IL156734A0 - 3,7-diazabicyclo[3.3.0] octanes and their use in the treatment of cardiac arrhythmias - Google Patents
3,7-diazabicyclo[3.3.0] octanes and their use in the treatment of cardiac arrhythmiasInfo
- Publication number
- IL156734A0 IL156734A0 IL15673402A IL15673402A IL156734A0 IL 156734 A0 IL156734 A0 IL 156734A0 IL 15673402 A IL15673402 A IL 15673402A IL 15673402 A IL15673402 A IL 15673402A IL 156734 A0 IL156734 A0 IL 156734A0
- Authority
- IL
- Israel
- Prior art keywords
- octanes
- diazabicyclo
- treatment
- cardiac arrhythmias
- arrhythmias
- Prior art date
Links
- QFCMBRXRVQRSSF-UHFFFAOYSA-N 1,2,3,3a,4,5,6,6a-octahydropyrrolo[3,4-c]pyrrole Chemical class C1NCC2CNCC21 QFCMBRXRVQRSSF-UHFFFAOYSA-N 0.000 title 1
- 206010003119 arrhythmia Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100326A SE0100326D0 (sv) | 2001-02-02 | 2001-02-02 | New compounds |
| PCT/SE2002/000152 WO2002060902A1 (en) | 2001-02-02 | 2002-01-29 | 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL156734A0 true IL156734A0 (en) | 2004-02-08 |
Family
ID=20282824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15673402A IL156734A0 (en) | 2001-02-02 | 2002-01-29 | 3,7-diazabicyclo[3.3.0] octanes and their use in the treatment of cardiac arrhythmias |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7144914B2 (cs) |
| EP (1) | EP1360187B1 (cs) |
| JP (1) | JP2004522749A (cs) |
| KR (1) | KR20030074764A (cs) |
| CN (2) | CN1854138A (cs) |
| AR (1) | AR035423A1 (cs) |
| AT (1) | ATE298339T1 (cs) |
| BG (1) | BG108035A (cs) |
| BR (1) | BR0206791A (cs) |
| CA (1) | CA2434970A1 (cs) |
| CZ (1) | CZ20032061A3 (cs) |
| DE (1) | DE60204755T2 (cs) |
| EE (1) | EE200300364A (cs) |
| ES (1) | ES2243706T3 (cs) |
| HU (1) | HUP0302538A3 (cs) |
| IL (1) | IL156734A0 (cs) |
| IS (1) | IS6874A (cs) |
| MX (1) | MXPA03006579A (cs) |
| MY (1) | MY136788A (cs) |
| NO (1) | NO20033434L (cs) |
| NZ (1) | NZ526992A (cs) |
| PL (1) | PL363454A1 (cs) |
| PT (1) | PT1360187E (cs) |
| RU (1) | RU2293085C2 (cs) |
| SE (1) | SE0100326D0 (cs) |
| SK (1) | SK9702003A3 (cs) |
| UA (1) | UA75382C2 (cs) |
| WO (1) | WO2002060902A1 (cs) |
| ZA (1) | ZA200305345B (cs) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002070523A1 (en) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| PL1761542T3 (pl) * | 2004-06-09 | 2008-06-30 | Hoffmann La Roche | Pochodne oktahydropirolo[3,4-c]pirolu i ich zastosowanie jako środków przeciwwirusowych |
| US7665658B2 (en) | 2005-06-07 | 2010-02-23 | First Data Corporation | Dynamic aggregation of payment transactions |
| GB0514018D0 (en) * | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| US8653263B2 (en) | 2009-10-23 | 2014-02-18 | Janssen Pharmaceutica | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| CN102718695B (zh) * | 2012-06-25 | 2014-04-02 | 华东师范大学 | 一种氮杂双环[3.3.0]辛烷衍生物的合成方法 |
| MX379228B (es) | 2013-03-15 | 2025-03-10 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulación de la hemoglobina. |
| CA2917050A1 (en) * | 2013-07-03 | 2015-01-08 | Todd K. Jones | Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| SG11201807597UA (en) | 2016-03-10 | 2018-10-30 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
| KR20190015492A (ko) | 2016-06-08 | 2019-02-13 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 화학적 화합물 |
| US11014927B2 (en) | 2017-03-20 | 2021-05-25 | Forma Therapeutics, Inc. | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators |
| EP3853206B1 (en) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| CN114650817A (zh) | 2019-09-19 | 2022-06-21 | 福马治疗股份有限公司 | 激活丙酮酸激酶r |
| RU2726120C1 (ru) * | 2019-09-24 | 2020-07-09 | Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук | N-алкил-n-{ [3-алкил-3,8-диазабицикло[3.2.1]окта-1(7),5-диен-8-ил]метил} амины, обладающие цитотоксической активностью в отношении клеточной линии нек 293 |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU482990A1 (ru) * | 1973-09-03 | 1978-04-15 | Предприятие П/Я Г-4059 | Способ получени 1,4-диазабицикло(2,2,2)-октана |
| DE2428792A1 (de) * | 1974-06-14 | 1976-01-02 | Knoll Ag | Neue antiarrhythmika |
| DE3112055A1 (de) * | 1981-03-27 | 1982-10-07 | Basf Ag, 6700 Ludwigshafen | Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel |
| DE3234697A1 (de) * | 1982-09-18 | 1984-03-22 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Neue diazabicyclo-(3,3,1)-nonane |
| PT88381B (pt) | 1987-09-09 | 1995-07-06 | Kali Chemie Pharma Gmbh | Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos |
| DE3732094A1 (de) | 1987-09-24 | 1989-04-06 | Basf Ag | Bispidinderivate als klasse iii-antiarrhythmika |
| DE3930266A1 (de) * | 1989-09-11 | 1991-03-14 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US5110933A (en) | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
| US5468858A (en) * | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
| DE4338396A1 (de) | 1993-11-10 | 1995-05-11 | Basf Ag | N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| DE4341403A1 (de) | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| DE4402931A1 (de) | 1994-02-01 | 1995-08-03 | Kali Chemie Pharma Gmbh | Neue 3-Phenylsulfonyl-3,7-diazabicyclo[3,3,1] nonan-Verbindungen enthaltende Arzneimittel |
| US5457121A (en) | 1994-09-02 | 1995-10-10 | Eli Lilly And Company | Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake |
| EP0728758B1 (de) * | 1995-02-27 | 2003-10-15 | F. Hoffmann-La Roche Ag | Dioxopyrrolo-pyrrolderivate |
| WO1996035691A1 (en) | 1995-05-11 | 1996-11-14 | Pharmacia & Upjohn Company | Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones |
| WO1996039407A1 (en) * | 1995-06-06 | 1996-12-12 | Abbott Laboratories | Quinolizinone type compounds |
| PT1019385E (pt) | 1995-09-15 | 2004-06-30 | Upjohn Co | N-oxidos de aminoaril-oxazolidinona |
| GB9519563D0 (en) * | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
| AU4053497A (en) | 1996-08-13 | 1998-03-06 | Merck & Co., Inc. | Palladium catalyzed indolization |
| US5808064A (en) * | 1996-08-13 | 1998-09-15 | Merck & Co., Inc. | Palladium catalyzed indolization |
| SE9704709D0 (sv) | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
| US6355641B1 (en) * | 1999-03-17 | 2002-03-12 | Syntex (U.S.A.) Llc | Oxazolone derivatives and uses thereof |
| RU2160738C2 (ru) * | 1999-03-29 | 2000-12-20 | ООО Научно-производственное предприятие "Новые технологии" | Способ получения 1,4-диазобицикло [2,2,2]октана |
| DE19932621A1 (de) * | 1999-07-13 | 2001-04-26 | Bayer Ag | Neue substituerte alpha, beta-anellierte Butyrolactone |
| MY137020A (en) * | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
| EP1339708A2 (en) * | 2000-11-20 | 2003-09-03 | Scios Inc. | Indole-type inhibitors of p38 kinase |
-
2001
- 2001-02-02 SE SE0100326A patent/SE0100326D0/xx unknown
-
2002
- 2002-01-25 AR ARP020100275A patent/AR035423A1/es not_active Application Discontinuation
- 2002-01-29 KR KR10-2003-7010119A patent/KR20030074764A/ko not_active Ceased
- 2002-01-29 PL PL02363454A patent/PL363454A1/xx not_active Application Discontinuation
- 2002-01-29 BR BR0206791-9A patent/BR0206791A/pt not_active IP Right Cessation
- 2002-01-29 HU HU0302538A patent/HUP0302538A3/hu unknown
- 2002-01-29 SK SK970-2003A patent/SK9702003A3/sk unknown
- 2002-01-29 CN CNA2006100847244A patent/CN1854138A/zh active Pending
- 2002-01-29 IL IL15673402A patent/IL156734A0/xx unknown
- 2002-01-29 JP JP2002561470A patent/JP2004522749A/ja active Pending
- 2002-01-29 ES ES02716531T patent/ES2243706T3/es not_active Expired - Lifetime
- 2002-01-29 EP EP02716531A patent/EP1360187B1/en not_active Expired - Lifetime
- 2002-01-29 PT PT02716531T patent/PT1360187E/pt unknown
- 2002-01-29 EE EEP200300364A patent/EE200300364A/xx unknown
- 2002-01-29 MX MXPA03006579A patent/MXPA03006579A/es active IP Right Grant
- 2002-01-29 UA UA2003076389A patent/UA75382C2/uk unknown
- 2002-01-29 CN CNB028044126A patent/CN1263758C/zh not_active Expired - Fee Related
- 2002-01-29 NZ NZ526992A patent/NZ526992A/en unknown
- 2002-01-29 AT AT02716531T patent/ATE298339T1/de not_active IP Right Cessation
- 2002-01-29 CZ CZ20032061A patent/CZ20032061A3/cs unknown
- 2002-01-29 CA CA002434970A patent/CA2434970A1/en not_active Abandoned
- 2002-01-29 US US10/467,043 patent/US7144914B2/en not_active Expired - Fee Related
- 2002-01-29 RU RU2003121308/04A patent/RU2293085C2/ru not_active IP Right Cessation
- 2002-01-29 DE DE60204755T patent/DE60204755T2/de not_active Expired - Fee Related
- 2002-01-29 WO PCT/SE2002/000152 patent/WO2002060902A1/en not_active Ceased
- 2002-01-31 MY MYPI20020360A patent/MY136788A/en unknown
-
2003
- 2003-07-10 ZA ZA200305345A patent/ZA200305345B/en unknown
- 2003-07-11 IS IS6874A patent/IS6874A/is unknown
- 2003-07-28 BG BG108035A patent/BG108035A/bg unknown
- 2003-08-01 NO NO20033434A patent/NO20033434L/no not_active Application Discontinuation
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