mmelse af proteaser og fremgangsmaade til laboratoriediagnosticering af proteaser

Info

Publication number
DK147495C
DK147495C DK420879A DK420879A DK147495C DK 147495 C DK147495 C DK 147495C DK 420879 A DK420879 A DK 420879A DK 420879 A DK420879 A DK 420879A DK 147495 C DK147495 C DK 147495C
Authority
DK
Denmark
Prior art keywords
proteases
diagnostication
substate
tripeptides
quantitative
Prior art date
Application number
DK420879A
Other languages
Danish (da)
English (en)
Other versions
DK420879A (da
DK147495B (da
Inventor
Karl Goeran Claeson
Leif Erik Aurell
Leif Roger Simonsson
Salo Arielly
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of DK420879A publication Critical patent/DK420879A/da
Publication of DK147495B publication Critical patent/DK147495B/da
Application granted granted Critical
Publication of DK147495C publication Critical patent/DK147495C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/20—Coumarin derivatives
    • C12Q2337/22—7-Amino-4-methylcoumarin, i.e. AMC, MCA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444—Factor X (3.4.21.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9723—Urokinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9726—Tissue plasminogen activator
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK420879A 1978-02-07 1979-10-05 Tripeptider til anvendelse som enzymsubstrat til kvantitativ beste mmelse af proteaser og fremgangsmaade til laboratoriediagnosticering af proteaser DK147495C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE7801373 1978-02-07
SE7801373A SE7801373L (sv) 1978-02-07 1978-02-07 Lett spjelkbara substrat for kvantifiering av proteaser
PCT/SE1979/000024 WO1979000602A1 (fr) 1978-02-07 1979-02-06 Substrats facilement dissociables pour la determination quantitative de proteases
SE7900024 1979-02-06

Publications (3)

Publication Number Publication Date
DK420879A DK420879A (da) 1979-10-05
DK147495B DK147495B (da) 1984-09-03
DK147495C true DK147495C (da) 1985-07-15

Family

ID=20333883

Family Applications (1)

Application Number Title Priority Date Filing Date
DK420879A DK147495C (da) 1978-02-07 1979-10-05 Tripeptider til anvendelse som enzymsubstrat til kvantitativ beste mmelse af proteaser og fremgangsmaade til laboratoriediagnosticering af proteaser

Country Status (18)

Country Link
US (2) US4279810A (fr)
EP (1) EP0004256B1 (fr)
JP (2) JPS6345397B2 (fr)
AT (1) AT368773B (fr)
AU (1) AU4394579A (fr)
CA (1) CA1136124A (fr)
DD (1) DD142550A5 (fr)
DE (1) DE2963358D1 (fr)
DK (1) DK147495C (fr)
ES (1) ES477501A1 (fr)
FI (1) FI790376A (fr)
IL (1) IL56520A0 (fr)
NO (1) NO790375L (fr)
PL (1) PL116682B1 (fr)
SE (1) SE7801373L (fr)
SU (1) SU1277904A3 (fr)
WO (1) WO1979000602A1 (fr)
ZA (1) ZA79424B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
EP0018002B1 (fr) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Procédé pour la détermination de protéases et d'anti-protéases
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
CA1161432A (fr) * 1980-02-12 1984-01-31 Lars G. Svendsen Derives de tripeptides et application pour le dosage des enzymes
ATE8130T1 (de) * 1980-08-25 1984-07-15 Kabivitrum Ab Peptidsubstrate zum bestimmen der proteaseaktivitaet.
FR2497798A1 (fr) * 1981-01-09 1982-07-16 Pharmindustrie Nouveaux peptides portant un fluorophore, procede pour leur preparation et leur application au dosage fluorimetrique des endotoxines
US4388233A (en) * 1981-05-15 1983-06-14 The Regents Of The University Of California Synthetic substrates for enzyme analysis
US4510241A (en) * 1981-09-03 1985-04-09 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
US4491541A (en) * 1982-11-10 1985-01-01 Farmitalia Carlo Erba Peptides
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
EP0128118B1 (fr) * 1983-06-03 1991-08-14 Pentapharm A.G. Dérivés de peptides et leur utilisation comme substrats pour la détermination quantitative d'enzymes
JPS6117956A (ja) * 1984-07-04 1986-01-25 Nitto Boseki Co Ltd 新規な尿中カリクレイン測定用基質
CA1293591C (fr) * 1985-01-11 1991-12-24 Charles A. Kettner Substrats peptidiques pour la detection de l'activite de la protease contre certains virus
US4694070A (en) * 1985-05-28 1987-09-15 Coulter Electronics, Inc. Water soluble xanthylium derivatives substrates
US4801534A (en) * 1985-05-28 1989-01-31 Coulter Electronics, Inc. Water soluble zanthylium derivative substrates
DE3635191A1 (de) * 1986-10-16 1988-04-21 Behringwerke Ag Verfahren zur bestimmung von plasminogen
US5231006A (en) * 1986-10-16 1993-07-27 Behringwerke Aktiengesellschaft Method for the determination of plasminogen
SE8701801L (sv) * 1987-04-30 1988-10-31 Kabivitrum Ab Foerfarande foer identifiering av mikroorganismer
US5115099A (en) * 1988-06-14 1992-05-19 Nitto Boseki Co., Ltd. Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates
JPH06104079B2 (ja) * 1988-07-14 1994-12-21 日東紡績株式会社 新規な酵素活性測定用基質
DE3839379A1 (de) * 1988-11-22 1990-05-23 Hoechst Ag Verfahren zur herstellung von tripeptiden
US5191065A (en) * 1988-11-22 1993-03-02 Hoechst Aktiengesellschaft Process for the preparation of tripeptides
SE8904188D0 (sv) * 1989-12-12 1989-12-12 Kabivitrum Ab Chromogenic substrate
JP2769243B2 (ja) * 1990-02-19 1998-06-25 ノボ ノルディスク アクティーゼルスカブ 溶液、特に発酵溶液から精製ｅｐｉ蛋白質の回収方法
US5871946A (en) * 1995-05-18 1999-02-16 Coulter Corporation Method for determining activity of enzymes in metabolically active whole cells
US5776720A (en) * 1995-05-18 1998-07-07 Coulter Corporation Assay reagent
US5698411A (en) * 1995-05-18 1997-12-16 Coulter Corporation Method for determining activity of enzymes in metabolically active whole cells
US5733719A (en) * 1995-05-18 1998-03-31 Coulter Corporation Method of making an assay compound
US6680178B2 (en) 2000-06-02 2004-01-20 The Regents Of The University Of California Profiling of protease specificity using combinatorial fluorogenic substrate libraries
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
IL42124A (en) * 1972-05-02 1977-02-28 Kabi Ab Substrate for the determination of proteolytic enzymes
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH622286A5 (fr) * 1975-06-23 1981-03-31 Pentapharm Ag
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
SE437153B (sv) * 1976-12-01 1985-02-11 Kabi Ab Specifika kromogena enzymsubstrat for serinproteaser
US4215047A (en) * 1977-06-06 1980-07-29 Ajinomoto Company Incorporated 7-(Arginylamino)-4-methylcoumarins

Also Published As

Publication number Publication date
EP0004256B1 (fr) 1982-07-21
IL56520A0 (en) 1979-03-12
ES477501A1 (es) 1979-11-16
DE2963358D1 (en) 1982-09-09
JPS6345397B2 (fr) 1988-09-09
DK420879A (da) 1979-10-05
ZA79424B (en) 1980-01-30
FI790376A (fi) 1979-08-08
JPS55500076A (fr) 1980-02-14
WO1979000602A1 (fr) 1979-08-23
PL116682B1 (en) 1981-06-30
ATA78279A (de) 1982-03-15
AU4394579A (en) 1979-08-16
US4335204A (en) 1982-06-15
SE7801373L (sv) 1979-08-08
DD142550A5 (de) 1980-07-02
SU1277904A3 (ru) 1986-12-15
PL213217A1 (fr) 1980-02-11
JPS63173600A (ja) 1988-07-18
EP0004256A1 (fr) 1979-09-19
US4279810A (en) 1981-07-21
CA1136124A (fr) 1982-11-23
NO790375L (no) 1979-08-08
DK147495B (da) 1984-09-03
AT368773B (de) 1982-11-10

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