SE465907B - Diagnosticeringsmedel innehaallande en paramagnetisk metall - Google Patents

Diagnosticeringsmedel innehaallande en paramagnetisk metall

Info

Publication number
SE465907B
SE465907B SE8405499A SE8405499A SE465907B SE 465907 B SE465907 B SE 465907B SE 8405499 A SE8405499 A SE 8405499A SE 8405499 A SE8405499 A SE 8405499A SE 465907 B SE465907 B SE 465907B
Authority
SE
Sweden
Prior art keywords
diagnostic agent
solution
product
agent according
macromolecular
Prior art date
Application number
SE8405499A
Other languages
English (en)
Swedish (sv)
Other versions
SE8405499L (sv
SE8405499D0 (sv
Inventor
T Jacobsen
Original Assignee
Nyegaard & Co As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Priority to SE8405499A priority Critical patent/SE465907B/sv
Publication of SE8405499D0 publication Critical patent/SE8405499D0/xx
Priority to AT85307737T priority patent/ATE54416T1/de
Priority to DE8585307737T priority patent/DE3578647D1/de
Priority to EP85307737A priority patent/EP0186947B1/en
Priority to NO854348A priority patent/NO168928C/no
Priority to DK499985A priority patent/DK167998B1/da
Priority to JP60244239A priority patent/JPH0667854B2/ja
Priority to US06/793,898 priority patent/US4986980A/en
Publication of SE8405499L publication Critical patent/SE8405499L/xx
Publication of SE465907B publication Critical patent/SE465907B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
SE8405499A 1984-11-01 1984-11-01 Diagnosticeringsmedel innehaallande en paramagnetisk metall SE465907B (sv)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SE8405499A SE465907B (sv) 1984-11-01 1984-11-01 Diagnosticeringsmedel innehaallande en paramagnetisk metall
AT85307737T ATE54416T1 (de) 1984-11-01 1985-10-25 Paramagnetische kontrastmittel fuer die anwendung in ''in vivo'' nmr-diagnostischen methoden und die herstellung davon.
DE8585307737T DE3578647D1 (de) 1984-11-01 1985-10-25 Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon.
EP85307737A EP0186947B1 (en) 1984-11-01 1985-10-25 Paramagnetic contrast agents for use in "in vivo" diagnostic methods using nmr, and their preparation
NO854348A NO168928C (no) 1984-11-01 1985-10-31 Diagnostisk middel
DK499985A DK167998B1 (da) 1984-11-01 1985-10-31 Diagnostisk middel indeholdende en ikke-radioaktiv metalspecies kemisk bundet til makromolekylaere forbindelser samt anvendelse af disse forbindelser med den bundne metalspecies til fremstilling af et middel til brug ved nmr- og ultralydsdiagnostik
JP60244239A JPH0667854B2 (ja) 1984-11-01 1985-11-01 診断剤
US06/793,898 US4986980A (en) 1984-11-01 1985-11-01 Water-soluble, carrier-bound paramagnetic metal containing diagnostic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8405499A SE465907B (sv) 1984-11-01 1984-11-01 Diagnosticeringsmedel innehaallande en paramagnetisk metall

Publications (3)

Publication Number Publication Date
SE8405499D0 SE8405499D0 (sv) 1984-11-01
SE8405499L SE8405499L (sv) 1986-05-02
SE465907B true SE465907B (sv) 1991-11-18

Family

ID=20357592

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8405499A SE465907B (sv) 1984-11-01 1984-11-01 Diagnosticeringsmedel innehaallande en paramagnetisk metall

Country Status (8)

Country Link
US (1) US4986980A (da)
EP (1) EP0186947B1 (da)
JP (1) JPH0667854B2 (da)
AT (1) ATE54416T1 (da)
DE (1) DE3578647D1 (da)
DK (1) DK167998B1 (da)
NO (1) NO168928C (da)
SE (1) SE465907B (da)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330801A1 (en) * 1983-02-08 1989-09-06 Schering Aktiengesellschaft Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US6203777B1 (en) * 1983-12-21 2001-03-20 Nycomed Imaging As Method of contrast enhanced magnetic resonance imaging using carbohydrate particles
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
US5217998A (en) * 1985-07-02 1993-06-08 Biomedical Frontiers, Inc. Composition for the stabilization of deferoxamine to chelate free ions in physiological fluid
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
WO1987002893A1 (en) * 1985-11-18 1987-05-21 Board Of Regents, The University Of Texas System Polychelating agents for image and spectral enhancement (and spectral shift)
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
US4951675A (en) * 1986-07-03 1990-08-28 Advanced Magnetics, Incorporated Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
US5219554A (en) 1986-07-03 1993-06-15 Advanced Magnetics, Inc. Hydrated biodegradable superparamagnetic metal oxides
US5342607A (en) * 1986-07-03 1994-08-30 Advanced Magnetics, Inc. Receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5141739A (en) * 1986-07-03 1992-08-25 Advanced Magnetics, Inc. Delivery of x-ray contrast agents using receptor mediated endocytosis
US5352432A (en) * 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US5284646A (en) * 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
US5554386A (en) * 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
US5336506A (en) * 1986-07-03 1994-08-09 Advanced Magnetics Inc. Targeting of therapeutic agents using polysaccharides
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
DE3640708C2 (de) * 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
FI80801C (fi) * 1987-01-14 1990-07-10 Innofarm Oy Konjugat av en monoklonal antikropp och anvaendning. eller ett fragment daerav och ett kelaterande aemne, dess framstaellning
DE3709851A1 (de) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te Nmr-diagnostische fluessigkeitszusammensetzungen
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
GB8813144D0 (en) * 1988-06-03 1988-07-06 Nycomed As Compositions
GB8813425D0 (en) * 1988-06-07 1988-07-13 Hall L D Magnetic resonance imaging
WO1990001295A1 (en) 1988-08-04 1990-02-22 Advanced Magnetics, Incorporated Receptor mediated endocytosis type mri contrast agents
US5213788A (en) * 1988-09-29 1993-05-25 Ranney David F Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement
AU628403B2 (en) * 1988-09-29 1992-09-17 Access Pharmaceuticals, Inc. Methods and compositions for magnetic resonance imaging
US5260050A (en) * 1988-09-29 1993-11-09 Ranney David F Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
US5393525A (en) * 1989-07-21 1995-02-28 Nycomed Imaging As Contrast medium comprising superparamagnetic or ferromagnetic particles capable of increasing viscosity after administration
GB8916780D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
GB8916782D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
JP2726520B2 (ja) * 1989-10-20 1998-03-11 名糖産業株式会社 有機磁性複合体
US5446145A (en) * 1990-01-19 1995-08-29 Nycomed Salutar, Inc. Polychelant compounds
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
US5236694A (en) * 1990-02-21 1993-08-17 The Board Of Regents, The University Of Texas System 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
US5494655A (en) * 1990-03-09 1996-02-27 The Regents Of The University Of California Methods for detecting blood perfusion variations by magnetic resonance imaging
US5358702A (en) * 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
US5420176A (en) * 1990-06-01 1995-05-30 Imarx Pharmaceutical Corp. Contrast media for ultrasonic imaging
US5268165A (en) * 1990-10-16 1993-12-07 Biomedical Frontiers, Inc. Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
US5236693A (en) * 1990-11-14 1993-08-17 Brigham And Women's Hospital Medical ultrasound contrast agent and method of using same
US5885549A (en) * 1991-02-01 1999-03-23 Imarx Pharmaceutical Corp. Phosphorylated materials as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
US5143716A (en) * 1991-02-01 1992-09-01 Unger Evan C Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5310539A (en) * 1991-04-15 1994-05-10 Board Of Regents, The University Of Texas System Melanin-based agents for image enhancement
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
EP0543020B1 (en) * 1991-06-11 1997-12-29 Meito Sangyo Kabushiki Kaisha Oxidized composite comprising water-soluble carboxypolysaccharide and magnetic iron oxide
JP2901787B2 (ja) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 核磁気共鳴造影剤
JP2894879B2 (ja) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 診断用造影剤
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
US5480990A (en) * 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5691423A (en) * 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
EP0664713B1 (en) * 1992-10-14 2000-01-19 Nycomed Imaging As Therapeutic and diagnostic imaging compositions and methods
JPH08502528A (ja) * 1992-10-14 1996-03-19 スターリング ウィンスロップ アイエヌシー． キレート化ポリマー
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
US5532006A (en) * 1993-04-23 1996-07-02 The Board Of Trustees Of The University Of Illinois Magnetic gels which change volume in response to voltage changes for MRI
NL9302163A (nl) * 1993-12-10 1995-07-03 Univ Delft Tech Gecarboxymethyleerde oligo- en polysacchariden als kristallisatie inhibitors.
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
CA2160819A1 (en) * 1994-10-21 1996-04-22 Yuji Hashiguchi Diagnostic imaging agent
DE19629494A1 (de) * 1996-07-09 1998-01-15 Schering Ag Pseudopolyrotaxane
NL1003776C2 (nl) * 1996-08-09 1998-02-20 Cooperatie Cosun U A Milieuvriendelijke complexanten voor zware metalen
NL1007320C2 (nl) * 1997-10-20 1999-04-21 Cooperatie Cosun U A Milieuvriendelijke complexanten voor zware metalen.
AU1464399A (en) * 1997-11-20 1999-06-15 David Platt Reagent for tumor therapy and/or imaging
US6113880A (en) * 1997-12-17 2000-09-05 Schering Aktiengesellschaft Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging
DE19808079A1 (de) * 1998-02-20 1999-08-26 Schering Ag Hydroxyethylstärke-Konjugate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US6361759B1 (en) 1998-05-26 2002-03-26 Wisconsin Alumni Research Foundation MR signal-emitting coatings
US6896874B2 (en) * 1998-05-26 2005-05-24 Wisconsin Alumni Research Foundation MR-signal emitting coatings
US5980863A (en) * 1998-11-02 1999-11-09 Eagle Vision Pharmaceutical Corporation Manganese compositions and methods for MRI
EP1031354A3 (en) 1999-01-19 2003-02-05 Rohm And Haas Company Polymeric MRI Contrast agents
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
US6409990B1 (en) 1999-05-14 2002-06-25 The Regents Of The University Of California Macromolecular carrier for drug and diagnostic agent delivery
US20040253292A1 (en) * 2003-04-23 2004-12-16 Wisconsin Alumni Research Foundation MR-signal emitting coatings
CN101137398B (zh) * 2005-01-05 2012-07-04 得克萨斯大学体系董事会 用于双重显像和放射化疗的缀合物：组合物、生产和应用
WO2006124726A2 (en) 2005-05-12 2006-11-23 The General Hospital Corporation Novel biotinylated compositions
US7713216B2 (en) * 2006-04-10 2010-05-11 Intrapartum, Llc Method for cervical dilation and/or measurement
US7527601B2 (en) * 2005-12-29 2009-05-05 Intrapartum Ventures, Llc Cervimeter
US7811239B2 (en) * 2005-12-29 2010-10-12 Intrapartum, Llc Cervical dilation measurement apparatus
US8457712B2 (en) * 2005-12-30 2013-06-04 Wisconsin Alumni Research Foundation Multi-mode medical device system and methods of manufacturing and using same
US20070156042A1 (en) * 2005-12-30 2007-07-05 Orhan Unal Medical device system and method for tracking and visualizing a medical device system under MR guidance
US8532742B2 (en) * 2006-11-15 2013-09-10 Wisconsin Alumni Research Foundation System and method for simultaneous 3DPR device tracking and imaging under MR-guidance for therapeutic endovascular interventions
US20080183070A1 (en) * 2007-01-29 2008-07-31 Wisconsin Alumni Research Foundation Multi-mode medical device system with thermal ablation capability and methods of using same
US8412306B2 (en) * 2007-02-28 2013-04-02 Wisconsin Alumni Research Foundation Voltage standing wave suppression for MR-guided therapeutic interventions
US10996218B2 (en) 2008-03-11 2021-05-04 Ournextbaby Llc Methods for chemotaxis / redox driven separation of X and Y chromosome bearing sperm and their insemination in gender specific menstrual cycles
US20100196272A1 (en) 2009-01-30 2010-08-05 Neoprobe Corporation Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran
KR101059285B1 (ko) * 2009-05-07 2011-08-24 가톨릭대학교 산학협력단 가돌리늄 착물, 그 제조방법, 및 그것을 포함하는 ｍｒｉ 조영제
EP2619573B1 (en) 2010-09-16 2017-06-14 Urobiologics LLC Use of female mammal's urine for determination of fetal gender related characteristics
WO2013158992A1 (en) * 2012-04-19 2013-10-24 Purdue Research Foundation Highly branched alpha-d-glucans
WO2014036427A1 (en) 2012-08-31 2014-03-06 The General Hospital Corporation Biotin complexes for treatment and diagnosis of alzheimer's disease
WO2021172030A1 (ja) * 2020-02-28 2021-09-02 国立大学法人九州大学 組成物、動的核偏極用組成物、高偏極化組成物、物質の高偏極化方法、高偏極化した物質およびｎｍｒ測定方法
CN116322669A (zh) * 2020-07-23 2023-06-23 普渡研究基金会 治疗sars-cov-2、其它病毒性疾病和癌症的ohpp配制的氯硝柳胺

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2862920A (en) * 1956-06-07 1958-12-02 Ohio Commw Eng Co Ferrous carboxymethyl dextran
GB1175834A (en) * 1966-04-07 1969-12-23 Atomic Energy Authority Uk Improvements in or relating to the Chemical Production of Metal-Containing Materials as Particles and other Configurations
US3563978A (en) * 1968-05-15 1971-02-16 Irving L Ochs Polyvalent metal complexes of natural polymers
US3928581A (en) * 1972-09-13 1975-12-23 Astra Laekemedel Ab Certain polymer-iron complexes for treatment of iron deficiency
SE431214B (sv) * 1977-06-02 1984-01-23 Klaus H Mosbach Sett att framstella magnetiska polymerpartiklar som berare av en foretredesvis biologiskt aktiv substans
US4370476A (en) * 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
CA1244082A (en) * 1983-01-10 1988-11-01 Robert T. Gordon Method for enhancing nmr imaging; and diagnostic use
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4423158A (en) * 1983-01-27 1983-12-27 Gelinnovation Handelsaktiebolag Ion adsorbent for metals having a coordination number greater than two
CA1242643A (en) * 1983-08-12 1988-10-04 Eric T. Fossel Nmr imaging utilizing chemical shift reagents
FR2550449B1 (fr) * 1983-08-12 1986-01-31 Commissariat Energie Atomique Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire
CA1243602A (en) * 1983-08-25 1988-10-25 Hong-Ning Yeung Methods for enhancing the contrast in nmr imaging
US4615879A (en) * 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
GB8413849D0 (en) * 1984-05-31 1984-07-04 Amersham Int Plc Nmr contrast agents
US4675173A (en) * 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
US4822594A (en) * 1987-01-27 1989-04-18 Gibby Wendell A Contrast enhancing agents for magnetic resonance images

Also Published As

Publication number Publication date
EP0186947B1 (en) 1990-07-11
DE3578647D1 (de) 1990-08-16
JPH0667854B2 (ja) 1994-08-31
DK499985D0 (da) 1985-10-31
US4986980A (en) 1991-01-22
EP0186947A1 (en) 1986-07-09
SE8405499L (sv) 1986-05-02
JPS61155337A (ja) 1986-07-15
NO168928B (no) 1992-01-13
DK167998B1 (da) 1994-01-17
NO854348L (no) 1986-05-02
DK499985A (da) 1986-05-02
NO168928C (no) 1992-04-22
ATE54416T1 (de) 1990-07-15
SE8405499D0 (sv) 1984-11-01

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