SE444939B - Forfarande for framstellning av en antiallergiskt verksam blandning av 1,3-bis(2-karboxikromon-5-yloxi)propan-2-ol och antihistamin - Google Patents
Forfarande for framstellning av en antiallergiskt verksam blandning av 1,3-bis(2-karboxikromon-5-yloxi)propan-2-ol och antihistaminInfo
- Publication number
- SE444939B SE444939B SE7803069A SE7803069A SE444939B SE 444939 B SE444939 B SE 444939B SE 7803069 A SE7803069 A SE 7803069A SE 7803069 A SE7803069 A SE 7803069A SE 444939 B SE444939 B SE 444939B
- Authority
- SE
- Sweden
- Prior art keywords
- antihistamine
- composition
- yloxy
- bis
- propan
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 35
- 239000000739 antihistaminic agent Substances 0.000 title claims description 25
- 230000003266 anti-allergic effect Effects 0.000 title claims 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title description 21
- 230000001387 anti-histamine Effects 0.000 title description 21
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 14
- 229960000265 cromoglicic acid Drugs 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 8
- ZZHLYYDVIOPZBE-UHFFFAOYSA-N Trimeprazine Chemical compound C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1 ZZHLYYDVIOPZBE-UHFFFAOYSA-N 0.000 claims description 6
- 229940125715 antihistaminic agent Drugs 0.000 claims description 4
- CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 claims description 4
- 229960001128 triprolidine Drugs 0.000 claims description 4
- 229960003790 alimemazine Drugs 0.000 claims description 3
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 claims description 3
- 229960003291 chlorphenamine Drugs 0.000 claims description 3
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 claims description 3
- 229960001140 cyproheptadine Drugs 0.000 claims description 3
- 229960001992 dimetindene Drugs 0.000 claims description 3
- MVMQESMQSYOVGV-UHFFFAOYSA-N dimetindene Chemical compound CN(C)CCC=1CC2=CC=CC=C2C=1C(C)C1=CC=CC=N1 MVMQESMQSYOVGV-UHFFFAOYSA-N 0.000 claims description 3
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 claims description 3
- 229960000582 mepyramine Drugs 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- IJHNSHDBIRRJRN-UHFFFAOYSA-N N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=CC=C1 IJHNSHDBIRRJRN-UHFFFAOYSA-N 0.000 claims description 2
- ZDIGNSYAACHWNL-UHFFFAOYSA-N brompheniramine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 ZDIGNSYAACHWNL-UHFFFAOYSA-N 0.000 claims description 2
- 229960000725 brompheniramine Drugs 0.000 claims description 2
- OJFSXZCBGQGRNV-UHFFFAOYSA-N carbinoxamine Chemical compound C=1C=CC=NC=1C(OCCN(C)C)C1=CC=C(Cl)C=C1 OJFSXZCBGQGRNV-UHFFFAOYSA-N 0.000 claims description 2
- 229960000428 carbinoxamine Drugs 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 239000000938 histamine H1 antagonist Substances 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 229960001190 pheniramine Drugs 0.000 claims description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 8
- 229960000686 benzalkonium chloride Drugs 0.000 description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 8
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 7
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 7
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 208000010668 atopic eczema Diseases 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 206010010741 Conjunctivitis Diseases 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 229940067107 phenylethyl alcohol Drugs 0.000 description 4
- WYUYEJNGHIOFOC-VVTVMFAVSA-N 2-[(z)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrochloride Chemical compound Cl.C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C\CN1CCCC1 WYUYEJNGHIOFOC-VVTVMFAVSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 206010039085 Rhinitis allergic Diseases 0.000 description 3
- 230000000172 allergic effect Effects 0.000 description 3
- 201000010105 allergic rhinitis Diseases 0.000 description 3
- -1 phenylethyl mercury nitrate Chemical compound 0.000 description 3
- 229960001593 triprolidine hydrochloride Drugs 0.000 description 3
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000008139 complexing agent Substances 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008174 sterile solution Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229940095064 tartrate Drugs 0.000 description 2
- JXYWFNAQESKDNC-BTJKTKAUSA-N (z)-4-hydroxy-4-oxobut-2-enoate;2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-dimethylazanium Chemical compound OC(=O)\C=C/C(O)=O.C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 JXYWFNAQESKDNC-BTJKTKAUSA-N 0.000 description 1
- HNSWSZHQXDJXSS-UHFFFAOYSA-N 5-[3-(2-carboxy-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCCCOC1=C2C(=O)C=C(C(=O)O)OC2=CC=C1 HNSWSZHQXDJXSS-UHFFFAOYSA-N 0.000 description 1
- 208000010370 Adenoviridae Infections Diseases 0.000 description 1
- 206010027654 Allergic conditions Diseases 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 208000019872 Drug Eruptions Diseases 0.000 description 1
- 208000005100 Herpetic Keratitis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000000592 Nasal Polyps Diseases 0.000 description 1
- 208000030880 Nose disease Diseases 0.000 description 1
- 206010073938 Ophthalmic herpes simplex Diseases 0.000 description 1
- 206010030865 Ophthalmic herpes zoster Diseases 0.000 description 1
- 241000721454 Pemphigus Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000036284 Rhinitis seasonal Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 244000250129 Trigonella foenum graecum Species 0.000 description 1
- UFLGIAIHIAPJJC-UHFFFAOYSA-N Tripelennamine Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CC=C1 UFLGIAIHIAPJJC-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 229940109248 cromoglycate Drugs 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 201000001371 inclusion conjunctivitis Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 201000010666 keratoconjunctivitis Diseases 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
- 206010044325 trachoma Diseases 0.000 description 1
- 229960003223 tripelennamine Drugs 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 208000018464 vernal keratoconjunctivitis Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB11390/77A GB1582362A (en) | 1977-03-17 | 1977-03-17 | Cromoglycic acid salts and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7803069L SE7803069L (sv) | 1978-09-18 |
| SE444939B true SE444939B (sv) | 1986-05-20 |
Family
ID=9985349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7803069A SE444939B (sv) | 1977-03-17 | 1978-03-16 | Forfarande for framstellning av en antiallergiskt verksam blandning av 1,3-bis(2-karboxikromon-5-yloxi)propan-2-ol och antihistamin |
Country Status (18)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA812811B (en) * | 1980-04-30 | 1982-06-30 | Fisons Ltd | Mixtures and salts of beta-2 selective bronchodilators with cromoglycic acid and salts thereof |
| EP0040489A1 (en) * | 1980-05-17 | 1981-11-25 | FISONS plc | Mixtures, salts, packages and pharmaceutical compositions containing 5-(2-hydroxypropoxy)-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid or a derivative thereof and an H2 receptor antagonist antihistamine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL44022A0 (en) * | 1973-01-23 | 1974-05-16 | Fisons Ltd | Novel salts of anti-inflammatory quinoline derivatives,their preparation and pharmaceutical compositions containing them |
| FR2217004A1 (en) * | 1973-02-15 | 1974-09-06 | Aries Robert | Sedatives and bronchodilatories - i.e. salts of 1,3-bis(2-carboxychromon-5-yloxy)propanes with 3-hydroxy-2-hydroxymethyl pyridines |
| FR2230358A2 (en) * | 1973-05-25 | 1974-12-20 | Fisons Ltd | Cromoglycate contg. solns. - contg. a second therapeutically active cpd. e.g. an antihistamine |
| DE2535258C2 (de) * | 1974-08-10 | 1993-06-03 | Fisons Plc, Ipswich, Suffolk | Inhalierbares Medikament in Pelletform |
-
1977
- 1977-03-17 GB GB11390/77A patent/GB1582362A/en not_active Expired
-
1978
- 1978-03-13 IL IL54264A patent/IL54264A/xx unknown
- 1978-03-13 BE BE185891A patent/BE864837A/xx not_active IP Right Cessation
- 1978-03-13 FI FI780782A patent/FI780782A7/fi not_active Application Discontinuation
- 1978-03-14 DK DK113378A patent/DK113378A/da not_active Application Discontinuation
- 1978-03-14 DE DE19782810974 patent/DE2810974A1/de active Granted
- 1978-03-15 IE IE530/78A patent/IE46581B1/en not_active IP Right Cessation
- 1978-03-15 ZA ZA00781520A patent/ZA781520B/xx unknown
- 1978-03-16 LU LU79253A patent/LU79253A1/xx unknown
- 1978-03-16 NL NL7802869A patent/NL7802869A/xx not_active Application Discontinuation
- 1978-03-16 CA CA299,237A patent/CA1113862A/en not_active Expired
- 1978-03-16 NZ NZ186712A patent/NZ186712A/xx unknown
- 1978-03-16 FR FR7807669A patent/FR2383937A1/fr active Granted
- 1978-03-16 NO NO780935A patent/NO152297C/no unknown
- 1978-03-16 SE SE7803069A patent/SE444939B/sv not_active IP Right Cessation
- 1978-03-16 CH CH289578A patent/CH628517A5/fr not_active IP Right Cessation
- 1978-03-17 AU AU34272/78A patent/AU516337B2/en not_active Expired
- 1978-03-17 JP JP3002278A patent/JPS53115823A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2383937A1 (fr) | 1978-10-13 |
| JPS53115823A (en) | 1978-10-09 |
| AU516337B2 (en) | 1981-05-28 |
| CH628517A5 (en) | 1982-03-15 |
| DE2810974A1 (de) | 1978-09-21 |
| NZ186712A (en) | 1979-12-11 |
| SE7803069L (sv) | 1978-09-18 |
| LU79253A1 (fr) | 1978-10-17 |
| NL7802869A (nl) | 1978-09-19 |
| DK113378A (da) | 1978-09-18 |
| AU3427278A (en) | 1979-09-20 |
| DE2810974C2 (enrdf_load_stackoverflow) | 1988-07-21 |
| BE864837A (fr) | 1978-09-13 |
| NO780935L (no) | 1978-09-19 |
| FI780782A7 (fi) | 1978-09-18 |
| GB1582362A (en) | 1981-01-07 |
| CA1113862A (en) | 1981-12-08 |
| IE780530L (en) | 1978-09-17 |
| IE46581B1 (en) | 1983-07-27 |
| NO152297C (no) | 1985-09-04 |
| NO152297B (no) | 1985-05-28 |
| IL54264A (en) | 1984-01-31 |
| IL54264A0 (en) | 1978-06-15 |
| FR2383937B1 (enrdf_load_stackoverflow) | 1982-07-23 |
| ZA781520B (en) | 1979-04-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2822683C (en) | Bepotastine compositions | |
| US20110021786A1 (en) | Pharmaceutical Solutions, Process of Preparation and Therapeutic Uses | |
| JP7257371B2 (ja) | 眼の病状の治療方法 | |
| JP2012520882A5 (enrdf_load_stackoverflow) | ||
| RU2561871C2 (ru) | Антагонист опиоидных рецепторов (налтрексон) для использования в терапии герпесного опоясывающего лишая | |
| JPS62178514A (ja) | 眼局所投与用眼圧降下剤 | |
| JPH1160505A (ja) | 防腐組成物 | |
| JP2020090547A (ja) | 神経学的及び神経変性疾患及び障害を処置するための鼻腔投与組成物 | |
| ES2246883T3 (es) | Composicion para inhalacion que comprende delt-9-tetrahidrocanabidol en un disolvente semiacuoso. | |
| WO2007023072A2 (en) | Use of ambroxol for the treatment of rhinovirus infections | |
| KR20080053319A (ko) | 브리부딘을 함유하는 헤르페스 각막염 치료용 광안정 약학조성물 | |
| JPH11189533A (ja) | 点眼薬 | |
| SE444939B (sv) | Forfarande for framstellning av en antiallergiskt verksam blandning av 1,3-bis(2-karboxikromon-5-yloxi)propan-2-ol och antihistamin | |
| JPH06500537A (ja) | アテローム硬化症の治療のためのアリールヒドロキシ尿素化合物の使用 | |
| JPS588013A (ja) | 緑内障および高眼圧症の治療用薬学的調合物 | |
| JP2019070026A (ja) | 外用剤 | |
| JP2002308764A (ja) | 眼科用医薬組成物 | |
| US4623664A (en) | Oil suspended phenylephrine | |
| SA90110074B1 (ar) | تركيبات صيدلانية متضمنة على محلول مائي من مشتق بيرانوكوينولين pyranoquinoline | |
| JP2002161032A (ja) | 粘膜適用組成物 | |
| CA1110170A (en) | Antihypertensive compositions | |
| WO2022060251A1 (ru) | Глазные капли для профилактики и лечения возрастной катаракты | |
| NZ782902B2 (en) | Oxymetazoline compositions and methods for treating ocular disorders | |
| WO2025022362A1 (en) | Compositions and methods for treating dyskinesia | |
| CA2929965C (en) | Method and composition for treating glaucoma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
Ref document number: 7803069-9 Format of ref document f/p: F |
|
| NUG | Patent has lapsed |
Ref document number: 7803069-9 Format of ref document f/p: F |