SE460419B - Substituerade 1-pyridyloxi-3-indolylalkylamino-2-propanoler, foerfarande foer framstaellning av dessa och en farmaceutisk komposition - Google Patents
Substituerade 1-pyridyloxi-3-indolylalkylamino-2-propanoler, foerfarande foer framstaellning av dessa och en farmaceutisk kompositionInfo
- Publication number
- SE460419B SE460419B SE8304751A SE8304751A SE460419B SE 460419 B SE460419 B SE 460419B SE 8304751 A SE8304751 A SE 8304751A SE 8304751 A SE8304751 A SE 8304751A SE 460419 B SE460419 B SE 460419B
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- formula
- acid addition
- amino
- dimethylethyl
- Prior art date
Links
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- 239000002253 acid Substances 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 17
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- 239000002585 base Substances 0.000 claims description 10
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- 230000007062 hydrolysis Effects 0.000 claims description 9
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- 238000002360 preparation method Methods 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
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- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 150000003222 pyridines Chemical class 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
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- 125000000217 alkyl group Chemical group 0.000 claims description 4
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- 125000001041 indolyl group Chemical group 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
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- WIHAMCMCPRDEMY-UHFFFAOYSA-N 4-[2-hydroxy-3-[[1-(1H-indol-3-yl)-2-methylpropan-2-yl]amino]propoxy]pyridine-3-carbonitrile Chemical compound OC(COC1=C(C=NC=C1)C#N)CNC(CC1=CNC2=CC=CC=C12)(C)C WIHAMCMCPRDEMY-UHFFFAOYSA-N 0.000 claims description 3
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- 231100000252 nontoxic Toxicity 0.000 claims description 3
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 3
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- 239000002244 precipitate Substances 0.000 claims description 2
- 239000002243 precursor Substances 0.000 claims description 2
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 2
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- PLNKBMZCVFBVSU-UHFFFAOYSA-N 2-[2-hydroxy-3-[[1-(1H-indol-3-yl)-2-methylpropan-2-yl]amino]propoxy]pyridine-3-carbonitrile Chemical compound OC(COC1=NC=CC=C1C#N)CNC(CC1=CNC2=CC=CC=C12)(C)C PLNKBMZCVFBVSU-UHFFFAOYSA-N 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical group CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41474882A | 1982-09-03 | 1982-09-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8304751D0 SE8304751D0 (sv) | 1983-09-02 |
| SE8304751L SE8304751L (sv) | 1984-03-04 |
| SE460419B true SE460419B (sv) | 1989-10-09 |
Family
ID=23642783
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8304751A SE460419B (sv) | 1982-09-03 | 1983-09-02 | Substituerade 1-pyridyloxi-3-indolylalkylamino-2-propanoler, foerfarande foer framstaellning av dessa och en farmaceutisk komposition |
| SE8802265A SE8802265D0 (sv) | 1982-09-03 | 1988-06-16 | Pyridyloxi-glycidoler och pyridyloxi-indolylalkyloxazolidiner |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8802265A SE8802265D0 (sv) | 1982-09-03 | 1988-06-16 | Pyridyloxi-glycidoler och pyridyloxi-indolylalkyloxazolidiner |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS5965087A (de) |
| KR (1) | KR870001019B1 (de) |
| AT (1) | AT387385B (de) |
| AU (4) | AU567112B2 (de) |
| BE (1) | BE897671A (de) |
| CA (1) | CA1236834A (de) |
| CH (2) | CH668593A5 (de) |
| CY (1) | CY1521A (de) |
| DE (1) | DE3331612A1 (de) |
| DK (1) | DK399783A (de) |
| ES (4) | ES8507537A1 (de) |
| FI (1) | FI79709C (de) |
| FR (1) | FR2543952B1 (de) |
| GB (1) | GB2126230B (de) |
| GR (1) | GR79061B (de) |
| HK (1) | HK17490A (de) |
| HU (2) | HU194164B (de) |
| IE (1) | IE56201B1 (de) |
| IL (1) | IL69618A (de) |
| IT (1) | IT1169459B (de) |
| LU (1) | LU84986A1 (de) |
| NL (1) | NL8303038A (de) |
| NO (1) | NO161258C (de) |
| NZ (1) | NZ205466A (de) |
| PT (1) | PT77282B (de) |
| SE (2) | SE460419B (de) |
| YU (2) | YU45150B (de) |
| ZA (1) | ZA836469B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2543952B1 (fr) * | 1982-09-03 | 1986-02-21 | Bristol Myers Co | Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique |
| DE3721260A1 (de) * | 1987-06-27 | 1989-01-12 | Beiersdorf Ag | Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| US5030640A (en) * | 1989-01-05 | 1991-07-09 | Merck & Co., Inc. | Novel β-adrenergic agonists and pharmaceutical compositions thereof |
| JP2004519428A (ja) * | 2000-10-25 | 2004-07-02 | スミスクライン・ビーチャム・コーポレイション | カルシライティック化合物 |
| KR100457857B1 (ko) * | 2002-05-23 | 2004-11-18 | (주) 비엔씨바이오팜 | 2-[2-(3-인돌릴)에틸아미노]피리딘 유도체, 그 제조방법및 이를 포함하는 항바이러스용 약학적 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4144343A (en) * | 1978-01-04 | 1979-03-13 | Merck & Co., Inc. | Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines |
| FR2463765A1 (fr) * | 1979-08-17 | 1981-02-27 | Clin Midy | Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire |
| FR2543952B1 (fr) * | 1982-09-03 | 1986-02-21 | Bristol Myers Co | Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique |
| CA1241660A (en) * | 1984-06-25 | 1988-09-06 | Yvan Guindon | Indole-2-alkanoic acids |
-
1983
- 1983-08-26 FR FR8313793A patent/FR2543952B1/fr not_active Expired
- 1983-08-30 ES ES525243A patent/ES8507537A1/es not_active Expired
- 1983-08-30 GR GR72336A patent/GR79061B/el unknown
- 1983-08-31 AU AU18592/83A patent/AU567112B2/en not_active Ceased
- 1983-08-31 FI FI833102A patent/FI79709C/fi not_active IP Right Cessation
- 1983-08-31 NL NL8303038A patent/NL8303038A/nl not_active Application Discontinuation
- 1983-08-31 ZA ZA836469A patent/ZA836469B/xx unknown
- 1983-09-01 DE DE19833331612 patent/DE3331612A1/de not_active Withdrawn
- 1983-09-01 DK DK399783A patent/DK399783A/da not_active Application Discontinuation
- 1983-09-01 IL IL69618A patent/IL69618A/xx unknown
- 1983-09-01 PT PT77282A patent/PT77282B/pt not_active IP Right Cessation
- 1983-09-01 CA CA000435880A patent/CA1236834A/en not_active Expired
- 1983-09-01 NO NO833128A patent/NO161258C/no unknown
- 1983-09-02 GB GB08323641A patent/GB2126230B/en not_active Expired
- 1983-09-02 LU LU84986A patent/LU84986A1/fr unknown
- 1983-09-02 HU HU864311A patent/HU194164B/hu not_active IP Right Cessation
- 1983-09-02 BE BE211466A patent/BE897671A/fr unknown
- 1983-09-02 AT AT0315583A patent/AT387385B/de not_active IP Right Cessation
- 1983-09-02 SE SE8304751A patent/SE460419B/sv not_active IP Right Cessation
- 1983-09-02 IE IE2063/83A patent/IE56201B1/en unknown
- 1983-09-02 HU HU833064A patent/HU192862B/hu not_active IP Right Cessation
- 1983-09-02 KR KR1019830004140A patent/KR870001019B1/ko not_active Expired
- 1983-09-02 NZ NZ205466A patent/NZ205466A/en unknown
- 1983-09-02 JP JP58160596A patent/JPS5965087A/ja active Pending
- 1983-09-02 IT IT22765/83A patent/IT1169459B/it active
- 1983-09-05 CH CH4390/86A patent/CH668593A5/fr not_active IP Right Cessation
- 1983-09-05 CH CH4855/83A patent/CH661512A5/fr not_active IP Right Cessation
- 1983-09-05 YU YU1803/83A patent/YU45150B/xx unknown
-
1984
- 1984-04-25 ES ES531872A patent/ES8505200A1/es not_active Expired
-
1985
- 1985-09-19 ES ES547110A patent/ES8604930A1/es not_active Expired
- 1985-09-19 ES ES547111A patent/ES8604931A1/es not_active Expired
-
1986
- 1986-12-25 YU YU2247/86A patent/YU44940B/xx unknown
-
1987
- 1987-10-30 AU AU80558/87A patent/AU609068B2/en not_active Ceased
- 1987-10-30 AU AU80559/87A patent/AU613589B2/en not_active Ceased
- 1987-10-30 AU AU80557/87A patent/AU609067B2/en not_active Ceased
-
1988
- 1988-06-16 SE SE8802265A patent/SE8802265D0/xx not_active Application Discontinuation
-
1990
- 1990-03-08 HK HK174/90A patent/HK17490A/xx unknown
- 1990-11-16 CY CY1521A patent/CY1521A/en unknown
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