GB2023135A - Derivatives of AT-125 and process for preparing AT-125 and derivatives - Google Patents

Derivatives of AT-125 and process for preparing AT-125 and derivatives

Info

Publication number
GB2023135A
GB2023135A GB7916822A GB7916822A GB2023135A GB 2023135 A GB2023135 A GB 2023135A GB 7916822 A GB7916822 A GB 7916822A GB 7916822 A GB7916822 A GB 7916822A GB 2023135 A GB2023135 A GB 2023135A
Authority
GB
United Kingdom
Prior art keywords
derivatives
analogues
amino
nr14r15
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7916822A
Other versions
GB2023135B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB2023135A publication Critical patent/GB2023135A/en
Application granted granted Critical
Publication of GB2023135B publication Critical patent/GB2023135B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Analogues of AT-125 having the formula <IMAGE> wherein R is hydrogen, alkyl, haloalkyl or aralkyl; X is halogen, alkoxy, alkylthio, aryloxy, arylthio, aralkoxy, aralkythio, amino, alkylamino or dialkylamino; and NR14R15 is amino or a blocked amino group, provided that X is not chlorine when R is hydrogen or alkyl and R14 or R15 is alkoxycarbonyl or NR14R15 is phthalimido. The analogues can have therapeutic activity. AT-125 and the analogues can be prepared by halogenation of a corresponding analogue of tricholomic acid.
GB7916822A 1978-05-15 1979-05-15 Derivatives of at-125 amd process for preparing at-125 andderivatives Expired GB2023135B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90596378A 1978-05-15 1978-05-15

Publications (2)

Publication Number Publication Date
GB2023135A true GB2023135A (en) 1979-12-28
GB2023135B GB2023135B (en) 1982-08-25

Family

ID=25421749

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7916822A Expired GB2023135B (en) 1978-05-15 1979-05-15 Derivatives of at-125 amd process for preparing at-125 andderivatives

Country Status (10)

Country Link
JP (1) JPS54148781A (en)
AU (1) AU526380B2 (en)
BE (1) BE876261A (en)
CH (1) CH646961A5 (en)
DE (1) DE2918878A1 (en)
FR (1) FR2426049A1 (en)
GB (1) GB2023135B (en)
IT (1) IT1116816B (en)
NL (1) NL7903771A (en)
SE (2) SE448376B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643807A (en) * 1985-12-13 1987-02-17 The Dow Chemical Company Process for electrochemically forming an aromatic compound containing one or more alpha-acyloxylated aliphatic substitutent(s)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856807A (en) * 1972-03-13 1974-12-24 Upjohn Co L-({60 s,5s)-{60 -amino-3-chloro-2-isoxazoline-5-acetic acid
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US3944562A (en) * 1974-04-17 1976-03-16 The Upjohn Company αS, 4S, 5R α-Amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid

Also Published As

Publication number Publication date
NL7903771A (en) 1979-11-19
DE2918878A1 (en) 1979-11-22
SE448376B (en) 1987-02-16
JPS54148781A (en) 1979-11-21
SE8501965L (en) 1985-04-23
FR2426049B1 (en) 1983-06-17
CH646961A5 (en) 1984-12-28
GB2023135B (en) 1982-08-25
IT7949040A0 (en) 1979-05-14
SE8501965D0 (en) 1985-04-23
AU526380B2 (en) 1983-01-06
IT1116816B (en) 1986-02-10
SE7904163L (en) 1979-11-16
FR2426049A1 (en) 1979-12-14
AU4672379A (en) 1979-11-22
BE876261A (en) 1979-11-16

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Legal Events

Date Code Title Description
727 Application made for amendment of specification (sect. 27/1977)
727A Application for amendment of specification now open to opposition (sect. 27/1977)
727B Case decided by the comptroller ** specification amended (sect. 27/1977)
SP Amendment (slips) printed
PCNP Patent ceased through non-payment of renewal fee