SE8501965L - PROCEDURES AND INTERMEDIATES FOR MANUFACTURING AT-125 - Google Patents

PROCEDURES AND INTERMEDIATES FOR MANUFACTURING AT-125

Info

Publication number
SE8501965L
SE8501965L SE8501965A SE8501965A SE8501965L SE 8501965 L SE8501965 L SE 8501965L SE 8501965 A SE8501965 A SE 8501965A SE 8501965 A SE8501965 A SE 8501965A SE 8501965 L SE8501965 L SE 8501965L
Authority
SE
Sweden
Prior art keywords
analogues
amino
intermediates
procedures
manufacturing
Prior art date
Application number
SE8501965A
Other languages
Swedish (sv)
Other versions
SE8501965D0 (en
Inventor
R C Kelly
W Wierenga
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of SE8501965D0 publication Critical patent/SE8501965D0/en
Publication of SE8501965L publication Critical patent/SE8501965L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Analogues of AT-125 having the formula <IMAGE> wherein R is hydrogen, alkyl, haloalkyl or aralkyl; X is halogen, alkoxy, alkylthio, aryloxy, arylthio, aralkoxy, aralkythio, amino, alkylamino or dialkylamino; and NR14R15 is amino or a blocked amino group, provided that X is not chlorine when R is hydrogen or alkyl and R14 or R15 is alkoxycarbonyl or NR14R15 is phthalimido. The analogues can have therapeutic activity. AT-125 and the analogues can be prepared by halogenation of a corresponding analogue of tricholomic acid.
SE8501965A 1978-05-15 1985-04-23 PROCEDURES AND INTERMEDIATES FOR MANUFACTURING AT-125 SE8501965L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90596378A 1978-05-15 1978-05-15

Publications (2)

Publication Number Publication Date
SE8501965D0 SE8501965D0 (en) 1985-04-23
SE8501965L true SE8501965L (en) 1985-04-23

Family

ID=25421749

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7904163A SE448376B (en) 1978-05-15 1979-05-11 PROCEDURE FOR THE PREPARATION OF (ALFAS, 55) -ALFA-AMINO-3-CHLORO-2-ISOXAZOLINE-5-ETHIC ACID (AT-125) AND ANALOGS THEREOF
SE8501965A SE8501965L (en) 1978-05-15 1985-04-23 PROCEDURES AND INTERMEDIATES FOR MANUFACTURING AT-125

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7904163A SE448376B (en) 1978-05-15 1979-05-11 PROCEDURE FOR THE PREPARATION OF (ALFAS, 55) -ALFA-AMINO-3-CHLORO-2-ISOXAZOLINE-5-ETHIC ACID (AT-125) AND ANALOGS THEREOF

Country Status (10)

Country Link
JP (1) JPS54148781A (en)
AU (1) AU526380B2 (en)
BE (1) BE876261A (en)
CH (1) CH646961A5 (en)
DE (1) DE2918878A1 (en)
FR (1) FR2426049A1 (en)
GB (1) GB2023135B (en)
IT (1) IT1116816B (en)
NL (1) NL7903771A (en)
SE (2) SE448376B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643807A (en) * 1985-12-13 1987-02-17 The Dow Chemical Company Process for electrochemically forming an aromatic compound containing one or more alpha-acyloxylated aliphatic substitutent(s)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856807A (en) * 1972-03-13 1974-12-24 Upjohn Co L-({60 s,5s)-{60 -amino-3-chloro-2-isoxazoline-5-acetic acid
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US3944562A (en) * 1974-04-17 1976-03-16 The Upjohn Company αS, 4S, 5R α-Amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid

Also Published As

Publication number Publication date
GB2023135B (en) 1982-08-25
AU4672379A (en) 1979-11-22
JPS54148781A (en) 1979-11-21
NL7903771A (en) 1979-11-19
BE876261A (en) 1979-11-16
GB2023135A (en) 1979-12-28
SE448376B (en) 1987-02-16
AU526380B2 (en) 1983-01-06
SE8501965D0 (en) 1985-04-23
CH646961A5 (en) 1984-12-28
SE7904163L (en) 1979-11-16
IT1116816B (en) 1986-02-10
FR2426049B1 (en) 1983-06-17
DE2918878A1 (en) 1979-11-22
FR2426049A1 (en) 1979-12-14
IT7949040A0 (en) 1979-05-14

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Legal Events

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NAV Patent application has lapsed

Ref document number: 8501965-1

Effective date: 19900414