SE389670B - Forfarande for framstellning av aroyl-substituerade pyrroler med terapeutisk verkan - Google Patents

Forfarande for framstellning av aroyl-substituerade pyrroler med terapeutisk verkan

Info

Publication number
SE389670B
SE389670B SE7100820A SE82071A SE389670B SE 389670 B SE389670 B SE 389670B SE 7100820 A SE7100820 A SE 7100820A SE 82071 A SE82071 A SE 82071A SE 389670 B SE389670 B SE 389670B
Authority
SE
Sweden
Prior art keywords
aroyl
procedure
production
therapeutic effect
pyroles
Prior art date
Application number
SE7100820A
Other languages
English (en)
Inventor
J R Carson
Original Assignee
Mcneilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneilab Inc filed Critical Mcneilab Inc
Publication of SE389670B publication Critical patent/SE389670B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
SE7100820A 1970-01-26 1971-01-25 Forfarande for framstellning av aroyl-substituerade pyrroler med terapeutisk verkan SE389670B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US595870A 1970-01-26 1970-01-26
US338461A US3865840A (en) 1970-01-26 1973-02-16 Process of preparing 1,4-diloweralkyl-3-loweralkoxy-carbonyl-2-acetates

Publications (1)

Publication Number Publication Date
SE389670B true SE389670B (sv) 1976-11-15

Family

ID=26674970

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7100820A SE389670B (sv) 1970-01-26 1971-01-25 Forfarande for framstellning av aroyl-substituerade pyrroler med terapeutisk verkan

Country Status (10)

Country Link
US (3) US3752826A (sv)
JP (4) JPS582936B2 (sv)
AT (4) AT308735B (sv)
BE (1) BE762060R (sv)
CH (2) CH547279A (sv)
DE (1) DE2102746A1 (sv)
FR (1) FR2081455B2 (sv)
GB (1) GB1327308A (sv)
NL (1) NL7101016A (sv)
SE (1) SE389670B (sv)

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DE2819463A1 (de) * 1977-05-10 1978-11-16 Beecham Group Ltd N-methyl-pyrrol-verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische praeparate
GB1592996A (en) * 1977-10-10 1981-07-15 Rolland Sa A Acylated pyrrole carboxylic acids and derivatives thereof
GB1592997A (en) * 1977-10-14 1981-07-15 Rolland Sa A Aroyl-pyrrole carboxylic acids and derivatives thereof
SE435278B (sv) * 1977-12-08 1984-09-17 Sagami Chem Res 5-cyano-1-legre(c?711?71-?714)alkyl-pyrrol-2-ettiksyra, framstellning derav och anvendningen som mellanprodukt vid framstellning av terapeutiskt verksamma pyrrolderivat
DE2861595D1 (en) * 1978-07-10 1982-03-11 Mcneilab Inc Pharmaceutical composition comprising a 5-aroyl-1-c1-5 alkyl-pyrrole-2-acetic acid compound and acetaminophen or acetylsalicylic acid
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CA1105039A (en) * 1978-10-19 1981-07-14 Douglas A. Robinson Process for producing substituted pyrrole diesters
EP0010553B1 (en) * 1978-10-27 1983-05-18 McNeilab, Inc. Process of reducing a loweralkyl 1-loweralkyl-pyrrole-2-glyoxylate to a loweralkyl 1-loweralkyl-pyrrole-2-acetate
US4246175A (en) * 1979-05-29 1981-01-20 Ethyl Corporation Synthesis of 5-cyano-1-hydrocarbylpyrrole-2-acetic acid
US4213905A (en) * 1979-06-25 1980-07-22 Mcneilab, Inc. Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid salts
ATE4202T1 (de) * 1979-08-13 1983-08-15 Mcneilab, Inc. Verfahren zur herstellung von pyrrol-2essigs[ureestern.
US4363918A (en) * 1979-09-11 1982-12-14 Janssen Pharmaceutica N.V. Method of preparing 1-alkyl-3-carboxy-1H pyrrole-2-acetic acids
US4284562A (en) * 1979-11-27 1981-08-18 Mcneilab, Inc. Process for preparing pyrrole-2-acetic acids
US4255335A (en) * 1980-04-03 1981-03-10 Mcneilab, Inc. Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives
US4374255A (en) * 1980-04-04 1983-02-15 Ethyl Corporation Process for producing substituted pyrroles
US4333878A (en) * 1980-04-04 1982-06-08 Ethyl Corporation Process for producing substituted pyrroles
US4388468A (en) * 1980-04-04 1983-06-14 Ethyl Corporation Process for producing substituted pyrroles
US4565879A (en) * 1980-04-04 1986-01-21 Ethyl Corporation Process for producing substituted pyrroles
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NZ196700A (en) * 1980-04-18 1983-04-12 Smith & Nephew Ass Anti-inflammatory compositions containing 5-benzoyl-1-methylpyrrole-2-acetic acid derivatives
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CA1161851A (en) * 1980-11-03 1984-02-07 G. Patrick Stahly Process for producing substituted pyrroles
ES497136A0 (es) * 1980-11-11 1981-10-16 Calzada & Co Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico
US4451658A (en) * 1980-11-24 1984-05-29 Ethyl Corporation Process for producing substituted pyrroles
JPS57501964A (sv) * 1980-12-15 1982-11-04
US4374254A (en) * 1981-01-23 1983-02-15 Ethyl Corporation Process for producing substituted pyrroles
AT370721B (de) * 1981-02-24 1983-04-25 Ciba Geigy Ag Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
US4511576A (en) * 1981-04-23 1985-04-16 Pfizer Inc. Antidiabetic pyrrolecarboxylic acids
US4374997A (en) * 1981-06-04 1983-02-22 Merck & Co., Inc. Process for the preparation of zomepirac and related compounds
US4380645A (en) * 1981-12-11 1983-04-19 Merck & Co., Inc. Process for preparing Benzoxepino- or Benzthiapino[4,3-b]pyrrole-2-acetic acids
US4383117A (en) * 1981-11-02 1983-05-10 Ethyl Corporation Process for producing substituted pyrroles
US4455433A (en) * 1981-11-02 1984-06-19 Ethyl Corporation Process for producing substituted pyrroles
ES8206468A1 (es) * 1981-11-16 1982-08-16 Pharmedical Sa Lab Procedimiento de preparacion de derivados del acido 2-pirrol-acetico.
DE3145510A1 (de) * 1981-11-17 1983-05-26 Rütgerswerke AG, 6000 Frankfurt Verbessertes verfahren zur herstellung von 1h-pyrrol-2-essigsaeureestern
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
IT1148117B (it) * 1982-03-05 1986-11-26 Medosan Ind Biochimi Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile
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IT1151731B (it) * 1982-04-21 1986-12-24 Montedison Spa Processo per la preparazione dell'acido 3-carbossi-1,4-dimetilpirrol-2-acetico
HU187137B (en) * 1982-06-22 1985-11-28 Richter Gedeon Vegyeszet Process for producing esters of 1-alkyl- orl,4-dialkyl-1h-pyrrol-acetic acid
IT1153750B (it) * 1982-09-21 1987-01-14 Montedison Spa Processo per la preparazione dell'acido 3-carbossi-1-metilpirrol-2-acetico
US4585784A (en) * 1983-01-26 1986-04-29 Mcneilab, Inc. Pyrrole-2-acetylamino acid derivative compounds
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FR2564831B3 (fr) * 1984-05-25 1986-09-05 Rolland Sa A Nouveaux derives des acides aroyl- ou hydroaroyl n-alcoyl pyrrolyl-2 carboxyliques et nouvelles compositions pharmaceutiques a action immuno-suppressive
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US4874872A (en) * 1987-01-14 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4317963Y1 (sv) * 1966-05-04 1968-07-25
GB1195628A (en) * 1967-07-26 1970-06-17 Mcneilab Inc Aroyl-Substituted Pyrroles

Also Published As

Publication number Publication date
GB1327308A (en) 1973-08-22
US4070368A (en) 1978-01-24
DE2102746A1 (de) 1971-08-12
BE762060R (sv) 1971-07-26
JPS5745428B2 (sv) 1982-09-28
AT313271B (de) 1974-02-11
JPS591711B2 (ja) 1984-01-13
CH566984A5 (sv) 1975-09-30
AT313270B (de) 1974-02-11
AT313268B (de) 1974-02-11
JPS5533401A (en) 1980-03-08
JPS582935B2 (ja) 1983-01-19
JPS55162767A (en) 1980-12-18
US3865840A (en) 1975-02-11
AT308735B (de) 1973-07-25
NL7101016A (sv) 1971-07-28
JPS5533402A (en) 1980-03-08
JPS55162766A (en) 1980-12-18
FR2081455B2 (sv) 1974-09-06
JPS582936B2 (ja) 1983-01-19
CH547279A (de) 1974-03-29
US3752826A (en) 1973-08-14
FR2081455A2 (sv) 1971-12-03

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