SE0201936D0 - Therapeutic agents - Google Patents
Therapeutic agentsInfo
- Publication number
- SE0201936D0 SE0201936D0 SE0201936A SE0201936A SE0201936D0 SE 0201936 D0 SE0201936 D0 SE 0201936D0 SE 0201936 A SE0201936 A SE 0201936A SE 0201936 A SE0201936 A SE 0201936A SE 0201936 D0 SE0201936 D0 SE 0201936D0
- Authority
- SE
- Sweden
- Prior art keywords
- group
- fluoro
- optionally substituted
- therapeutic agents
- och3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0201936A SE0201936D0 (sv) | 2002-06-20 | 2002-06-20 | Therapeutic agents |
ES03732714T ES2299703T3 (es) | 2002-06-20 | 2003-06-17 | Derivados de acido benzoico orto-sustituidos para el tratamiento de la resistencia a la insulina. |
BR0311839-8A BR0311839A (pt) | 2002-06-20 | 2003-06-17 | Composto, formulação farmacêutica, método para tratar ou prevenir a resistência à insulina, uso de um composto, processo para preparar um composto, e, tratamento combinado |
KR10-2004-7020689A KR20050014015A (ko) | 2002-06-20 | 2003-06-17 | 인슐린 내성 치료를 위한 오르소-치환 벤조산 유도체 |
SI200331174T SI1517679T1 (sl) | 2002-06-20 | 2003-06-17 | Orto-substituirani derivati benzojske kisline za zdravljenje insulinske rezistence |
MXPA04012685A MXPA04012685A (es) | 2002-06-20 | 2003-06-17 | Derivados de acido benzoico orto-sustituidos para el tratamiento de la resistencia a la insulina. |
TW092116410A TW200407114A (en) | 2002-06-20 | 2003-06-17 | Therapeutic agents |
RU2004135543/04A RU2288912C2 (ru) | 2002-06-20 | 2003-06-17 | Ортозамещенные производные бензойной кислоты, способ и промежуточные соединения для их получения, фармацевтическая композиция на их основе и применение |
US10/519,376 US7351858B2 (en) | 2002-06-20 | 2003-06-17 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
CA002490684A CA2490684A1 (en) | 2002-06-20 | 2003-06-17 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
CNB038198533A CN1307988C (zh) | 2002-06-20 | 2003-06-17 | 用于治疗胰岛素耐受性的邻位取代苯甲酸衍生物 |
PCT/GB2003/002591 WO2004000294A1 (en) | 2002-06-20 | 2003-06-17 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
JP2004515008A JP2005535618A (ja) | 2002-06-20 | 2003-06-17 | 治療用薬剤 |
AT03732714T ATE385790T1 (de) | 2002-06-20 | 2003-06-17 | Ortho-substituierte benzoesäurederivate zur behandlung von insulinresistenz |
UA20041210012A UA76627C2 (en) | 2002-06-20 | 2003-06-17 | Benzoic acid derivatives with ortho-substituents for treating insulin resistance |
DK03732714T DK1517679T3 (da) | 2002-06-20 | 2003-06-17 | Ortosubstituerede benzoesyrederivater til behandling af insulinresistens |
PL03375080A PL375080A1 (en) | 2002-06-20 | 2003-06-17 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
AU2003240100A AU2003240100B2 (en) | 2002-06-20 | 2003-06-17 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
DE60319082T DE60319082T2 (de) | 2002-06-20 | 2003-06-17 | Ortho-substituierte benzoesäurederivate zur behandlung von insulinresistenz |
PT03732714T PT1517679E (pt) | 2002-06-20 | 2003-06-17 | Derivados do ácido benzóico substituído na posição orto para o tratamento de resistência à insulina |
NZ536971A NZ536971A (en) | 2002-06-20 | 2003-06-17 | Ortho-substituted benzoic acid derivatives |
EP03732714A EP1517679B1 (en) | 2002-06-20 | 2003-06-17 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
ARP030102198A AR039714A1 (es) | 2002-06-20 | 2003-06-20 | Derivados de acido benzoico orto sustituidos para el tratamiento de resistencia a la insulina |
NO20045223A NO20045223L (no) | 2002-06-20 | 2004-11-29 | Orto-substituerte benzosyrederivater for behandling av insulinresistens |
ZA200409693A ZA200409693B (en) | 2002-06-20 | 2004-11-30 | Ortho-substituted benzoic acid derivatives for thetreatment of insulin resistance. |
IL16567004A IL165670A0 (en) | 2002-06-20 | 2004-12-09 | Ortho-substituted benzoic acid derivatives for thetreatment of insulin resistance |
IS7626A IS7626A (is) | 2002-06-20 | 2005-01-05 | Orþó-útskiptar bensósýruafleiður til að meðhöndlainsúlínviðnám |
HK05107074A HK1074779A1 (en) | 2002-06-20 | 2005-08-16 | Ortho-substituted benzoic acid derivatives for thetreatment of insulin resistance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0201936A SE0201936D0 (sv) | 2002-06-20 | 2002-06-20 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0201936D0 true SE0201936D0 (sv) | 2002-06-20 |
Family
ID=20288294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0201936A SE0201936D0 (sv) | 2002-06-20 | 2002-06-20 | Therapeutic agents |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1517679B1 (xx) |
JP (1) | JP2005535618A (xx) |
KR (1) | KR20050014015A (xx) |
CN (1) | CN1307988C (xx) |
AR (1) | AR039714A1 (xx) |
AT (1) | ATE385790T1 (xx) |
AU (1) | AU2003240100B2 (xx) |
BR (1) | BR0311839A (xx) |
CA (1) | CA2490684A1 (xx) |
DE (1) | DE60319082T2 (xx) |
DK (1) | DK1517679T3 (xx) |
ES (1) | ES2299703T3 (xx) |
HK (1) | HK1074779A1 (xx) |
IL (1) | IL165670A0 (xx) |
IS (1) | IS7626A (xx) |
MX (1) | MXPA04012685A (xx) |
NO (1) | NO20045223L (xx) |
NZ (1) | NZ536971A (xx) |
PL (1) | PL375080A1 (xx) |
PT (1) | PT1517679E (xx) |
RU (1) | RU2288912C2 (xx) |
SE (1) | SE0201936D0 (xx) |
TW (1) | TW200407114A (xx) |
UA (1) | UA76627C2 (xx) |
WO (1) | WO2004000294A1 (xx) |
ZA (1) | ZA200409693B (xx) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
DK1517883T3 (da) | 2002-06-20 | 2008-05-26 | Astrazeneca Ab | Ortho-substituerede benzoesyrederivater til behandling af insulinresistens |
PL219045B1 (pl) * | 2010-10-16 | 2015-03-31 | Inst Chemii Organicznej Polskiej Akademii Nauk | Nowe estry (acyloksymetylo)akrylamidu, kompozycja farmaceutyczna zawierająca je oraz ich zastosowanie |
US10653681B2 (en) | 2016-03-16 | 2020-05-19 | Recurium Ip Holdings, Llc | Analgesic compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
JP4618845B2 (ja) * | 1999-06-09 | 2011-01-26 | 杏林製薬株式会社 | ヒトペルオキシゾーム増殖薬活性化受容体(PPAR)αアゴニストとしての置換フェニルプロピオン酸誘導体 |
US6509374B2 (en) * | 2000-04-17 | 2003-01-21 | Novo Nordisk A/S | Compounds, their preparation and use |
-
2002
- 2002-06-20 SE SE0201936A patent/SE0201936D0/xx unknown
-
2003
- 2003-06-17 CN CNB038198533A patent/CN1307988C/zh not_active Expired - Fee Related
- 2003-06-17 ES ES03732714T patent/ES2299703T3/es not_active Expired - Lifetime
- 2003-06-17 PT PT03732714T patent/PT1517679E/pt unknown
- 2003-06-17 DE DE60319082T patent/DE60319082T2/de not_active Expired - Lifetime
- 2003-06-17 TW TW092116410A patent/TW200407114A/zh unknown
- 2003-06-17 EP EP03732714A patent/EP1517679B1/en not_active Expired - Lifetime
- 2003-06-17 AU AU2003240100A patent/AU2003240100B2/en not_active Ceased
- 2003-06-17 KR KR10-2004-7020689A patent/KR20050014015A/ko not_active Application Discontinuation
- 2003-06-17 UA UA20041210012A patent/UA76627C2/uk unknown
- 2003-06-17 RU RU2004135543/04A patent/RU2288912C2/ru not_active IP Right Cessation
- 2003-06-17 NZ NZ536971A patent/NZ536971A/en unknown
- 2003-06-17 AT AT03732714T patent/ATE385790T1/de not_active IP Right Cessation
- 2003-06-17 WO PCT/GB2003/002591 patent/WO2004000294A1/en active IP Right Grant
- 2003-06-17 PL PL03375080A patent/PL375080A1/xx not_active Application Discontinuation
- 2003-06-17 BR BR0311839-8A patent/BR0311839A/pt not_active IP Right Cessation
- 2003-06-17 CA CA002490684A patent/CA2490684A1/en not_active Abandoned
- 2003-06-17 JP JP2004515008A patent/JP2005535618A/ja active Pending
- 2003-06-17 MX MXPA04012685A patent/MXPA04012685A/es active IP Right Grant
- 2003-06-17 DK DK03732714T patent/DK1517679T3/da active
- 2003-06-20 AR ARP030102198A patent/AR039714A1/es unknown
-
2004
- 2004-11-29 NO NO20045223A patent/NO20045223L/no not_active Application Discontinuation
- 2004-11-30 ZA ZA200409693A patent/ZA200409693B/en unknown
- 2004-12-09 IL IL16567004A patent/IL165670A0/xx unknown
-
2005
- 2005-01-05 IS IS7626A patent/IS7626A/is unknown
- 2005-08-16 HK HK05107074A patent/HK1074779A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AR039714A1 (es) | 2005-03-09 |
CA2490684A1 (en) | 2003-12-31 |
TW200407114A (en) | 2004-05-16 |
IL165670A0 (en) | 2006-01-15 |
CN1674883A (zh) | 2005-09-28 |
AU2003240100A1 (en) | 2004-01-06 |
NO20045223L (no) | 2005-03-17 |
UA76627C2 (en) | 2006-08-15 |
DE60319082T2 (de) | 2009-01-29 |
HK1074779A1 (en) | 2005-11-25 |
DK1517679T3 (da) | 2008-05-19 |
JP2005535618A (ja) | 2005-11-24 |
NZ536971A (en) | 2006-05-26 |
RU2288912C2 (ru) | 2006-12-10 |
PL375080A1 (en) | 2005-11-14 |
BR0311839A (pt) | 2005-04-05 |
KR20050014015A (ko) | 2005-02-05 |
EP1517679B1 (en) | 2008-02-13 |
IS7626A (is) | 2005-01-05 |
ES2299703T3 (es) | 2008-06-01 |
RU2004135543A (ru) | 2005-08-10 |
ATE385790T1 (de) | 2008-03-15 |
EP1517679A1 (en) | 2005-03-30 |
ZA200409693B (en) | 2005-10-11 |
DE60319082D1 (de) | 2008-03-27 |
CN1307988C (zh) | 2007-04-04 |
MXPA04012685A (es) | 2005-03-23 |
PT1517679E (pt) | 2008-04-21 |
AU2003240100B2 (en) | 2006-06-01 |
WO2004000294A1 (en) | 2003-12-31 |
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