SE425798B - Forfarande for framstellning av nya antitumor-antracyklinantibiotika benemnda ma 144 med sina utgivna formler genom odling av i och for sig forut kenda streptomycess-stammar och utvinning av de angivna substanserna - Google Patents

Forfarande for framstellning av nya antitumor-antracyklinantibiotika benemnda ma 144 med sina utgivna formler genom odling av i och for sig forut kenda streptomycess-stammar och utvinning av de angivna substanserna

Info

Publication number
SE425798B
SE425798B SE7710972A SE7710972A SE425798B SE 425798 B SE425798 B SE 425798B SE 7710972 A SE7710972 A SE 7710972A SE 7710972 A SE7710972 A SE 7710972A SE 425798 B SE425798 B SE 425798B
Authority
SE
Sweden
Prior art keywords
streptomycess
antra
stems
exploitation
cultivation
Prior art date
Application number
SE7710972A
Other languages
English (en)
Swedish (sv)
Other versions
SE7710972L (sv
Inventor
H Umezawa
T Takeuchi
T Oki
T Inui
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12023776A external-priority patent/JPS5344555A/ja
Priority claimed from JP6090877A external-priority patent/JPS5463067A/ja
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Publication of SE7710972L publication Critical patent/SE7710972L/xx
Publication of SE425798B publication Critical patent/SE425798B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/48—Streptomyces antibioticus ; Actinomyces antibioticus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/888—Streptomyces antibioticus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
SE7710972A 1976-10-05 1977-09-30 Forfarande for framstellning av nya antitumor-antracyklinantibiotika benemnda ma 144 med sina utgivna formler genom odling av i och for sig forut kenda streptomycess-stammar och utvinning av de angivna substanserna SE425798B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12023776A JPS5344555A (en) 1976-10-05 1976-10-05 Anthracyclin.glycoside antibiotics
JP6090877A JPS5463067A (en) 1977-05-24 1977-05-24 Oncostatic drugs and their preparation

Publications (2)

Publication Number Publication Date
SE7710972L SE7710972L (sv) 1978-04-06
SE425798B true SE425798B (sv) 1982-11-08

Family

ID=26401967

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7710972A SE425798B (sv) 1976-10-05 1977-09-30 Forfarande for framstellning av nya antitumor-antracyklinantibiotika benemnda ma 144 med sina utgivna formler genom odling av i och for sig forut kenda streptomycess-stammar och utvinning av de angivna substanserna

Country Status (18)

Country Link
US (2) US4207313A (de)
AU (1) AU505971B2 (de)
CA (1) CA1100895A (de)
CH (1) CH637160A5 (de)
DE (1) DE2743654B2 (de)
DK (1) DK145200C (de)
ES (1) ES471823A1 (de)
FI (1) FI57444C (de)
FR (1) FR2403350A1 (de)
GB (1) GB1589536A (de)
GR (1) GR63996B (de)
HU (1) HU181999B (de)
IE (1) IE46236B1 (de)
LU (1) LU78242A1 (de)
NL (1) NL176004C (de)
NO (2) NO148959C (de)
SE (1) SE425798B (de)
YU (1) YU40483B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123608A (en) * 1977-07-18 1978-10-31 Bristol-Myers Company Antibiotic compound
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5648893A (en) * 1979-09-07 1981-05-02 Sanraku Inc Preparation of anthracycline glycoside
EP0030255B1 (de) * 1979-09-07 1986-01-29 Sanraku Incorporated 2-Hydroxyaclacinomycin A, dies enthaltende pharmazeutische Zusammensetzung; 2-Hydroxyaclavinon und fermentatives Verfahren zu dessen Herstellung
CH648327A5 (de) * 1980-10-16 1985-03-15 Hoffmann La Roche Anthracycline.
JPS5874694A (ja) * 1981-10-29 1983-05-06 Sanraku Inc アントラサイクリン誘導体
JPS5995891A (ja) * 1982-11-26 1984-06-02 Kitasato Inst:The 新規な制癌性抗生物質８０−２１７およびその製造法
JPS61236792A (ja) * 1985-04-12 1986-10-22 Sanraku Inc 新規アントラサイクリン抗生物質
DE3524117A1 (de) * 1985-07-05 1987-02-05 Hoechst Ag Neue anthracyclin-tetrasaccharide, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatik
DE3641833A1 (de) * 1986-12-08 1988-06-09 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate
US4977084A (en) * 1989-02-16 1990-12-11 Board Of Trustees Operating Michigan State University Production, isolation, and identification of novel antifungal compounds
US5013549A (en) * 1989-02-16 1991-05-07 Board Of Trustees Operating Michigan State University Production, isolation, and identification of novel antifungal compounds
US5066585A (en) * 1990-07-09 1991-11-19 Board Of Trustees Operating Michigan State University Method of inhibiting fungus using novel antifungal compounds
KR970000591B1 (ko) * 1993-09-03 1997-01-14 동국제약 주식회사 신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법
US6589591B1 (en) * 2001-07-10 2003-07-08 Baylor College Of Medicine Method for treating medical devices using glycerol and an antimicrobial agent
US20040256561A1 (en) * 2003-06-17 2004-12-23 Allyson Beuhler Wide band light sensing pixel array
TW200510719A (en) * 2003-08-06 2005-03-16 Pharmacia Italia Spa Method for detecting contaminants in pharmaceutical products
WO2005096990A2 (en) * 2004-04-02 2005-10-20 Baylor College Of Medicine Novel modification of medical prostheses

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB846130A (en) 1956-03-23 1960-08-24 Ciba Ltd New antibiotic and derivatives and salts thereof, preparations containing the same and process for the manufacture of these substances
CH362490A (de) 1957-10-29 1962-06-15 Ciba Geigy Verfahren zur Herstellung eines neuen Antibiotikums
US3092550A (en) * 1957-10-29 1963-06-04 Ciba Geigy Corp Antibiotic danubomycin and process for its manufacture
FR1533151A (fr) 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
FR1527892A (fr) 1967-03-15 1968-06-07 Rhone Poulenc Sa Nouveau procédé de préparation de l'antibiotique 13057 r.p.
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3686163A (en) * 1968-05-14 1972-08-22 Farmaceutici Italia Dihydrodaunomycin antibiotic and derivatives thereof
FR1593235A (de) 1968-11-18 1970-05-25
US3616624A (en) * 1969-11-04 1971-11-02 Becton Dickinson Co Laminar flow work bench
US3828021A (en) * 1972-06-14 1974-08-06 Merck & Co Inc Gentamicin c1 derivatives
GB1440626A (de) * 1973-05-02 1976-06-23 Farmaceutici Italia
GB1426637A (en) 1973-12-04 1976-03-03 Vnii Izyskaniju Novykh Antibio Manthracyclic antibiotic and a method of production thereof
US3864480A (en) * 1974-05-06 1975-02-04 Merck & Co Inc Cinerubin A and B As Antiparasitic Agents
JPS5134915B2 (de) * 1974-07-27 1976-09-29
US4009328A (en) * 1975-05-02 1977-02-22 Schering Corporation Aminoglycoside 66-40C, method for its manufacture, method for its use as an intermediate in the preparation of known antibiotics and novel antibacterials
JPS5231051A (en) * 1975-09-03 1977-03-09 Kowa Co Preparation of amino sugar derivatives
US4039736A (en) * 1976-04-15 1977-08-02 Bristol-Myers Company Antibiotic compounds marcellomycin and musettamycin

Also Published As

Publication number Publication date
US4207313A (en) 1980-06-10
ES471823A1 (es) 1979-02-01
AU505971B2 (en) 1979-12-06
NL176004B (nl) 1984-09-03
NO773353L (no) 1978-04-06
NL7710380A (nl) 1978-04-07
NO148959B (no) 1983-10-10
FI57444C (fi) 1980-08-11
AU2933777A (en) 1979-04-12
DK145200B (da) 1982-10-04
DE2743654B2 (de) 1979-12-13
US4245045A (en) 1981-01-13
YU40483B (en) 1986-02-28
IE46236L (en) 1978-04-05
NO781949L (no) 1978-04-06
FI772915A (fi) 1978-04-06
CH637160A5 (fr) 1983-07-15
HU181999B (en) 1983-11-28
DK435577A (da) 1978-04-06
DE2743654C3 (de) 1980-08-21
NO148959C (no) 1984-01-18
FR2403350A1 (fr) 1979-04-13
LU78242A1 (de) 1978-01-26
IE46236B1 (en) 1983-04-06
NO147953C (no) 1983-07-20
GB1589536A (en) 1981-05-13
GR63996B (en) 1980-01-18
FI57444B (fi) 1980-04-30
DK145200C (da) 1983-02-28
NO147953B (no) 1983-04-05
DE2743654A1 (de) 1978-04-06
FR2403350B1 (de) 1981-04-30
NL176004C (nl) 1985-02-01
CA1100895A (en) 1981-05-12
YU235277A (en) 1982-06-30
SE7710972L (sv) 1978-04-06

Similar Documents

Publication Publication Date Title
SE425798B (sv) Forfarande for framstellning av nya antitumor-antracyklinantibiotika benemnda ma 144 med sina utgivna formler genom odling av i och for sig forut kenda streptomycess-stammar och utvinning av de angivna substanserna
FI801968A (fi) Testanordning i vilken reagensomraodena ej reagerar i kors med varandra och foerfarande foer framstaellning av denna
SE435059B (sv) Forfarande for framstellning av med kveveheterocykliska grupper substituerade 1-fenyl-2-alkylaminoetanol-foreningar
RO69516A (ro) Procedeu pentru prepararea unor copolimeri grefati
SE416203B (sv) Forfarande for framstellning av 4,5,6,7-tetrahydro-furo (respektive - tieno)-(3,2-c)pyridinderivat
FI803550L (fi) Nya ti02-pigment med goda dispergeringsegenskaper och foerfarande foer deras framstaellning
SE431227B (sv) Forfarande for framstellning av ett glukosisomerasenzym med god vermestabilitet och lagringsbestendighet genom odling av stammar av bacillus coagualans
BE838194A (fr) Nouveaux derives de l'oxadiazolinone, leur preparation et les compositions qui les contiennent
PT65442A (fr) Nouveaux derives de la thiazolo(3,4-b)isoquinoleine,leur preparation et les compositions qui les contiennent
SE431100B (sv) Forfarande for framstellning av nya rifamyciner benemnda rifamycin p, q, r och u genom odling av nya stammar av nocardia mediterranea
FI772253A (fi) Foerfarande och anlaeggning foer framstaellning av formade artiklar
SE429973B (sv) Forfarande for framstellning av ett nytt polyen-makrolid-antibiotikum benemt luknomycin genom odling av en ny stam av streptomyces diastatochromogenes med nummer cbs 101.74
NO155780C (no) Fremgangsmaate for fremstilling av et antitumor- og antibiotisk kompleks.
AR205041A1 (es) Procedimiento de preparacion de la tieno(3,2-c)piridina o de la tieno(2,3-c)piridina
SE421528B (sv) Forfarande for framstellning av 8,8-disubstituerade 6-metylergoliner och derivat derav
SE435069B (sv) Forfarande for framstellning av nya antracyklinglykosider, benemnda rhodirubin a och b, genom odling av vissa stammar tillhorande slektet streptomyces
RO77922A (ro) Procedeu pentru prepararea unor indoldihidroindol-3-carboxamide dimere
SE7705183L (sv) Framstellning av nya bensodiazepinderivat
SE426845B (sv) Framstellning av nya isomera antibiotika benemnda 890a, och 890a3 med angiven formel genom odling av streptomyces flavogriseus nrrl 8139 eller 8140
FR2351656A1 (fr) Nouveaux derives de la dibenzo(de, h) quinoleine, leur preparation et les compositions qui les contiennent
AR215611A1 (es) Procedimiento de preparacion de derivados de alcoxicarbonil-2-tetrahidro tieno (3,2-c)piridina
SE7813428L (sv) 5,6-dihydro-prostacyklinderivat och forfarande for framstellning av dem
FR2290208A1 (fr) Nouveaux derives de l'oxathiinno(1,4)(2,3-c)pyrrole, leur preparation et les compositions qui les contiennent
BE844927A (fr) NOUVEAUX DERIVES DE LA THIAZOLO (3,4-b) ISOQUINOLEINE, LEUR PREPARATION ET LES COMPOSITIONS QUI LES CONTIENNENT
AR205040A1 (es) Procedimiento de preparacion de derivados de la tetrahidro-4,5,6,7,-tieno(3,2-c)o(2,3-c)piridina

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7710972-6

Effective date: 19880627

Format of ref document f/p: F