SE448376B - Forfarande for framstellning av (alfas,55)-alfa-amino-3-kloro-2-isoxazolin-5-ettiksyra (at-125) och analoger derav - Google Patents

Forfarande for framstellning av (alfas,55)-alfa-amino-3-kloro-2-isoxazolin-5-ettiksyra (at-125) och analoger derav

Info

Publication number
SE448376B
SE448376B SE7904163A SE7904163A SE448376B SE 448376 B SE448376 B SE 448376B SE 7904163 A SE7904163 A SE 7904163A SE 7904163 A SE7904163 A SE 7904163A SE 448376 B SE448376 B SE 448376B
Authority
SE
Sweden
Prior art keywords
acid
solution
formula
mmol
reaction
Prior art date
Application number
SE7904163A
Other languages
English (en)
Swedish (sv)
Other versions
SE7904163L (sv
Inventor
R C Kelly
W Wierenga
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of SE7904163L publication Critical patent/SE7904163L/xx
Publication of SE448376B publication Critical patent/SE448376B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7904163A 1978-05-15 1979-05-11 Forfarande for framstellning av (alfas,55)-alfa-amino-3-kloro-2-isoxazolin-5-ettiksyra (at-125) och analoger derav SE448376B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90596378A 1978-05-15 1978-05-15

Publications (2)

Publication Number Publication Date
SE7904163L SE7904163L (sv) 1979-11-16
SE448376B true SE448376B (sv) 1987-02-16

Family

ID=25421749

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7904163A SE448376B (sv) 1978-05-15 1979-05-11 Forfarande for framstellning av (alfas,55)-alfa-amino-3-kloro-2-isoxazolin-5-ettiksyra (at-125) och analoger derav
SE8501965A SE8501965D0 (sv) 1978-05-15 1985-04-23 Forfarande och mellanprodukter for framstellning av at-125

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8501965A SE8501965D0 (sv) 1978-05-15 1985-04-23 Forfarande och mellanprodukter for framstellning av at-125

Country Status (10)

Country Link
JP (1) JPS54148781A (fr)
AU (1) AU526380B2 (fr)
BE (1) BE876261A (fr)
CH (1) CH646961A5 (fr)
DE (1) DE2918878A1 (fr)
FR (1) FR2426049A1 (fr)
GB (1) GB2023135B (fr)
IT (1) IT1116816B (fr)
NL (1) NL7903771A (fr)
SE (2) SE448376B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643807A (en) * 1985-12-13 1987-02-17 The Dow Chemical Company Process for electrochemically forming an aromatic compound containing one or more alpha-acyloxylated aliphatic substitutent(s)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856807A (en) * 1972-03-13 1974-12-24 Upjohn Co L-({60 s,5s)-{60 -amino-3-chloro-2-isoxazoline-5-acetic acid
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US3944562A (en) * 1974-04-17 1976-03-16 The Upjohn Company αS, 4S, 5R α-Amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid

Also Published As

Publication number Publication date
CH646961A5 (de) 1984-12-28
SE8501965L (sv) 1985-04-23
DE2918878A1 (de) 1979-11-22
GB2023135B (en) 1982-08-25
SE8501965D0 (sv) 1985-04-23
AU4672379A (en) 1979-11-22
NL7903771A (nl) 1979-11-19
BE876261A (fr) 1979-11-16
IT1116816B (it) 1986-02-10
JPS54148781A (en) 1979-11-21
AU526380B2 (en) 1983-01-06
FR2426049A1 (fr) 1979-12-14
GB2023135A (en) 1979-12-28
IT7949040A0 (it) 1979-05-14
FR2426049B1 (fr) 1983-06-17
SE7904163L (sv) 1979-11-16

Similar Documents

Publication Publication Date Title
TW442490B (en) Tricyclic erythromycin derivatives
US20090312548A1 (en) Modified pictet-spengler reaction and products prepared therefrom
FR2514350A1 (fr) N-(4- (3-aminopropyl) aminobutyl)-2-(o-guanidino (acide gras)amido)-ethanamides substitues en position 2 et leurs sels, procede pour leur preparation et leur application therapeutique
SE460541B (sv) Nya 6-oxo-2-piperazinkarboxylsyraestrar samt foerfarande foer framstaellning daerav
FR2460919A1 (fr) Amino-ethers oxydes, leur procede de preparation et leur application en therapeutique
DE60114028T2 (de) Verfahren zur herstellung von wasserfreiem azithromycin
CA2187484C (fr) Methode de preparation d'enantiomeres purs de composes imidazolyliques
BE823841A (fr) Derives de 5-(1-hydroxy-2-amino substitue) alkyl-8-carbostyryle substitue et de 5-(1-hydroxy-2-amino substitue) alkyl-8-(3,4-dihydro) carbostyryle substitue et leur procede de preparation
ITRM930147A1 (it) Procedimento per la preparazione di sali dell'acido clavulanico.
JPS62181248A (ja) ２−（２−アミノチアゾリル）−２−ヒドロキシイミノ酢酸誘導体及びその製造法
FR2526434A1 (fr) Nouveaux azepino-indoles, leur preparation et leur utilisation comme medicaments
US2742462A (en) New n-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidones
PT91206A (pt) Processo para a preparacao de agentes fungicidas triazolicos
SE448376B (sv) Forfarande for framstellning av (alfas,55)-alfa-amino-3-kloro-2-isoxazolin-5-ettiksyra (at-125) och analoger derav
US4256898A (en) α(substituted) Amino-3-substituted-2-isoxazoline-5-acetic acids (esters)
BG62490B1 (bg) Соли на клавулановата киселина
CN103570639B (zh) 一种利奈唑胺的合成方法
BG62971B1 (bg) Диклавуланатна сол с диаминоетер и метод за получаването й
US4275214A (en) Substituted alkoxy carbonyl-3-oxo-α-phthalimido-5-isoxozolidineacetic acids
DE3044970A1 (de) 3',4'-dideoxyparomomycin, verfahren zu dessen herstellung und diese verbindung enthaltende arzneimittel
JPS606958B2 (ja) 抗生物質の精製法
Ruano et al. Enantiomerically pure 2-alkyl and 2, 3-dialkylaziridines from 2-sulfinylimines
US4455430A (en) Process for preparing tricholomic acid and derivatives thereof
US3912738A (en) Isomers of N,N{40 -bis-{8 (1-formamido-2,2,2-trichloro)-ethyl{9 -piperazine and method of isolating the same
DE2609862A1 (de) Verbindungen mit antidepressiver wirkung

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7904163-8

Effective date: 19900518

Format of ref document f/p: F