SE7713233L - ALFA-PROTECTED OXIIMINO-BETA-OXO-GAMMA-HALOGENOSMORIC ACID DERIVATIVES FOR USE AS AN INTERMEDIATE PRODUCT FOR THE PREPARATION OF PHARMACEUTICALLY APPLICABLE CEFEM COMPOUNDS - Google Patents
ALFA-PROTECTED OXIIMINO-BETA-OXO-GAMMA-HALOGENOSMORIC ACID DERIVATIVES FOR USE AS AN INTERMEDIATE PRODUCT FOR THE PREPARATION OF PHARMACEUTICALLY APPLICABLE CEFEM COMPOUNDSInfo
- Publication number
- SE7713233L SE7713233L SE7713233A SE7713233A SE7713233L SE 7713233 L SE7713233 L SE 7713233L SE 7713233 A SE7713233 A SE 7713233A SE 7713233 A SE7713233 A SE 7713233A SE 7713233 L SE7713233 L SE 7713233L
- Authority
- SE
- Sweden
- Prior art keywords
- protected
- beta
- preparation
- halogenosmoric
- oxiimino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
NEW MATERIAL:A compound of formula I [X is halogen: Y and Z incorporate to form a group, =NR<5> (R<5> is protected hydroxyl)], its salt or ester. EXAMPLE:Ethyl alpha-ethoxyimino-2-aminothiazol-4-ylacetate hydrobromide. USE:A synthetic intermediate of antibacterials. PREPARATION:The customary halogenation of a compound of formula II such as a beta-ketobutyric acid bearing a protected oxyimino group in the alpha-position gives the compound of formula I . In the compound of formula I , methyl, phenyl or acetyl is cited as a protecting group for the hydroxyl and methyl, tolyl or benzyl for the carboxyl. The protected oxyimino group has syn- and anti-forms theoretically.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1336578A JPS53121400A (en) | 1977-02-07 | 1978-02-07 | Method of supplying fuel with aeroplane and device for the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB24611/75A GB1536281A (en) | 1975-06-09 | 1975-06-09 | Cephem compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7713233L true SE7713233L (en) | 1977-11-23 |
SE444809B SE444809B (en) | 1986-05-12 |
Family
ID=10214399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7713233A SE444809B (en) | 1975-06-09 | 1977-11-23 | ALFA-PROTECTED OXIIMINO-BETA-OXO-GAMMA-HALOGENSORIC ACID DERIVATIVES FOR USE AS INTERMEDIATE FOR THE PREPARATION OF PHARMACEUTICAL USEFUL CEFEM SOCIETIES |
Country Status (7)
Country | Link |
---|---|
JP (5) | JPS5822039B2 (en) |
AT (2) | AT344894B (en) |
GB (1) | GB1536281A (en) |
HK (1) | HK2282A (en) |
HU (1) | HU172304B (en) |
MY (1) | MY8200219A (en) |
SE (1) | SE444809B (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK154939C (en) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF |
GB1536281A (en) * | 1975-06-09 | 1978-12-20 | Takeda Chemical Industries Ltd | Cephem compounds |
FR2346014A1 (en) * | 1976-01-23 | 1977-10-28 | Roussel Uclaf | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
SE440655B (en) * | 1976-01-23 | 1985-08-12 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID |
GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
FI771866A (en) * | 1976-06-28 | 1977-12-29 | Fujisawa Pharmaceutical Co | |
PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
AU520269B2 (en) * | 1977-03-14 | 1982-01-21 | Fujisawa Pharmaceutical Co., Ltd. | Cephem and cepham compounds |
JPS5444695A (en) * | 1977-09-13 | 1979-04-09 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation |
US4370326A (en) * | 1977-09-13 | 1983-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and composition |
FR2410655A1 (en) * | 1977-12-05 | 1979-06-29 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-SUBSTITUTE 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
DE2758001A1 (en) * | 1977-12-24 | 1979-07-12 | Hoechst Ag | CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
FR2387235A1 (en) * | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3,7-DISUBSTITUE-3-CEPHEM-4-CARBOXYLIC ACID AND NEW PRODUCTS THUS OBTAINED, HAVING A STRONG ANTIBACTERIAL ACTIVITY |
JPS54106495A (en) * | 1978-02-09 | 1979-08-21 | Dai Ichi Seiyaku Co Ltd | Cephem derivative |
JPS54128594A (en) * | 1978-03-27 | 1979-10-05 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid derivative |
FR2432521A1 (en) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS |
DE2818263A1 (en) * | 1978-04-26 | 1979-11-08 | Bayer Ag | BETA LACTAMANTIBIOTICS |
US4703046A (en) * | 1978-09-08 | 1987-10-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and processes for preparation thereof |
BE878637A (en) * | 1978-09-11 | 1980-03-06 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIMICROBIAL ACTIVITIES |
JPS5543089A (en) * | 1978-09-12 | 1980-03-26 | Fujisawa Pharmaceut Co Ltd | Preparation of 3-cephem compound |
JPS5594354A (en) * | 1979-01-12 | 1980-07-17 | Fujisawa Pharmaceut Co Ltd | Syn-isomer of 2-substituted imino-3-oxo-4-halobutyric acid, its salt, and their preparation |
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
JPS56125392A (en) * | 1980-03-06 | 1981-10-01 | Fujisawa Pharmaceut Co Ltd | Cepham and cephem compound and preparation thereof |
JPS57154175A (en) * | 1981-03-16 | 1982-09-22 | Mitsui Toatsu Chem Inc | 2-thiazoleamine derivative, its preparation, and drug composition comprising it |
US4457929A (en) * | 1982-03-29 | 1984-07-03 | Bristol-Myers Company | 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives |
ATE30724T1 (en) | 1982-06-28 | 1987-11-15 | Bristol Myers Co | CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
IL69246A (en) * | 1982-08-07 | 1986-07-31 | Tanabe Seiyaku Co | 7-((2-aminothiazolyl-2-pyrrolidonyl or(piperidonyl)-oxyimino)acetamido)cephem carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them |
JPS6150973A (en) * | 1983-11-16 | 1986-03-13 | Fujisawa Pharmaceut Co Ltd | Substituted iminoacetic acid derivative and salt and preparation thereof |
IT1180207B (en) * | 1984-07-30 | 1987-09-23 | Istituto Biochimico Italiano | PROCEDURE FOR THE PREPARATION, WITH HIGH YIELD AND PURITY, OF BETA-LACTAMIC ANTIBIOTICS |
JPS60155167A (en) * | 1984-07-31 | 1985-08-15 | Fujisawa Pharmaceut Co Ltd | Substituted iminoacetic acid derivative and its salt |
JPS61121746U (en) * | 1985-01-16 | 1986-07-31 | ||
EP0210815A3 (en) * | 1985-07-25 | 1988-04-20 | Beecham Group Plc | 6-beta-(alpha-etherified oxyimino)-acylamino penicillanic-acid derivatives, their preparation and use |
GB8519606D0 (en) * | 1985-08-05 | 1985-09-11 | Fujisawa Pharmaceutical Co | 3 7-d substituted-3-cephem compounds |
EP0373216A4 (en) * | 1987-02-02 | 1992-08-12 | Teijin Limited | Cephalosporin compounds or their salts, process for their preparation, and parmaceutical compositions |
AU1228988A (en) * | 1987-02-03 | 1988-08-24 | Teijin Limited | Cephalosporin compounds or their salts, process for their preparation, and pharmaceutical compositions |
JPH02281051A (en) * | 1989-04-21 | 1990-11-16 | Toyo Tire & Rubber Co Ltd | Tread rubber composition for tire |
JPH09110877A (en) | 1995-10-17 | 1997-04-28 | Katayama Seiyakushiyo:Kk | Cephem compound, its production and antibacterial agent containing the compound |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1536281A (en) * | 1975-06-09 | 1978-12-20 | Takeda Chemical Industries Ltd | Cephem compounds |
-
1975
- 1975-06-09 GB GB24611/75A patent/GB1536281A/en not_active Expired
- 1975-12-17 HU HU75TA00001381A patent/HU172304B/en unknown
- 1975-12-19 AT AT967775A patent/AT344894B/en not_active IP Right Cessation
-
1976
- 1976-06-08 JP JP51067524A patent/JPS5822039B2/en not_active Expired
-
1977
- 1977-07-18 AT AT517177A patent/AT347587B/en not_active IP Right Cessation
- 1977-11-23 SE SE7713233A patent/SE444809B/en not_active IP Right Cessation
-
1981
- 1981-06-05 JP JP56087403A patent/JPS5858353B2/en not_active Expired
-
1982
- 1982-01-14 HK HK22/82A patent/HK2282A/en unknown
- 1982-12-30 MY MY219/82A patent/MY8200219A/en unknown
-
1983
- 1983-01-27 JP JP58012560A patent/JPS58185553A/en active Granted
- 1983-09-28 JP JP58178160A patent/JPS5989686A/en active Pending
-
1985
- 1985-10-16 JP JP60232072A patent/JPS61143388A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
ATA967775A (en) | 1977-12-15 |
JPS61143388A (en) | 1986-07-01 |
JPS6155905B2 (en) | 1986-11-29 |
JPS5756485A (en) | 1982-04-05 |
SE444809B (en) | 1986-05-12 |
JPS51149296A (en) | 1976-12-22 |
HK2282A (en) | 1982-01-22 |
AT344894B (en) | 1978-08-10 |
ATA517177A (en) | 1978-05-15 |
JPS5858353B2 (en) | 1983-12-24 |
JPS5989686A (en) | 1984-05-23 |
HU172304B (en) | 1978-07-28 |
AT347587B (en) | 1979-01-10 |
JPH0346474B2 (en) | 1991-07-16 |
JPS5822039B2 (en) | 1983-05-06 |
JPS58185553A (en) | 1983-10-29 |
GB1536281A (en) | 1978-12-20 |
MY8200219A (en) | 1982-12-31 |
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