SE1212311T5 - - Google Patents
Info
- Publication number
- SE1212311T5 SE1212311T5 SE00965902T SE00965902T SE1212311T5 SE 1212311 T5 SE1212311 T5 SE 1212311T5 SE 00965902 T SE00965902 T SE 00965902T SE 00965902 T SE00965902 T SE 00965902T SE 1212311 T5 SE1212311 T5 SE 1212311T5
- Authority
- SE
- Sweden
- Prior art keywords
- cell growth
- agents
- hydroxyphenyllactate
- antitumor
- analogues
- Prior art date
Links
- 230000010261 cell growth Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000006028 immune-suppresssive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- PDFUCDWETSQSSU-UHFFFAOYSA-N methyl 2-hydroxy-3-(4-hydroxyphenyl)propanoate Chemical compound COC(=O)C(O)CC1=CC=C(O)C=C1 PDFUCDWETSQSSU-UHFFFAOYSA-N 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Glass Compositions (AREA)
- Fire-Extinguishing Compositions (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9920908.2A GB9920908D0 (en) | 1999-09-03 | 1999-09-03 | Chalcone coumarins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE1212311T3 SE1212311T3 (enExample) | 2003-05-06 |
| SE1212311T5 true SE1212311T5 (enExample) | 2003-06-10 |
Family
ID=10860344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE00965902T SE1212311T5 (enExample) | 1999-09-03 | 2000-08-28 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6767916B2 (enExample) |
| EP (1) | EP1212311B1 (enExample) |
| JP (1) | JP2003508523A (enExample) |
| KR (1) | KR100819574B1 (enExample) |
| CN (1) | CN1142927C (enExample) |
| AT (1) | ATE235480T1 (enExample) |
| AU (1) | AU775083B2 (enExample) |
| CA (1) | CA2382112A1 (enExample) |
| CZ (1) | CZ2002786A3 (enExample) |
| DE (1) | DE60001850T2 (enExample) |
| DK (1) | DK1212311T3 (enExample) |
| ES (1) | ES2191643T3 (enExample) |
| GB (1) | GB9920908D0 (enExample) |
| HK (1) | HK1043997B (enExample) |
| HU (1) | HUP0202581A3 (enExample) |
| NO (1) | NO20021048L (enExample) |
| PL (1) | PL353245A1 (enExample) |
| PT (1) | PT1212311E (enExample) |
| RU (1) | RU2266291C2 (enExample) |
| SE (1) | SE1212311T5 (enExample) |
| SK (1) | SK3102002A3 (enExample) |
| WO (1) | WO2001017984A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030229136A1 (en) | 2002-04-18 | 2003-12-11 | Nurulain Zaveri | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents |
| US7638554B2 (en) | 2002-04-18 | 2009-12-29 | Sri International | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents |
| WO2006132947A2 (en) | 2005-06-08 | 2006-12-14 | Temple University- Of The Commonwealth System Of Higher Education | 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof |
| CN101041646B (zh) * | 2007-04-30 | 2011-07-20 | 浙江大学 | 含氮查耳酮衍生物的制备方法和用途 |
| CN101121706B (zh) * | 2007-09-18 | 2010-11-24 | 南京中瑞药业有限公司 | 一种香豆素衍生物及其制备方法和用途 |
| JP5479105B2 (ja) * | 2007-11-05 | 2014-04-23 | 国立大学法人佐賀大学 | 新規ユビキリン結合性小分子 |
| EP2601183A1 (en) | 2010-08-05 | 2013-06-12 | Council Of Scientific & Industrial Research | Coumarin-chalcones as anticancer agents |
| US10071945B2 (en) | 2011-06-15 | 2018-09-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nuclear receptor modulators and their use for the treatment and prevention of cancer |
| CN104987328A (zh) * | 2012-05-23 | 2015-10-21 | 复旦大学 | 7-氧、硫或氮杂取代香豆素及其衍生物和用途 |
| CN102731457A (zh) * | 2012-06-25 | 2012-10-17 | 西南石油大学 | 一种水溶性荧光示踪聚合物及其制备方法 |
| WO2019096397A1 (en) * | 2017-11-16 | 2019-05-23 | The Institute Of Cancer Research: Royal Cancer Hospital | Coumarin derivative for therapy or prophylaxis of a cell proliferative disorder |
| CN109293616B (zh) * | 2018-09-29 | 2022-06-21 | 贵州大学 | 一种含香豆素查尔酮类衍生物、其制备方法及应用 |
| JP2022547358A (ja) | 2019-09-13 | 2022-11-14 | ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル | 治療組成物、組み合わせ、及び使用方法 |
| US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2387956A1 (fr) * | 1977-04-20 | 1978-11-17 | Unicler | Derives de la pyridine et leur preparation |
| US5399561A (en) * | 1989-09-19 | 1995-03-21 | Allergan, Inc. | Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity |
| US5023341A (en) * | 1989-09-19 | 1991-06-11 | Allergan, Inc. | Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity |
| CA2084208A1 (en) * | 1990-05-17 | 1991-11-18 | Barry Markaverich | Growth inhibitors and methods of treating cancer and cell proliferative diseases |
| IT1271301B (it) | 1994-12-20 | 1997-05-27 | Indena Spa | Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono |
| US5525625A (en) | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
-
1999
- 1999-09-03 GB GBGB9920908.2A patent/GB9920908D0/en not_active Ceased
-
2000
- 2000-08-28 CN CNB00812163XA patent/CN1142927C/zh not_active Expired - Fee Related
- 2000-08-28 PT PT00965902T patent/PT1212311E/pt unknown
- 2000-08-28 CA CA002382112A patent/CA2382112A1/en not_active Abandoned
- 2000-08-28 CZ CZ2002786A patent/CZ2002786A3/cs unknown
- 2000-08-28 ES ES00965902T patent/ES2191643T3/es not_active Expired - Lifetime
- 2000-08-28 DK DK00965902T patent/DK1212311T3/da active
- 2000-08-28 AT AT00965902T patent/ATE235480T1/de not_active IP Right Cessation
- 2000-08-28 WO PCT/EP2000/008367 patent/WO2001017984A1/en not_active Ceased
- 2000-08-28 JP JP2001521731A patent/JP2003508523A/ja not_active Withdrawn
- 2000-08-28 HK HK02105581.2A patent/HK1043997B/en unknown
- 2000-08-28 EP EP00965902A patent/EP1212311B1/en not_active Expired - Lifetime
- 2000-08-28 RU RU2002108567/04A patent/RU2266291C2/ru not_active IP Right Cessation
- 2000-08-28 SK SK310-2002A patent/SK3102002A3/sk unknown
- 2000-08-28 DE DE60001850T patent/DE60001850T2/de not_active Expired - Fee Related
- 2000-08-28 PL PL00353245A patent/PL353245A1/xx not_active IP Right Cessation
- 2000-08-28 AU AU76488/00A patent/AU775083B2/en not_active Ceased
- 2000-08-28 HU HU0202581A patent/HUP0202581A3/hu unknown
- 2000-08-28 SE SE00965902T patent/SE1212311T5/xx unknown
- 2000-08-28 KR KR1020027002799A patent/KR100819574B1/ko not_active Expired - Fee Related
-
2002
- 2002-02-15 US US10/075,625 patent/US6767916B2/en not_active Expired - Fee Related
- 2002-03-01 NO NO20021048A patent/NO20021048L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20021048D0 (no) | 2002-03-01 |
| NO20021048L (no) | 2002-05-03 |
| KR100819574B1 (ko) | 2008-04-04 |
| ATE235480T1 (de) | 2003-04-15 |
| AU775083B2 (en) | 2004-07-15 |
| EP1212311B1 (en) | 2003-03-26 |
| CZ2002786A3 (cs) | 2002-06-12 |
| CN1371370A (zh) | 2002-09-25 |
| RU2266291C2 (ru) | 2005-12-20 |
| DE60001850D1 (de) | 2003-04-30 |
| KR20020030800A (ko) | 2002-04-25 |
| US20020161036A1 (en) | 2002-10-31 |
| AU7648800A (en) | 2001-04-10 |
| HK1043997B (en) | 2003-08-15 |
| SE1212311T3 (enExample) | 2003-05-06 |
| CA2382112A1 (en) | 2001-03-15 |
| DE60001850T2 (de) | 2003-12-11 |
| CN1142927C (zh) | 2004-03-24 |
| US6767916B2 (en) | 2004-07-27 |
| RU2002108567A (ru) | 2004-01-10 |
| EP1212311A1 (en) | 2002-06-12 |
| JP2003508523A (ja) | 2003-03-04 |
| SK3102002A3 (en) | 2003-10-07 |
| WO2001017984A1 (en) | 2001-03-15 |
| HUP0202581A3 (en) | 2003-07-28 |
| HK1043997A1 (en) | 2002-10-04 |
| DK1212311T3 (da) | 2003-06-23 |
| HUP0202581A2 (hu) | 2002-11-28 |
| GB9920908D0 (en) | 1999-11-10 |
| ES2191643T3 (es) | 2003-09-16 |
| PL353245A1 (en) | 2003-11-03 |
| PT1212311E (pt) | 2003-08-29 |
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