SE448879B - Analgetiskt verksamma peptider, farmaceutisk beredning innehallande dessa peptider samt forfarande for deras framstellning - Google Patents
Analgetiskt verksamma peptider, farmaceutisk beredning innehallande dessa peptider samt forfarande for deras framstellningInfo
- Publication number
- SE448879B SE448879B SE8006596A SE8006596A SE448879B SE 448879 B SE448879 B SE 448879B SE 8006596 A SE8006596 A SE 8006596A SE 8006596 A SE8006596 A SE 8006596A SE 448879 B SE448879 B SE 448879B
- Authority
- SE
- Sweden
- Prior art keywords
- seryl
- tyr
- tyrosyl
- prolyl
- phe
- Prior art date
Links
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- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Natural products NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 description 1
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- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- 150000002429 hydrazines Chemical class 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
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- 238000006460 hydrolysis reaction Methods 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
- 238000000185 intracerebroventricular administration Methods 0.000 description 1
- 238000007914 intraventricular administration Methods 0.000 description 1
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000037230 mobility Effects 0.000 description 1
- WVKNBCACIPKHEW-UHFFFAOYSA-N n,n-diethylethanamine;n,n-dimethylformamide Chemical compound CN(C)C=O.CCN(CC)CC WVKNBCACIPKHEW-UHFFFAOYSA-N 0.000 description 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
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- 108010065135 phenylalanyl-phenylalanyl-phenylalanine Proteins 0.000 description 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 1
- 229940067157 phenylhydrazine Drugs 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
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- 238000003127 radioimmunoassay Methods 0.000 description 1
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- 150000003462 sulfoxides Chemical class 0.000 description 1
- UJJDEOLXODWCGK-UHFFFAOYSA-N tert-butyl carbonochloridate Chemical compound CC(C)(C)OC(Cl)=O UJJDEOLXODWCGK-UHFFFAOYSA-N 0.000 description 1
- DKACXUFSLUYRFU-UHFFFAOYSA-N tert-butyl n-aminocarbamate Chemical compound CC(C)(C)OC(=O)NN DKACXUFSLUYRFU-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical compound OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 description 1
- 229950001139 timonacic Drugs 0.000 description 1
- BJBUEDPLEOHJGE-IMJSIDKUSA-N trans-3-hydroxy-L-proline Chemical compound O[C@H]1CC[NH2+][C@@H]1C([O-])=O BJBUEDPLEOHJGE-IMJSIDKUSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
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- ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7932590 | 1979-09-20 | ||
| GB8015412 | 1980-05-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8006596L SE8006596L (sv) | 1981-03-21 |
| SE448879B true SE448879B (sv) | 1987-03-23 |
Family
ID=26272950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8006596A SE448879B (sv) | 1979-09-20 | 1980-09-19 | Analgetiskt verksamma peptider, farmaceutisk beredning innehallande dessa peptider samt forfarande for deras framstellning |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4350627A (de) |
| AT (1) | AT381100B (de) |
| AU (1) | AU535769B2 (de) |
| CA (1) | CA1156221A (de) |
| CH (1) | CH645342A5 (de) |
| DE (1) | DE3034897A1 (de) |
| DK (1) | DK149754C (de) |
| FI (1) | FI73699C (de) |
| FR (1) | FR2465713A1 (de) |
| GB (1) | GB2070618B (de) |
| HU (1) | HU186749B (de) |
| IE (1) | IE50793B1 (de) |
| IL (1) | IL61037A (de) |
| IT (1) | IT1196916B (de) |
| NL (1) | NL8005121A (de) |
| NZ (1) | NZ194961A (de) |
| SE (1) | SE448879B (de) |
| YU (1) | YU240880A (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK28377A (da) | 1976-02-02 | 1977-08-03 | Sandoz Ag | Fremgangsmade til fremstilling af polypeptidderivater |
| US4533657A (en) * | 1981-07-24 | 1985-08-06 | Sterling Drug Inc. | Analgesic dipeptide amides and method of use and composition thereof |
| US4450155A (en) * | 1981-07-24 | 1984-05-22 | Sterling Drug Inc. | Analgesic dipeptide amides and method of use and compositions thereof |
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| DE3138233A1 (de) * | 1981-09-25 | 1983-04-07 | Farmitalia Carlo Erba S.p.A., 20159 Milano | Neuropsychotropisches arzneimittel |
| US4407746A (en) * | 1981-12-14 | 1983-10-04 | G. D. Searle & Co. | Cyclohexyl and phenyl substituted enkephalins |
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| US4900811A (en) * | 1983-07-21 | 1990-02-13 | Scripps Clinic And Research Foundation | Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same |
| US4460501A (en) * | 1983-08-30 | 1984-07-17 | Research Corporation | Process for the synthesis of peptides utilizing thioxanthylmethyloxycarbonyl dioxides |
| DE3333752A1 (de) * | 1983-09-19 | 1985-04-11 | Victor Dipl.- Chem. 8000 München Brantl | Pharmakologisch aktive peptide |
| DE3585936D1 (de) * | 1984-09-20 | 1992-06-04 | Erba Carlo Spa | Biologisch aktive peptide, deren verfahren zur herstellung und pharmazeutische zusammensetzungen. |
| GB2166139B (en) * | 1984-10-25 | 1988-06-22 | Erba Farmitalia | Biologically active penta-and heptapeptides |
| JPS62501147A (ja) * | 1984-12-14 | 1987-05-07 | オーストラリアン コマーシャル リサーチ アンド ディベロップメント リミティド | ヒト白血球エラスタ−ゼのアミノ酸阻害剤及びペプチド阻害剤 |
| US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
| JPS6360939A (ja) * | 1986-08-29 | 1988-03-17 | Shin Etsu Chem Co Ltd | 抗菌物質 |
| US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US5047502A (en) * | 1987-10-23 | 1991-09-10 | Merck And Co., Inc. | Gastrin releasing peptide antagonist |
| WO1989007110A1 (en) * | 1988-01-28 | 1989-08-10 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US5602100A (en) * | 1988-06-30 | 1997-02-11 | Astra Ab | Dermorphin analogs having pharmacological activity |
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| DE4124283A1 (de) * | 1991-07-15 | 1993-01-21 | Degussa | Umesterung von peptiden |
| SE9203496D0 (sv) * | 1992-11-20 | 1992-11-20 | Kabi Pharmacia Ab | New oligopeptides |
| EP1164141A3 (de) * | 1994-02-21 | 2002-01-02 | AstraZeneca AB | Opioid-Peptide und ihre Verwendung zur Behandlung von Schmerz |
| GB9403263D0 (en) * | 1994-02-21 | 1994-04-13 | Iaf Biochem Int | Novel opiod peptides |
| IS4261A (is) * | 1994-02-21 | 1995-08-22 | Astra Aktiebolag | Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra |
| DE4411025A1 (de) * | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| RU2067000C1 (ru) * | 1994-06-29 | 1996-09-27 | Владислав Исакович Дейгин | Пептид и способ его получения |
| US6184208B1 (en) * | 1994-06-29 | 2001-02-06 | Immunotech Developments Inc. | Peptide, a method for its preparation and a pharmaceutical composition containing the peptide |
| US6248716B1 (en) * | 1995-06-27 | 2001-06-19 | Immunotech Developments Inc. | Peptide, a method for its preparation and a pharmaceutical composition containing the peptide |
| GB9516994D0 (en) * | 1995-08-18 | 1995-10-18 | Iaf Biochem Int | Solution synthesis of peripheral acting analgestic opioid tetrapeptides |
| US5885958A (en) * | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
| US6083908A (en) * | 1998-01-16 | 2000-07-04 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| CA2318558A1 (en) * | 1998-01-16 | 1999-07-22 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| HRP20050242B1 (en) * | 2005-03-15 | 2010-09-30 | Institut Ruđer Bošković | Synthetic peptides containing unnatural adamantane related amino acids for use as antitumour drugs |
| EP1782819A1 (de) * | 2005-11-03 | 2007-05-09 | Cognis IP Management GmbH | Oligopeptide und deren Verwendung |
| AU2021300202A1 (en) * | 2020-07-01 | 2023-02-02 | PreveCeutical Medical Inc. | Peptides and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO773013L (no) * | 1976-09-01 | 1978-03-02 | David Howard Coy | Fremgangsmaate ved fremstilling av methionin-enkefalin-derivater |
| HU178001B (en) * | 1976-09-16 | 1982-02-28 | Gyogyszekutato Intezet | Process for preparing new pentapeptides with morphine-like activity and derivatives thereof |
| US4127532A (en) * | 1977-06-16 | 1978-11-28 | Coy David Howard | Novel heptapeptides, intermediates therefor, and compositions and methods employing said heptapeptides |
| GB2000784B (en) * | 1977-07-05 | 1982-01-20 | American Home Prod | Analgesic polypetide |
| IT1107551B (it) * | 1977-07-22 | 1985-11-25 | Wellcome Found | Pentapeptidi utili come medicamenti nella medicina umana e veterinaria e composizioni farmaceutiche che li contengono coem ingrediente attivo |
| DE2936099A1 (de) * | 1979-09-06 | 1981-04-02 | Victor Dipl.- Chem. 8000 München Brantl | Pharmakologisch aktive peptide |
| US4254024A (en) * | 1979-10-16 | 1981-03-03 | Pennwalt Corporation | Tetrapeptides and derivatives having opiate activity |
-
1980
- 1980-09-11 NL NL8005121A patent/NL8005121A/nl not_active Application Discontinuation
- 1980-09-15 NZ NZ194961A patent/NZ194961A/xx unknown
- 1980-09-15 IL IL61037A patent/IL61037A/xx unknown
- 1980-09-15 AU AU62403/80A patent/AU535769B2/en not_active Ceased
- 1980-09-15 FI FI802876A patent/FI73699C/fi not_active IP Right Cessation
- 1980-09-16 FR FR8019916A patent/FR2465713A1/fr active Granted
- 1980-09-16 AT AT0463580A patent/AT381100B/de not_active IP Right Cessation
- 1980-09-16 DE DE19803034897 patent/DE3034897A1/de not_active Ceased
- 1980-09-17 DK DK394280A patent/DK149754C/da not_active IP Right Cessation
- 1980-09-17 GB GB8029999A patent/GB2070618B/en not_active Expired
- 1980-09-17 IE IE1947/80A patent/IE50793B1/en unknown
- 1980-09-17 CA CA000360511A patent/CA1156221A/en not_active Expired
- 1980-09-19 YU YU02408/80A patent/YU240880A/xx unknown
- 1980-09-19 HU HU802306A patent/HU186749B/hu unknown
- 1980-09-19 IT IT24755/80A patent/IT1196916B/it active
- 1980-09-19 SE SE8006596A patent/SE448879B/sv not_active IP Right Cessation
- 1980-09-19 CH CH706580A patent/CH645342A5/de not_active IP Right Cessation
- 1980-12-03 US US06/212,586 patent/US4350627A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ194961A (en) | 1983-09-30 |
| CH645342A5 (de) | 1984-09-28 |
| IL61037A0 (en) | 1980-11-30 |
| FR2465713B1 (de) | 1984-08-31 |
| IL61037A (en) | 1984-02-29 |
| IE50793B1 (en) | 1986-07-23 |
| FI802876A7 (fi) | 1981-03-21 |
| DK394280A (da) | 1981-03-21 |
| IE801947L (en) | 1981-03-20 |
| AT381100B (de) | 1986-08-25 |
| DE3034897A1 (de) | 1981-04-09 |
| AU535769B2 (en) | 1984-04-05 |
| SE8006596L (sv) | 1981-03-21 |
| US4350627A (en) | 1982-09-21 |
| IT1196916B (it) | 1988-11-25 |
| DK149754B (da) | 1986-09-22 |
| GB2070618A (en) | 1981-09-09 |
| YU240880A (en) | 1984-02-29 |
| AU6240380A (en) | 1981-03-26 |
| ATA463580A (de) | 1986-01-15 |
| GB2070618B (en) | 1983-06-02 |
| FI73699B (fi) | 1987-07-31 |
| FI73699C (fi) | 1987-11-09 |
| CA1156221A (en) | 1983-11-01 |
| IT8024755A0 (it) | 1980-09-19 |
| HU186749B (en) | 1985-09-30 |
| DK149754C (da) | 1987-03-23 |
| NL8005121A (nl) | 1981-03-24 |
| FR2465713A1 (fr) | 1981-03-27 |
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