SE504489C2 - Komposition för att inducera och stimulera hårtillväxt och bromsa håravfall, vilken komposition är baserad på nikotinsyraestrar och pyrimidindierivat samt ett förfarande för kosmetisk behandling av hår - Google Patents
Komposition för att inducera och stimulera hårtillväxt och bromsa håravfall, vilken komposition är baserad på nikotinsyraestrar och pyrimidindierivat samt ett förfarande för kosmetisk behandling av hårInfo
- Publication number
- SE504489C2 SE504489C2 SE8703461A SE8703461A SE504489C2 SE 504489 C2 SE504489 C2 SE 504489C2 SE 8703461 A SE8703461 A SE 8703461A SE 8703461 A SE8703461 A SE 8703461A SE 504489 C2 SE504489 C2 SE 504489C2
- Authority
- SE
- Sweden
- Prior art keywords
- carbon atoms
- composition
- alkyl
- hair
- composition according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 150000003230 pyrimidines Chemical class 0.000 title claims abstract description 14
- 230000003779 hair growth Effects 0.000 title claims abstract description 10
- 230000004936 stimulating effect Effects 0.000 title claims abstract description 8
- 230000001939 inductive effect Effects 0.000 title claims abstract description 4
- 210000004209 hair Anatomy 0.000 title claims description 24
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title claims description 16
- 201000004384 Alopecia Diseases 0.000 title claims description 13
- 230000003676 hair loss Effects 0.000 title claims description 13
- 208000024963 hair loss Diseases 0.000 title claims description 12
- 238000000034 method Methods 0.000 title claims description 7
- 239000002537 cosmetic Substances 0.000 title claims description 4
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 42
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
- 239000001257 hydrogen Substances 0.000 claims abstract description 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 7
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 6
- 239000002253 acid Substances 0.000 claims abstract description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 150000007513 acids Chemical class 0.000 claims abstract description 3
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims abstract description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 3
- 150000002431 hydrogen Chemical class 0.000 claims abstract 3
- 125000002393 azetidinyl group Chemical group 0.000 claims abstract 2
- 125000004069 aziridinyl group Chemical group 0.000 claims abstract 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims abstract 2
- -1 nicotinic acid ester Chemical class 0.000 claims description 25
- 235000001968 nicotinic acid Nutrition 0.000 claims description 20
- 239000011664 nicotinic acid Substances 0.000 claims description 18
- 229960003512 nicotinic acid Drugs 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 10
- YNBADRVTZLEFNH-UHFFFAOYSA-N methyl nicotinate Chemical compound COC(=O)C1=CC=CN=C1 YNBADRVTZLEFNH-UHFFFAOYSA-N 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 210000004761 scalp Anatomy 0.000 claims description 6
- 229960001238 methylnicotinate Drugs 0.000 claims description 5
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 4
- 125000003386 piperidinyl group Chemical group 0.000 claims description 4
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 2
- RQAITHJHUFFEIV-UHFFFAOYSA-N thurfyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1CCCO1 RQAITHJHUFFEIV-UHFFFAOYSA-N 0.000 claims description 2
- 229950006036 thurfyl nicotinate Drugs 0.000 claims description 2
- 239000002609 medium Substances 0.000 claims 5
- KUMSUDPUHCCKIQ-UHFFFAOYSA-N 3-hydroxy-6-piperidin-1-yl-2h-pyrimidine-2,4-diamine Chemical compound C1=C(N)N(O)C(N)N=C1N1CCCCC1 KUMSUDPUHCCKIQ-UHFFFAOYSA-N 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- QXNDZONIWRINJR-UHFFFAOYSA-N azocane Chemical compound C1CCCNCCC1 QXNDZONIWRINJR-UHFFFAOYSA-N 0.000 abstract description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000004948 alkyl aryl alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- NRHDCQLCSOWVTF-UHFFFAOYSA-N azonane Chemical compound C1CCCCNCCC1 NRHDCQLCSOWVTF-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002034 haloarylalkyl group Chemical group 0.000 abstract 1
- 125000004634 hexahydroazepinyl group Chemical group N1(CCCCCC1)* 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 230000000979 retarding effect Effects 0.000 abstract 1
- 229920001222 biopolymer Polymers 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 229920002678 cellulose Polymers 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 229920001285 xanthan gum Polymers 0.000 description 6
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- 230000003698 anagen phase Effects 0.000 description 4
- 229920006317 cationic polymer Polymers 0.000 description 4
- 239000003349 gelling agent Substances 0.000 description 4
- 230000003797 telogen phase Effects 0.000 description 4
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- ZIMGGGWCDYVHOY-UHFFFAOYSA-N 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Chemical compound N=C1N(O)C(N)=CC(N2CCCCC2)=N1 ZIMGGGWCDYVHOY-UHFFFAOYSA-N 0.000 description 2
- 241000588986 Alcaligenes Species 0.000 description 2
- XBLVHTDFJBKJLG-UHFFFAOYSA-N Ethyl nicotinate Chemical compound CCOC(=O)C1=CC=CN=C1 XBLVHTDFJBKJLG-UHFFFAOYSA-N 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical group O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- DQULIMIQTCDUAN-UHFFFAOYSA-N butyl pyridine-3-carboxylate Chemical compound CCCCOC(=O)C1=CC=CN=C1 DQULIMIQTCDUAN-UHFFFAOYSA-N 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000031774 hair cycle Effects 0.000 description 2
- RVYGVBZGSFLJKH-UHFFFAOYSA-N hexyl pyridine-3-carboxylate Chemical compound CCCCCCOC(=O)C1=CC=CN=C1 RVYGVBZGSFLJKH-UHFFFAOYSA-N 0.000 description 2
- 229940051295 hexylnicotinate Drugs 0.000 description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- 230000000304 vasodilatating effect Effects 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical group CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 description 1
- WECIKJKLCDCIMY-UHFFFAOYSA-N 2-chloro-n-(2-cyanoethyl)acetamide Chemical compound ClCC(=O)NCCC#N WECIKJKLCDCIMY-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 241000194105 Paenibacillus polymyxa Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000589634 Xanthomonas Species 0.000 description 1
- NJSSICCENMLTKO-HRCBOCMUSA-N [(1r,2s,4r,5r)-3-hydroxy-4-(4-methylphenyl)sulfonyloxy-6,8-dioxabicyclo[3.2.1]octan-2-yl] 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)O[C@H]1C(O)[C@@H](OS(=O)(=O)C=2C=CC(C)=CC=2)[C@@H]2OC[C@H]1O2 NJSSICCENMLTKO-HRCBOCMUSA-N 0.000 description 1
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 description 1
- 150000003926 acrylamides Chemical class 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- YIOJGTBNHQAVBO-UHFFFAOYSA-N dimethyl-bis(prop-2-enyl)azanium Chemical class C=CC[N+](C)(C)CC=C YIOJGTBNHQAVBO-UHFFFAOYSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940064982 ethylnicotinate Drugs 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- VZTGWJFIMGVKSN-UHFFFAOYSA-O trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium Chemical compound CC(=C)C(=O)NCCC[N+](C)(C)C VZTGWJFIMGVKSN-UHFFFAOYSA-O 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU86574A LU86574A1 (fr) | 1986-09-08 | 1986-09-08 | Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8703461D0 SE8703461D0 (sv) | 1987-09-07 |
| SE8703461L SE8703461L (sv) | 1988-03-09 |
| SE504489C2 true SE504489C2 (sv) | 1997-02-24 |
Family
ID=19730765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8703461A SE504489C2 (sv) | 1986-09-08 | 1987-09-07 | Komposition för att inducera och stimulera hårtillväxt och bromsa håravfall, vilken komposition är baserad på nikotinsyraestrar och pyrimidindierivat samt ett förfarande för kosmetisk behandling av hår |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4968685A (da) |
| JP (1) | JP2613222B2 (da) |
| KR (1) | KR880003611A (da) |
| AT (1) | AT400671B (da) |
| AU (1) | AU609055B2 (da) |
| BE (1) | BE1001047A5 (da) |
| CA (1) | CA1294883C (da) |
| CH (1) | CH673391A5 (da) |
| DE (1) | DE3729953C2 (da) |
| DK (1) | DK173080B1 (da) |
| ES (1) | ES2008735A6 (da) |
| FR (1) | FR2603482B1 (da) |
| GB (1) | GB2194734B (da) |
| GR (1) | GR871387B (da) |
| IT (1) | IT1211374B (da) |
| LU (1) | LU86574A1 (da) |
| NL (1) | NL193980C (da) |
| PT (1) | PT85653B (da) |
| SE (1) | SE504489C2 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2653015B1 (fr) * | 1989-10-12 | 1993-10-29 | Oreal | Composition cosmetique ou pharmaceutique pour application topique contenant au moins un derive retinouide et au moins un derive de pyrimidine, son utilisation comme medicament et procede de traitement correspondant. |
| FR2653016B1 (fr) * | 1989-10-13 | 1994-09-16 | Oreal | Composition de lavage des matieres keratiniques, en particulier des cheveux et/ou de la peau. |
| US5043162A (en) * | 1990-09-05 | 1991-08-27 | Trager Seymour F | Hair growth promoter |
| GB9026354D0 (en) * | 1990-12-04 | 1991-01-23 | Unilever Plc | Cosmetic composition |
| FR2677884B1 (fr) * | 1991-06-20 | 1993-07-09 | Oreal | Composition pour freiner la chute des cheveux a base de pyrimidines n-oxyde trisubstitues ou leurs derives sulfoconjugues, nouveaux composes pyrimidines n-oxyde ou leurs derives sulfoconjugues. |
| AU690069B2 (en) * | 1993-02-09 | 1998-04-23 | Tulsa Forte Pharmacy Enterprises, Inc. | A method for stimulating hair growth with cationic derivatives of minoxidil using therapeutic iontophoresis |
| US5451407A (en) * | 1993-06-21 | 1995-09-19 | Alza Corporation | Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug |
| US5496827A (en) * | 1994-07-15 | 1996-03-05 | Patrick; Jay | Compositions for the transdermal delivery of nutrients |
| US5750108A (en) * | 1995-09-18 | 1998-05-12 | Regenix Marketing Systems, Inc. | Hair treatment system and kit for invigorating hair growth |
| US5738879A (en) * | 1995-11-15 | 1998-04-14 | Rine; Jasper M. | Scalp hair treatment method and composition |
| US6248763B1 (en) | 1998-05-19 | 2001-06-19 | Scivoletto Rosemarie | Composition for treating skin conditions |
| US6429218B1 (en) | 1997-05-19 | 2002-08-06 | Joseph Scivoletto | Method of controlling niacin concentration in lotion |
| PT1143954E (pt) | 1998-12-01 | 2004-12-31 | Univ Kentucky Res Found | Utilizacao de derivados de acido nocotinico para o tratamento de danos no adn em celulas da pele |
| US7238375B1 (en) | 2004-12-20 | 2007-07-03 | Perry Stephen C | Composition and method to promote human hair growth |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2431558A (en) * | 1945-05-22 | 1947-11-25 | Winthrop Stearns Inc | Vasodilator compositions comprising alkyl nicotinates |
| DE835038C (de) * | 1951-01-16 | 1952-03-27 | Nordmark Werke Gmbh | Haarpflegemittel |
| US3168438A (en) * | 1962-08-09 | 1965-02-02 | Synergistics Inc | Vasodilation by nitric acid ester derivatives of nicotinic acid |
| US3382248A (en) * | 1965-11-01 | 1968-05-07 | Upjohn Co | 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines |
| US4596812A (en) * | 1976-05-24 | 1986-06-24 | The Upjohn Company | Methods and solutions for treating male pattern alopecia |
| US4139619A (en) * | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| HU184626B (en) * | 1979-06-01 | 1984-09-28 | Ferrokemia Ipari | Congesting cosmetics first of all hair-restorers |
| IT1137375B (it) * | 1981-04-15 | 1986-09-10 | Lab Farmaco Biolog Crosara S R | Composto ad attivita' vasodilatatrice periferica utile come rubefacente, procedimento per la sua preparazione e composizioni farmaceutiche a base di detto composto |
| WO1983002558A1 (en) * | 1981-11-09 | 1983-08-04 | Gail Sansone Bazzano | The use of retinoids and minoxidil (2,4,-diamino-6-piperidino-pyrimidine-3-oxide) to increase the rate of growth of human scalp hair and to treat certain types of alopecias |
| JPS5888307A (ja) * | 1981-11-19 | 1983-05-26 | Takeo Kinji | ミノキシジル配合養毛剤 |
| EP0129197B1 (en) * | 1983-06-20 | 1989-10-18 | Kao Corporation | Hair growth promoting composition |
| JPS6064910A (ja) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | 養毛料 |
| DE3504695A1 (de) * | 1985-02-12 | 1986-08-14 | Roshdy Dipl.-Chem. Dr. 5000 Köln Ismail | Haarwuchsmittel |
| JPS6168408A (ja) * | 1984-09-12 | 1986-04-08 | Pola Chem Ind Inc | 養毛料 |
| NZ214397A (en) * | 1984-12-21 | 1989-04-26 | Richardson Vicks Inc | Minoxidil and acrylate polymer topical compositions |
| JPS61165312A (ja) * | 1985-01-14 | 1986-07-26 | Takeo Kinji | 養毛化粧品 |
| JPS61165311A (ja) * | 1985-01-14 | 1986-07-26 | Takeo Kinji | 養毛化粧料 |
| JPS6233111A (ja) * | 1985-08-06 | 1987-02-13 | Nakanishi Michio | 養毛組成物 |
| JPS62135409A (ja) * | 1985-12-10 | 1987-06-18 | Lion Corp | 養毛化粧料 |
| JPH072628B2 (ja) * | 1986-03-31 | 1995-01-18 | 日東電工株式会社 | 養毛組成物 |
| LU86547A1 (fr) * | 1986-08-07 | 1988-03-02 | Oreal | Suspension pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de la pyrimidine |
-
1986
- 1986-09-08 LU LU86574A patent/LU86574A1/fr unknown
-
1987
- 1987-09-03 CA CA000546026A patent/CA1294883C/fr not_active Expired - Lifetime
- 1987-09-04 PT PT85653A patent/PT85653B/pt not_active IP Right Cessation
- 1987-09-04 AT AT0224187A patent/AT400671B/de not_active IP Right Cessation
- 1987-09-07 IT IT8767764A patent/IT1211374B/it active
- 1987-09-07 FR FR8712392A patent/FR2603482B1/fr not_active Expired - Lifetime
- 1987-09-07 CH CH3434/87A patent/CH673391A5/fr not_active IP Right Cessation
- 1987-09-07 AU AU78102/87A patent/AU609055B2/en not_active Ceased
- 1987-09-07 SE SE8703461A patent/SE504489C2/sv not_active IP Right Cessation
- 1987-09-07 GR GR871387A patent/GR871387B/el unknown
- 1987-09-07 NL NL8702110A patent/NL193980C/nl not_active IP Right Cessation
- 1987-09-07 ES ES8702574A patent/ES2008735A6/es not_active Expired
- 1987-09-07 DE DE3729953A patent/DE3729953C2/de not_active Expired - Fee Related
- 1987-09-08 US US07/093,709 patent/US4968685A/en not_active Expired - Lifetime
- 1987-09-08 GB GB8721105A patent/GB2194734B/en not_active Expired - Lifetime
- 1987-09-08 DK DK198704686A patent/DK173080B1/da not_active IP Right Cessation
- 1987-09-08 KR KR870009922A patent/KR880003611A/ko not_active Withdrawn
- 1987-09-08 BE BE8701009A patent/BE1001047A5/fr not_active IP Right Cessation
- 1987-09-08 JP JP62223190A patent/JP2613222B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA1294883C (fr) | 1992-01-28 |
| PT85653B (pt) | 1990-05-31 |
| ATA224187A (de) | 1995-07-15 |
| DK173080B1 (da) | 1999-12-20 |
| KR880003611A (ko) | 1988-05-28 |
| CH673391A5 (da) | 1990-03-15 |
| SE8703461L (sv) | 1988-03-09 |
| GB2194734B (en) | 1991-03-27 |
| NL8702110A (nl) | 1988-04-05 |
| LU86574A1 (fr) | 1988-04-05 |
| GB2194734A (en) | 1988-03-16 |
| DE3729953A1 (de) | 1988-03-17 |
| DK468687D0 (da) | 1987-09-08 |
| US4968685A (en) | 1990-11-06 |
| AU609055B2 (en) | 1991-04-26 |
| SE8703461D0 (sv) | 1987-09-07 |
| GR871387B (en) | 1988-01-12 |
| GB8721105D0 (en) | 1987-10-14 |
| AU7810287A (en) | 1988-03-10 |
| DE3729953C2 (de) | 1996-10-31 |
| BE1001047A5 (fr) | 1989-06-20 |
| IT8767764A0 (it) | 1987-09-07 |
| FR2603482A1 (fr) | 1988-03-11 |
| ES2008735A6 (es) | 1989-08-01 |
| IT1211374B (it) | 1989-10-18 |
| FR2603482B1 (fr) | 1991-10-04 |
| PT85653A (fr) | 1987-10-01 |
| NL193980B (nl) | 2000-12-01 |
| JP2613222B2 (ja) | 1997-05-21 |
| AT400671B (de) | 1996-02-26 |
| NL193980C (nl) | 2001-04-03 |
| DK468687A (da) | 1988-03-09 |
| JPS6368515A (ja) | 1988-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |