FR2426049A1 - PROCESS FOR THE PREPARATION OF ACID (AS, 5S) -A-AMINO-3-CHLORO-A-ISOXAZOLINE-5-ACETIC, NEW ANALOGUES OF THIS ACID, AND PREPARATION OF THESE ANALOGUES - Google Patents

PROCESS FOR THE PREPARATION OF ACID (AS, 5S) -A-AMINO-3-CHLORO-A-ISOXAZOLINE-5-ACETIC, NEW ANALOGUES OF THIS ACID, AND PREPARATION OF THESE ANALOGUES

Info

Publication number
FR2426049A1
FR2426049A1 FR7912246A FR7912246A FR2426049A1 FR 2426049 A1 FR2426049 A1 FR 2426049A1 FR 7912246 A FR7912246 A FR 7912246A FR 7912246 A FR7912246 A FR 7912246A FR 2426049 A1 FR2426049 A1 FR 2426049A1
Authority
FR
France
Prior art keywords
acid
preparation
analogues
chloro
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7912246A
Other languages
French (fr)
Other versions
FR2426049B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2426049A1 publication Critical patent/FR2426049A1/en
Application granted granted Critical
Publication of FR2426049B1 publication Critical patent/FR2426049B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention a trait au domaine de la chimie médicale. Elle concerne des mélanges racémiques et des isomères optiquement actifs de l'acide ( alpha s-5S)- alpha -amino-3-chloro- alpha -isoxazoline-5-acétique, un procédé de production de cet acide et de ses analogues, et des composés intermédiaires utilisés dans ce procédé. Les composés de l'invention sont doués de propriétés antitumorales et antimicrobiennes.The invention relates to the field of medical chemistry. It relates to racemic mixtures and optically active isomers of (alpha s-5S) - alpha -amino-3-chloro-alpha -isoxazolin-5-acetic acid, a process for the production of this acid and its analogs, and intermediate compounds used in this process. The compounds of the invention are endowed with antitumor and antimicrobial properties.

FR7912246A 1978-05-15 1979-05-14 PROCESS FOR THE PREPARATION OF ACID (AS, 5S) -A-AMINO-3-CHLORO-A-ISOXAZOLINE-5-ACETIC, NEW ANALOGUES OF THIS ACID, AND PREPARATION OF THESE ANALOGUES Granted FR2426049A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90596378A 1978-05-15 1978-05-15

Publications (2)

Publication Number Publication Date
FR2426049A1 true FR2426049A1 (en) 1979-12-14
FR2426049B1 FR2426049B1 (en) 1983-06-17

Family

ID=25421749

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7912246A Granted FR2426049A1 (en) 1978-05-15 1979-05-14 PROCESS FOR THE PREPARATION OF ACID (AS, 5S) -A-AMINO-3-CHLORO-A-ISOXAZOLINE-5-ACETIC, NEW ANALOGUES OF THIS ACID, AND PREPARATION OF THESE ANALOGUES

Country Status (10)

Country Link
JP (1) JPS54148781A (en)
AU (1) AU526380B2 (en)
BE (1) BE876261A (en)
CH (1) CH646961A5 (en)
DE (1) DE2918878A1 (en)
FR (1) FR2426049A1 (en)
GB (1) GB2023135B (en)
IT (1) IT1116816B (en)
NL (1) NL7903771A (en)
SE (2) SE448376B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643807A (en) * 1985-12-13 1987-02-17 The Dow Chemical Company Process for electrochemically forming an aromatic compound containing one or more alpha-acyloxylated aliphatic substitutent(s)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183680A1 (en) * 1972-03-13 1973-12-21 Upjohn Co
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
FR2267779A1 (en) * 1974-04-17 1975-11-14 Upjohn Co

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183680A1 (en) * 1972-03-13 1973-12-21 Upjohn Co
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
FR2267779A1 (en) * 1974-04-17 1975-11-14 Upjohn Co

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *
EXBK/79 *

Also Published As

Publication number Publication date
NL7903771A (en) 1979-11-19
DE2918878A1 (en) 1979-11-22
SE448376B (en) 1987-02-16
JPS54148781A (en) 1979-11-21
SE8501965L (en) 1985-04-23
FR2426049B1 (en) 1983-06-17
CH646961A5 (en) 1984-12-28
GB2023135B (en) 1982-08-25
IT7949040A0 (en) 1979-05-14
SE8501965D0 (en) 1985-04-23
AU526380B2 (en) 1983-01-06
IT1116816B (en) 1986-02-10
SE7904163L (en) 1979-11-16
AU4672379A (en) 1979-11-22
BE876261A (en) 1979-11-16
GB2023135A (en) 1979-12-28

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