SE0100326D0 - New compounds - Google Patents

New compounds

Info

Publication number
SE0100326D0
SE0100326D0 SE0100326A SE0100326A SE0100326D0 SE 0100326 D0 SE0100326 D0 SE 0100326D0 SE 0100326 A SE0100326 A SE 0100326A SE 0100326 A SE0100326 A SE 0100326A SE 0100326 D0 SE0100326 D0 SE 0100326D0
Authority
SE
Sweden
Prior art keywords
sup
new compounds
arrhythmias
prophylaxis
useful
Prior art date
Application number
SE0100326A
Other languages
English (en)
Swedish (sv)
Inventor
Magnus Bjoersne
Fritiof Ponten
Gert Strandlund
Peder Svensson
Michael Wilstermann
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0100326A priority Critical patent/SE0100326D0/xx
Publication of SE0100326D0 publication Critical patent/SE0100326D0/xx
Priority to ARP020100275A priority patent/AR035423A1/es
Priority to MXPA03006579A priority patent/MXPA03006579A/es
Priority to US10/467,043 priority patent/US7144914B2/en
Priority to DE60204755T priority patent/DE60204755T2/de
Priority to KR10-2003-7010119A priority patent/KR20030074764A/ko
Priority to BR0206791-9A priority patent/BR0206791A/pt
Priority to PL02363454A priority patent/PL363454A1/xx
Priority to AT02716531T priority patent/ATE298339T1/de
Priority to ES02716531T priority patent/ES2243706T3/es
Priority to SI200230173T priority patent/SI1360187T1/xx
Priority to HK04106414.1A priority patent/HK1063629B/xx
Priority to IL15673402A priority patent/IL156734A0/xx
Priority to CNB028044126A priority patent/CN1263758C/zh
Priority to EEP200300364A priority patent/EE200300364A/xx
Priority to PT02716531T priority patent/PT1360187E/pt
Priority to EP02716531A priority patent/EP1360187B1/en
Priority to CA002434970A priority patent/CA2434970A1/en
Priority to CNA2006100847244A priority patent/CN1854138A/zh
Priority to RU2003121308/04A priority patent/RU2293085C2/ru
Priority to DK02716531T priority patent/DK1360187T3/da
Priority to PCT/SE2002/000152 priority patent/WO2002060902A1/en
Priority to CZ20032061A priority patent/CZ20032061A3/cs
Priority to UA2003076389A priority patent/UA75382C2/uk
Priority to SK970-2003A priority patent/SK9702003A3/sk
Priority to HU0302538A priority patent/HUP0302538A3/hu
Priority to NZ526992A priority patent/NZ526992A/en
Priority to JP2002561470A priority patent/JP2004522749A/ja
Priority to MYPI20020360A priority patent/MY136788A/en
Priority to ZA200305345A priority patent/ZA200305345B/en
Priority to IS6874A priority patent/IS6874A/is
Priority to BG108035A priority patent/BG108035A/bg
Priority to NO20033434A priority patent/NO20033434L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE0100326A 2001-02-02 2001-02-02 New compounds SE0100326D0 (sv)

Priority Applications (33)

Application Number Priority Date Filing Date Title
SE0100326A SE0100326D0 (sv) 2001-02-02 2001-02-02 New compounds
ARP020100275A AR035423A1 (es) 2001-02-02 2002-01-25 3,7-diazabiciclo (3.3.0) octanos, formulacion farmaceutica, uso de estos compuestos para la manufactura de medicamentos para ser usados en la profilaxis o el tratamiento de arritmias, procedimiento para la preparacion de estos compuestos, e intermediarios.
JP2002561470A JP2004522749A (ja) 2001-02-02 2002-01-29 ３，７−ジアザビシクロ［３．３．０］オクタンと心不整脈の治療におけるその使用
EEP200300364A EE200300364A (et) 2001-02-02 2002-01-29 3,7-diasabitsüklo[3,3,0]oktaanid ja nende kasutamine südame arütmiate ravis
CA002434970A CA2434970A1 (en) 2001-02-02 2002-01-29 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias
DE60204755T DE60204755T2 (de) 2001-02-02 2002-01-29 "3,7-diazabicyclo(3.3.0)octane und deren verwendung bei der behandlung von herzrhythmusstörungen"
KR10-2003-7010119A KR20030074764A (ko) 2001-02-02 2002-01-29 심부정맥의 치료용 3,7-디아자비시클로[3.3.0]옥탄 화합물, 이를 포함하는 약학 조성물 및 이의 제조방법
BR0206791-9A BR0206791A (pt) 2001-02-02 2002-01-29 Composto, formulação farmacêutica, uso de um composto, método de profilaxia ou tratamento de uma arritmia, e, processo para a preparação de um composto
PL02363454A PL363454A1 (en) 2001-02-02 2002-01-29 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias
AT02716531T ATE298339T1 (de) 2001-02-02 2002-01-29 ß3,7-DIAZABICYCLO(3.3.0)OCTANE UND DEREN VERWENDUNG BEI DER BEHANDLUNG VON HERZRHYTHMUSSTÖRUNGENß
ES02716531T ES2243706T3 (es) 2001-02-02 2002-01-29 3,7-diazabiciclo(3.3.0)octanos y su uso en el tratamiento de arritmias cardiacas.
SI200230173T SI1360187T1 (en) 2001-02-02 2002-01-29 3,7-diazabicyclo(3.3.0)octanes and their use in the treatment of cardiac arrhythmias
HK04106414.1A HK1063629B (zh) 2001-02-02 2002-01-29 3，7-二氮杂双环[3‧3‧0]辛烷及其在治疗心脏心律失常中的用途
IL15673402A IL156734A0 (en) 2001-02-02 2002-01-29 3,7-diazabicyclo[3.3.0] octanes and their use in the treatment of cardiac arrhythmias
CNB028044126A CN1263758C (zh) 2001-02-02 2002-01-29 3，7－二氮杂双环[3.3.0]辛烷及其在治疗心脏心律失常中的用途
MXPA03006579A MXPA03006579A (es) 2001-02-02 2002-01-29 3,7-diazabiciclo[3.3.0]octanos y su utilizacion en el tratamiento de arritmias cardiacas.
PT02716531T PT1360187E (pt) 2001-02-02 2002-01-29 3,7-diazabiciclo(3.3.0)octanos e a sua utilizacao no tratamento de arritmias cardiacas
EP02716531A EP1360187B1 (en) 2001-02-02 2002-01-29 3,7-diazabicyclo(3.3.0)octanes and their use in the treatment of cardiac arrhythmias
US10/467,043 US7144914B2 (en) 2001-02-02 2002-01-29 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias
CNA2006100847244A CN1854138A (zh) 2001-02-02 2002-01-29 3,7－二氮杂双环[3.3.0]辛烷及其在治疗心脏心律失常中的用途
RU2003121308/04A RU2293085C2 (ru) 2001-02-02 2002-01-29 3,7-диазабицикло[3.3.0]октаны и их применение при лечении сердечных аритмий
DK02716531T DK1360187T3 (da) 2001-02-02 2002-01-29 3,7-diazabicyclo[3.3.0]octaner og deres anvendelse til behandling af arrhythmia cardiac
PCT/SE2002/000152 WO2002060902A1 (en) 2001-02-02 2002-01-29 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias
CZ20032061A CZ20032061A3 (cs) 2001-02-02 2002-01-29 3,7-Diazabicyklo[3.3.0]oktany a jejich použití k léčení srdečních arytmií
UA2003076389A UA75382C2 (en) 2001-02-02 2002-01-29 3,7-diazodicyclo[3.3.0]octanes and use thereof in the treatment of cardiac arrhythmias
SK970-2003A SK9702003A3 (en) 2001-02-02 2002-01-29 3,7-Diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias
HU0302538A HUP0302538A3 (en) 2001-02-02 2002-01-29 3,7-diazabicyclo[3.3.0]oczanes and their use in the treatment of cardiac arrhythmias, process for their preparation and pharmaceutical compositions containing them
NZ526992A NZ526992A (en) 2001-02-02 2002-01-29 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias
MYPI20020360A MY136788A (en) 2001-02-02 2002-01-31 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment or cardiac arrhythmias
ZA200305345A ZA200305345B (en) 2001-02-02 2003-07-10 3,7-Diazabicyclo(3.3.0)octanes and their use in the treatment of cardiac arrhythmias.
IS6874A IS6874A (is) 2001-02-02 2003-07-11 3,7-díasabísýkló[3.3.0]oktön og notkun þeirra í meðhöndlun á hjartsláttarglöpum
BG108035A BG108035A (bg) 2001-02-02 2003-07-28 3,7-диазабицикло[3.3.0] октани и тяхното използване при лечение на сърдечни аритмии
NO20033434A NO20033434L (no) 2001-02-02 2003-08-01 3,7-diazabicyklo(3.3.0)oktaner og anvendelse derav ved behandling av hjertearrytmier

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0100326A SE0100326D0 (sv) 2001-02-02 2001-02-02 New compounds

Publications (1)

Publication Number Publication Date
SE0100326D0 true SE0100326D0 (sv) 2001-02-02

Family

ID=20282824

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0100326A SE0100326D0 (sv) 2001-02-02 2001-02-02 New compounds

Country Status (29)

Country Link
US (1) US7144914B2 (cs)
EP (1) EP1360187B1 (cs)
JP (1) JP2004522749A (cs)
KR (1) KR20030074764A (cs)
CN (2) CN1854138A (cs)
AR (1) AR035423A1 (cs)
AT (1) ATE298339T1 (cs)
BG (1) BG108035A (cs)
BR (1) BR0206791A (cs)
CA (1) CA2434970A1 (cs)
CZ (1) CZ20032061A3 (cs)
DE (1) DE60204755T2 (cs)
EE (1) EE200300364A (cs)
ES (1) ES2243706T3 (cs)
HU (1) HUP0302538A3 (cs)
IL (1) IL156734A0 (cs)
IS (1) IS6874A (cs)
MX (1) MXPA03006579A (cs)
MY (1) MY136788A (cs)
NO (1) NO20033434L (cs)
NZ (1) NZ526992A (cs)
PL (1) PL363454A1 (cs)
PT (1) PT1360187E (cs)
RU (1) RU2293085C2 (cs)
SE (1) SE0100326D0 (cs)
SK (1) SK9702003A3 (cs)
UA (1) UA75382C2 (cs)
WO (1) WO2002060902A1 (cs)
ZA (1) ZA200305345B (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070523A1 (en) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
PL1761542T3 (pl) * 2004-06-09 2008-06-30 Hoffmann La Roche Pochodne oktahydropirolo[3,4-c]pirolu i ich zastosowanie jako środków przeciwwirusowych
US7665658B2 (en) 2005-06-07 2010-02-23 First Data Corporation Dynamic aggregation of payment transactions
GB0514018D0 (en) * 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
US8653263B2 (en) 2009-10-23 2014-02-18 Janssen Pharmaceutica Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
CN102718695B (zh) * 2012-06-25 2014-04-02 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
MX379228B (es) 2013-03-15 2025-03-10 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulación de la hemoglobina.
CA2917050A1 (en) * 2013-07-03 2015-01-08 Todd K. Jones Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
SG11201807597UA (en) 2016-03-10 2018-10-30 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
KR20190015492A (ko) 2016-06-08 2019-02-13 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 화학적 화합물
US11014927B2 (en) 2017-03-20 2021-05-25 Forma Therapeutics, Inc. Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
EP3853206B1 (en) 2018-09-19 2024-04-10 Novo Nordisk Health Care AG Treating sickle cell disease with a pyruvate kinase r activating compound
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
CN114650817A (zh) 2019-09-19 2022-06-21 福马治疗股份有限公司 激活丙酮酸激酶r
RU2726120C1 (ru) * 2019-09-24 2020-07-09 Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук N-алкил-n-{ [3-алкил-3,8-диазабицикло[3.2.1]окта-1(7),5-диен-8-ил]метил} амины, обладающие цитотоксической активностью в отношении клеточной линии нек 293
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU482990A1 (ru) * 1973-09-03 1978-04-15 Предприятие П/Я Г-4059 Способ получени 1,4-диазабицикло(2,2,2)-октана
DE2428792A1 (de) * 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
PT88381B (pt) 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
DE3930266A1 (de) * 1989-09-11 1991-03-14 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
DE4338396A1 (de) 1993-11-10 1995-05-11 Basf Ag N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4341403A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
DE4402931A1 (de) 1994-02-01 1995-08-03 Kali Chemie Pharma Gmbh Neue 3-Phenylsulfonyl-3,7-diazabicyclo[3,3,1] nonan-Verbindungen enthaltende Arzneimittel
US5457121A (en) 1994-09-02 1995-10-10 Eli Lilly And Company Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
EP0728758B1 (de) * 1995-02-27 2003-10-15 F. Hoffmann-La Roche Ag Dioxopyrrolo-pyrrolderivate
WO1996035691A1 (en) 1995-05-11 1996-11-14 Pharmacia & Upjohn Company Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
WO1996039407A1 (en) * 1995-06-06 1996-12-12 Abbott Laboratories Quinolizinone type compounds
PT1019385E (pt) 1995-09-15 2004-06-30 Upjohn Co N-oxidos de aminoaril-oxazolidinona
GB9519563D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
AU4053497A (en) 1996-08-13 1998-03-06 Merck & Co., Inc. Palladium catalyzed indolization
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
SE9704709D0 (sv) 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
US6355641B1 (en) * 1999-03-17 2002-03-12 Syntex (U.S.A.) Llc Oxazolone derivatives and uses thereof
RU2160738C2 (ru) * 1999-03-29 2000-12-20 ООО Научно-производственное предприятие "Новые технологии" Способ получения 1,4-диазобицикло [2,2,2]октана
DE19932621A1 (de) * 1999-07-13 2001-04-26 Bayer Ag Neue substituerte alpha, beta-anellierte Butyrolactone
MY137020A (en) * 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
EP1339708A2 (en) * 2000-11-20 2003-09-03 Scios Inc. Indole-type inhibitors of p38 kinase

Also Published As

Publication number Publication date
EP1360187B1 (en) 2005-06-22
US20040053986A1 (en) 2004-03-18
NO20033434L (no) 2003-09-23
MY136788A (en) 2008-11-28
HK1063629A1 (en) 2005-01-07
EP1360187A1 (en) 2003-11-12
CN1263758C (zh) 2006-07-12
US7144914B2 (en) 2006-12-05
AR035423A1 (es) 2004-05-26
EE200300364A (et) 2003-10-15
CA2434970A1 (en) 2002-08-08
DE60204755D1 (de) 2005-07-28
HUP0302538A3 (en) 2006-05-29
NO20033434D0 (no) 2003-08-01
BG108035A (bg) 2003-07-28
UA75382C2 (en) 2006-04-17
RU2293085C2 (ru) 2007-02-10
NZ526992A (en) 2005-01-28
ES2243706T3 (es) 2005-12-01
RU2003121308A (ru) 2005-03-10
BR0206791A (pt) 2004-01-27
HUP0302538A2 (hu) 2003-11-28
PT1360187E (pt) 2005-10-31
SK9702003A3 (en) 2004-01-08
PL363454A1 (en) 2004-11-15
ZA200305345B (en) 2004-10-11
DE60204755T2 (de) 2006-05-18
ATE298339T1 (de) 2005-07-15
KR20030074764A (ko) 2003-09-19
IL156734A0 (en) 2004-02-08
IS6874A (is) 2004-07-11
CN1854138A (zh) 2006-11-01
MXPA03006579A (es) 2003-09-22
CN1489592A (zh) 2004-04-14
CZ20032061A3 (cs) 2003-10-15
WO2002060902A1 (en) 2002-08-08
JP2004522749A (ja) 2004-07-29

Similar Documents

Publication Publication Date Title
SE0100326D0 (sv) New compounds
SE9704709D0 (sv) Pharmaceutically active compounds
AP1536A (en) New oxabispidine compounds useful in the treatment of cardiac arrhythmias.
ECSP044992A (es) Inhibidores de la alquín-aril fosfodiesterasa-4
CY1107427T1 (el) Αμιδια ανθρανιλικου οξεος με ετεροαρυλοσουλφονικη πλευρικη αλυσιδα και η χρηση τους ως αντιαρρυθμιστικες δραστικες ουσιες
DE60012188D1 (de) Fungizide
BR0114045A (pt) Poliarilcarboxamidas úteis como agentes redutores de lipìdeos
SE0004245D0 (sv) Novel compounds and their use
EA200300836A1 (ru) Производные фталазинон-пиперидина в качестве ингибиторов pde4
MY133785A (en) Azabicyclooctane derivatives useful in the treatment of cardiac arrhythmias
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
EP1667976A4 (en) Isoquinolinone POTASSIUM CHANNEL INHIBITORS
SE0003795D0 (sv) Pharmaceutically useful compounds
ATE263160T1 (de) Tocotrienolchinon- zyklisierungsprodukte mit antihypercholesterin wirkung
NO20031414L (no) Ny oksabispidinforbindelse som er nyttig i behandlingen av hjertearrytmier
BR0012751A (pt) Benzofuranos serotonérgicos
SE0401540D0 (sv) New compounds
SE0002603D0 (sv) New compounds
SE9902268D0 (sv) Pharmaceutically active compounds
WO2002074735A3 (de) Biurethanderivate
SE9902270D0 (sv) Pharmaceutically active compounds
SE0302035D0 (sv) New compound
SE9902269D0 (sv) Pharmaceutically active compounds
TR200103660T2 (tr) Kardiyak aritmaların tedavisinde faydalı yeni bispidin bileşikleri
SE9901530D0 (sv) Novel compounds